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Alpha-Linolenic Acid from Perilla frutescens var. japonica Oil Protects Aβ-Induced Cognitive Impairment through Regulation of APP Processing and Aβ Degradation

Journal of agricultural and food chemistry, v.65 no.49, 2017년, pp.10719 - 10729  

Lee, Ah Young (Department of Food Science and Nutrition and Kimchi Research Institute, Pusan National University, Busan 46241,) ,  Lee, Myoung Hee (Department of Southern Area Crop Science, National Institute of Crop Science, Rural Development Administration, Gyeongnam 50424,) ,  Lee, Sanghyun (Department of Integrative Plant Science, Chung-Ang University, Gyeonggi 17546,) ,  Cho, Eun Ju (Department of Food Science and Nutrition and Kimchi Research Institute, Pusan National University, Busan 46241,)

Abstract AI-Helper 아이콘AI-Helper

Alzheimer’s disease (AD) is characterized by progressive cognitive and memory impairment. The major pathological hallmark of AD is the accumulation of amyloid beta (Aβ), which is produced from the amyloid precursor protein (APP) through cleavage of β- and γ-secretase. Recently,...

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