[논문]The effect of inter-unit HLA matching in double umbilical cord blood transplantation for acute leukemia

Brunstein, Claudio; Zhang, Mei-Jie; Barker, Juliet; St. Martin, Andrew; Bashey, Asad; de Lima, Marcos; Dehn, Jason; Hematti, Peiman; Perales, Miguel-Angel; Rocha, Vanderson; Territo, Mary; Weisdorf, Daniel; Eapen, Mary

doi:10.3324/haematol.2016.158584

The effect of inter-unit HLA matching in double umbilical cord blood transplantation for acute leukemia 원문보기

Haematologica, v.102 no.5, 2017년, pp.941 - 947

Brunstein, Claudio (University of Minnesota Medical Center, Minneapolis, MN, USA) , Zhang, Mei-Jie (Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA) , Barker, Juliet (Adult Bone Marrow Transplant Services, Department of Medicine, Memorial Sloan-Kettering Cancer Center, and Department of Medicine, Weill Cornell Medical College, New York, NY, USA) , St. Martin, Andrew (Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA) , Bashey, Asad (Blood and Marrow Transplant Program at Northside Hospital, Atlanta, GA, USA) , de Lima, Marcos (Department of Medicine, Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH, USA) , Dehn, Jason (National Marrow Donor Program) , Hematti, Peiman (Division of Hematology) , Perales, Miguel-Angel (Adult Bone Marrow Transplant Services, Department of Medicine, Memorial Sl) , Rocha, Vanderson , Territo, Mary , Weisdorf, Daniel , Eapen, Mary

Abstract ▼ AI-Helper

The effects of inter-unit HLA-match on early outcomes with regards to double cord blood transplantation have not been established. Therefore, we studied the effect of inter-unit HLA-mismatching on the outcomes of 449 patients with acute leukemia after double cord blood transplantation. Patients were divided into two groups: one group that included transplantations with inter-unit mismatch at 2 or less HLA-loci (n=381) and the other group with inter-unit mismatch at 3 or 4 HLA-loci (n=68). HLA-match considered low resolution matching at HLA-A and -B loci and allele-level at HLA-DRB1, the accepted standard for selecting units for double cord blood transplants. Patients’, disease, and transplant characteristics were similar in the two groups. We observed no effect of the degree of inter-unit HLA-mismatch on neutrophil (Hazard Ratio 1.27, P=0.11) or platelet (Hazard Ratio 0.1.13, P=0.42) recovery, acute graft-versus-host disease (Hazard Ratio 1.17, P=0.36), treatment-related mortality (Hazard Ratio 0.92, P=0.75), relapse (Hazard Ratio 1.18, P=0.49), treatment failure (Hazard Ratio 0.99, P=0.98), or overall survival (Hazard Ratio 0.98, P=0.91). There were no differences in the proportion of transplants with engraftment of both units by three months (5% after transplantation of units with inter-unit mismatch at ≤2 HLA-loci and 4% after transplantation of units with inter-unit mismatch at 3 or 4 HLA-loci). Our observations support the elimination of inter-unit HLA-mismatch criterion when selecting cord blood units in favor of optimizing selection based on individual unit characteristics.

참고문헌 (24)

1. Barker JN Weisdorf DJ DeFor TE Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy . Blood . 2005 ; 105 ( 3 ): 1343 – 1347 . 15466923

상세보기
2. Brunstein CG Barker JN Weisdorf DJ Umbilical cord blood transplantation after nonmyeloablative conditioning: impact on transplantation outcomes in 110 adults with hematologic disease . Blood . 2007 ; 110 ( 8 ): 3064 – 3070 . 17569820

상세보기
3. Ponce DM Zheng J Gonzales AM Reduced late mortality risk contributes to similar survival after double-unit cord blood transplantation compared with related and unrelated donor hematopoietic stem cell transplantation . Biol Blood Marrow Transplant . 2011 ; 17 ( 9 ): 1316 – 1326 . 21232625

상세보기
4. Wagner JE Jr Eapen M Carter S One-unit versus two-unit cord-blood transplantation for hematologic cancers . N Engl J Med . 2014 ; 371 ( 18 ): 1685 – 1694 . 25354103

상세보기
5. Kanda J Rizzieri DA Gasparetto C Adult dual umbilical cord blood transplantation using myeloablative total body irradiation (1350 cGy) and fludarabine conditioning . Biol Blood Marrow Transplant . 2011 ; 17 ( 6 ): 867 – 874 . 20868761

상세보기
6. Ostronoff F Milano F Gooley T Double umbilical cord blood transplantation in patients with hematologic malignancies using a reduced-intensity preparative regimen without antithymocyte globulin . Bone Marrow Transplant . 2013 ; 48 ( 6 ): 782 – 786 . 23241738

상세보기
7. Avery S Shi W Lubin M Influence of infused cell dose and HLA match on engraftment after double-unit cord blood allografts . Blood . 2011 ; 117 ( 12 ): 3277 – 3285 ; quiz 3478 . 21149633
8. Purtill D Smith K Devlin S Dominant unit CD34+ cell dose predicts engraftment after double-unit cord blood transplantation and is influenced by bank practice . Blood . 2014 ; 124 ( 19 ): 2905 – 2912 . 25185264

상세보기
9. Kaplan EL Meier P Nonparametric Estimation from Incomplete Observations . J Am Stat Assoc . 1958 ; 53 ( 282 ): 457 – 481 .

상세보기
10. Lin DY Non-parametric inference for cumulative incidence functions in competing risks studies . Stat Med . 1997 ; 16 ( 8 ): 901 – 910 . 9160487

상세보기
11. Cox DR Regression Models and Life-Tables . J R Stat Soc Series B Stat Methodol . 1972 ; 34 ( 2 ): 187 – 220 .
12. Andersen PK Klein JP Zhang MJ Testing for centre effects in multi-centre survival studies: a Monte Carlo comparison of fixed and random effects tests . Stat Med . 1999 ; 18 ( 12 ): 1489 – 1500 . 10398287

상세보기
13. Gragert L Eapen M Williams E HLA match likelihoods for hematopoietic stem-cell grafts in the U.S. registry . N Engl J Med . 2014 ; 371 ( 4 ): 339 – 348 . 25054717

상세보기
14. Luger SM Ringden O Zhang MJ Similar outcomes using myeloablative vs reduced-intensity allogeneic transplant preparative regimens for AML or MDS . Bone Marrow Transplant . 2012 ; 47 ( 2 ): 203 – 211 . 21441963

상세보기
15. Marks DI Wang T Perez WS The outcome of full-intensity and reduced-intensity conditioning matched sibling or unrelated donor transplantation in adults with Philadelphia chromosome-negative acute lymphoblastic leukemia in first and second complete remission . Blood . 2010 ; 116 ( 3 ): 366 – 374 . 20404137
16. Cutler C Kim HT Sun L Donor-specific anti-HLA antibodies predict outcome in double umbilical cord blood transplantation . Blood . 2011 ; 118 ( 25 ): 6691 – 6697 . 21940825

상세보기
17. Eapen M Klein JP Ruggeri A Impact of allele-level HLA matching on outcomes after myeloablative single unit umbilical cord blood transplantation for hematologic malignancy . Blood . 2014 ; 123 ( 1 ): 133 – 140 . 24141369

상세보기
18. Eapen M Klein JP Sanz GF Effect of donor-recipient HLA matching at HLA A, B, C, and DRB1 on outcomes after umbilical-cord blood transplantation for leukaemia and myelodysplastic syndrome: a retrospective analysis . Lancet Oncol . 2011 ; 12 ( 13 ): 1214 – 1221 . 21982422

상세보기
19. Sanz J Sanz MA Saavedra S Cord blood transplantation from unrelated donors in adults with high-risk acute myeloid leukemia . Biol Blood Marrow Transplant . 2010 ; 16 ( 1 ): 86 – 94 . 19744570

상세보기
20. Wagner JE Barker JN DeFor TE Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant diseases: influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival . Blood . 2002 ; 100 ( 5 ): 1611 – 1618 . 12176879
21. Brunstein CG Petersdorf EW DeFor TE Impact of Allele-Level HLA Mismatch on Outcomes in Recipients of Double Umbilical Cord Blood Transplantation . Biol Blood Marrow Transplant . 2016 ; 22 ( 3 ): 487 – 492 . 26431630

상세보기
22. Brunstein CG Noreen H DeFor TE Maurer D Miller JS Wagner JE Anti-HLA antibodies in double umbilical cord blood transplantation . Biol Blood Marrow Transplant . 2011 ; 17 ( 11 ): 1704 – 1708 . 21601639

상세보기
23. Dahi PB Ponce DM Devlin S Donor-recipient allele-level HLA matching of unrelated cord blood units reveals high degrees of mismatch and alters graft selection . Bone Marrow Transplant . 2014 ; 49 ( 9 ): 1184 – 1186 . 25000459

상세보기
24. Ballen KK Logan BR Laughlin MJ Effect of cord blood processing on transplantation outcomes after single myeloablative umbilical cord blood transplantation . Biol Blood Marrow Transplant . 2015 ; 21 ( 4 ): 688 – 695 . 25543094

상세보기

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

The effect of inter-unit HLA matching in double umbilical cord blood transplantation for acute leukemia 원문보기

Abstract ▼ AI-Helper

참고문헌 (24)

이 논문을 인용한 문헌

관련 콘텐츠

원문 보기

원문 URL 링크

오픈액세스(OA) 유형

이 논문과 함께 이용한 콘텐츠

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트