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IGF-I regulates HT1080 fibrosarcoma cell migration through a syndecan-2/Erk/ezrin signaling axis

Experimental cell research, v.361 no.1, 2017년, pp.9 - 18  

Mytilinaiou, Maria (Laboratory of Anatomy-Histology-Embryology, School of Medicine, University of Crete) ,  Nikitovic, Dragana (Laboratory of Anatomy-Histology-Embryology, School of Medicine, University of Crete) ,  Berdiaki, Aikaterini (Laboratory of Anatomy-Histology-Embryology, School of Medicine, University of Crete) ,  Papoutsidakis, Antonis (Laboratory of Anatomy-Histology-Embryology, School of Medicine, University of Crete) ,  Papachristou, Dionysios J. (Laboratory of Toxicology, School of Medicine, University of Crete) ,  Tsatsakis, Aristidis (Laboratory of Anatomy-Histology-Embryology, Unit of Bone and Soft Tissue Studies, School of Medicine, University of Patras, Patras) ,  Tzanakakis, George N. (Laboratory of Anatomy-Histology-Embryology, School of Medicine, University of Crete)

Abstract AI-Helper 아이콘AI-Helper

Abstract Fibrosarcoma is a tumor of mesenchymal origin, originating from fibroblasts. IGF-I is an anabolic growth factor which exhibits significant involvement in cancer progression. In this study, we investigated the possible participation of syndecan-2 (SDC-2), a cell membrane heparan sulfate (HS...

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