[논문]The Impact of Fentanyl Matrix on Pain and Function in Spinal Disorder-Related Chronic Pain: An Open Label Trial in Korea

Lee, Jae Hyup; Yun, Sung-Cheol; Lee, Jung-Gil; Choi, Kyoung Hyo; Kim, Dong-Soo; Chung, Kook-Jin; Park, Ye-Soo; Eoh, Whan

doi:10.4184/asj.2011.5.2.91

The Impact of Fentanyl Matrix on Pain and Function in Spinal Disorder-Related Chronic Pain: An Open Label Trial in Korea 원문보기

Asian spine journal : Official Journal of Korean Society of Spine Surgery, v.5 no.2, 2011년, pp.91 - 99

Lee, Jae Hyup (Department of Orthopedic Surgery, Institute of Medical and Biological Engineering, Seoul National University Medical Research Center, SMG-SNU Boramae Medical Center, Seoul National University College of Medicine, Seoul, Korea.) , Yun, Sung-Cheol (Department of Preventive Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.) , Lee, Jung-Gil (Department of Neurosurgery, Chonnam National University Medical School, Gwangju, Korea.) , Choi, Kyoung Hyo (Department of Rehabilitation Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.) , Kim, Dong-Soo (Department of Orthopedic Surgery, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Korea.) , Chung, Kook-Jin (Department of Orthopedic Surgery, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.) , Park, Ye-Soo (Department of Orthopedic Surgery, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea.) , Eoh, Whan (Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan U)

Abstract ▼ AI-Helper

Study DesignThis is a multicenter, open-label prospective, non interventional study.PurposeWe wanted to evaluate the impact of fentanyl matrix on the pain and function of patients with spinal disorder-related chronic, non-malignant pain.Overview of LiteraturePatients with severe non-malignant chronic low back pain may require opioid analgesics for effective pain management.MethodsA total of 1,576 patients with severe pain (numeric rating scale = 7) were evaluated for their pain intensity at the initial visit and at weeks 4 and 8 (Visits 1, 2, and 3, respectively). Disturbances in sleep, daily living and social activities, the Oswestry Disability Index (ODI), the researchers' and patients' global assessment and the patients' treatment preference were also assessed.ResultsThe pain intensity score significantly decreased from 8.1 at Visit 1 to 5.4 and 4.4 at Visits 2 and 3, respectively. Sleep disturbance also significantly decreased and the extent of disturbance of daily and social activities was also significantly improved. The ODI significantly decreased from 61.9% to 45.8% and 38.2% at Visits 1, 2, and 3, respectively. Adverse events were reported by 197 (12.5%) patients and severe adverse events were reported by 12 (0.76%) patients. Overall, 76.3% of the patients and 78.4% of the investigators rated the test drug as effective.ConclusionsThe fentanyl matrix is believed to be effective for the treatment of pain, sleep disturbance and the impact upon daily and social activities, yet physicians should pay attention to the risks of abuse and the adverse events.

주제어

참고문헌 (18)

1 Cherkin DC Wheeler KJ Barlow W Deyo RA Medication use for low back pain in primary care Spine (Phila Pa 1976) 1998 23 607 614 9530793
2 Yang JY The pathogenesis and medical treatment of spondylogenic pain Asian Spine J 2010 4 57 63 20622957
3 Woolf CJ Recent advances in the pathophysiology of acute pain Br J Anaesth 1989 63 139 146 2669905

상세보기
4 Portenoy RK Opioid therapy for chronic nonmalignant pain: a review of the critical issues J Pain Symptom Manage 1996 11 203 217 8869456
5 Arkinstall W Sandler A Goughnour B Babul N Harsanyi Z Darke AC Efficacy of controlled-release codeine in chronic non-malignant pain: a randomized, placebo-controlled clinical trial Pain 1995 62 169 178 8545142

상세보기
6 Moulin DE Iezzi A Amireh R Sharpe WK Boyd D Merskey H Randomised trial of oral morphine for chronic non-cancer pain Lancet 1996 347 143 147 8544547
7 Watson CP Babul N Efficacy of oxycodone in neuropathic pain: a randomized trial in postherpetic neuralgia Neurology 1998 50 1837 1841 9633737

상세보기
8 Simpson RK Jr Edmondson EA Constant CF Collier C Transdermal fentanyl as treatment for chronic low back pain J Pain Symptom Manage 1997 14 218 224 9379069
9 Jeal W Benfield P Transdermal fentanyl: a review of its pharmacological properties and therapeutic efficacy in pain control Drugs 1997 53 109 138 9010652
10 Ringe JD Faber H Bock O Transdermal fentanyl for the treatment of back pain caused by vertebral osteoporosis Rheumatol Int 2002 22 199 203 12215866

상세보기
11 Langford R McKenna F Ratcliffe S Vojtassák J Richarz U Transdermal fentanyl for improvement of pain and functioning in osteoarthritis: a randomized, placebo-controlled trial Arthritis Rheum 2006 54 1829 1837 16729276
12 Dellemijn PL Vanneste JA Randomised double-blind active-placebo-controlled crossover trial of intravenous fentanyl in neuropathic pain Lancet 1997 349 753 758 9074573
13 Herrero-Beaumont G Bjorneboe O Richarz U Transdermal fentanyl for the treatment of pain caused by rheumatoid arthritis Rheumatol Int 2004 24 325 332 15480678

상세보기
14 Milligan K Lanteri-Minet M Borchert K Evaluation of long-term efficacy and safety of transdermal fentanyl in the treatment of chronic noncancer pain J Pain 2001 2 197 204 14622817

상세보기
15 Stumpf M Bornhöovd K Treatment-initiation with transdermal fentanyl 12.5 µg/h compared to transdermal fentanyl >= 25 µg/h (Durogesic® SMAT) in patients with chronic non-malignant pain 2006 5th Congress of the European Federation of IASP Chapters 2006 Sep 13-16 Istanbul, Turkey Amsterdam Elsevier
16 Donner B Zenz M Tryba M Strumpf M Direct conversion from oral morphine to transdermal fentanyl: a multicenter study in patients with cancer pain Pain 1996 64 527 534 8783318

상세보기
17 Clark AJ Ahmedzai SH Allan LG Efficacy and safety of transdermal fentanyl and sustained-release oral morphine in patients with cancer and chronic non-cancer pain Curr Med Res Opin 2004 20 1419 1428 15383190

상세보기
18 Choquette D McCarthy TG Rodrigues JF Transdermal fentanyl improves pain control and functionality in patients with osteoarthritis: an open-label Canadian trial Clin Rheumatol 2008 27 587 595 18038178

상세보기

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

The Impact of Fentanyl Matrix on Pain and Function in Spinal Disorder-Related Chronic Pain: An Open Label Trial in Korea 원문보기

Abstract ▼ AI-Helper

주제어

참고문헌 (18)

이 논문을 인용한 문헌

관련 콘텐츠

원문 보기

원문 URL 링크

오픈액세스(OA) 유형

이 논문과 함께 이용한 콘텐츠

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트