[논문]Leukocyte telomere length and depression, anxiety and stress and adjustment disorders in primary health care patients

Wang, Xiao; Sundquist, Kristina; Hedelius, Anna; Palmé; r, Karolina; Memon, Ashfaque A.; Sundquist, Jan

doi:10.1186/s12888-017-1308-0

Leukocyte telomere length and depression, anxiety and stress and adjustment disorders in primary health care patients 원문보기

BMC psychiatry, v.17, 2017년, pp.148 -

Wang, Xiao (Center for Primary Health Care Research, Lund University) , Sundquist, Kristina (ne, Malmö) , Hedelius, Anna (, Sweden) , Palmér, Karolina (Center for Primary Health Care Research, Lund University) , Memon, Ashfaque A. (ne, Malmö) , Sundquist, Jan (, Sweden)

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BackgroundThe primary aim was to examine possible differences in telomere length between primary health care patients, with depression, anxiety or stress and adjustment disorders, and healthy controls. The second aim was to examine the association between telomere length and baseline characteristics in the patients. The third aim was to examine the potential effects of the 8-week treatments (mindfulness-based group therapy or treatment as usual, i.e. mostly cognitive-based therapy) on telomere length, and to examine whether there was a difference in the potential effect on telomere length between the two groups.MethodsA total of 501 individuals including 181 patients (aged 20–64 years), with depression, anxiety and stress and adjustment disorders, and 320 healthy controls (aged 19–70 years) were recruited in the study. Patient data were collected from a randomized controlled trial comparing mindfulness-based group therapy with treatment as usual. We isolated genomic DNA from blood samples, collected at baseline and after the 8-week follow-up. Telomere length was measured by quantitative real-time (qRT)-PCR.ResultsTelomere length was significantly shorter in the patients (mean = 0.77 ± 0.12,), compared to the controls (mean = 0.81 ± 0.14) (p = 0.006). The difference in telomere length remained significant after controlling for age and sex. Old age, male sex and being overweight were associated with shorter telomere length. There was no significant difference in telomere length between baseline and at the 8-week follow-up in any of the treatment groups and no difference between the two groups.ConclusionOur findings confirm that telomere length, as compared with healthy controls, is shortened in patients with depression, anxiety and stress and adjustment disorders. In both groups (mindfulness-based group therapy or treatment as usual), the telomere length remained unchanged after the 8-week treatment/follow-up and there was no difference between the two groups.Trial registration(ClinicalTrials.gov ID: NCT01476371) Registered November 11, 2011.Electronic supplementary materialThe online version of this article (doi:10.1186/s12888-017-1308-0) contains supplementary material, which is available to authorized users.

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참고문헌 (59)

1. Vazquez-Barquero JL Garcia J Simon JA Iglesias C Montejo J Herran A Dunn G Mental health in primary care. An epidemiological study of morbidity and use of health resources Br J Psychiatry 1997 170 529 535 10.1192/bjp.170.6.529 9330019

상세보기
2. Nordstrom A Bodlund O Every third patient in primary care suffers from depression, anxiety or alcohol problems Nord J Psychiatry 2008 62 3 250 255 10.1080/08039480802141129 18609025

상세보기
3. Irwin MR Miller AH Depressive disorders and immunity: 20 years of progress and discovery Brain Behav Immun 2007 21 4 374 383 10.1016/j.bbi.2007.01.010 17360153

상세보기
4. Lindqvist D Epel ES Mellon SH Penninx BW Revesz D Verhoeven JE Reus VI Lin J Mahan L Hough CM Psychiatric disorders and leukocyte telomere length: underlying mechanisms linking mental illness with cellular aging Neurosci Biobehav Rev 2015 55 333 364 10.1016/j.neubiorev.2015.05.007 25999120

상세보기
5. Nemeroff CB Musselman DL Evans DL Depression and cardiac disease Depress Anxiety 1998 8 Suppl 1 71 79 10.1002/(SICI)1520-6394(1998)8:1+ 3.0.CO;2-X

상세보기
6. Evans DL Charney DS Lewis L Golden RN Gorman JM Krishnan KR Nemeroff CB Bremner JD Carney RM Coyne JC Mood disorders in the medically ill: scientific review and recommendations Biol Psychiatry 2005 58 3 175 189 10.1016/j.biopsych.2005.05.001 16084838

상세보기
7. Kyrou I, Kollia N, Panagiotakos D, Georgousopoulou E, Chrysohoou C, Tsigos C, Randeva HS, Yannakoulia M, Stefanadis C, Papageorgiou C, et al. Association of depression and anxiety status with 10-year cardiovascular disease incidence among apparently healthy Greek adults: the ATTICA study. Eur J Prev Cardiol. 2017;24(2):145–52.
8. Svensson E Farkas DK Gradus JL Lash TL Sorensen HT Adjustment disorder and risk of Parkinson's disease Eur J Neurol 2016 23 4 751 756 10.1111/ene.12933 26756302

상세보기
9. Roy S Chakraborty A Ghosh C Banerjee B Systematic analysis of integrated Gene functional network of four chronic stress-related lifestyle disorders Genome Integrity 2015 6 1 10.4103/2041-9414.155952 27330735

상세보기
10. Gradus JL Farkas DK Svensson E Ehrenstein V Lash TL Milstein A Adler N Sorensen HT Associations between stress disorders and cardiovascular disease events in the Danish population BMJ Open 2015 5 12 e009334 10.1136/bmjopen-2015-009334 26667014

상세보기
11. Wolkowitz OM Mellon SH Epel ES Lin J Dhabhar FS Su Y Reus VI Rosser R Burke HM Kupferman E Leukocyte telomere length in major depression: correlations with chronicity, inflammation and oxidative stress--preliminary findings PLoS One 2011 6 3 e17837 10.1371/journal.pone.0017837 21448457

상세보기
12. Verhoeven JE Revesz D Epel ES Lin J Wolkowitz OM Penninx BW Major depressive disorder and accelerated cellular aging: results from a large psychiatric cohort study Mol Psychiatry 2014 19 8 895 901 10.1038/mp.2013.151 24217256

상세보기
13. Hartmann N Boehner M Groenen F Kalb R Telomere length of patients with major depression is shortened but independent from therapy and severity of the disease Depress Anxiety 2010 27 12 1111 1116 10.1002/da.20749 21053332

상세보기
14. Epel ES Blackburn EH Lin J Dhabhar FS Adler NE Morrow JD Cawthon RM Accelerated telomere shortening in response to life stress Proc Natl Acad Sci U S A 2004 101 49 17312 17315 10.1073/pnas.0407162101 15574496

상세보기
15. Blackburn EH Switching and signaling at the telomere Cell 2001 106 6 661 673 10.1016/S0092-8674(01)00492-5 11572773

상세보기
16. de Lange T Shelterin: the protein complex that shapes and safeguards human telomeres Genes Dev 2005 19 18 2100 2110 10.1101/gad.1346005 16166375

상세보기
17. Blackburn EH Telomere states and cell fates Nature 2000 408 6808 53 56 10.1038/35040500 11081503

상세보기
18. Beyne-Rauzy O Prade-Houdellier N Demur C Recher C Ayel J Laurent G Mansat-De Mas V Tumor necrosis factor-alpha inhibits hTERT gene expression in human myeloid normal and leukemic cells Blood 2005 106 9 3200 3205 10.1182/blood-2005-04-1386 16020509

상세보기
19. Shay JW Wright WE Hallmarks of telomeres in ageing research J Pathol 2007 211 2 114 123 10.1002/path.2090 17200948

상세보기
20. De Meyer T Rietzschel ER De Buyzere ML Van Criekinge W Bekaert S Studying telomeres in a longitudinal population based study Front Biosci 2008 13 2960 2970 10.2741/2901 17981769

상세보기
21. von Zglinicki T Oxidative stress shortens telomeres Trends Biochem Sci 2002 27 7 339 344 10.1016/S0968-0004(02)02110-2 12114022

상세보기
22. Wu X Amos CI Zhu Y Zhao H Grossman BH Shay JW Luo S Hong WK Spitz MR Telomere dysfunction: a potential cancer predisposition factor J Natl Cancer Inst 2003 95 16 1211 1218 10.1093/jnci/djg011 12928346

상세보기
23. Willeit P Willeit J Mayr A Weger S Oberhollenzer F Brandstatter A Kronenberg F Kiechl S Telomere length and risk of incident cancer and cancer mortality JAMA 2010 304 1 69 75 10.1001/jama.2010.897 20606151

상세보기
24. Calado RT Young NS Telomere diseases N Engl J Med 2009 361 24 2353 2365 10.1056/NEJMra0903373 20007561

상세보기
25. Brouilette SW Moore JS McMahon AD Thompson JR Ford I Shepherd J Packard CJ Samani NJ Telomere length, risk of coronary heart disease, and statin treatment in the west of Scotland primary prevention study: a nested case-control study Lancet 2007 369 9556 107 114 10.1016/S0140-6736(07)60071-3 17223473

상세보기
26. Zhao J Zhu Y Lin J Matsuguchi T Blackburn E Zhang Y Cole SA Best LG Lee ET Howard BV Short leukocyte telomere length predicts risk of diabetes in american indians: the strong heart family study Diabetes 2014 63 1 354 362 10.2337/db13-0744 23949319

상세보기
27. Garcia-Rizo C Fernandez-Egea E Miller BJ Oliveira C Justicia A Griffith JK Heaphy CM Bernardo M Kirkpatrick B Abnormal glucose tolerance, white blood cell count, and telomere length in newly diagnosed, antidepressant-naive patients with depression Brain Behav Immun 2013 28 49 53 10.1016/j.bbi.2012.11.009 23207109

상세보기
28. Hoen PW de Jonge P Na BY Farzaneh-Far R Epel E Lin J Blackburn E Whooley MA Depression and leukocyte telomere length in patients with coronary heart disease: data from the heart and soul study Psychosom Med 2011 73 7 541 547 10.1097/PSY.0b013e31821b1f6e 21597035

상세보기
29. Lung FW Chen NC Shu BC Genetic pathway of major depressive disorder in shortening telomeric length Psychiatr Genet 2007 17 3 195 199 10.1097/YPG.0b013e32808374f6 17417064

상세보기
30. Simon NM Smoller JW McNamara KL Maser RS Zalta AK Pollack MH Nierenberg AA Fava M Wong KK Telomere shortening and mood disorders: preliminary support for a chronic stress model of accelerated aging Biol Psychiatry 2006 60 5 432 435 10.1016/j.biopsych.2006.02.004 16581033

상세보기
31. Cai N Chang S Li Y Li Q Hu J Liang J Song L Kretzschmar W Gan X Nicod J Molecular signatures of major depression Curr Biol 2015 25 9 1146 1156 10.1016/j.cub.2015.03.008 25913401

상세보기
32. Karabatsiakis A Kolassa IT Kolassa S Rudolph KL Dietrich DE Telomere shortening in leukocyte subpopulations in depression BMC Psychiatry 2014 14 192 10.1186/1471-244X-14-192 24996455

상세보기
33. Martinsson L Wei Y Xu D Melas PA Mathe AA Schalling M Lavebratt C Backlund L Long-term lithium treatment in bipolar disorder is associated with longer leukocyte telomeres Transl Psychiatry 2013 3 10.1038/tp.2013.37 23695236

상세보기
34. Epel E Daubenmier J Moskowitz JT Folkman S Blackburn E Can meditation slow rate of cellular aging? Cognitive stress, mindfulness, and telomeres Ann N Y Acad Sci 2009 1172 34 53 10.1111/j.1749-6632.2009.04414.x 19735238

상세보기
35. Oei TP Bullbeck K Campbell JM Cognitive change process during group cognitive behaviour therapy for depression J Affect Disord 2006 92 2–3 231 241 10.1016/j.jad.2006.02.004 16542734

상세보기
36. Basu N Skinner HG Litzelman K Vanderboom R Baichoo E Boardman LA Telomeres and telomere dynamics: relevance to cancers of the GI tract Expert Rev Gastroenterol Hepatol 2013 7 8 733 748 10.1586/17474124.2013.848790 24161135

상세보기
37. Carlson LE Beattie TL Giese-Davis J Faris P Tamagawa R Fick LJ Degelman ES Speca M Mindfulness-based cancer recovery and supportive-expressive therapy maintain telomere length relative to controls in distressed breast cancer survivors Cancer 2015 121 3 476 484 10.1002/cncr.29063 25367403

상세보기
38. Schutte NS Malouff JM A meta-analytic review of the effects of mindfulness meditation on telomerase activity Psychoneuroendocrinology 2014 42 45 48 10.1016/j.psyneuen.2013.12.017 24636500

상세보기
39. Daubenmier J Lin J Blackburn E Hecht FM Kristeller J Maninger N Kuwata M Bacchetti P Havel PJ Epel E Changes in stress, eating, and metabolic factors are related to changes in telomerase activity in a randomized mindfulness intervention pilot study Psychoneuroendocrinology 2012 37 7 917 928 10.1016/j.psyneuen.2011.10.008 22169588

상세보기
40. Lavretsky H Epel ES Siddarth P Nazarian N Cyr NS Khalsa DS Lin J Blackburn E Irwin MR A pilot study of yogic meditation for family dementia caregivers with depressive symptoms: effects on mental health, cognition, and telomerase activity Int J Geriatr Psychiatry 2013 28 1 57 65 10.1002/gps.3790 22407663

상세보기
41. Sundquist J Lilja A Palmer K Memon AA Wang X Johansson LM Sundquist K Mindfulness group therapy in primary care patients with depression, anxiety and stress and adjustment disorders: randomised controlled trial Br J Psychiatry 2015 206 2 128 135 10.1192/bjp.bp.114.150243 25431430

상세보기
42. Wang X Sundquist K Hedelius A Palmer K Memon AA Sundquist J Circulating microRNA-144-5p is associated with depressive disorders Clin Epigenetics 2015 7 1 69 10.1186/s13148-015-0099-8 26199675

상세보기
43. Blood donation in Sweden https://geblodnu/english-engelska/.
44. Cawthon RM Telomere measurement by quantitative PCR Nucleic Acids Res 2002 30 10 10.1093/nar/30.10.e47 12000852

상세보기
45. Cawthon RM Smith KR O'Brien E Sivatchenko A Kerber RA Association between telomere length in blood and mortality in people aged 60 years or older Lancet 2003 361 9355 393 395 10.1016/S0140-6736(03)12384-7 12573379

상세보기
46. Nordfjall K Osterman P Melander O Nilsson P Roos G hTERT (−1327)T/C polymorphism is not associated with age-related telomere attrition in peripheral blood Biochem Biophys Res Commun 2007 358 1 215 218 10.1016/j.bbrc.2007.04.099 17481586

상세보기
47. Bojesen SE Telomeres and human health J Intern Med 2013 274 5 399 413 10.1111/joim.12083 24127938

상세보기
48. Rode L Nordestgaard BG Bojesen SE Peripheral blood leukocyte telomere length and mortality among 64,637 individuals from the general population J Natl Cancer Inst 2015 107 6 djv074 10.1093/jnci/djv074 25862531

상세보기
49. Lin J Epel E Cheon J Kroenke C Sinclair E Bigos M Wolkowitz O Mellon S Blackburn E Analyses and comparisons of telomerase activity and telomere length in human T and B cells: insights for epidemiology of telomere maintenance J Immunol Methods 2010 352 1–2 71 80 10.1016/j.jim.2009.09.012 19837074

상세보기
50. Wolkowitz OM Epel ES Reus VI Mellon SH Depression gets old fast: do stress and depression accelerate cell aging? Depress Anxiety 2010 27 4 327 338 10.1002/da.20686 20376837

상세보기
51. Gururajan A Clarke G Dinan TG Cryan JF Molecular biomarkers of depression Neurosci Biobehav Rev 2016 64 101 133 10.1016/j.neubiorev.2016.02.011 26906761

상세보기
52. Szebeni A Szebeni K DiPeri T Chandley MJ Crawford JD Stockmeier CA Ordway GA Shortened telomere length in white matter oligodendrocytes in major depression: potential role of oxidative stress Int J Neuropsychopharmacol 2014 17 10 1579 1589 10.1017/S1461145714000698 24967945

상세보기
53. Kawanishi S Oikawa S Mechanism of telomere shortening by oxidative stress Ann N Y Acad Sci 2004 1019 278 284 10.1196/annals.1297.047 15247029

상세보기
54. von Zglinicki T Saretzki G Ladhoff J d'Adda di Fagagna F Jackson SP Human cell senescence as a DNA damage response Mech Ageing Dev 2005 126 1 111 117 10.1016/j.mad.2004.09.034 15610769

상세보기
55. Hoge EA Chen MM Orr E Metcalf CA Fischer LE Pollack MH De Vivo I Simon NM Loving-kindness meditation practice associated with longer telomeres in women Brain Behav Immun 2013 32 159 163 10.1016/j.bbi.2013.04.005 23602876

상세보기
56. Weischer M Bojesen SE Nordestgaard BG Telomere shortening unrelated to smoking, body weight, physical activity, and alcohol intake: 4,576 general population individuals with repeat measurements 10 years apart PLoS Genet 2014 10 3 e1004191 10.1371/journal.pgen.1004191 24625632

상세보기
57. Lynch SM Peek MK Mitra N Ravichandran K Branas C Spangler E Zhou W Paskett ED Gehlert S DeGraffinreid C Race, ethnicity, psychosocial factors, and telomere length in a multicenter setting PLoS One 2016 11 1 e0146723 10.1371/journal.pone.0146723 26752285

상세보기
58. Revesz D Verhoeven JE Milaneschi Y Penninx BW Depressive and anxiety disorders and short leukocyte telomere length: mediating effects of metabolic stress and lifestyle factors Psychol Med 2016 46 11 2337 2349 10.1017/S0033291716000891 27266474

상세보기
59. Folkhälsorapport FHS. http://www.socialstyrelsen.se/ , 2012.

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Leukocyte telomere length and depression, anxiety and stress and adjustment disorders in primary health care patients 원문보기

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