[논문]Standardized Mori ramulus extract improves insulin secretion and insulin sensitivity in C57BLKS/J db/db mice and INS-1 cells

Park, Soo-yeon; Jin, Bora; Shin, Jae-Ho; Adisakwattana, Sirichai; Kwon, Oran

doi:10.1016/j.biopha.2017.05.080

Standardized Mori ramulus extract improves insulin secretion and insulin sensitivity in C57BLKS/J db/db mice and INS-1 cells

Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie, v.92, 2017년, pp.308 - 315

Park, Soo-yeon (Department of Nutritional Science and Food Management, Ewha Womans University) , Jin, Bora (Department of Nutritional Science and Food Management, Ewha Womans University) , Shin, Jae-Ho (Department of Biomedical Laboratory Science, Eulji University) , Adisakwattana, Sirichai (Department of Nutrition and Dietetics, Faculty of Allied Health Sciences, Chulalongkorn University) , Kwon, Oran (Department of Nutritional Science and Food Management, Ewha Womans University)

Abstract ▼ AI-Helper

Abstract Abnormalities in the hyperbolic relationship between insulin sensitivity and insulin secretion may cause oxidative stress and non-enzymatic glycation, resulting in an increased risk of type 2 diabetes. Here, we performed a 14-week study to investigate the effects of ethanolic extract of Mori ramulus (MRE; 0, 800, and 1600mg/kg body weight) and its signature component oxyresveratrol (OXY; 800mg/kg body weight) on β-cell dysfunction and insulin resistance in C57BLKS/J db/db mice fed with a high-fat diet. Compared with the diabetic control group, the high-dose MRE group showed a significant decrease in fasting blood glucose (p =0.0024); a significant increase in insulin secretion as measured by insulin (p =0.0012) and C-peptide (p =0.0103) levels in plasma and insulin content (p =0.0440) and homeobox factor-1 protein expression (p =0.0148) in the pancreas; and a significant increase in insulin sensitivity as measured by insulin receptor mRNA expression in the liver (p =0.0179) and adipose tissue (p =0.0491). In addition, improvements in the reactive oxygen species level and inflammatory pancreatic and hepatic tissue damage were also observed in the MRE group as assessed by histological findings. A similar but weaker effect was found in the OXY group. Furthermore, we observed a potentiating effect of MRE and OXY on insulin secretion in INS-1 cells in the presence of 27mM glucose, together with an anti-glycation effect as indicated by methylglyoxal-trapping capacity and inhibition of advanced glycation end-product formation. Taken together, these data suggest that MRE could ameliorate β-cell dysfunction and insulin resistance by reducing oxidative damage and advanced glycation end-product (Wagenknecht et al., 2003) formation and that these effects are due, at least in part, to OXY.

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Standardized Mori ramulus extract improves insulin secretion and insulin sensitivity in C57BLKS/J db/db mice and INS-1 cells

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Standardized Mori ramulus extract improves insulin secretion and insulin sensitivity in C57BLKS/J db/db mice and INS-1 cells

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