$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

[해외논문] Thermodynamic Insights and Conceptual Design of Skin-Sensitive Chitosan Coated Ceramide/PLGA Nanodrug for Regeneration of Stratum Corneum on Atopic Dermatitis 원문보기

Scientific reports, v.5, 2015년, pp.18089 -   

Jung, Sang-Myung (Department of Biological Engineering, Inha University , Incheon, 402-751, Korea) ,  Yoon, Gwang Heum (Department of Biological Engineering, Inha University , Incheon, 402-751, Korea) ,  Lee, Hoo Chul (Department of Biological Engineering, Inha University , Incheon, 402-751, Korea) ,  Jung, Moon Hee (Department of Biological Engineering, Inha University , Incheon, 402-751, Korea) ,  Yu, Sun Il (Department of Biological Engineering, Inha University , Incheon, 402-751, Korea) ,  Yeon, Seung Ju (Department of Biological Engineering, Inha University , Incheon, 402-751, Korea) ,  Min, Seul Ki (Department of Biological Engineering, Inha University , Incheon, 402-751, Korea) ,  Kwon, Yeo Seon (Department of Biological Engineering, Inha University , Incheon, 402-751, Korea) ,  Hwang, Jin Ha (Department of Biological Engineering, Inha University , Incheon, 402-751, Korea) ,  Shin, Hwa Sung (Department of Biological Eng)

Abstract AI-Helper 아이콘AI-Helper

Atopic dermatitis (AD) is a complex skin disease primarily characterized by psoriasis of the stratum corneum. AD drugs have usually been used in acidic and hydrophilic solvents to supply moisture and prevent lipid defects. Ceramide is a typical treatment agent to regenerate the stratum corneum and r...

참고문헌 (37)

  1. Wertz P. W. et al. The composition of the ceramides from human stratum corneum and from comedones . J Invest Dermatol 84 , 410 – 412 ( 1985 ). 3158712 

  2. Di Nardo A. et al. Ceramide and cholesterol composition of the skin of patients with atopic dermatitis . Acta Derm Venereol(stockh) 78 , 27 – 30 ( 1998 ). 9498022 

  3. Imokawa G. et al. Decreased level of ceramides in stratum corneum of atopic dermatitis: an etiologic factor in atopic dry skin? J Invest Dermatol 96 , 523 – 526 ( 1991 ). 2007790 

  4. Ohnishi Y. et al. Ceramidase activity in bacterial skin flora as a possible cause of ceramide deficiency in atopic dermatitis . Clin Diagn Lab Immun 6 , 101 – 104 ( 1999 ). 

  5. Hamanaka S. et al. Human epidermal glucosylceramides are major precursors of stratum corneum ceramides . J Invest Dermatol 119 , 416 – 423 ( 2002 ). 12190865 

  6. Pillai S. et al. Ceramide potentiates, but sphingomyelin inhibits, vitamin D-induced keratinocyte differentiation: comparison between keratinocytes and HL-60 cells . Arch Dermatol Res 291 , 284 – 289 ( 1999 ). 10367711 

  7. Lamour N. F. & Chalfant C. E. Ceramide-1-phosphate: the “missing” link in eicosanoid biosynthesis and inflammation . Mol Interv 5 , 358 ( 2005 ). 16394251 

  8. Teichgräber V. et al. Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis . Nat Med 14 , 382 – 391 ( 2008 ). 18376404 

  9. Lew B.-L. et al. Ceramides and cell signaling molecules in psoriatic epidermis: reduced levels of ceramides, PKC-α, and JNK . J Korean Med Sci 21 , 95 – 99 ( 2006 ). 16479073 

  10. Schliemann. et al. Protective creams fail to prevent solvent‐induced cumulative skin irritation–results of a randomized double‐blind study . Contact Derm 69 , 363 – 371 ( 2013 ). 23844768 

  11. Panther D. J. et al. The Importance of Acidification in Atopic Eczema: An Underexplored Avenue for Treatment . J Clin Med 4 , 970 – 978 ( 2015 ). 26239459 

  12. Jung J. Y. et al. Clinical use of a ceramide-based moisturizer for treating dogs with atopic dermatitis . J Vet Sci 14 , 199 – 205 ( 2013 ). 23814473 

  13. Makadia H. K. & Siegel S. J. Poly lactic-co-glycolic acid (PLGA) as biodegradable controlled drug delivery carrier . Polymers 3 , 1377 – 1397 ( 2011 ). 22577513 

  14. Lü J.-M. et al. Current advances in research and clinical applications of PLGA-based nanotechnology . Expert Rev Mol Diagn 9 , 325 – 341 ( 2009 ). 19435455 

  15. Wischke C. et al. Principles of encapsulating hydrophobic drugs in PLA/PLGA microparticles . International Journal of pharmaceutics 364 , 298 – 327 ( 2008 ). 18621492 

  16. Jain R. A. et al. Controlled release of drugs from injectable in situ formed biodegradable PLGA microspheres: effect of various formulation variables . Eur J Pharm Biopharm 50 , 257 – 262 ( 2000 ). 10962236 

  17. Nikkola L. et al. Temporal control of drug release from biodegradable polymer: multicomponent diclofenac sodium releasing PLGA 80/20 rod . J Biomed Mater Res Part B Appl Biomater 89 , 518 – 526 ( 2009 ). 19003897 

  18. Allison S. D. Analysis of initial burst in PLGA microparticles . Expert Opin Drug Deliv 5 , 615 – 625 ( 2008 ). 18532918 

  19. Liu Y.-j. et al. Control of dimensional stability and degradation rate in electrospun composite scaffolds composed of poly (d, l-lactide-co-glycolide) and poly (ε-caprolactone) . Chin J Polym Sci 26 , 63 – 71 ( 2008 ). 

  20. Kean T. & Thanou M. Biodegradation, biodistribution and toxicity of chitosan . Adv Drug Delivery Rev 62 , 3 – 11 ( 2010 ). 

  21. Raphael R. et al. J. Chitosan and Chitosan Derivatives in Drug Delivery and Tissue Engineering . Adv Polym Sci 244 19 – 44 ( 2011 ). 

  22. Lee K. Y. et al. Blood compatibility and biodegradability of partially N-acylated chitosan derivatives . Biomaterials 16 , 1211 – 1216 ( 1995 ). 8589189 

  23. Chronopoulou L. et al. Chitosan-coated PLGA nanoparticles: a sustained drug release strategy for cell cultures . Colloids Surf B 103 , 310 – 317 ( 2013 ). 

  24. Wydro P. et al. Chitosan as a lipid binder: a langmuir monolayer study of chitosan-lipid interactions . Biomacromolecules 8 , 2611 – 2617 ( 2007 ). 17630796 

  25. El-hefian E. A. et al. Surface investigation of chitosan film with fatty acid monolayers . Maejo Int J Sci Tech 3 , 277 – 286 ( 2009 ). 

  26. Sahoo S. K. et al. Residual polyvinyl alcohol associated with poly (D, L-lactide-co-glycolide) nanoparticles affects their physical properties and cellular uptake . J Control Release 82 , 105 – 114 ( 2002 ). 12106981 

  27. Aryaei A. et al. Nano and micro mechanical properties of uncross-linked and cross-linked chitosan films . J Mech Behav Biomed Mater 5 , 82 – 89 ( 2012 ). 22100082 

  28. Guo C. & Gemeinhart R. A. Understanding the adsorption mechanism of chitosan onto poly (lactide-co-glycolide) particles . Eur J Pharm Biopharm 70 , 597 – 604 ( 2008 ). 18602994 

  29. Haring M. M. Colloid and Capillary Chemistry (Freundlich, Herbert) . J Chem Educ 3 , 1454 ( 1926 ). 

  30. Knor T. et al. Stratum corneum hydration and skin surface pH in patients with atopic dermatitis . Acta Dermatovenerol Croat: ADC 19 , 242 – 247 ( 2010 ). 

  31. Mattson S. Cataphoresis and the Electrical Neutralization of Colloidal Material . J Phys Chem 32 , 1532 – 1552 ( 1928 ). 

  32. Williams A. C. & Barry B. W. Penetration enhancers . Adv Drug Deliv Rev. 64 , 128 – 137 ( 2012 ). 

  33. Kowalzick L. Novel topical therapy for mild-to-moderate plaque psoriasis: focus on calcitriol . Clin Cosmet Investig Dermatol: CCID 2 , 153 ( 2009 ). 

  34. O’Regan G. M. & Alan D. I. The role of filaggrin loss-of-function mutations in atopic dermatitis . Curr Opin Allergy Clin Immunol 8.5 , 406 – 410 ( 2008 ). 18769192 

  35. Xia M. & Sui Z. Recent developments in CCR2 antagonists . Expert Opin Ther Pat. 19 , 295 – 303 ( 2009 ) 19441905 

  36. Langmuir I. The constitution and fundamental properties of solids and liquids. part i. solids . J Am Chem Soc 38 , 2221 – 2295 ( 1916 ). 

  37. Brunauer S. et al. Adsorption of gases in multimolecular layers . J Am Chem Soc 60 , 309 – 319 ( 1938 ). 

LOADING...
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로