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NTIS 바로가기European journal of medicinal chemistry, v.143, 2018년, pp.48 - 65
Li, Ridong (Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, PR China) , Ning, Xianling (Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, PR China) , Zhou, Shuo (Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentuchy, 789 South Lime-stone Street, Lexington, KY 40536, USA) , Lin, Zhiqiang (Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, PR China) , Wu, Xingyu (Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, PR China) , Chen, Hong (Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, PR China) , Bai, Xinyu (Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, PR China) , Wang, Xin (State Key Laboratory of Natural and Biomimet) , Ge, Zemei , Li, Runtao , Yin, Yuxin
Abstract Pyruvate kinase M2 isoform (PKM2) is a crucial protein responsible for aerobic glycolysis of cancer cells. Activation of PKM2 may alter aberrant metabolism in cancer cells. In this study, we discovered a 4-hydroxy-thiazolidine-2-thione compound 2 as a novel PKM2 activator from a random scr...
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