[논문]The Osmanthus fragrans flower phenylethanoid glycoside-rich extract: Acute and subchronic toxicity studies

Lu, B.; Li, M.; Zhou, F.; Huang, W.; Jiang, Y.; Mao, S.; Zhao, Y.; Lou, T.

doi:10.1016/j.jep.2016.04.049

[해외논문] The Osmanthus fragrans flower phenylethanoid glycoside-rich extract: Acute and subchronic toxicity studies

Journal of ethnopharmacology, v.187, 2016년, pp.205 - 212

Lu, B. , Li, M. , Zhou, F. , Huang, W. , Jiang, Y. , Mao, S. , Zhao, Y. , Lou, T.

Abstract ▼ AI-Helper

Ethnopharmacological relevance: Osmanthus fragrans var. thunbergii (O. fragrans) flower has been consumed as folk medicine for thousands of years. O. fragrans flower extract is a well-characterized phenylethanoid glycoside-rich extract, which has been used as a natural anti-oxidant. The aim of this study was to evaluate the safety of O. fragrans flower phenylethanoid glycoside-rich extract (OFFE). Materials and methods: The OFFE was extracted by 80% (v/v) aqueous ethanol with 0.01% sodium isoascorbate (w/v) from the O. fragrans flower and purified on HPD300 resins. The total phenylethanoid glycosides content and individual phenylethanoid glycosides was determined by photocolorimetric method and reversed phase UPLC respectively. An acute oral toxicity study, reverse mutation test, bone marrow cell micronucleus test, and sperm abnormality test as well as a 90-day oral toxicity study were performed on experimental animals. Results: The total content of phenylethanoid glycosides in OFFE was 73.4g acteoside equivalent per 100g of extract, include acteoside (52.5g per 100g of extract), salidroside (13.8g per 100g of extract), and isoacteoside (2.6g per 100g of extract) and so on. No acute lethal effect at the maximal tested OFFE dose of 10g/kg body weight (bw) in either rats or mice was observed, suggesting that OFFE can be considered nontoxic. No evidence for mutagenicity was detected in any of the three mutagenic tests. Administration at levels of 0.50, 1.00, and 2.00g/kg bw to rats for 90 days failed to induce any significant hematological, clinical, chemical, or histopathological changes. The no-observed adverse-effect-level for OFFE was >2.00g/kg bw for the study on subchronic toxicity. Conclusion: The results showed that consuming OFFE has no adverse effects and poses no health risk in the acute oral toxicity study, subchronic oral toxicity study, and in the micronucleus test, which may provide supportive evidence for the safety of OFFE powder that has been used in medicine as well as in functional foods, and dietary supplements.

Keyword

참고문헌 (24)

Mutat. Res. Ames 31 347 1975 10.1016/0165-1161(75)90046-1 Methods for detecting carcinogens and mutagens with the Salmonella/mammalian microsome mutagenicity test

상세보기
Sci. Technol. Cereals Oils Foods Can 13 16 2005 Study on optimum extracting conditions of flavonoids from sweet-scented osmanthus
Chin. Pharmacol. Bull. Gan 30 3 417 2014 Pharmacokinetics and tissue distribution of acteoside in rats
Molecules Guo 17 4 4733 2012 10.3390/molecules17044733 Simultaneous determination of salidroside and its aglycone metabolite p-tyrosol in rat plasma by liquid chromatography-tandem mass spectrometry

상세보기
Mutat. Res. Hayashi 245 245 1990 10.1016/0165-7992(90)90153-B The micronucleus assay with mouse peripheral blood reticulocytes using acridine orange-coated slides

상세보기
Evid. Based Complement. Alter. Med. Hung 2013 211 2013 10.1155/2013/304290 The ethanol extract of Osmanthus fragrans flowers reduces oxidative stress and allergic airway inflammation in an animal model

상세보기
Biochem. Pharmacol. Lee 74 7 960 2007 10.1016/j.bcp.2007.06.007 Rosmarinic acid induces melanogenesis through protein kinase A activation signaling

상세보기
Int. J. Pharm. Toxicol. Lin 2 1 8 2014 The safety of Osmanthus fragrans ethanol extract treatment in BALB/c mice
Biotechnol. Lett. Lu 25 1437 2003 10.1023/A:1025055612517 Improvement of phenylethanoid glycosides production by a fungal elicitor

상세보기
Lu B.Y., Mao S.Q., Jiang Y.R., Xiong L.N., Zhou F., Yang J.J., Hu Y.Z., Shen C.X., Sun Q.H., 2014a. The application of the Osmanthus fragrans flower phenylethanoid glycoside-rich extract on the preparation of Anti-aging medicine or health products. China National Invention Patent, CN2014100434886.
Lu B.Y., Sun Q.H., Xiong L.N., Mao S.Q., Zhou F., Hu Y.Z., Jiang Y.R., Yang J.J., Shen C.X., 2014b. The application of the Osmanthus fragrans flower phenylethanoid glycoside-rich extract on the preparation of whitening cosmetics. China National Invention Patent, CN2014100434867.
Lu B.Y., Xiong L.N., Mao S.Q., Zhou F., Jiang Y.R., Sun Q.H., Yang J.J., Hu Y.Z., Shen C.X., 2014c. The Osmanthus fragrans flower phenylethanoid glycoside-rich extract, its preparation method and uses. China National Invention Patent, 2014100435018.
Mutat. Res. Maron 113 173 1983 10.1016/0165-1161(83)90010-9 Revised methods for the Salmonella mutagenicity test

상세보기
Ministry of Health, P.R. China. GB 15193.1-2014. Food Safety Toxicology evaluation program. National Food Safety Standards.
Jiang Xi Sci. Peng 22 221 2004 The general condition on the studies of Osmanthus in China and its development and utilization
FASEB J. Reagan-Shaw 22 3 659 2008 10.1096/fj.07-9574LSF Dose translation from animal to human studies revisited

상세보기
Toxicol. Lett. Santoro 178 2 71 2008 10.1016/j.toxlet.2008.02.006 Verminoside-and verbascoside-induced genotoxicity on human lymphocytes: involvement of PARP-1 and p53 proteins

상세보기
Planta Med. Smejkal 74 12 1 2008 10.1055/s-2008-1081339 Cytotoxic activity of C-geranyl compounds from Paulownia tomentosa fruits

상세보기
World J. Gastroenterol. Teschke 21 15 4466 2015 10.3748/wjg.v21.i15.4466 Herbal traditional Chinese medicine and its evidence base in gastrointestinal disorders

상세보기
LWT-Food Sci. Technol. Wang 43 2 319 2010 10.1016/j.lwt.2009.08.003 Antioxidant capacity of the extracts from pulp of Osmanthus fragrans and Its components

상세보기
LWT-Food Sci. Technol. Wu 42 9 1513 2009 10.1016/j.lwt.2009.04.004 Antioxidant activity and melanogenesis inhibitory effect of the acetonic extract of Osmanthus fragrans: a potential natural and functional food flavor additive

상세보기
Proc. Natl. Acad. Sci. USA Wyrobek 72 4425 1975 10.1073/pnas.72.11.4425 Chemical induction of sperm abnormalities in mice

상세보기
J. Nanjing For. Univ. Xiang 28 104 2004 The present and development strategy of production, development,popularization and utilization of sweet osmanthus
J. Med. Food Xiong 19 1 54 2016 10.1089/jmf.2015.3462 Osmanthus fragrans flower extract and acteoside against d-galactose-induced aging in an ICR mouse model

상세보기

활용도 분석정보

상세보기

다운로드

내보내기

활용도 Top5 논문

해당 논문의 주제분야에서 활용도가 높은 상위 5개 콘텐츠를 보여줍니다.
더보기 버튼을 클릭하시면 더 많은 관련자료를 살펴볼 수 있습니다.

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

[해외논문] The Osmanthus fragrans flower phenylethanoid glycoside-rich extract: Acute and subchronic toxicity studies

Abstract ▼ AI-Helper

Keyword

참고문헌 (24)

이 논문을 인용한 문헌

활용도 분석정보

활용도 Top5 논문

관련 콘텐츠

원문 URL 링크

이 논문과 함께 이용한 콘텐츠

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트

연합인증

[해외논문] The Osmanthus fragrans flower phenylethanoid glycoside-rich extract: Acute and subchronic toxicity studies

Abstract ▼ AI-Helper

Keyword

참고문헌 (24)

이 논문을 인용한 문헌

활용도 분석정보

활용도 Top5 논문 더보기

관련 콘텐츠

원문 URL 링크

이 논문과 함께 이용한 콘텐츠

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트

활용도 Top5 논문