참고문헌 (19)

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2. 2 Brennan , A. J. , Shevitz , J. , Macmillan , J. D. 1987 . A perfusion system for antibody production by shear‐sensitive hybridoma cells in a stirred reactor . Biotechnol. Techniques 1 : 169 – 174 . 

3. 3 de la Broise , D. , Noiseux , M. , Lemieux , R. , Massie , B. 1991 . Long‐term perfusion culture of hybridoma: A “grow or die” cell cycle systems . Biotechnol. Bioeng. 38 : 781 – 787 . 

4. 4 Flickinger , M. C. , Goebel , N. K. , and Bohn , M. A. 1990 . Determination of specific monoclonal antibody secretion rate during very slow hybridoma growth . Bioproc. Eng. 5 : 155 – 164 . 

5. 5 King , G. A. , Daugulis , A. J. , Faulkner , P. , Goosen , M. F. A. 1987 . Alginate‐polylysine macrocapsule of controlled membrane molecular weight cut‐off for mammalian cell culture engineering . Biotechnol. Prog. 3 : 231 – 240 . 

6. 6 Klement , G. , Scheirer , W. , Katinger , H. W. D. 1987 . Construction of a large scale membrane reactor system with different compartments for cells, medium and product . Dev. Biol. Standard 66 : 221 – 226 . 

7. 7 Knazek , R. A. , Gullino , P. M. , Kohler , P. O. , Dedrick , R. L. 1972 . Cell culture on artificial capillaries: an approach to tissue growth in vitro . Nature 178 : 65 – 67 . 

8. 8 Knight , P. 1988 . Trends in contract cell culture . Bio/Technology 6 : 961 – 963 . 

9. 9 Martel , M. , Bazin , R. , Verrette , S. , Lemieux , R. 1988 . Characterization of higher avidity monoclonal antibodies produced by murine B‐Cell hybridoma variants selected for increased antigen binding of membrane Ig . J. Immunol. 141 : 1624 – 1626 . 

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10. 10 Nakamura , Y. , Watanabe , K. , Noto , T. , Tajima , T. , Yamamura , M. 1989 . A new compact and cell dense continuous culture system . J. Immunol. Meth. 118 : 31 – 35 . 

11. 11 Piret , J. M. , Cooney , C. L. 1990 . Mammalian cell and protein distributions in ultrafiltration hollow fiber bioreactors . Biotechnol. Bioeng. 36 : 902 – 910 . 

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12. 12 Ray , N. G. , Karkare , S. B. , Runstadler , P. W. , Jr. 1988 . Cultivation of hybridoma cells in continuous cultures: Kinetics of growth and product formation . Biotechnol. Bioeng. 33 : 724 – 730 . 

13. 13 Reuveny , S. , Velez , D. , Miller , L. , Macmillan , J. D. 1986 . Comparison of cell propagation methods for their effect on monoclonal antibody yield in fermentors . J. Immunol. Meth. 86 : 61 – 69 . 

14. 14 Sinacore , M. S. , Creswick , B. C. , Buehler , R. 1989 . Entrapment and growth of murine hybridoma cells in calacium alginate gel microbeads . Bio/Technology 7 : 1275 – 1279 . 

15. 15 Smith , C. G. , Guillaume , J.‐M. , Greenfield , P. F. , Randerson , D. H. 1991 . Experience in scale‐up of homogeneous perfusion culture for hybridomas . Bioproc. Eng. 6 : 213 – 219 . 

16. 16 Susuki , E. , Ollis , D. F. 1989 . Cell cycle model for antibody production kinetics . Biotechnol. Bioeng. 34 : 1398 – 1402 . 

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17. 17 Tolbert , W. R. , Lewis , C. , White , P. J. , Feder , J. 1985 . Perfusion culture systems for production of mammalian cell biomolecules ,pp. 97 – 123 . In: J. Feder and W. R. Tolbert (eds.), Large scale mammalian cell cultures . Academic Press , New York . 

18. 18 Velez , D. , Miller , L. , Macmillan , J. D. 1989 . Use of tangential flow filtration in perfusion propagation of hybridoma cells for production of monoclonal antibodies . Biotechnol. Bioeng. 33 : 938 – 940 . 

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19. 19 Vournakis , J. N. , Runstadler , P. W. 1989 . Microenvironment: The Key to improved cell culture products . Bio/Technology 7 : 143 – 145 .