Ethnapharmacological relevance: Stephania japonica is a common plant, widely distributed in all over Bangladesh. Traditionally, this plant is considered as one of the important ingredients in treatment of a variety of ailments including inflammation, pain, rheumatism, cancer, bone fracture, fever et...
Ethnapharmacological relevance: Stephania japonica is a common plant, widely distributed in all over Bangladesh. Traditionally, this plant is considered as one of the important ingredients in treatment of a variety of ailments including inflammation, pain, rheumatism, cancer, bone fracture, fever etc. However, the scientific reports regarding the antinociceptive effect of this plant are very limited. This study evaluated the antinociceptive effect of methanolic extract of S. japonica (MESJ) leaves. Materials and methods: The antinociceptive effect of MESJ was investigated using both heat- and chemical-induced nociceptive models such as hot plate, tail immersion, acetic acid-induced writhing, formalin and glutamate tests at the doses of 50, 100 and 200mg/kg. Morphine (5mg/kg) and diclofenac sodium (10mg/kg) were used as reference drugs in thermal and chemical models, respectively. Moreover, naloxone (2mg/kg) was used in the thermal models to justify the possible role of the opioid receptors. Results: MESJ produced a significant and dose-dependent increase in the hot plate and tail immersion latencies which were reversed by the treatment with naloxone, suggests the possible involvement of opioid receptors in this activity. Moreover, MESJ inhibited acetic acid-induced writhing, formalin and glutamate-induced lickings in a dose-dependent manner. In parallel, the reference drugs also produced desired antinociceptive effects in this study. Conclusion: These results strongly support the antinociceptive activity of the leaves of Stephania japonica and rationalize the traditional use of the leaves in treatment of different painful conditions.
Ethnapharmacological relevance: Stephania japonica is a common plant, widely distributed in all over Bangladesh. Traditionally, this plant is considered as one of the important ingredients in treatment of a variety of ailments including inflammation, pain, rheumatism, cancer, bone fracture, fever etc. However, the scientific reports regarding the antinociceptive effect of this plant are very limited. This study evaluated the antinociceptive effect of methanolic extract of S. japonica (MESJ) leaves. Materials and methods: The antinociceptive effect of MESJ was investigated using both heat- and chemical-induced nociceptive models such as hot plate, tail immersion, acetic acid-induced writhing, formalin and glutamate tests at the doses of 50, 100 and 200mg/kg. Morphine (5mg/kg) and diclofenac sodium (10mg/kg) were used as reference drugs in thermal and chemical models, respectively. Moreover, naloxone (2mg/kg) was used in the thermal models to justify the possible role of the opioid receptors. Results: MESJ produced a significant and dose-dependent increase in the hot plate and tail immersion latencies which were reversed by the treatment with naloxone, suggests the possible involvement of opioid receptors in this activity. Moreover, MESJ inhibited acetic acid-induced writhing, formalin and glutamate-induced lickings in a dose-dependent manner. In parallel, the reference drugs also produced desired antinociceptive effects in this study. Conclusion: These results strongly support the antinociceptive activity of the leaves of Stephania japonica and rationalize the traditional use of the leaves in treatment of different painful conditions.
Brain Res. Beirith 924 219 2002 10.1016/S0006-8993(01)03240-1 Mechanisms underlying the nociception and paw oedema caused by injection of glutamate in to the mouse paw
Arzneimittelforschung del Valle-Laisequilla 62 603 2012 10.1055/s-0032-1327678 Ketorolac tromethamine improves the analgesic effect of hyoscine butylbromide in patients with intense cramping pain from gastrointestinal or genitourinary origin
J. Ethnopharmacol. Moniruzzaman 161 82 2015 10.1016/j.jep.2014.12.011 Evaluation of antinociceptive effect of ethanol extract of Hedyotis corymbosa Linn. whole plant in mice
J. Chem. Pharm. Res. Senthamarai 4 1457 2012 Pharmacognostical and phytochemical studies on leaves of Stephania japonica Linn
Afr. J. Tradit. Complement. Altern. Med. Seraj 10 26 2013 Tribal formulations for treatment of pain: a study of the bede community traditional medicinal practitioners of porabari village in dhaka district, Bangladesh
J. Med. Plant Res. Uddin 8 1127 2014 10.5897/JMPR2014.5443 Phytochemical screening and study of antioxidant and analgesic potentials of ethanolic extract of Stephania japonica Linn
AI-Helper
※ AI-Helper는 부적절한 답변을 할 수 있습니다.