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The fruits of Gleditsia sinensis Lam. inhibits adipogenesis through modulation of mitotic clonal expansion and STAT3 activation in 3T3-L1 cells

Journal of ethnopharmacology, v.222, 2018년, pp.61 - 70  

Lee, Ji-Hye (Corresponding authors.) ,  Go, Younghoon (Corresponding authors.) ,  Lee, Bonggi ,  Hwang, Youn-Hwan ,  Park, Kwang Il ,  Cho, Won-Kyung ,  Ma, Jin Yeul

Abstract AI-Helper 아이콘AI-Helper

Abstract Ethnopharmacological relevance Gleditsia sinensis Lam. (G. sinensis) has been used in Oriental medicine for tumor, thrombosis, inflammation-related disease, and obesity. Aim of the study The pharmacological inhibitory effects of fruits of G. sinensis (GFE) on hyperlipidemia have been re...

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참고문헌 (48)

  1. Am. J. Manag. Care Apovian 22 7 Suppl s176 2016 Obesity: definition, comorbidities, causes, and burden 

  2. Cell Metab. Berry 19 1 8 2014 10.1016/j.cmet.2013.10.003 Weighing in on adipocyte precursors 

  3. Endocrinology Cernkovich 149 4 1581 2008 10.1210/en.2007-1148 Adipose-specific disruption of signal transducer and activator of transcription 3 increases body weight and adiposity 

  4. Int. J. Mol. Med. Cheung 16 5 925 2005 Inhibition of proteasome activity in Gleditsia sinensis fruit extract-mediated apoptosis on human carcinoma cells 

  5. Exp. Ther. Med. Choi 8 2 454 2014 10.3892/etm.2014.1771 Genistein inhibits the proliferation and differentiation of MCF-7 and 3T3-L1 cells via the regulation of ERalpha expression and induction of apoptosis 

  6. Front. Pharmacol. Choi 8 511 2017 10.3389/fphar.2017.00511 Eupatorium fortunei and its components increase antiviral immune responses against RNA viruses 

  7. Evid.-Based Complement. Altern. Med.: eCAM Choi 2012 974713 2012 10.1155/2012/974713 Protective effect of the fruit hull of gleditsia sinensis on LPS-induced acute lung injury is associated with Nrf2 activation 

  8. Biol. Pharm. Bull. Dai 25 9 1179 2002 10.1248/bpb.25.1179 Antiallergic and anti-inflammatory properties of the ethanolic extract from Gleditsia sinensis 

  9. Endocrinology Deng 141 7 2370 2000 10.1210/endo.141.7.7551 Activation of signal transducer and activator of transcription-3 during proliferative phases of 3T3-L1 adipogenesis 

  10. Dev. Cell Fajas 3 1 39 2002 10.1016/S1534-5807(02)00190-9 E2Fs regulate adipocyte differentiation 

  11. Biochem. Biophys. Rep. Ferguson 5 16 2016 Curcumin inhibits 3T3-L1 preadipocyte proliferation by mechanisms involving post-transcriptional p27 regulation 

  12. Evid. Based Complement. Altern. Med.: eCAM Gao 2016 3898957 2016 10.1155/2016/3898957 From traditional usage to pharmacological evidence: a systematic mini-review of Spina Gleditsiae 

  13. Anal. Biochem. Gillies 159 1 109 1986 10.1016/0003-2697(86)90314-3 Determination of cell number in monolayer cultures 

  14. Biochem. Biophys. Res. Commun. Harp 281 4 907 2001 10.1006/bbrc.2001.4460 Differential expression of signal transducers and activators of transcription during human adipogenesis 

  15. PLoS One He 8 7 e70135 2013 10.1371/journal.pone.0070135 Ursolic acid inhibits adipogenesis in 3T3-L1 adipocytes through LKB1/AMPK pathway 

  16. Proc. Natl. Acad. Sci. USA Hengst 91 12 5291 1994 10.1073/pnas.91.12.5291 A cell cycle-regulated inhibitor of cyclin-dependent kinases 

  17. Int. J. Mol. Sci. Jung 15 4 6184 2014 10.3390/ijms15046184 Obesity and its metabolic complications: the role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia and nonalcoholic fatty liver disease 

  18. PLoS One Kang 8 4 e61411 2013 10.1371/journal.pone.0061411 Dimethylfumarate suppresses adipogenic differentiation in 3T3-L1 preadipocytes through inhibition of STAT3 activity 

  19. BMB Rep. Kim 49 2 111 2016 10.5483/BMBRep.2016.49.2.128 Caffeine inhibits adipogenesis through modulation of mitotic clonal expansion and the AKT/GSK3 pathway in 3T3-L1 adipocytes 

  20. Evid.-Based Complement. Altern. Med.: eCAM Kim 2016 7480971 2016 10.1155/2016/7480971 The fruit hull of gleditsia sinensis enhances the anti-tumor effect of cis-diammine dichloridoplatinum II (Cisplatin) 

  21. Life Sci. Kim 101 1-2 64 2014 10.1016/j.lfs.2014.02.012 Apigenin isolated from Daphne genkwa Siebold et Zucc. inhibits 3T3-L1 preadipocyte differentiation through a modulation of mitotic clonal expansion 

  22. Biochim. et Biophys. Acta Konige 1842 3 393 2014 10.1016/j.bbadis.2013.05.007 Role of adipose specific lipid droplet proteins in maintaining whole body energy homeostasis 

  23. J. Cell. Biochem. Kramer 116 7 1232 2015 10.1002/jcb.25076 Dynamic mitochondrial localisation of STAT3 in the cellular adipogenesis model 3T3-L1 

  24. PLoS One Kwak 7 11 e49530 2012 10.1371/journal.pone.0049530 Aristolochia manshuriensis Kom inhibits adipocyte differentiation by regulation of ERK1/2 and Akt pathway 

  25. J. Ethnopharmacol. Lai 137 3 1061 2011 10.1016/j.jep.2011.06.023 Aqueous extract of Gleditsia sinensis Lam. fruits improves serum and liver lipid profiles and attenuates atherosclerosis in rabbits fed a high-fat diet 

  26. PLoS One Lee 10 12 e0142041 2015 10.1371/journal.pone.0142041 The herbal medicine KBH-1 inhibits fat accumulation in 3T3-L1 adipocytes and reduces high fat diet-induced obesity through regulation of the AMPK pathway 

  27. Am. J. Chin. Med. Lee 40 2 373 2012 10.1142/S0192415X12500292 Gleditsia sinensis thorn extract inhibits proliferation and TNF-alpha-induced MMP-9 expression in vascular smooth muscle cells 

  28. Trends Endocrinol. Metab.: TEM Lefterova 20 3 107 2009 10.1016/j.tem.2008.11.005 New developments in adipogenesis 

  29. J. Clin. Investig. Levy 109 9 1143 2002 10.1172/JCI0215650 What does Stat3 do? 

  30. Int. J. Mol. Sci. Moseti 17 1 2016 10.3390/ijms17010124 Molecular regulation of adipogenesis and potential anti-adipogenic bioactive molecules 

  31. FASEB J.: Off. Publ. Fed. Am. Soc. Exp. Biol. Naaz 18 15 1925 2004 10.1096/fj.04-2631fje Loss of cyclin-dependent kinase inhibitors produces adipocyte hyperplasia and obesity 

  32. J. Biol. Chem. Patel 275 23 17653 2000 10.1074/jbc.M910445199 Mitotic clonal expansion during preadipocyte differentiation: calpain-mediated turnover of p27 

  33. Genes Dev. Polyak 8 1 9 1994 10.1101/gad.8.1.9 p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest 

  34. BioFactors Rahman 42 6 716 2016 10.1002/biof.1310 Methyl gallate, a potent antioxidant inhibits mouse and human adipocyte differentiation and oxidative stress in adipocytes through impairment of mitotic clonal expansion 

  35. J. Biol. Chem. Sakai 282 3 2038 2007 10.1074/jbc.M608144200 Skp2 controls adipocyte proliferation during the development of obesity 

  36. Mol. Med. Rep. Seo 12 3 4773 2015 10.3892/mmr.2015.3936 Quantitative analysis and anti-inflammatory effects of Gleditsia sinensis thorns in RAW 264.7 macrophages and HaCaT keratinocytes 

  37. J. Biol. Chem. Student 255 10 4745 1980 10.1016/S0021-9258(19)85559-X Induction of fatty acid synthetase synthesis in differentiating 3T3-L1 preadipocytes 

  38. Proc. Natl. Acad. Sci. USA Tang 100 3 850 2003 10.1073/pnas.0337434100 CCAAT/enhancer-binding protein beta is required for mitotic clonal expansion during adipogenesis 

  39. Proc. Natl. Acad. Sci. USA Tang 100 1 44 2003 10.1073/pnas.0137044100 Mitotic clonal expansion: a synchronous process required for adipogenesis 

  40. Genes Dev. Timchenko 10 7 804 1996 10.1101/gad.10.7.804 CCAAT/enhancer-binding protein alpha (C/EBP alpha) inhibits cell proliferation through thep21 (WAF-1/CIP-1/SDI-1) protein 

  41. Biol. Cell Wang 102 1 1 2009 10.1042/BC20090070 Signal transducer and activator of transcription 3 (STAT3) regulates adipocyte differentiation via peroxisome-proliferator-activated receptor gamma (PPARgamma) 

  42. Planta Med. Wang 82 18 1558 2016 10.1055/s-0042-110206 Separation and characterization of triterpenoid saponins in gleditsia sinensis by comprehensive two-dimensional liquid chromatography coupled with mass spectrometry 

  43. Obes. Rev.: Off. J. Int. Assoc. Study Obes. Withrow 12 2 131 2011 10.1111/j.1467-789X.2009.00712.x The economic burden of obesity worldwide: a systematic review of the direct costs of obesity 

  44. Phytother. Res.: PTR Woo 29 3 398 2015 10.1002/ptr.5264 Ellagic acid suppresses lipid accumulation by suppressing early adipogenic events and cell cycle arrest 

  45. BMC Complement. Altern. Med. Yi 12 243 2012 10.1186/1472-6882-12-243 Ethanol extract of Gleditsia sinensis thorn suppresses angiogenesis in vitro and in vivo 

  46. J. Microbiol. Biotechnol. Yun 22 6 806 2012 10.4014/jmb.1110.10039 Widdrol blocks 3T3-L1 preadipocytes growth and differentiation due to inhibition of mitotic clonal expansion 

  47. J. Ethnopharmacol. Zhang 178 155 2016 10.1016/j.jep.2015.11.044 Gleditsia species: an ethnomedical, phytochemical and pharmacological review 

  48. J. Cell. Biochem. Zhang 112 2 488 2011 10.1002/jcb.22936 JAK2/STAT3 pathway is involved in the early stage of adipogenesis through regulating C/EBPbeta transcription 

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