[논문]Guillain–Barré syndrome: a century of progress

Goodfellow, John A.; Willison, Hugh J.

doi:10.1038/nrneurol.2016.172

Guillain–Barré syndrome: a century of progress 원문보기

Nature reviews. Neurology, v.12 no.12, 2016년, pp.723 - 731

Goodfellow, John A. (Neuroimmunology Laboratory, Laboratory Building, Queen Elizabeth University Hospital, Glasgow, G51 4TF, Scotland, UK.) , Willison, Hugh J. (Institute of Infection, Immunity and Inflammation, University of Glasgow, University Place, Glasgow, G12 8TA, Scotland, UK.)

Abstract ▼ AI-Helper

In 1916, Guillain, Barré and Strohl reported on two cases of acute flaccid paralysis with high cerebrospinal fluid protein levels and normal cell counts — novel findings that identified the disease we now know as Guillain–Barré syndrome (GBS). 100 years on, we have made great progress with the clinical and pathological characterization of GBS. Early clinicopathological and animal studies indicated that GBS was an immune-mediated demyelinating disorder, and that severe GBS could result in secondary axonal injury; the current treatments of plasma exchange and intravenous immunoglobulin, which were developed in the 1980s, are based on this premise. Subsequent work has, however, shown that primary axonal injury can be the underlying disease. The association of Campylobacter jejuni strains has led to confirmation that anti-ganglioside antibodies are pathogenic and that axonal GBS involves an antibody and complement-mediated disruption of nodes of Ranvier, neuromuscular junctions and other neuronal and glial membranes. Now, ongoing clinical trials of the complement inhibitor eculizumab are the first targeted immunotherapy in GBS.

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Lancet R van Koningsveld 363 192 2004 10.1016/S0140-6736(03)15324-X van Koningsveld, R. et al. Effect of methylprednisolone when added to standard treatment with intravenous immunoglobulin for Guillain-Barré syndrome: randomised trial. Lancet 363, 192-196 (2004).

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10.1016/0140-6736(93)90351-G [No authors listed.] Double-blind trial of intravenous methylprednisolone in Guillain-Barré syndrome. Guillain-Barré Syndrome Steroid Trial Group. Lancet 341, 586-590 (1993).

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Cochrane Database Syst. Rev. RA Hughes 8 CD001446 2012 Hughes, R. A. & van Doorn, P. A. Corticosteroids for Guillain-Barré syndrome. Cochrane Database Syst. Rev. 8, CD001446 (2012).
Netherlands Trial Register. trialregister.nl http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=2224 (2016)
J. Physiol. JJ Plomp 587 3979 2009 10.1113/jphysiol.2009.171702 Plomp, J. J. & Willison, H. J. Pathophysiological actions of neuropathy-related anti-ganglioside antibodies at the neuromuscular junction. J. Physiol. 587, 3979-3999 (2009).

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Brain SK Halstead 131 1197 2008 10.1093/brain/awm316 Halstead, S. K. et al. Eculizumab prevents anti-ganglioside antibody-mediated neuropathy in a murine model. Brain 131, 1197-1208 (2008).

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J. Peripher. Nerv. Syst. AM Fitzpatrick 16 84 2011 10.1111/j.1529-8027.2011.00328.x Fitzpatrick, A. M. et al. An open label clinical trial of complement inhibition in multifocal motor neuropathy. J. Peripher. Nerv. Syst. 16, 84-91 (2011).

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US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT02029378 (2014).
US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT02493725 (2016).

표제어: PCR

동의어: Packet Collision Rate

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용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

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구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

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