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Biochimica et biophysica acta. Molecular basis of disease, v.1863 no.5, 2017년, pp.1054 - 1065
Gerencser, A.A. , Mookerjee, S.A. , Jastroch, M. , Brand, M.D.
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Analysis of the cellular mechanisms of metabolic disorders, including type 2 diabetes mellitus, is complicated by the large number of reactions and interactions in metabolic networks. Metabolic control analysis with appropriate modularization is a powerful method for simplifying and analyzing these ...
Physiol. Rev. Nicholls 96 1385 2016 10.1152/physrev.00009.2016 The pancreatic β-cell: a bioenergetic perspective
J. Biol. Chem. Antinozzi 277 11746 2002 10.1074/jbc.M108462200 Mitochondrial metabolism sets the maximal limit of fuel-stimulated insulin secretion in a model pancreatic beta cell: a survey of four fuel secretagogues
Am. J. Physiol. Endocrinol. Metab. Heart 290 E143 2006 10.1152/ajpendo.00216.2005 Glucose-dependent increase in mitochondrial membrane potential, but not cytoplasmic calcium, correlates with insulin secretion in single islet cells
Mol. Cell. Endocrinol. Mulder 297 34 2009 10.1016/j.mce.2008.05.015 Mitochondrial dysfunction in pancreatic β-cells in Type 2 Diabetes
Corkey 53 2008 Pancreatic beta cells in health and disease Metabolic regulation of insulin secretion
J. Biol. Chem. Malmgren 284 32395 2009 10.1074/jbc.M109.026708 Tight coupling between glucose and mitochondrial metabolism in clonal beta-cells is required for robust insulin secretion
Int. J. Biochem. Cell Biol. Maechler 38 696 2006 10.1016/j.biocel.2005.12.006 In beta-cells, mitochondria integrate and generate metabolic signals controlling insulin secretion
Diabetes Yalow 9 254 1960 10.2337/diab.9.4.254 Plasma insulin concentrations in nondiabetic and early diabetic subjects. Determinations by a new sensitive immuno-assay technic
Diabetes Del Prato 51 Suppl. 1 S109 2002 10.2337/diabetes.51.2007.S109 Phasic insulin release and metabolic regulation in type 2 diabetes
Metabolism Varsano-Aharon 19 409 1970 10.1016/0026-0495(70)90092-2 Early insulin responses to glucose and to tolbutamide in maturity-onset diabetes
Diabetologia Kahn 46 3 2003 10.1007/s00125-002-1009-0 The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes
J. Clin. Endocrinol. Metab. Brunzell 42 222 1976 10.1210/jcem-42-2-222 Relationships between fasting plasma glucose levels and insulin secretion during intravenous glucose tolerance tests
Diabetologia Haffner 39 1201 1996 10.1007/BF02658507 Decreased insulin action and insulin secretion predict the development of impaired glucose tolerance
Curr. Diab. Rep. Zheng 14 519 2014 10.1007/s11892-014-0519-8 Metabolic abnormalities in the pathogenesis of type 1 diabetes
Trends Endocrinol. Metab. Supale 23 477 2012 10.1016/j.tem.2012.06.002 Mitochondrial dysfunction in pancreatic beta cells
Endocrinology Gerencser 156 en20151552 2015 10.1210/en.2015-1552 Bioenergetic analysis of single pancreatic β-cells indicates an impaired metabolic signature in type 2 diabetic subjects
Eur. J. Biochem. Hafner 188 313 1990 10.1111/j.1432-1033.1990.tb15405.x Analysis of the control of respiration rate, phosphorylation rate, proton leak rate and protonmotive force in isolated mitochondria using the “top-down” approach of metabolic control theory
Eur. J. Biochem. Ainscow 266 737 1999 10.1046/j.1432-1327.1999.00856.x Internal regulation of ATP turnover, glycolysis and oxidative phosphorylation in rat hepatocytes
J. Exp. Biol. Brand 200 193 1997 10.1242/jeb.200.2.193 Regulation analysis of energy metabolism
Biochem. J. Amo 404 345 2007 10.1042/BJ20061609 Were inefficient mitochondrial haplogroups selected during migrations of modern humans? A test using modular kinetic analysis of coupling in mitochondria from cybrid cell lines
Anal. Chem. Gerencser 81 6868 2009 10.1021/ac900881z Quantitative microplate-based respirometry with correction for oxygen diffusion
J. Physiol. Gerencser 590 2845 2012 10.1113/jphysiol.2012.228387 Quantitative measurement of mitochondrial membrane potential in cultured cells: calcium-induced de- and hyperpolarization of neuronal mitochondria
Am. J. Physiol. Endocrinol. Metab. Doliba 302 E87 2012 10.1152/ajpendo.00218.2011 Glucokinase activation repairs defective bioenergetics of islets of Langerhans isolated from type 2 diabetics
Diabetes Hohmeier 49 424 2000 10.2337/diabetes.49.3.424 Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion
PLoS One Gerencser 11 2016 10.1371/journal.pone.0159199 Measurement of the absolute magnitude and time courses of mitochondrial membrane potential in primary and clonal pancreatic beta-cells
Anticancer Res. Slate 15 811 1995 RS-33295-198: a novel, potent modulator of P-glycoprotein-mediated multidrug resistance
Mol. Cell Gerencser 61 642 2016 10.1016/j.molcel.2016.02.026 Exploiting mitochondria in vivo as chemical reaction chambers dependent on membrane potential
Pflugers Arch. Ullrich 432 630 1996 10.1007/s004240050179 Effects of glucose, forskolin and tolbutamide on membrane potential and insulin secretion in the insulin-secreting cell line INS-1
Methods Mol. Biol. Affourtit 810 165 2012 10.1007/978-1-61779-382-0_11 Measurement of proton leak and electron leak in isolated mitochondria
Biosystems Ainscow 49 151 1999 10.1016/S0303-2647(98)00040-9 Quantifying elasticity analysis: how external effectors cause changes to metabolic systems
Diabetologia Goehring 54 2584 2011 10.1007/s00125-011-2249-7 Identification of an intracellular metabolic signature impairing beta cell function in the rat beta cell line INS-1E and human islets
Biochem. J. Gerencser 471 111 2015 10.1042/BJ20150616 Calcium modulation of exocytosis-linked plasma membrane potential oscillations in INS-1 832/13 cells
J. Theor. Biol. Ainscow 194 223 1998 10.1006/jtbi.1998.0760 Errors associated with metabolic control analysis. Application of Monte-Carlo simulation of experimental data
J. Biol. Chem. Lorenz 288 10923 2013 10.1074/jbc.M112.414961 Metabolome response to glucose in the β-cell line INS-1 832/13
J. Biol. Chem. Goehring 287 15706 2012 10.1074/jbc.M111.314567 Plasma membrane potential oscillations in insulin secreting Ins-1 832/13 cells do not require glycolysis and are not initiated by fluctuations in mitochondrial bioenergetics
Am. J. Physiol. Endocrinol. Metab. Gray 301 E113 2011 10.1152/ajpendo.00673.2010 Plasma membrane electron transport in pancreatic β-cells is mediated in part by NQO1
Mol. Cell. Biochem. Brand 184 13 1998 10.1023/A:1006893619101 Top-down elasticity analysis and its application to energy metabolism in isolated mitochondria and intact cells
Am. J. Phys. Sweet 268 E775 1995 Mathematical model of beta-cell glucose metabolism and insulin release. I. Glucokinase as glucosensor hypothesis
J. Diabetes Investig. Nakamura 6 124 2015 10.1111/jdi.12294 Present status of clinical deployment of glucokinase activators
Endocrinology Zhang 151 4688 2010 10.1210/en.2009-1185 Fructose-1,6-bisphosphatase regulates glucose-stimulated insulin secretion of mouse pancreatic beta-cells
Eur. J. Biochem. Brown 188 321 1990 10.1111/j.1432-1033.1990.tb15406.x A “top-down” approach to the determination of control coefficients in metabolic control theory
Biochem. J. Affourtit 393 151 2006 10.1042/BJ20051280 Stronger control of ATP/ADP by proton leak in pancreatic beta-cells than skeletal muscle mitochondria
Free Radic. Biol. Med. Affourtit 50 609 2011 10.1016/j.freeradbiomed.2010.12.020 Uncoupling protein-2 attenuates glucose-stimulated insulin secretion in INS-1E insulinoma cells by lowering mitochondrial reactive oxygen species
Eur. J. Biochem. Ainscow 265 1043 1999 10.1046/j.1432-1327.1999.00820.x The responses of rat hepatocytes to glucagon and adrenaline. Application of quantified elasticity analysis
Int. J. Biochem. Cell Biol. Deschodt-Arsac 45 4 2013 10.1016/j.biocel.2012.07.007 Non-invasive integrative analysis of contraction energetics in intact beating heart
Diabetologia Rountree 56 803 2013 10.1007/s00125-012-2808-6 Loss of coupling between calcium influx, energy consumption and insulin secretion associated with development of hyperglycaemia in the UCD-T2DM rat model of type 2 diabetes
Diabetes Lu 59 448 2010 10.2337/db09-0129 Molecular and metabolic evidence for mitochondrial defects associated with beta-cell dysfunction in a mouse model of type 2 diabetes
Diabetologia Anello 48 282 2005 10.1007/s00125-004-1627-9 Functional and morphological alterations of mitochondria in pancreatic beta cells from type 2 diabetic patients
Bioenergetics Kim 3 110 2014 Comparative analysis of the mitochondrial physiology of pancreatic β cells
PLoS One Ruas 11 2016 10.1371/journal.pone.0150967 Underestimation of the maximal capacity of the mitochondrial electron transport system in oligomycin-treated cells
PLoS One Merrins 7 2012 10.1371/journal.pone.0034036 Phosphofructo-2-kinase/fructose-2,6-bisphosphatase modulates oscillations of pancreatic islet metabolism
Eur. J. Biochem. Brown 192 355 1990 10.1111/j.1432-1033.1990.tb19234.x Control of respiration and oxidative phosphorylation in isolated rat liver cells
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