[논문]The first report of siglec-3/CD33 gene in a teleost (rock bream, Oplegnathus fasciatus): An analysis of its spatial expression during stimulation to red seabream iridovirus (RSIV) and two bacterial pathogens

Jeswin, Joseph; Joo, Min-Soo; Jeong, Ji-Min; Bae, Jin-Sol; Choi, Kwang-Min; Cho, Dong-Hee; Park, Son-Il; Park, Chan-Il

doi:10.1016/j.dci.2018.02.005

The first report of siglec-3/CD33 gene in a teleost (rock bream, Oplegnathus fasciatus): An analysis of its spatial expression during stimulation to red seabream iridovirus (RSIV) and two bacterial pathogens

Developmental and comparative immunology, v.84, 2018년, pp.117 - 122

Jeswin, Joseph (Department of Marine Biology & Aquaculture, College of Marine Science, Gyeongsang National University) , Joo, Min-Soo (Department of Marine Biology & Aquaculture, College of Marine Science, Gyeongsang National University) , Jeong, Ji-Min (Department of Marine Biology & Aquaculture, College of Marine Science, Gyeongsang National University) , Bae, Jin-Sol (Department of Marine Biology & Aquaculture, College of Marine Science, Gyeongsang National University) , Choi, Kwang-Min (Department of Marine Biology & Aquaculture, College of Marine Science, Gyeongsang National University) , Cho, Dong-Hee (Department of Marine Biology & Aquaculture, College of Marine Science, Gyeongsang National University) , Park, Son-Il (College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University) , Park, Chan-Il (Department of Marin)

Abstract ▼ AI-Helper

Abstract Siglec-3/CD33 is a myeloid-specific inhibitory receptor that is expressed on cells of the immune system, where it is believed to play a regulatory role, modulating the inflammatory and immune responses. We characterized CD33 (RbCD33) in rock bream which is a transmembrane protein with two IG-like domains and a cytoplasmic tail. It has a deduced amino acid sequence of 390 residues and has tyrosine-based signaling motifs in the cytoplasmic tail. The RbCD33 mRNA was highly expressed in peripheral blood leukocytes and was also detected in the muscle, spleen, skin, head kidney, gills, trunk kidney, heart, stomach, brain, intestine and liver by quantitative real-time PCR. A temporal variation in expression of RbCD33 was observed in different tissues after stimulating with E. tarda, S. iniae and red seabream iridovirus (RSIV). In the head kidney tissue, E. tarda and S. iniae induced RbCD33, while a down regulation was observed with RSIV. In addition, in spleen tissue, S. iniae caused a very high induction of RbCD33 in comparison with an E. tarda and RSIV challenge. In the liver and gill tissues, all three pathogens induced a high expression of RbCD33. The expression pattern in various tissues and its high induction after pathogen stimulation suggests that RbCD33 plays an important role in initiating the immune response via the inhibition of signal transduction of the myeloid lineage cells. Highlights Characterized CD33 is a transmembrane protein with two IG like domains. Presence of inhibitory motif indicates its regulatory role in innate immunity. CD33 highly induced in peripheral blood leukocytes, muscle, spleen and skin. E. tarda, S. inia and RSIV stimulation in rock bream induced the expression of CD33.

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참고문헌 (22)

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The first report of siglec-3/CD33 gene in a teleost (rock bream, Oplegnathus fasciatus): An analysis of its spatial expression during stimulation to red seabream iridovirus (RSIV) and two bacterial pathogens

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The first report of siglec-3/CD33 gene in a teleost (rock bream, Oplegnathus fasciatus): An analysis of its spatial expression during stimulation to red seabream iridovirus (RSIV) and two bacterial pathogens

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