Ginseng has a long history of use as a tonic for restoration of vigor. One example of ginseng-derived tonic effect is that it can improve physical stamina under conditions of stress. However, the active ingredient and the underlying molecular mechanism responsible for the ergogenic effect are unknow...
Ginseng has a long history of use as a tonic for restoration of vigor. One example of ginseng-derived tonic effect is that it can improve physical stamina under conditions of stress. However, the active ingredient and the underlying molecular mechanism responsible for the ergogenic effect are unknown. Recent studies show that ginseng contains a novel ingredient, gintonin, which consists of a unique class of herbal medicine lysophosphatidic acids (LPAs). Gintonin activates G protein-coupled LPA receptors to produce a transient [Ca2+](i) signal, which is coupled to diverse intra- and inter-cellular signal transduction pathways that stimulate hormone or neurotransmitter release. However, relatively little is known about how gintonin-mediated cellular modulation is linked to physical endurance. In the present study, systemic administration of gintonin, but not ginsenosides, in fasted mice increased blood glucose concentrations in a dose-dependent manner. Gintonin treatment elevated blood glucose to a maximum level after 30 min. This elevation in blood glucose level could be abrogated by the LPA1/3 receptor antagonist, Ki16425, or the beta-adrenergic receptor antagonist, propranolol. Furthermore, gintonin-dependent enhanced performance of fasted mice in rotarod test was likewise abrogated by Ki16425. Gintonin also elevated plasma epinephrine and norepinephrine concentrations. The present study shows that gintonin mediates catecholamine release through activation of the LPA receptor and that activation of the beta-adrenergic receptor is coupled to liver glycogenolysis, thereby increasing the supply of glucose and enhancing performance in the rotarod test. Thus, gintonin acts via the LPA-catecholamine-glycogenolysis axis, representing a candidate mechanism that can explain how ginseng treatment enhances physical stamina. (c) 2015 Elsevier Ireland Ltd. All rights reserved.
Ginseng has a long history of use as a tonic for restoration of vigor. One example of ginseng-derived tonic effect is that it can improve physical stamina under conditions of stress. However, the active ingredient and the underlying molecular mechanism responsible for the ergogenic effect are unknown. Recent studies show that ginseng contains a novel ingredient, gintonin, which consists of a unique class of herbal medicine lysophosphatidic acids (LPAs). Gintonin activates G protein-coupled LPA receptors to produce a transient [Ca2+](i) signal, which is coupled to diverse intra- and inter-cellular signal transduction pathways that stimulate hormone or neurotransmitter release. However, relatively little is known about how gintonin-mediated cellular modulation is linked to physical endurance. In the present study, systemic administration of gintonin, but not ginsenosides, in fasted mice increased blood glucose concentrations in a dose-dependent manner. Gintonin treatment elevated blood glucose to a maximum level after 30 min. This elevation in blood glucose level could be abrogated by the LPA1/3 receptor antagonist, Ki16425, or the beta-adrenergic receptor antagonist, propranolol. Furthermore, gintonin-dependent enhanced performance of fasted mice in rotarod test was likewise abrogated by Ki16425. Gintonin also elevated plasma epinephrine and norepinephrine concentrations. The present study shows that gintonin mediates catecholamine release through activation of the LPA receptor and that activation of the beta-adrenergic receptor is coupled to liver glycogenolysis, thereby increasing the supply of glucose and enhancing performance in the rotarod test. Thus, gintonin acts via the LPA-catecholamine-glycogenolysis axis, representing a candidate mechanism that can explain how ginseng treatment enhances physical stamina. (c) 2015 Elsevier Ireland Ltd. All rights reserved.
Am. J. Clin. Nutr. Bucci 72 Suppl. 2 72624S 2000 Selected herbals and human exercise performance
Bucci 379 2004 Nutritional Ergogenic Aids
Int. J. Sport Nutr. Ziemba 9 4 371 1999 10.1123/ijsn.9.4.371 Ginseng treatment improves psychomotor performance at rest and during graded exercise in young athletes
Mol. Cells Hwang 33 151 2012 10.1007/s10059-012-2216-z Gintonin, newly identified compounds from ginseng, is novel lysophosphatidic acids-protein complexes and activates G protein-coupled lysophosphatidic acid receptors with high affinity
Acta Crystallogr. D Biol. Crystallogr. Choi 71 1039 2015 10.1107/S139900471500259X Structure of ginseng major latex-like protein 151 and its proposed lysophosphatidic acid-binding mechanism
Neurosci. Lett. Lee 548 143 2013 10.1016/j.neulet.2013.05.048 Activation of lysophosphatidic acid receptor by gintonin inhibits Kv1.2 channel activity: involvement of tyrosine kinase and receptor protein tyrosine phosphatase alpha
J. Neurophysiol. Park 113 1493 2015 10.1152/jn.00667.2014 Synaptic enhancement induced by gintonin via lysophosphatidic acid receptor activation in central synapses
J. Neurochem. Ma 109 603 2009 10.1111/j.1471-4159.2009.05987.x Evidence for lysophosphatidic acid 1 receptor signaling in the early phase of neuropathic pain mechanisms in experiments using Ki-16425, a lysophosphatidic acid 1 receptor antagonist
J. Chromatogr. Mitsui 344 61 1985 10.1016/S0378-4347(00)82007-1 High-performance liquid chromatography of plasma catecholamines using 1,2-diphenylethylenediamine as precolumn fluorescence derivatization reagent
Korean J. Pharmacogn. Shin 37 246 2006 Effect of heat processed ginseng on anti-fatigue
Diabetes Care Reeds 34 5 1071 2011 10.2337/dc10-2299 Ginseng and ginsenoside Re do not improve β-cell function or insulin sensitivity in overweight and obese subjects with impaired glucose tolerance or diabetes
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