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[해외논문] Combination strategy of multi-layered surface camouflage using hyperbranched polyethylene glycol and immunosuppressive drugs for the prevention of immune reactions against transplanted porcine islets

Biomaterials, v.84, 2016년, pp.144 - 156  

Haque, Muhammad R. (Research Institute of Pharmaceutical Science, College of Pharmacy, Seoul National University, Seoul, Republic of Korea) ,  Jeong, Jee-Heon (College of Pharmacy, Yeungnam University, Gyeongsan, Republic of Korea) ,  Byun, Youngro (Research Institute of Pharmaceutical Science, College of Pharmacy, Seoul National University, Seoul, Republic of Korea)

Abstract AI-Helper 아이콘AI-Helper

This study suggests a novel method of stabilizing fragile porcine islets to prevent the dissociation after isolation and reducing immune cell invasion in a combination therapy of 'surface camouflaging' and immunosuppressive drugs (FK506, Rapamycin, MR-1, anti-CD19 mAb, and Clodrosome (R)) to effecti...

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