[논문]The Impact of High-Risk HPV Genotypes Other Than HPV 16/18 on the Natural Course of Abnormal Cervical Cytology: A Korean HPV Cohort Study

So, Kyeong A; Kim, Mi Jung; Lee, Ki-Heon; Lee, In-Ho; Kim, Mi Kyung; Lee, Yoo Kyung; Hwang, Chang-Sun; Jeong, Mi Seon; Kee, Mee-Kyung; Kang, Chun; Cho, Chi Heum; Kim, Seok Mo; Hong, Sung Ran; Kim, Ki Tae; Lee, Won-Chul; Park, Jong Sup; Kim, Tae Jin

doi:10.4143/crt.2016.013

The Impact of High-Risk HPV Genotypes Other Than HPV 16/18 on the Natural Course of Abnormal Cervical Cytology: A Korean HPV Cohort Study 원문보기

Cancer research and treatment : official journal of Korean Cancer Association, v.48 no.4, 2016년, pp.1313 - 1320

So, Kyeong A (Department of Obstetrics and Gynecology, Cheil General Hospital and Women’s Healthcare Center, Dankook University College of Medicine, Seoul, Korea) , Kim, Mi Jung (Department of Obstetrics and Gynecology, Cheil General Hospital and Women’s Healthcare Center, Dankook University College of Medicine, Seoul, Korea) , Lee, Ki-Heon (Department of Obstetrics and Gynecology, Cheil General Hospital and Women’s Healthcare Center, Dankook University College of Medicine, Seoul, Korea) , Lee, In-Ho (Department of Obstetrics and Gynecology, Cheil General Hospital and Women’s Healthcare Center, Dankook University College of Medicine, Seoul, Korea) , Kim, Mi Kyung (Department of Obstetrics and Gynecology, Cheil General Hospital and Women’s Healthcare Center, Dankook University College of Medicine, Seoul, Korea) , Lee, Yoo Kyung (Department of Obstetrics and Gynecology, Cheil General Hospital and Women’s Healthcare Center, Dankook Unive) , Hwang, Chang-Sun , Jeong, Mi Seon , Kee, Mee-Kyung , Kang, Chun , Cho, Chi Heum , Kim, Seok Mo , Hong, Sung Ran , Kim, Ki Tae , Lee, Won-Chul , Park, Jong Sup , Kim, Tae Jin

Abstract ▼ AI-Helper

PurposeThe purpose of this study is to evaluate the impact of high-risk human papillomaviruses (HPVs) other than HPV 16/18 on the natural course of atypical squamous cells of undetermined significance (ASC-US) or low-grade squamous intraepithelial lesion (LSIL).Materials and MethodsThe study population was derived from the Korean HPV cohort (2010-2014). Women aged 20 to 60 who satisfied the criteria of having both HPV infection and abnormal cervical cytology of either ASC-US or LSIL were recruited from five institutions nationwide. Enrolled patients underwent cervical cytology and HPV DNA testing every 6 months.ResultsA total of 1,158 patients were enrolled. The 10 most common HPV types were HPV 16 (12.3%), 58 (10.0%), 56 (8.8%), 53 (8.4%), 52 (7.7%), 39 (6.2%), 18 (6.0%), 51 (5.7%), 68 (5.1%), and 66 (4.6%). Among these patients, 636 women were positive for high-risk HPVs other than HPV 16 or 18, and 429 women were followed for more than 6 months. Cytology evaluations showed progression in 15.3% of women, no change in 22.6%, and regression in 62.1% of women at 12 months. In cases of HPV 58 single infection, a more highly significant progression rate, compared to other high-risk types, was observed at 6 months (relative risk [RR], 3.3; 95% confidence interval [CI], 2.04 to 5.30; p < 0.001) and 12 months (RR, 5.03; 95% CI, 2.56 to 9.91; p < 0.001).ConclusionHPV genotypes numbered in the 50s were frequent in Korean women with ASC-US and LSIL. HPV 58 was the second most common type, with a high progression rate of cervical cytology.

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The Impact of High-Risk HPV Genotypes Other Than HPV 16/18 on the Natural Course of Abnormal Cervical Cytology: A Korean HPV Cohort Study 원문보기

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