다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기
Scientific reports, v.6, 2016년, pp.38357 -
Bieber, Katja (Lü) , Witte, Mareike (beck Institute of Experimental Dermatology (LIED), University of Lü) , Sun, Shijie (beck , Ratzeburger Allee 160, D-23538 Lü) , Hundt, Jennifer E. (beck, Germany) , Kalies, Kathrin (Lü) , Dräger, Sören (beck Institute of Experimental Dermatology (LIED), University of Lü) , Kasprick, Anika (beck , Ratzeburger Allee 160, D-23538 Lü) , Twelkmeyer, Trix (beck, Germany) , Manz, Rudolf A. (Lü) , König, Peter (beck Institute of Experimental Dermatology (LIED), University of Lü) , Köhl, Jörg (beck , Ratzeburger Allee 160, D-23538 Lü) , Zillikens, Detlef (beck, Germany) , Ludwig, Ralf J. (Lü)
AI-Helper
T cells are key players in autoimmune diseases by supporting the production of autoantibodies. However, their contribution to the effector phase of antibody-mediated autoimmune dermatoses, i.e., tissue injury and inflammation of the skin, has not been investigated. In this paper, we demonstrate that...
Cope A. P. , Schulze-Koops H. & Aringer M. The central role of T cells in rheumatoid arthritis . Clin Exp Rheumatol 25 , S4 – 11 ( 2007 ). 17977483
Masopust D. & Schenkel J. M. The integration of T cell migration, differentiation and function . Nat Rev Immunol 13 , 309 – 320 ( 2013 ). 23598650
Wherry E. J. & Kurachi M. Molecular and cellular insights into T cell exhaustion . Nat Rev Immunol 15 , 486 – 499 ( 2015 ). 26205583
Hammers C. M. . Complement-fixing anti-type VII collagen antibodies are induced in Th1-polarized lymph nodes of epidermolysis bullosa acquisita-susceptible mice . J Immunol 187 , 5043 – 5050 ( 2011 ). 21967893
Iwata H. . B cells, dendritic cells, and macrophages are required to induce an autoreactive CD4 helper T cell response in experimental epidermolysis bullosa acquisita . J Immunol 191 , 2978 – 2988 ( 2013 ). 23960233
Ludwig R. J. , Kalies K. , Kohl J. , Zillikens D. & Schmidt E. Emerging treatments for pemphigoid diseases . Trends Mol Med 19 , 501 – 512 ( 2013 ). 23831338
Kasperkiewicz M. . Epidermolysis Bullosa Acquisita: From Pathophysiology to Novel Therapeutic Options . J Invest Dermatol 136 , 24 – 33 ( 2016 ). 26763420
Witte M. , Koga H. , Hashimoto T. , Ludwig R. J. & Bieber K. Discovering potential drug-targets for personalized treatment of autoimmune disorders - what we learn from epidermolysis bullosa acquisita . Expert Opin Ther Targets 1 – 14 ( 2016 ).
Sitaru C. . Induction of dermal-epidermal separation in mice by passive transfer of antibodies specific to type VII collagen . J Clin Invest 115 , 870 – 878 ( 2005 ). 15841176
Woodley D. T. . Evidence that anti-type VII collagen antibodies are pathogenic and responsible for the clinical, histological, and immunological features of epidermolysis bullosa acquisita . J Invest Dermatol 124 , 958 – 964 ( 2005 ). 15854036
Iwata H. , Bieber K. , Hirose M. & Ludwig R. J. Animal models to investigate pathomechanisms and evaluate novel treatments for autoimmune bullous dermatoses . Curr Pharm Des 21 , 2422 – 2439 ( 2015 ). 25777758
Ludwig R. J. Clinical, Presentation Pathogenesis, Diagnosis, and Treatment of Epidermolysis Bullosa Acquisita . Hindawi Publishing Corporation, ISRN Dermatology 2013 , 25 ( 2013 ).
Chiriac M. T. . NADPH oxidase is required for neutrophil-dependent autoantibody-induced tissue damage . J Pathol 212 , 56 – 65 ( 2007 ). 17380558
Nandakumar K. S. , Backlund J. , Vestberg M. & Holmdahl R. Collagen type II (CII)-specific antibodies induce arthritis in the absence of T or B cells but the arthritis progression is enhanced by CII-reactive T cells . Arthritis Res Ther 6 , R544 – 550 ( 2004 ). 15535832
Matsui S. . Transfer of rabbit autoimmune cardiomyopathy into severe combined immunodeficiency mice . J Cardiovasc Pharmacol 42 Suppl 1, S99 – 103 ( 2003 ). 14871038
Di Paolo J. A. . Specific Btk inhibition suppresses B cell- and myeloid cell-mediated arthritis . Nat Chem Biol 7 , 41 – 50 ( 2011 ). 21113169
Korganow A. S. . From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins . Immunity 10 , 451 – 461 ( 1999 ). 10229188
Cua D. J. & Tato C. M. Innate IL-17-producing cells: the sentinels of the immune system . Nat Rev Immunol 10 , 479 – 489 ( 2010 ). 20559326
Pelletier M. . Evidence for a cross-talk between human neutrophils and Th17 cells . Blood 115 , 335 – 343 ( 2010 ). 19890092
Davey M. S. . Human neutrophil clearance of bacterial pathogens triggers anti-microbial gammadelta T cell responses in early infection . PLoS Pathog 7 , e1002040 ( 2011 ). 21589907
Shibata K. , Yamada H. , Hara H. , Kishihara K. & Yoshikai Y. Resident Vdelta1+ gammadelta T cells control early infiltration of neutrophils after Escherichia coli infection via IL-17 production . J Immunol 178 , 4466 – 4472 ( 2007 ). 17372004
Ishii N. . Autoantibody-induced intestinal inflammation and weight loss in experimental epidermolysis bullosa acquisita . J Pathol 224 , 234 – 244 ( 2011 ). 21381035
Yamaguchi J. . Comprehensive application of an mtDsRed2-Tg mouse strain for mitochondrial imaging . Transgenic Res 21 , 439 – 447 ( 2012 ). 21792696
Faust N. , Varas F. , Kelly L. M. , Heck S. & Graf T. Insertion of enhanced green fluorescent protein into the lysozyme gene creates mice with green fluorescent granulocytes and macrophages . Blood 96 , 719 – 726 ( 2000 ). 10887140
Murphy K. M. , Heimberger A. B. & Loh D. Y. Induction by antigen of intrathymic apoptosis of CD4 + CD8 + TCRlo thymocytes in vivo . Science 250 , 1720 – 1723 ( 1990 ). 2125367
Hisaeda H. . Contribution of extrathymic gamma delta T cells to the expression of heat-shock protein and to protective immunity in mice infected with Toxoplasma gondii . Immunology 88 , 551 – 557 ( 1996 ). 8881756
Kumar V. NKT-cell subsets: promoters and protectors in inflammatory liver disease . J Hepatol 59 , 618 – 620 ( 2013 ). 23669283
Bernard F. X. . Keratinocytes under Fire of Proinflammatory Cytokines: Bona Fide Innate Immune Cells Involved in the Physiopathology of Chronic Atopic Dermatitis and Psoriasis . J Allergy (Cairo) 2012 , 718725 ( 2012 ). 23193414
McKee S. J. , Mattarollo S. R. & Leggatt G. R. Immunosuppressive roles of natural killer T (NKT) cells in the skin . J Leukoc Biol 96 , 49 – 54 ( 2014 ). 24799605
Law S. C. , Benham H. , Reid H. H. , Rossjohn J. & Thomas R. Identification of self-antigen-specific T cells reflecting loss of tolerance in autoimmune disease underpins preventative immunotherapeutic strategies in rheumatoid arthritis . Rheum Dis Clin North Am 40 , 735 – 752 ( 2014 ). 25437289
Tang B. . Characterization of T cell phenotype and function in a double transgenic (collagen-specific TCR/HLA-DR1) humanized model of arthritis . Arthritis Res Ther 16 , R7 ( 2014 ). 24405551
Tiburzy B. . Persistent autoantibody-production by intermediates between short-and long-lived plasma cells in inflamed lymph nodes of experimental epidermolysis bullosa acquisita . PLoS One 8 , e83631 ( 2013 ). 24386241
Takahashi H. . Desmoglein 3-specific CD4 + T cells induce pemphigus vulgaris and interface dermatitis in mice . J Clin Invest 121 , 3677 – 3688 ( 2011 ). 21821914
Tong P. L. . The skin immune atlas: three-dimensional analysis of cutaneous leukocyte subsets by multiphoton microscopy . J Invest Dermatol 135 , 84 – 93 ( 2015 ). 25007044
Sumaria N. . Cutaneous immunosurveillance by self-renewing dermal gammadelta T cells . J Exp Med 208 , 505 – 518 ( 2011 ). 21339323
O’Brien R. L. & Born W. K. Dermal gammadelta T cells–What have we learned? Cell Immunol 296 , 62 – 69 ( 2015 ). 25649119
Bonish B. . Overexpression of CD1d by keratinocytes in psoriasis and CD1d-dependent IFN-gamma production by NK-T cells . J Immunol 165 , 4076 – 4085 ( 2000 ). 11034419
Cai Y. , Fleming C. & Yan J. New insights of T cells in the pathogenesis of psoriasis . Cell Mol Immunol 9 , 302 – 309 ( 2012 ). 22705915
Becher B. & Pantelyushin S. Hiding under the skin: Interleukin-17-producing gammadelta T cells go under the skin? Nat Med 18 , 1748 – 1750 ( 2012 ). 23223063
Cross A. H. , O’Mara T. & Raine C. S. Chronologic localization of myelin-reactive cells in the lesions of relapsing EAE: implications for the study of multiple sclerosis . Neurology 43 , 1028 – 1033 ( 1993 ). 7684116
Ghani S. . T cells as pioneers: antigen-specific T cells condition inflamed sites for high-rate antigen-non-specific effector cell recruitment . Immunology 128 , e870 – 880 ( 2009 ). 19740348
Schmidt E. . Autoantibodies to BP180 associated with bullous pemphigoid release interleukin-6 and interleukin-8 from cultured human keratinocytes . J Invest Dermatol 115 , 842 – 848 ( 2000 ). 11069622
Scapini P. & Cassatella M. A. Social networking of human neutrophils within the immune system . Blood 124 , 710 – 719 ( 2014 ). 24923297
Mocsai A. Diverse novel functions of neutrophils in immunity, inflammation, and beyond . J Exp Med 210 , 1283 – 1299 ( 2013 ). 23825232
Duffy D. . Neutrophils transport antigen from the dermis to the bone marrow, initiating a source of memory CD8 + T cells . Immunity 37 , 917 – 929 ( 2012 ). 23142782
Sitaru C. . Induction of complement-fixing autoantibodies against type VII collagen results in subepidermal blistering in mice . J Immunol 177 , 3461 – 3468 ( 2006 ). 16920988
Stremnitzer C. . Papain Degrades Tight Junction Proteins of Human Keratinocytes In Vitro and Sensitizes C57BL/6 Mice via the Skin Independent of its Enzymatic Activity or TLR4 Activation . J Invest Dermatol ( 2015 ).
Hellberg L. . Methylprednisolone blocks autoantibody-induced tissue damage in experimental models of bullous pemphigoid and epidermolysis bullosa acquisita through inhibition of neutrophil activation . J Invest Dermatol 133 , 2390 – 2399 ( 2013 ). 23448878
Stamm C. . Dose-dependent induction of murine Th1/Th2 responses to sheep red blood cells occurs in two steps: antigen presentation during second encounter is decisive . PLoS One 8 , e67746 ( 2013 ). 23840769
Samavedam U. K. . GM-CSF modulates autoantibody production and skin blistering in experimental epidermolysis bullosa acquisita . J Immunol 192 , 559 – 571 ( 2014 ). 24337383
*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.
오픈액세스 학술지에 출판된 논문
Copyright KISTI. All Rights Reserved.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.