[논문]Cutaneous and renal vasodilatory response to local pressure application: A comparative study in mice

Begey, Anne-Laure; Liu, Kiao Ling; Lo, Ming; Josset-Lamaugarny, Audrey; Picard, Nicolas; Gauthier, Catherine; Fromy, Berengere; Sigaudo-Roussel, Dominique; Dubourg, Laurence

doi:10.1016/j.mvr.2017.08.007

Cutaneous and renal vasodilatory response to local pressure application: A comparative study in mice

Microvascular research, v.115, 2018년, pp.44 - 51

Begey, Anne-Laure (Laboratory of Tissue Biology and Therapeutic Engineering, UMR 5305 CNRS, University Lyon 1, France) , Liu, Kiao Ling (Laboratory of Tissue Biology and Therapeutic Engineering, UMR 5305 CNRS, University Lyon 1, France) , Lo, Ming (Laboratory of Tissue Biology and Therapeutic Engineering, UMR 5305 CNRS, University Lyon 1, France) , Josset-Lamaugarny, Audrey (Laboratory of Tissue Biology and Therapeutic Engineering, UMR 5305 CNRS, University Lyon 1, France) , Picard, Nicolas (ERL 8228, INSERM UMR S1138, Centre de Recherche des Cordeliers, University Paris VI, France) , Gauthier, Catherine (Laboratory of Tissue Biology and Therapeutic Engineering, UMR 5305 CNRS, University Lyon 1, France) , Fromy, Berengere (Laboratory of Tissue Biology and Therapeutic Engineering, UMR 5305 CNRS, University Lyon 1, France) , Sigaudo-Roussel, Dominique (Laboratory of Tissue Biology and Therapeutic Engineering, UMR 5305 CNRS, University Lyon 1, France) , Dubourg, Laurence (Laboratory of Tissue Biology and Therapeutic Engineering, UMR 5305 CNRS, University Lyon 1, France)

Abstract ▼ AI-Helper

Abstract Background and aim We have reported a novel relationship involving mechanical stimulation and vasodilation in rodent and human skin, referred to as pressure-induced vasodilation (PIV). It is unknown whether this mechanism exists in kidney and reflects the microcirculation in deep organs. Therefore, we compared the skin and kidney PIV to determine whether their changes were similar. Methods In anesthetized mice fed a normal salt-diet, laser Doppler flux (LDF) signals were measured when an increase in local pressure was applied to the surface of the head skin with the rate of 2.2Pa/s (1mmHg/min) and to the left kidney with a rate of 4.4Pa/s (2mmHg/min). The mechanism underlying renal PIV was also investigated. The skin and kidney PIV were also compared during salt load (4% NaCl diet). Results The kidney had higher baseline LDF and vascular conductance compared to those of the skin. Pressure application increased the LDF in the kidney as well as in the skin with a comparable maximal magnitude (about 25% from baseline value), despite different kinetics of PIV evolution. As we previously reported in the skin, the kidney PIV response was mediated by the activation of transient receptor potential vanilloid type 1 channels, the release of calcitonin gene-related peptide, and the participation of prostaglandins and nitric oxide. In the absence of hypertension, high salt intake abolished the cutaneous PIV response and markedly impaired the renal one. Conclusion PIV response in the mouse kidney results from a neuro-vascular interaction. Despite some differences between the skin and the kidney PIV, the similarities in their response and signaling mechanisms suggest that the cutaneous microcirculation could reflect, in part, the microcirculation of the renal cortex.

주제어

참고문헌 (36)

Microcirculation Boegehold 9 225 2002 10.1038/sj.mn.7800139 Microvascular structure and function in salt-sensitive hypertension

상세보기
Annu. Rev. Neurosci. Caterina 24 487 2001 10.1146/annurev.neuro.24.1.487 The vanilloid receptor: a molecular gateway to the pain pathway

상세보기
Nature Caterina 389 816 1997 10.1038/39807 The capsaicin receptor: a heat-activated ion channel in the pain pathway

상세보기
PLoS One Chen 9 2014 Role of TRPV1 channels in ischemia/reperfusion-induced acute kidney injury

상세보기
J. Hum. Hypertens. Coulon 26 56 2012 10.1038/jhh.2010.117 Impairment of skin blood flow during post-occlusive reactive hyperhemy assessed by laser Doppler flowmetry correlates with renal resistive index

상세보기
Diabetes Demiot 55 1478 2006 10.2337/db05-1433 Aldose reductase pathway inhibition improved vascular and C-fiber functions, allowing for pressure-induced vasodilation restoration during severe diabetic neuropathy

상세보기
Atherosclerosis Dickinson 233 32 2014 10.1016/j.atherosclerosis.2013.11.078 A reduction of 3g/day from a usual 9g/day salt diet improves endothelial function and decreases endothelin-1 in a randomised crossover study in normotensive overweight and obese subjects

상세보기
Brain Res. Fromy 16 166 1998 10.1016/S0006-8993(98)00973-1 Non-nociceptive capsaicin-sensitive nerve terminal stimulation allows for an original vasodilatory reflex in the human skin

상세보기
Br. J. Pharmacol. Fromy 131 1161 2000 10.1038/sj.bjp.0703685 Mechanisms of the cutaneous vasodilator response to local external pressure application in rats: involvement of CGRP, neurokinins, prostaglandins and NO

상세보기
J. Invest. Dermatol. Fromy 130 849 2010 10.1038/jid.2009.279 Aging-associated sensory neuropathy alters pressure-induced vasodilation in humans

상세보기
Nat. Med. Fromy 18 1205 2012 10.1038/nm.2844 Asic3 is a neuronal mechanosensor for pressure-induced vasodilation that protects against pressure ulcers

상세보기
J. Physiol. Gaubert 585 617 2007 10.1113/jphysiol.2007.143750 Endothelium-derived hyperpolarizing factor as an in vivo back-up mechanism in the cutaneous microcirculation in old mice

상세보기
Cell Biosci. Han 6 37 2016 10.1186/s13578-016-0085-7 Paeoniflorin protects diabetic mice against myocardial ischemic injury via the transient receptor potential vanilloid 1/calcitonin gene-related peptide pathway

상세보기
J. Hypertens. de Jongh 25 1887 2007 10.1097/HJH.0b013e32825e1db7 Microvascular function: a potential link between salt sensitivity, insulin resistance and hypertension

상세보기
Am. J. Anat. Knight 190 31 1991 10.1002/aja.1001900105 Calcitonin gene-related peptide-immunoreactive nerves in the rat kidney

상세보기
Am. J. Phys. Kopp 246 F67 1984 Renorenal reflex responses to mechano- and chemo-receptor stimulation in the dog and rat
Pflugers Arch. Kusche-Vihrog 467 499 2015 10.1007/s00424-014-1657-1 Salt controls endothelial and vascular phenotype

상세보기
Pharmacol. Res. Li 57 239 2008 10.1016/j.phrs.2008.01.011 Increased GFR and renal excretory function by activation of TRPV1 in the isolated perfused kidney

상세보기
Hypertension Li 64 397 2014 10.1161/HYPERTENSIONAHA.114.03105 Transient receptor potential vanilloid 1 activation by dietary capsaicin promotes urinary sodium excretion by inhibiting epithelial sodium channel α subunit-mediated sodium reabsorption

상세보기
Clin. Exp. Pharmacol. Physiol. Liu 36 455 2009 10.1111/j.1440-1681.2009.05153.x Regulation of renal medullary circulation by the renin-angiotensin system in genetically hypertensive rats

상세보기
Atherosclerosis Matsue 232 186 2014 10.1016/j.atherosclerosis.2013.11.038 Peripheral microvascular dysfunction predicts residual risk in coronary artery disease patients on statin therapy

상세보기
J. Appl. Physiol. Matthews 118 1510 2015 10.1152/japplphysiol.00023.2015 High dietary sodium reduces brachial artery flow-mediated dilation in humans with salt-sensitive and salt-resistant blood pressure

상세보기
Am. J. Physiol. Regul. Integr. Comp. Physiol. Mulder 304 R675 2013 10.1152/ajpregu.00599.2012 Renal sensory and sympathetic nerves reinnervate the kidney in a similar time-dependent fashion after renal denervation in rats

상세보기
Microvasc. Res. Nguyen-Tu 90 138 2013 10.1016/j.mvr.2013.10.001 Skin microvascular response to pressure load in obese mice

상세보기
Genome Biol. Nilius 12 218 2011 10.1186/gb-2011-12-3-218 The transient receptor potential family of ion channels

상세보기
Ann. Med. Oberleithner 44 S143 2012 10.3109/07853890.2011.653397 Two barriers for sodium in vascular endothelium?

상세보기
Proc. Natl. Acad. Sci. U. S. A. Oberleithner 104 16281 2007 10.1073/pnas.0707791104 Plasma sodium stiffens vascular endothelium and reduces nitric oxide release

상세보기
Am. J. Physiol. Regul. Integr. Comp. Physiol. Roman 251 F115 1986 10.1152/ajprenal.1986.251.1.F115 Laser-Doppler determination of papillary blood flow in young and adult rats

상세보기
Am. J. Hypertens. Sarkis 15 212 2002 10.1016/S0895-7061(01)02339-1 Renal medullary blood flow and salt load in Lyon hypertensive rats

상세보기
Diabetes Sigaudo-Roussel 53 1564 2004 10.2337/diabetes.53.6.1564 Early endothelial dysfunction severely impairs skin blood flow response to local pressure application in streptozotocin-induced diabetic mice

상세보기
J. Cardiovasc. Pharmacol. Ueda 51 513 2008 10.1097/FJC.0b013e31816f6884 Preventive effect of TRPV1 agonist capsaicin and resiniferatoxin on ischemia/reperfusion-induced renal injury in rats

상세보기
J. Hypertens. Wang 21 403 2003 10.1097/00004872-200302000-00033 Increased salt sensitivity induced by impairment of sensory nerves: is nephropathy the cause?

상세보기
Hypertension Wang 32 649 1998 10.1161/01.HYP.32.4.649 Salt-sensitive hypertension induced by sensory denervation

상세보기
J. Clin. Invest. Wiig 123 2803 2013 10.1172/JCI60113 Immune cells control skin lymphatic electrolyte homeostasis and blood pressure

상세보기
Br. J. Pharmacol. Withrington 107 296 1992 10.1111/j.1476-5381.1992.tb12741.x The actions of two sensory neuropeptides, substance P and calcitonin gene-related peptide, on the canine hepatic arterial and portal vascular beds

상세보기
Am. J. Phys. Zager 251 F87 1986 Body temperature: an important determinant of severity of ischemic renal injury

표제어: PCR

동의어: Packet Collision Rate

용어 설명 출처 목록 (6)

용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

Cutaneous and renal vasodilatory response to local pressure application: A comparative study in mice

Abstract ▼ AI-Helper

주제어

참고문헌 (36)

이 논문을 인용한 문헌

관련 콘텐츠

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트