[논문]Aster koraiensis extract prevents diabetes-induced retinal vascular dysfunction in spontaneously diabetic Torii rats

Kim, Junghyun; Jo, Kyuhyung; Kim, Chan-Sik; Kim, Jin Sook

doi:10.1186/s12906-017-1998-3

[해외논문] Aster koraiensis extract prevents diabetes-induced retinal vascular dysfunction in spontaneously diabetic Torii rats 원문보기

Bmc complementary and alternative medicine, v.17, 2017년, pp.497 -

Kim, Junghyun (Korean Medicine Convergence Research Division, Korea Institute of Oriental Medicine, 1672 Yusengdae-ro, Daejeon, 34054 South Korea) , Jo, Kyuhyung (Korean Medicine Convergence Research Division, Korea Institute of Oriental Medicine, 1672 Yusengdae-ro, Daejeon, 34054 South Korea) , Kim, Chan-Sik (Korean Medicine Convergence Research Division, Korea Institute of Oriental Medicine, 1672 Yusengdae-ro, Daejeon, 34054 South Korea) , Kim, Jin Sook (Korean Medicine Convergence Research Division, Korea Institute of Oriental Medicine, 1672 Yusengdae-ro, Daejeon, 34054 South Korea)

Abstract ▼ AI-Helper

BackgroundAster koraiensis extract (AKE) is a standard dietary herbal supplement. The aim of this study is to investigate the inhibitory effects of AKE on diabetes-induced retinal vascular dysfunction in Spontaneously Diabetic Torii (SDT) rats.MethodsAKE (50 and 100 mg/kg body weight/day) was administered for 16 weeks. The effects of orally administered AKE on blood glucose levels, retinal vascular leakage, apoptosis, and accumulation of advanced glycation end products (AGEs) in the retina were evaluated.ResultsSDT rats exhibited hyperglycemia and retinal vascular leakage, and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining was clearly detected apoptosis in the retinal microvasculature. Immunofluorescence staining revealed the accumulation of AGEs in the retinal vasculature of the SDT rats. However, oral administration of AKE for 16 weeks blocked diabetes-induced blood–retinal barrier (BRB) breakdown and the loss of occludin, which is an important tight junction protein. Apoptosis of retinal vascular cells and AGE accumulation were significantly inhibited after AKE treatment.ConclusionThese results indicate that, as a dietary herbal supplement, AKE may have beneficial effects on patients with diabetic retinopathy.

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참고문헌 (26)

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[해외논문] Aster koraiensis extract prevents diabetes-induced retinal vascular dysfunction in spontaneously diabetic Torii rats 원문보기

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[해외논문] Aster koraiensis extract prevents diabetes-induced retinal vascular dysfunction in spontaneously diabetic Torii rats 원문보기

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