[논문]Immunomodulatory effects of Pseudostellaria heterophylla (Miquel) Pax on regulation of Th1/Th2 levels in mice with atopic dermatitis

Choi, You Yeon; Kim, Mi Hye; Ahn, Kwang Seok; Um, Jae-Young; Lee, Seok-Geun; Yang, Woong Mo

doi:10.3892/mmr.2016.6093

[해외논문] Immunomodulatory effects of Pseudostellaria heterophylla (Miquel) Pax on regulation of Th1/Th2 levels in mice with atopic dermatitis 원문보기

Molecular medicine reports, v.15 no.2, 2017년, pp.649 - 656

Choi, You Yeon (Department of Convergence Korean Medical Science, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea) , Kim, Mi Hye (Department of Convergence Korean Medical Science, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea) , Ahn, Kwang Seok (Department of Korean Pathology, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea) , Um, Jae-Young (Department of Korean Pharmacology, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea) , Lee, Seok-Geun (Cancer Preventive Material Development Research Center, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea) , Yang, Woong Mo (Department of Convergence Korean Medical Science, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea)

Abstract ▼ AI-Helper

Pseudostellaria heterophylla (PH) has various pharmacological effects that include immunologic enhancement and anti-oxidation. However, it remains unclear whether PH exerts beneficial effects in dermatological diseases. The present study examined the effects of PH on a 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD) mouse model and elucidated its underlying mechanism of action. PH extract (1 and 100 mg/ml) was applied topically to DNCB-treated dorsal skin of mice every day for 11 days. The immunomodulatory effects of PH were evaluated by measuring skin thickness, mast cell infiltration, serum levels of immunoglobulin E (IgE), and mRNA expression levels of T helper (h)1/Th2 and pro-inflammatory cytokines in dorsal skin. In addition, cluster of differentiation (CD)4+ T cells were detected in dorsal skin by immunohistochemistry. Topical application of PH significantly reduced the thickness of dermis, epidermis and serum IgE production compared with the DNCB group. PH treatment inhibited infiltration of inflammatory cells, including mast cells and CD4+ T cells, and suppressed the mRNA expression levels of cytokines (interferon-γ, interleukin-4, −6, −8 and −1β, and tumor necrosis factor-α) associated with the immune response. Furthermore, PH treatment significantly downregulated the protein expression levels of nuclear factor-κB, phosphorylated inhibitor of κBα and mitogen-activated protein kinases. The results suggested that PH may be a potential therapeutic strategy for the treatment of AD via the modulation of Th1 and Th2 levels.

주제어

참고문헌 (24)

1 Levy ML Atopic dermatitis: Understanding the disease and its management Curr Med Res Opin 23 3091 3103 2007 10.1185/030079907X242593 17971284

상세보기
2 Minnicozzi M Sawyer RT Fenton MJ Innate immunity in allergic disease Immunol Rev 242 106 127 2011 10.1111/j.1600-065X.2011.01025.x 21682741

상세보기
3 Mosmann TR Coffman RL Th1 and th2 cells: Different patterns of lymphokine secretion lead to different functional properties Annu Rev Immunol 7 145 173 1989 10.1146/annurev.iy.07.040189.001045 2523712

상세보기
4 Leung DY Boguniewicz M Howell MD Nomura I Hamid QA New insights into atopic dermatitis J Clin Invest 113 651 657 2004 10.1172/JCI21060E1 351324 --> 14991059

상세보기
5 Nakamura K Pathogenesis and treatment of allergic skin disease-atopic dermatitis Arerugi 64 703 706 2015 (In Japanese) 26108752
6 Liu J Pei M Zheng C Li Y Wang Y Lu A Yang L A systems-pharmacology analysis of herbal medicines used in health improvement treatment: Predicting potential new drugs and targets Evid Based Complement Alternat Med 2013 938764 2013 10.1155/2013/938764 3863530 --> 24369484

상세보기
7 Ng TB Liu F Wang HX The antioxidant effects of aqueous and organic extracts of panax quinquefolium, panax notoginseng, codonopsis pilosula, pseudostellaria heterophylla and glehnia littoralis J Ethnopharmacol 93 285 288 2004 10.1016/j.jep.2004.03.040 15234766

상세보기
8 Pang W Lin S Dai Q Zhang H Hu J Antitussive activity of pseudostellaria heterophylla (miq.) pax extracts and improvement in lung function via adjustment of multi-cytokine levels Molecules 16 3360 3370 2011 10.3390/molecules16043360 21512444

상세보기
9 Li X Chen Y Lai Y Yang Q Hu H Wang Y Sustainable utilization of traditional chinese medicine resources: Systematic evaluation on different production modes Evid Based Complement Alternat Med 2015 218901 2015 4449915 --> 26074987

상세보기
10 Li Y Yang XW Studies on chemical constituents of root tuber of cultivated pseudostellaria heterophylla (Zheshen No1) Zhongguo Zhong Yao Za Zhi 33 2353 2355 2008 (In Chinese) 19157126

상세보기
11 Wong CK Leung KN Fung MC Fung KP Choy YM The induction of cytokine gene expression in murine peritoneal macrophages by pseudostellaria heterophylla Immunopharmacol Immunotoxicol 16 347 357 1994 10.3109/08923979409007098 7798590

상세보기
12 Choi YY Kim MH Hong J Kim K Yang WM Effect of Dangguibohyul-Tang, a mixed extract of astragalus membranaceus and angelica sinensis, on allergic and inflammatory skin reaction compared with single extracts of astragalus membranaceus or angelica sinensis Evid Based Complement Alternat Med 2016 5936354 2016 10.1155/2016/5936354 4802015 --> 27051450

상세보기
13 Shin HS See HJ Jung SY Choi DW Kwon DA Bae MJ Sung KS Shon DH Turmeric (curcuma longa) attenuates food allergy symptoms by regulating type 1/type 2 helper t cells (th1/th2) balance in a mouse model of food allergy J Ethnopharmacol 175 21 29 2015 10.1016/j.jep.2015.08.038 26342520

상세보기
14 Kang H Lee CH Kim JR Kwon JY Seo SG Han JG Kim BG Kim JE Lee KW Chlorella vulgaris attenuates dermatophagoides farinae-induced atopic dermatitis-like symptoms in nc/nga mice Int J Mol Sci 16 21021 21034 2015 10.3390/ijms160921021 4613239 --> 26404252

상세보기
15 Park S Kim da S Kang S Shin BK Synergistic topical application of salt-processed phellodendron amurense and sanguisorba officinalis linne alleviates atopic dermatitis symptoms by reducing levels of immunoglobulin e and pro-inflammatory cytokines in nc/nga mice Mol Med Rep 12 7657 7664 2015 26397864
16 Vocanson M Hennino A Chavagnac C Saint-Mezard P Dubois B Kaiserlian D Nicolas JF Contribution of cd4(+)and cd8(+) T-cells in contact hypersensitivity and allergic contact dermatitis Expert Rev Clin Immunol 1 75 86 2005 10.1586/1744666X.1.1.75 20477656

상세보기
17 Zhang EY Chen AY Zhu BT Mechanism of dinitrochlorobenzene-induced dermatitis in mice: Role of specific antibodies in pathogenesis PLoS One 4 e7703 2009 10.1371/journal.pone.0007703 2766640 --> 19890385

상세보기
18 Lee HS Kim SK Han JB Choi HM Park JH Kim EC Choi MS An HJ Um JY Kim HM Min BI Inhibitory effects of Rumex japonicus Houtt. On the development of atopic dermatitis-like skin lesions in Nc/Nga mice Br J Dermatol 155 33 38 2006 10.1111/j.1365-2133.2006.07303.x 16792749

상세보기
19 Chen L Martinez O Overbergh L Mathieu C Prabhakar BS Chan LS Early up-regulation of Th2 cytokines and late surge of Th1 cytokines in an atopic dermatitis model Clin Exp Immunol 138 375 387 2004 10.1111/j.1365-2249.2004.02649.x 1809236 --> 15544612

상세보기
20 Lee HJ Lee HP Ha SJ Byun DG Kim JW Spontaneous expression of mrna for iL-10, GM-CSF, TGF-beta, TGF-alpha, and IL-6 in peripheral blood mononuclear cells from atopic dermatitis Ann Allergy Asthma Immunol 84 553 558 2000 10.1016/S1081-1206(10)62522-7 10831012

상세보기
21 Szegedi K Lutter R Res PC Bos JD Luiten RM Kezic S Middelkamp-Hup MA Cytokine profiles in interstitial fluid from chronic atopic dermatitis skin J Eur Acad Dermatol Venereol 29 2136 2144 2015 10.1111/jdv.13160 25980674

상세보기
22 Li W Zhao Y Xu X Ma W Gao P Wang Y Liang K Li R Rebamipide suppresses TNF-α mediated inflammation in vitro and attenuates the severity of dermatitis in mice FEBS J 282 2317 2326 2015 10.1111/febs.13278 25817390

상세보기
23 Lee J Choi YY Kim MH Han JM Lee JE Kim EH Hong J Kim J Yang WM Topical application of angelica sinensis improves pruritus and skin inflammation in mice with atopic dermatitis-like symptoms J Med Food 19 98 105 2016 10.1089/jmf.2015.3489 26305727

상세보기
24 Mishra S Tripathi A Chaudhari BP Dwivedi PD Pandey HP Das M Deoxynivalenol induced mouse skin cell proliferation and inflammation via MAPK pathway Toxicol Appl Pharmacol 279 186 197 2014 10.1016/j.taap.2014.06.003 24937323

상세보기

LOADING...

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

[해외논문] Immunomodulatory effects of Pseudostellaria heterophylla (Miquel) Pax on regulation of Th1/Th2 levels in mice with atopic dermatitis 원문보기

Abstract ▼ AI-Helper

주제어

참고문헌 (24)

이 논문을 인용한 문헌

연구과제 타임라인

관련 콘텐츠

원문 보기

원문 URL 링크

오픈액세스(OA) 유형

이 논문과 함께 이용한 콘텐츠

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트

연합인증

[해외논문] Immunomodulatory effects of Pseudostellaria heterophylla (Miquel) Pax on regulation of Th1/Th2 levels in mice with atopic dermatitis 원문보기

Abstract ▼ AI-Helper

주제어

참고문헌 (24)

이 논문을 인용한 문헌

연구과제 타임라인

전체(0) 논문(0) 특허(0) 보고서(0)

전체(0) 논문(0) 특허(0) 보고서(0)

관련 콘텐츠

원문 보기

원문 URL 링크

오픈액세스(OA) 유형

이 논문과 함께 이용한 콘텐츠

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트