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NTIS 바로가기Cancer discovery, v.2 no.7, 2012년, pp.586 - 587
Melief, Cornelis J.M.
AbstractSummary: Hypoxia-inducing transcription factor-1α (HIF-1α) in hypoxic tumors induces the TNF receptor family member CD137 on tumor-infiltrating lymphocytes. This can be exploited for intratumoral low-dose injection of effective systemic immunotherapy with agonist CD137-specific m...
Cancer Discov Palazón 2 608 2012 10.1158/2159-8290.CD-11-0314 The HIF-1α hypoxia response in tumor-infiltrating T lymphocytes induces functional CD137 (4-1BB) for immunotherapy
Mol Cancer Ther Vinay 11 1062 2012 10.1158/1535-7163.MCT-11-0677 Immunotherapy of cancer with 4-1BB
Semin Oncol Ascierto 37 508 2010 10.1053/j.seminoncol.2010.09.008 Clinical experiences with anti-CD137 and anti-PD1 therapeutic antibodies
J Leukoc Biol Shao 89 21 2011 10.1189/jlb.0510315 CD137 ligand, a member of the tumor necrosis factor family, regulates immune responses via reverse signal transduction
Nat Rev Cancer Keith 12 9 2012 10.1038/nrc3183 HIF1alpha and HIF2alpha: sibling rivalry in hypoxic tumour growth and progression
Clin Cancer Res Fransen 17 2270 2011 10.1158/1078-0432.CCR-10-2888 Local activation of CD8 T cells and systemic tumor eradication without toxicity via slow release and local delivery of agonistic CD40 antibody
J Clin Oncol Brody 28 4324 2010 10.1200/JCO.2010.28.9793 In situ vaccination with a TLR9 agonist induces systemic lymphoma regression: a phase I/II study
Blood Kim 119 355 2012 10.1182/blood-2011-05-355222 In situ vaccination against mycosis fungoides by intratumoral injection of a TLR9 agonist combined with radiation: a phase 1/2 study
Blood Kohrt 117 2423 2011 10.1182/blood-2010-08-301945 CD137 stimulation enhances the antilymphoma activity of anti-CD20 antibodies
Cancer Res Ly 70 8339 2010 10.1158/0008-5472.CAN-10-2288 Peptide vaccination after T-cell transfer causes massive clonal expansion, tumor eradication, and manageable cytokine storm
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