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Stem Cell Implants for Cancer Therapy: TRAIL-Expressing Mesenchymal Stem Cells Target Cancer Cells In Situ 원문보기

Journal of breast cancer= 한국유방암학회지, v.15 no.3, 2012년, pp.273 - 282  

Reagan, Michaela R. (Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, USA.) ,  Seib, F. Philipp (Department of Biomedical Engineering, Tufts University, Medford, USA.) ,  McMillin, Douglas W. (Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, USA.) ,  Sage, Elizabeth K. (Centre for Respiratory Research, University College London, London, UK.) ,  Mitsiades, Constantine S. (Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, USA.) ,  Janes, Sam M. (Centre for Respiratory Research, University College London, London, UK.) ,  Ghobrial, Irene M. (Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, USA.) ,  Kaplan, David L. (Department of Biomedical Engineering, Tufts University, Medford, USA.)

Abstract AI-Helper 아이콘AI-Helper

PurposeTumor-specific delivery of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), an apoptosis-inducing peptide, at effective doses remains challenging. Herein we demonstrate the utility of a scaffold-based delivery system for sustained therapeutic cell release that capitalizes on t...

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참고문헌 (24)

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  7. 7 El-Deiry WS Death Receptors in Cancer Therapy 2005 Totowa Humana Press 374 

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  10. 10 Dörr J Bechmann I Waiczies S Aktas O Walczak H Krammer PH Lack of tumor necrosis factor-related apoptosis-inducing ligand but presence of its receptors in the human brain J Neurosci 2002 22 RC209 11844843 

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  12. 12 Wang Y Rudym DD Walsh A Abrahamsen L Kim HJ Kim HS In vivo degradation of three-dimensional silk fibroin scaffolds Biomaterials 2008 29 3415 3428 18502501 

  13. 13 Zhao X Kim J Cezar CA Huebsch N Lee K Bouhadir K Active scaffolds for on-demand drug and cell delivery Proc Natl Acad Sci USA 2011 108 67 72 21149682 

  14. 14 Ali OA Huebsch N Cao L Dranoff G Mooney DJ Infection-mimicking materials to program dendritic cells in situ Nat Mater 2009 8 151 158 19136947 

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  16. 16 Moreau JE Anderson K Mauney JR Nguyen T Kaplan DL Rosenblatt M Tissue-engineered bone serves as a target for metastasis of human breast cancer in a mouse model Cancer Res 2007 67 10304 10308 17974972 

  17. 17 McMillin DW Delmore J Weisberg E Negri JM Geer DC Klippel S Tumor cell-specific bioluminescence platform to identify stroma-induced changes to anticancer drug activity Nat Med 2010 16 483 489 20228816 

  18. 18 Bhardwaj N Nguyen QT Chen AC Kaplan DL Sah RL Kundu SC Potential of 3-D tissue constructs engineered from bovine chondrocytes/silk fibroin-chitosan for in vitro cartilage tissue engineering Biomaterials 2011 32 5773 5781 21601277 

  19. 19 Lü K Xu L Xia L Zhang Y Zhang X Kaplan DL An ectopic study of apatite-coated silk fibroin scaffolds seeded with AdBMP-2-modified canine bMSCs J Biomater Sci Polym Ed 2012 23 509 526 21294971 

  20. 20 Wang H Cao F De A Cao Y Contag C Gambhir SS Trafficking mesenchymal stem cell engraftment and differentiation in tumor-bearing mice by bioluminescence imaging Stem Cells 2009 27 1548 1558 19544460 

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  22. 22 Lee RH Pulin AA Seo MJ Kota DJ Ylostalo J Larson BL Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6 Cell Stem Cell 2009 5 54 63 19570514 

  23. 23 Roodhart JM Daenen LG Stigter EC Prins HJ Gerrits J Houthuijzen JM Mesenchymal stem cells induce resistance to chemotherapy through the release of platinum-induced fatty acids Cancer Cell 2011 20 370 383 21907927 

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