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Unfolding of a ClC chloride transporter retains memory of its evolutionary history 원문보기

Nature chemical biology, v.14 no.5, 2018년, pp.489 - 496  

Min, Duyoung (Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095, USA) ,  Jefferson, Robert E. (Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095, USA) ,  Qi, Yifei (College of Chemistry and Molecular Engineering, East China Normal University, Shanghai, China) ,  Wang, Jing Yang (Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095, USA) ,  Arbing, Mark A. (Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095, USA) ,  Im, Wonpil (Departments of Biological Sciences and Bioengineering, Lehigh University, Bethlehem PA, USA) ,  Bowie, James U. (Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095, USA)

Abstract AI-Helper 아이콘AI-Helper

ClC chloride channels and transporters are important for chloride homeostasis in species from bacteria to human. Mutations in ClC proteins cause genetically inherited diseases, some of which are likely to have folding defects. The ClC proteins present a challenging and unusual biological folding pro...

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