다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기
Frontiers in immunology, v.3, 2012년, pp.20 -
Yoshimura, Akihiko (Department of Microbiology and Immunology, Keio University School of Medicine, Shinanomachi Tokyo, Japan) , Suzuki, Mayu (Department of Microbiology and Immunology, Keio University School of Medicine, Shinanomachi Tokyo, Japan) , Sakaguchi, Ryota (Department of Microbiology and Immunology, Keio University School of Medicine, Shinanomachi Tokyo, Japan) , Hanada, Toshikatsu (Department of Microbiology and Immunology, Keio University School of Medicine, Shinanomachi Tokyo, Japan) , Yasukawa, Hideo (Division of Cardiovascular Medicine, Kurume University School of Medicine Kurume, Japan)
AI-Helper
Cytokines play essential roles in innate and adaptive immunity. However, excess cytokines or dysregulation of cytokine signaling will cause a variety of diseases, including allergies, autoimmune diseases, inflammation, and cancer. Most cytokines utilize the so-called Janus kinase–signal trans...
Adamson A. S. Collins K. Laurence A. O’Shea J. J. ( 2009 ). The Current STATus of lymphocyte signaling: new roles for old players . Curr. Opin. Immunol. 21 , 161 – 166 10.1016/j.coi.2009.03.013 19362457
Alexander W. S. Starr R. Fenner J. E. Scott C. L. Handman E. Sprigg N. S. Corbin J. E. Cornish A. L. Darwiche R. Owczarek C. M. Kay T. W. Nicola N. A. Hertzog P. J. Metcalf D. Hilton D. J. ( 1999 ). SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine . Cell 98 , 597 – 608 10.1016/S0092-8674(00)80047-1 10490099
Bhattacharyya S. Zhao Y. Kay T. W. Muglia L. J. ( 2011 ). Glucocorticoids target suppressor of cytokine signaling 1 (SOCS1) and type 1 interferons to regulate Toll-like receptor-induced STAT1 activation . Proc. Natl. Acad. Sci. U.S.A. 108 , 9554 – 9559 10.1073/pnas.1017296108 21606371
Bjorbak C. Lavery H. J. Bates S. H. Olson R. K. Davis S. M. Flier J. S. Myers M. G. Jr. ( 2000 ). SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985 . J. Biol. Chem. 275 , 40649 – 40657 10.1074/jbc.M007577200 11018044
Cacalano N. A. Sanden D. Johnston J. A. ( 2001 ). Tyrosine-phosphorylated SOCS-3 inhibits STAT activation but binds to p120 RasGAP and activates Ras . Nat. Cell Biol. 3 , 460 – 465 10.1038/35074525 11331873
Cao W. Yang Y. Wang Z. Liu A. Fang L. Wu F. Hong J. Shi Y. Leung S. Dong C. Zhang J. Z. ( 2011 ). Leukemia inhibitory factor inhibits T helper 17 cell differentiation and confers treatment effects of neural progenitor cell therapy in autoimmune disease . Immunity 35 , 273 – 284 10.1016/j.immuni.2011.06.011 21835648
Carow B. Ye X. Gavier-Widen D. Bhuju S. Oehlmann W. Singh M. Skold M. Ignatowicz L. Yoshimura A. Wigzell H. Rottenberg M. E. ( 2011 ). Silencing suppressor of cytokine signaling-1 (SOCS1) in macrophages improves Mycobacterium tuberculosis control in an interferon-gamma (IFN-gamma)-dependent manner . J. Biol. Chem. 286 , 26873 – 26887 10.1074/jbc.M111.238287 21622562
Chen Z. Laurence A. Kanno Y. Pacher-Zavisin M. Zhu B. M. Tato C. Yoshimura A. Hennighausen L. O’Shea J. J. ( 2006 ). Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells . Proc. Natl. Acad. Sci. U.S.A. 103 , 8137 – 8142 10.1073/pnas.0606381103 16698929
Chinen T. Komai K. Muto G. Morita R. Inoue N. Yoshida H. Sekiya T. Yoshida R. Nakamura K. Takayanagi R. Yoshimura A. ( 2011 ). Prostaglandin E2 and SOCS1 have a role in intestinal immune tolerance . Nat. Commun. 2 , 190 10.1038/ncomms1181 21304519
Croker B. A. Kiu H. Pellegrini M. Toe J. Preston S. Metcalf D. O’Donnell J. A. Cengia L. H. McArthur K. Nicola N. A. Alexander W. S. Roberts A. W. ( 2012 ). IL-6 promotes acute and chronic inflammatory disease in the absence of SOCS3 . Immunol. Cell Biol. 90 , 124 – 129 10.1038/icb.2011.29 21519345
Croker B. A. Metcalf D. Robb L. Wei W. Mifsud S. DiRago L. Cluse L. A. Sutherland K. D. Hartley L. Williams E. Zhang J. G. Hilton D. J. Nicola N. A. Alexander W. S. Roberts A. W. ( 2004 ). SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis . Immunity 20 , 153 – 165 10.1016/S1074-7613(04)00022-6 14975238
Endo T. A. Masuhara M. Yokouchi M. Suzuki R. Sakamoto H. Mitsui K. Matsumoto A. Tanimura S. Ohtsubo M. Misawa H. Miyazaki T. Leonor N. Taniguchi T. Fujita T. Kanakura Y. Komiya S. Yoshimura A. ( 1997 ). A new protein containing an SH2 domain that inhibits JAK kinases . Nature 387 , 921 – 924 10.1038/43213 9202126
Guillem V. Amat P. Cervantes F. Alvarez-Larran A. Cervera J. Maffioli M. Bellosillo B. Collado M. Marugan I. Martinez-Ruiz F. Hernández-Boluda J. C. ( 2012 ). Functional polymorphisms in SOCS1 and PTPN22 genes correlate with the response to imatinib treatment in newly diagnosed chronic-phase chronic myeloid leukemia . Leuk. Res. 36 , 174 – 181 10.1016/j.leukres.2011.06.011 21724255
Haffner M. C. Jurgeit A. Berlato C. Geley S. Parajuli N. Yoshimura A. Doppler W. ( 2008 ). Interaction and functional interference of glucocorticoid receptor and SOCS1 . J. Biol. Chem. 283 , 22089 – 22096 10.1074/jbc.M801041200 18524780
Hanada T. Kobayashi T. Chinen T. Saeki K. Takaki H. Koga K. Minoda Y. Sanada T. Yoshioka T. Mimata H. Kato S. Yoshimura A. ( 2006 ). IFNgamma-dependent, spontaneous development of colorectal carcinomas in SOCS1-deficient mice . J. Exp. Med. 203 , 1391 – 1397 10.1084/jem.20060436 16717119
Hanada T. Tanaka K. Matsumura Y. Yamauchi M. Nishinakamura H. Aburatani H. Mashima R. Kubo M. Kobayashi T. Yoshimura A. ( 2005 ). Induction of hyper Th1 cell-type immune responses by dendritic cells lacking the suppressor of cytokine signaling-1 gene . J. Immunol. 174 , 4325 – 4332 15778397
Hanada T. Yoshida H. Kato S. Tanaka K. Masutani K. Tsukada J. Nomura Y. Mimata H. Kubo M. Yoshimura A. ( 2003 ). Suppressor of cytokine signaling-1 is essential for suppressing dendritic cell activation and systemic autoimmunity . Immunity 19 , 437 – 450 10.1016/S1074-7613(03)00240-1 14499118
Harada M. Nakashima K. Hirota T. Shimizu M. Doi S. Fujita K. Shirakawa T. Enomoto T. Yoshikawa M. Moriyama H. Matsumoto K. Saito H. Suzuki Y. Nakamura Y. Tamari M. ( 2007 ). Functional polymorphism in the suppressor of cytokine signaling 1 gene associated with adult asthma . Am. J. Respir. Cell Mol. Biol. 36 , 491 – 496 10.1165/rcmb.2006-0090OC 17099141
Hashimoto M. Ayada T. Kinjyo I. Hiwatashi K. Yoshida H. Okada Y. Kobayashi T. Yoshimura A. ( 2009 ). Silencing of SOCS1 in macrophages suppresses tumor development by enhancing antitumor inflammation . Cancer Sci. 100 , 730 – 736 10.1111/j.1349-7006.2009.01098.x 19469017
Hashimoto M. Hiwatashi K. Ichiyama K. Morita R. Sekiya T. Kimura A. Sugiyama Y. Sibata T. Kuroda K. Takahashi R. Yoshimura A. ( 2011 ). SOCS1 regulates type I/type II NKT cell balance by regulating IFNgamma signaling . Int. Immunol. 23 , 165 – 176 10.1093/intimm/dxq469 21393632
Hiwatashi K. Tamiya T. Hasegawa E. Fukaya T. Hashimoto M. Kakoi K. Kashiwagi I. Kimura A. Inoue N. Morita R. Yasukawa H. Yoshimura A. ( 2011 ). Suppression of SOCS3 in macrophages prevents cancer metastasis by modifying macrophage phase and MCP2/CCL8 induction . Cancer Lett. 308 , 172 – 180 10.1016/j.canlet.2011.04.024 21624767
Horino J. Fujimoto M. Terabe F. Serada S. Takahashi T. Soma Y. Tanaka K. Chinen T. Yoshimura A. Nomura S. Kawase I. Hayashi N. Kishimoto T. Naka T. ( 2008 ). Suppressor of cytokine signaling-1 ameliorates dextran sulfate sodium-induced colitis in mice . Int. Immunol. 20 , 753 – 762 10.1093/intimm/dxn033 18381351
Ichiyama K. Hashimoto M. Sekiya T. Nakagawa R. Wakabayashi Y. Sugiyama Y. Komai K. Saba I. Moroy T. Yoshimura A. ( 2009 ). Gfi1 negatively regulates T(h)17 differentiation by inhibiting RORgammat activity . Int. Immunol. 21 , 881 – 889 10.1093/intimm/dxp054 19505891
Ichiyama K. Sekiya T. Inoue N. Tamiya T. Kashiwagi I. Kimura A. Morita R. Muto G. Shichita T. Takahashi R. Yoshimura A. ( 2011 ). Transcription factor Smad-independent T helper 17 cell induction by transforming-growth factor-beta is mediated by suppression of eomesodermin . Immunity 34 , 741 – 754 10.1016/j.immuni.2011.02.021 21600798
Kamizono S. Hanada T. Yasukawa H. Minoguchi S. Kato R. Minoguchi M. Hattori K. Hatakeyama S. Yada M. Morita S. Kitamura T. Kato H. Nakayama K. I. Yoshimura A. ( 2001 ). The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2 . J. Biol. Chem. 276 , 12530 – 12538 10.1074/jbc.M010074200 11278610
Kamura T. Maenaka K. Kotoshiba S. Matsumoto M. Kohda D. Conaway R. C. Conaway J. W. Nakayama K. I. ( 2004 ). VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases . Genes Dev. 18 , 3055 – 3065 10.1101/gad.1252404 15601820
Kimura A. Kinjyo I. Matsumura Y. Mori H. Mashima R. Harada M. Chien K. R. Yasukawa H. Yoshimura A. ( 2004 ). SOCS3 is a physiological negative regulator for granulopoiesis and granulocyte colony-stimulating factor receptor signaling . J. Biol. Chem. 279 , 6905 – 6910 10.1074/jbc.C300496200 14699146
Kinjyo I. Hanada T. Inagaki-Ohara K. Mori H. Aki D. Ohishi M. Yoshida H. Kubo M. Yoshimura A. ( 2002 ). SOCS1/JAB is a negative regulator of LPS-induced macrophage activation . Immunity 17 , 583 – 591 10.1016/S1074-7613(02)00446-6 12433365
Kinjyo I. Inoue H. Hamano S. Fukuyama S. Yoshimura T. Koga K. Takaki H. Himeno K. Takaesu G. Kobayashi T. Yoshimura A. ( 2006 ). Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor-beta 1 . J. Exp. Med. 203 , 1021 – 1031 10.1084/jem.20052333 16606674
Kobayashi T. Takaesu G. Yoshimura A. ( 2006 ). Mal-function of TLRs by SOCS . Nat. Immunol. 7 , 123 – 124 10.1038/ni0206-123 16424886
Koga K. Takaesu G. Yoshida R. Nakaya M. Kobayashi T. Kinjyo I. Yoshimura A. ( 2009 ). Cyclic adenosine monophosphate suppresses the transcription of proinflammatory cytokines via the phosphorylated c-Fos protein . Immunity 30 , 372 – 383 10.1016/j.immuni.2008.12.021 19285436
Kubo M. Hanada T. Yoshimura A. ( 2003 ). Suppressors of cytokine signaling and immunity . Nat. Immunol. 4 , 1169 – 1176 10.1038/ni1012 14639467
Lehmann U. Schmitz J. Weissenbach M. Sobota R. M. Hortner M. Friederichs K. Behrmann I. Tsiaris W. Sasaki A. Schneider-Mergener J. Yoshimura A. Neel B. G. Heinrich P. C. Schaper F. ( 2003 ). SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130 . J. Biol. Chem. 278 , 661 – 671 10.1074/jbc.M300376200 12403768
Li Y. Chu N. Rostami A. Zhang G. X. ( 2006 ). Dendritic cells transduced with SOCS-3 exhibit a tolerogenic/DC2 phenotype that directs type 2 Th cell differentiation in vitro and in vivo . J. Immunol. 177 , 1679 – 1688 16849477
Liu Y. Stewart K. N. Bishop E. Marek C. J. Kluth D. C. Rees A. J. Wilson H. M. ( 2008 ). Unique expression of suppressor of cytokine signaling 3 is essential for classical macrophage activation in rodents in vitro and in vivo . J. Immunol. 180 , 6270 – 6278 18424750
Lu L. F. Boldin M. P. Chaudhry A. Lin L. L. Taganov K. D. Hanada T. Yoshimura A. Baltimore D. Rudensky A. Y. ( 2010 ). Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses . Cell 142 , 914 – 929 10.1016/j.cell.2010.08.012 20850013
Lu Y. Fukuyama S. Yoshida R. Kobayashi T. Saeki K. Shiraishi H. Yoshimura A. Takaesu G. ( 2006 ). Loss of SOCS3 gene expression converts STAT3 function from anti-apoptotic to pro-apoptotic . J. Biol. Chem. 281 , 36683 – 36690 10.1074/jbc.M607374200 17028185
Lu L. F. Thai T. H. Calado D. P. Chaudhry A. Kubo M. Tanaka K. Loeb G. B. Lee H. Yoshimura A. Rajewsky K. Rudensky A. Y. ( 2009 ). Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein . Immunity 30 , 80 – 91 10.1016/j.immuni.2008.11.010 19144316
Madonna S. Scarponi C. De Pita O. Albanesi C. ( 2008 ). Suppressor of cytokine signaling 1 inhibits IFN-gamma inflammatory signaling in human keratinocytes by sustaining ERK1/2 activation . FASEB J. 22 , 3287 – 3297 10.1096/fj.08-106831 18556463
Marine J. C. Topham D. J. McKay C. Wang D. Parganas E. Stravopodis D. Yoshimura A. Ihle J. N. ( 1999 ). SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality . Cell 98 , 609 – 616 10.1016/S0092-8674(00)80048-3 10490100
Masuhara M. Sakamoto H. Matsumoto A. Suzuki R. Yasukawa H. Mitsui K. Wakioka T. Tanimura S. Sasaki A. Misawa H. Yokouchi M. Ohtsubo M. Yoshimura A. ( 1997 ). Cloning and characterization of novel CIS family genes . Biochem. Biophys. Res. Commun. 239 , 439 – 446 10.1006/bbrc.1997.7484 9344848
Matsumoto A. Seki Y. Kubo M. Ohtsuka S. Suzuki A. Hayashi I. Tsuji K. Nakahata T. Okabe M. Yamada S. Yoshimura A. ( 1999 ). Suppression of STAT5 functions in liver, mammary glands, and T cells in cytokine-inducible SH2-containing protein 1 transgenic mice . Mol. Cell. Biol. 19 , 6396 – 6407 10454585
Matsumura Y. Kobayashi T. Ichiyama K. Yoshida R. Hashimoto M. Takimoto T. Tanaka K. Chinen T. Shichita T. Wyss-Coray T. Sato K. Yoshimura A. ( 2007 ). Selective expansion of foxp3-positive regulatory T cells and immunosuppression by suppressors of cytokine signaling 3-deficient dendritic cells . J. Immunol. 179 , 2170 – 2179 17675476
Mori H. Hanada R. Hanada T. Aki D. Mashima R. Nishinakamura H. Torisu T. Chien K. R. Yasukawa H. Yoshimura A. ( 2004 ). Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity . Nat. Med. 10 , 739 – 743 10.1038/nm1071 15208705
Mori T. Miyamoto T. Yoshida H. Asakawa M. Kawasumi M. Kobayashi T. Morioka H. Chiba K. Toyama Y. Yoshimura A. ( 2011 ). IL-1{beta} and TNF{alpha}-initiated IL-6-STAT3 pathway is critical in mediating inflammatory cytokines and RANKL expression in inflammatory arthritis . Int. Immunol. 23 , 701 – 712 10.1093/intimm/dxr077 21937456
Moriwaki A. Inoue H. Nakano T. Matsunaga Y. Matsuno Y. Matsumoto T. Fukuyama S. Kan O. K. Matsumoto K. Tsuda-Eguchi M. Nagakubo D. Yoshie O. Yoshimura A. Kubo M. Nakanishi Y. ( 2011 ). T cell treatment with small interfering RNA for suppressor of cytokine signaling 3 modulates allergic airway responses in a murine model of asthma . Am. J. Respir. Cell Mol. Biol. 44 , 448 – 455 10.1165/rcmb.2009-0051OC 20508071
Mostecki J. Cassel S. L. Klimecki W. T. Stern D. A. Knisz J. Iwashita S. Graves P. Miller R. L. van Peer M. Halonen M. Martinez F. D. Vercelli D. Rothman P. B. ( 2011 ). A SOCS-1 promoter variant is associated with total serum IgE levels . J. Immunol. 187 , 2794 – 2802 10.4049/jimmunol.0902569 21795592
Mottok A. Renne C. Seifert M. Oppermann E. Bechstein W. Hansmann M. L. Kuppers R. Brauninger A. ( 2009 ). Inactivating SOCS1 mutations are caused by aberrant somatic hypermutation and restricted to a subset of B-cell lymphoma entities . Blood 114 , 4503 – 4506 10.1182/blood-2009-06-225839 19734449
Murray P. J. Wynn T. A. ( 2011 ). Obstacles and opportunities for understanding macrophage polarization . J. Leukoc. Biol. 89 , 557 – 563 10.1189/jlb.0710409 21248152
Naka T. Narazaki M. Hirata M. Matsumoto T. Minamoto S. Aono A. Nishimoto N. Kajita T. Taga T. Yoshizaki K. Akira S. Kishimoto T. ( 1997 ). Structure and function of a new STAT-induced STAT inhibitor . Nature 387 , 924 – 929 10.1038/43219 9202127
Nakaya M. Hamano S. Kawasumi M. Yoshida H. Yoshimura A. Kobayashi T. ( 2011 ). Aberrant IL-4 production by SOCS3-over-expressing T cells during infection with Leishmania major exacerbates disease manifestations . Int. Immunol. 23 , 195 – 202 10.1093/intimm/dxq472 21393635
Nakaya M. Hashimoto M. Nakagawa R. Wakabayashi Y. Ishizaki T. Takada I. Komai K. Yoshida H. Yoshimura A. ( 2009 ). SOCS3 in T and NKT cells negatively regulates cytokine production and ameliorates ConA-induced hepatitis . J. Immunol. 183 , 7047 – 7053 10.4049/jimmunol.0900547 19915050
Ogata H. Chinen T. Yoshida T. Kinjyo I. Takaesu G. Shiraishi H. Iida M. Kobayashi T. Yoshimura A. ( 2006a ). Loss of SOCS3 in the liver promotes fibrosis by enhancing STAT3-mediated TGF-beta1 production . Oncogene 25 , 2520 – 2530 10.1038/sj.onc.1209281 16474852
Ogata H. Kobayashi T. Chinen T. Takaki H. Sanada T. Minoda Y. Koga K. Takaesu G. Maehara Y. Iida M. Yoshimura A. ( 2006b ). Deletion of the SOCS3 gene in liver parenchymal cells promotes hepatitis-induced hepatocarcinogenesis . Gastroenterology 131 , 179 – 193 10.1053/j.gastro.2006.04.025 16831601
Okumura A. Pitha P. M. Yoshimura A. Harty R. N. ( 2010 ). Interaction between Ebola virus glycoprotein and host toll-like receptor 4 leads to induction of proinflammatory cytokines and SOCS1 . J. Virol. 84 , 27 – 33 10.1128/JVI.01462-09 19846529
O’Shea J. J. Gadina M. Schreiber R. D. ( 2002 ). Cytokine signaling in 2002: new surprises in the Jak/Stat pathway . Cell 109 (Suppl.), S121 – S131 10.1016/S0092-8674(02)00701-8 11983158
Pellegrini M. Calzascia T. Toe J. G. Preston S. P. Lin A. E. Elford A. R. Shahinian A. Lang P. A. Lang K. S. Morre M. Assouline B. Lahl K. Sparwasser T. Tedder T. F. Paik J. H. DePinho R. A. Basta S. Ohashi P. S. Mak T. W. ( 2011 ). IL-7 engages multiple mechanisms to overcome chronic viral infection and limit organ pathology . Cell 144 , 601 – 613 10.1016/j.cell.2011.01.011 21295337
Russell R. C. Sufan R. I. Zhou B. Heir P. Bunda S. Sybingco S. S. Greer S. N. Roche O. Heathcote S. A. Chow V. W. ( 2011 ). Loss of JAK2 regulation via a heterodimeric VHL-SOCS1 E3 ubiquitin ligase underlies Chuvash polycythemia . Nat. Med. 17 , 845 – 853 10.1038/nm.2370 21685897
Sachithanandan N. Graham K. L. Galic S. Honeyman J. E. Fynch S. L. Hewitt K. A. Steinberg G. R. Kay T. W. ( 2011 ). Macrophage deletion of SOCS1 increases sensitivity to LPS and palmitic acid and results in systemic inflammation and hepatic insulin resistance . Diabetes 60 , 2023 – 2031 10.2337/db11-0259 21646388
Sasaki A. Yasukawa H. Shouda T. Kitamura T. Dikic I. Yoshimura A. ( 2000 ). CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2 . J. Biol. Chem. 275 , 29338 – 29347 10.1074/jbc.M003456200 10882725
Sasaki A. Yasukawa H. Suzuki A. Kamizono S. Syoda T. Kinjyo I. Sasaki M. Johnston J. A. Yoshimura A. ( 1999 ). Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain . Genes Cells 4 , 339 – 351 10.1046/j.1365-2443.1999.00263.x 10421843
Sawa S. Kamimura D. Jin G. H. Morikawa H. Kamon H. Nishihara M. Ishihara K. Murakami M. Hirano T. ( 2006 ) Autoimmune arthritis associated with mutated interleukin (IL)-6 receptor gp130 is driven by STAT3/IL-7-dependent homeostatic proliferation of CD4+ T cells . J. Exp. Med. 203 , 1459 – 1470 10.1084/jem.20052187 16717113
Schmitz J. Weissenbach M. Haan S. Heinrich P. C. Schaper F. ( 2000 ). SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130 . J. Biol. Chem. 275 , 12848 – 12856 10.1074/jbc.275.20.15357 10777583
Seki Y. Inoue H. Nagata N. Hayashi K. Fukuyama S. Matsumoto K. Komine O. Hamano S. Himeno K. Inagaki-Ohara K. Cacalano N. O’Garra A. Oshida T. Saito H. Johnston J. A. Yoshimura A. Kubo M. ( 2003 ). SOCS-3 regulates onset and maintenance of T(H)2-mediated allergic responses . Nat. Med. 9 , 1047 – 1054 10.1038/nm896 12847520
Shouda T. Yoshida T. Hanada T. Wakioka T. Oishi M. Miyoshi K. Komiya S. Kosai K. Hanakawa Y. Hashimoto K. Nagata K. Yoshimura A. ( 2001 ). Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis . J. Clin. Invest. 108 , 1781 – 1788 10.1172/JCI13568 11748261
Starr R. Willson T. A. Viney E. M. Murray L. J. Rayner J. R. Jenkins B. J. Gonda T. J. Alexander W. S. Metcalf D. Nicola N. A. Hilton D. J. ( 1997 ). A family of cytokine-inducible inhibitors of signalling . Nature 387 , 917 – 921 10.1038/43206 9202125
Stutz A. Kessler H. Kaschel M. E. Meissner M. Dalpke A. H. ( 2012 ). Cell invasion and strain dependent induction of suppressor of cytokine signaling-1 by Toxoplasma gondii . Immunobiology 217 , 28 – 36 10.1016/j.imbio.2011.08.008 22015046
Suzuki A. Hanada T. Mitsuyama K. Yoshida T. Kamizono S. Hoshino T. Kubo M. Yamashita A. Okabe M. Takeda K. Akira S. Matsumoto S. Toyonaga A. Sata M. Yoshimura A. ( 2001 ). CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation . J. Exp. Med. 193 , 471 – 481 10.1084/jem.193.4.471 11181699
Takahashi R. Nishimoto S. Muto G. Sekiya T. Tamiya T. Kimura A. Morita R. Asakawa M. Chinen T. Yoshimura A. ( 2011 ). SOCS1 is essential for regulatory T cell functions by preventing loss of Foxp3 expression as well as IFN-{gamma} and IL-17A production . J. Exp. Med. 208 , 2055 – 2067 10.1084/jem.20110428 21893603
Taleb S. Romain M. Ramkhelawon B. Uyttenhove C. Pasterkamp G. Herbin O. Esposito B. Perez N. Yasukawa H. Van Snick J. Yoshimura A. Tedgui A. Mallat Z. ( 2009 ). Loss of SOCS3 expression in T cells reveals a regulatory role for interleukin-17 in atherosclerosis . J. Exp. Med. 206 , 2067 – 2077 10.1084/jem.20090545 19737863
Tamiya T. Kashiwagi I. Takahashi R. Yasukawa H. Yoshimura A. ( 2011 ). Suppressors of cytokine signaling (SOCS) proteins and JAK/STAT pathways: regulation of T-cell inflammation by SOCS1 and SOCS3 . Arterioscler. Thromb. Vasc. Biol. 31 , 980 – 985 10.1161/ATVBAHA.110.207464 21508344
Tanaka K. Ichiyama K. Hashimoto M. Yoshida H. Takimoto T. Takaesu G. Torisu T. Hanada T. Yasukawa H. Fukuyama S. Inoue H. Nakanishi Y. Kobayashi T. Yoshimura A. ( 2008 ). Loss of suppressor of cytokine signaling 1 in helper T cells leads to defective Th17 differentiation by enhancing antagonistic effects of IFN-gamma on STAT3 and Smads . J. Immunol. 180 , 3746 – 3756 18322180
Torisu T. Nakaya M. Watanabe S. Hashimoto M. Yoshida H. Chinen T. Yoshida R. Okamoto F. Hanada T. Torisu K. Takaesu G. Kobayashi T. Yasukawa H. Yoshimura A. ( 2008 ). Suppressor of cytokine signaling 1 protects mice against concanavalin A-induced hepatitis by inhibiting apoptosis . Hepatology 47 , 1644 – 1654 10.1002/hep.22214 18393318
Torisu T. Sato N. Yoshiga D. Kobayashi T. Yoshioka T. Mori H. Iida M. Yoshimura A. ( 2007 ). The dual function of hepatic SOCS3 in insulin resistance in vivo . Genes Cells 12 , 143 – 154 10.1111/j.1365-2443.2007.01044.x 17295835
Wang Y. C. He F. Feng F. Liu X. W. Dong G. Y. Qin H. Y. Hu X. B. Zheng M. H. Liang L. Feng L. Liang Y. M. Han H. ( 2010 ). Notch signaling determines the M1 versus M2 polarization of macrophages in antitumor immune responses . Cancer Res. 70 , 4840 – 4849 10.1158/0008-5472.CAN-09-4697 20501839
Whitmarsh R. J. Gray C. M. Gregg B. Christian D. A. May M. J. Murray P. J. Hunter C. A. ( 2011 ). A Critical Role for SOCS3 in Innate Resistance to Toxoplasma gondii . Cell Host Microbe 10 , 224 – 236 10.1016/j.chom.2011.07.009 21925110
Wong P. K. Egan P. J. Croker B. A. O’Donnell K. Sims N. A. Drake S. Kiu H. McManus E. J. Alexander W. S. Roberts A. W. Wicks I. P. ( 2006 ). SOCS-3 negatively regulates innate and adaptive immune mechanisms in acute IL-1-dependent inflammatory arthritis . J. Clin. Invest. 116 , 1571 – 1581 10.1172/JCI25660 16710471
Yamamoto K. Yamaguchi M. Miyasaka N. Miura O. ( 2003 ). SOCS-3 inhibits IL-12-induced STAT4 activation by binding through its SH2 domain to the STAT4 docking site in the IL-12 receptor beta2 subunit . Biochem. Biophys. Res. Commun. 310 , 1188 – 1193 10.1016/j.bbrc.2003.09.140 14559241
Yasukawa H. Misawa H. Sakamoto H. Masuhara M. Sasaki A. Wakioka T. Ohtsuka S. Imaizumi T. Matsuda T. Ihle J. N. Yoshimura A. ( 1999 ). The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop . EMBO J. 18 , 1309 – 1320 10.1093/emboj/18.5.1309 10064597
Yasukawa H. Ohishi M. Mori H. Murakami M. Chinen T. Aki D. Hanada T. Takeda K. Akira S. Hoshijima M. Hirano T. Chien K. R. Yoshimura A. ( 2003 ). IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages . Nat. Immunol. 4 , 551 – 556 10.1038/ni938 12754507
Yoshida T. Ogata H. Kamio M. Joo A. Shiraishi H. Tokunaga Y. Sata M. Nagai H. Yoshimura A. ( 2004 ). SOCS1 is a suppressor of liver fibrosis and hepatitis-induced carcinogenesis . J. Exp. Med. 199 , 1701 – 1707 10.1084/jem.20031675 15197228
Yoshimura A. ( 2006 ). Signal transduction of inflammatory cytokines and tumor development . Cancer Sci. 97 , 439 – 447 10.1111/j.1349-7006.2006.00197.x 16734720
Yoshimura A. Naka T. Kubo M. ( 2007 ). SOCS proteins, cytokine signalling and immune regulation . Nat. Rev. Immunol. 7 , 454 – 465 10.1038/nri2093 17525754
Yoshimura A. Ohkubo T. Kiguchi T. Jenkins N. A. Gilbert D. J. Copeland N. G. Hara T. Miyajima A. ( 1995 ). A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors . EMBO J. 14 , 2816 – 2826 7796808
Zhang R. Dhillon H. Yin H. Yoshimura A. Lowell B. B. Maratos-Flier E. Flier J. S. ( 2008 ). Selective inactivation of Socs3 in SF1 neurons improves glucose homeostasis without affecting body weight . Endocrinology 149 , 5654 – 5661 10.1210/en.2008-0263 18669597
Zhang Y. Ma C. J. Ni L. Zhang C. L. Wu X. Y. Kumaraguru U. Li C. F. Moorman J. P. Yao Z. Q. ( 2011 ). Cross-talk between programmed death-1 and suppressor of cytokine signaling-1 in inhibition of IL-12 production by monocytes/macrophages in hepatitis C virus infection . J. Immunol. 186 , 3093 – 3103 10.4049/jimmunol.1002946 21263070
*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.
오픈액세스 학술지에 출판된 논문
Copyright KISTI. All Rights Reserved.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.