[논문]Associations among Gastric Juice pH, Atrophic Gastritis, Intestinal Metaplasia and Helicobacter pylori Infection

Sung, Jihee; Kim, Nayoung; Lee, Jongchan; Hwang, Young-Jae; Kim, Hyoung Woo; Chung, Jung Wha; Kim, Jin-Wook; Lee, Dong Ho

doi:10.5009/gnl17063

Associations among Gastric Juice pH, Atrophic Gastritis, Intestinal Metaplasia and Helicobacter pylori Infection 원문보기

Gut and liver, v.12 no.2, 2018년, pp.158 - 164

Sung, Jihee (Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea) , Kim, Nayoung (Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea) , Lee, Jongchan (Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea) , Hwang, Young-Jae (Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea) , Kim, Hyoung Woo (Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea) , Chung, Jung Wha (Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea) , Kim, Jin-Wook (Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea) , Lee, Dong Ho (Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea)

Abstract ▼ AI-Helper

Background/AimsGastric juice plays a crucial role in the physiology of the stomach. The aim of this study is to evaluate associations among the pH of gastric juice, atrophic gastritis (AG), intestinal metaplasia (IM), pepsinogen, and Helicobacter pylori infection.MethodsGastric biopsies and juice were collected from 46 subjects who underwent endoscopies at Seoul National University Bundang Hospital between November 2011 and March 2013. H. pylori, AG and IM were evaluated, and pepsinogen I or II, I/II ratio, and interleukin (IL)-1β levels were measured.ResultsThe mean pH of gastric juice was higher in the H. pylori-positive group (n=17) than that in the H. pylori-negative group (n=29) (4.54 vs 2.46, p=0.002). When patients were divided into pH <3 (n=28) and pH ≥3 (n=18) groups, H. pylori was lower in the pH <3 group (21.4%) than in the pH ≥3 group (61.1%) (p=0.007). The pH ≥3 group demonstrated AG and IM more frequently than the pH <3 group in the body (p=0.047 and p=0.051, respectively) but not in the antrum. There were no differences in pepsinogen I or II, I/II ratio, and IL-1β levels between the two groups.ConclusionsThere is a relationship between chronic H. pylori infection and gastric juice pH ≥3, which may originate from AG and IM in the body.

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참고문헌 (28)

1 Waldum HL Hauso Ø Fossmark R The regulation of gastric acid secretion: clinical perspectives Acta Physiol (Oxf) 2014 210 239 256 10.1111/apha.12208 24279703

상세보기
2 Berstad A A modified hemoglobin substrate method for the estimation of pepsin in gastric juice Scand J Gastroenterol 1970 5 343 348 4917140

상세보기
3 Merki HS Fimmel CJ Walt RP Harre K Röhmel J Witzel L Pattern of 24 hour intragastric acidity in active duodenal ulcer disease and in healthy controls Gut 1988 29 1583 1587 10.1136/gut.29.11.1583 1433850 --> 3209116

상세보기
4 Wilder-Smith CH Spirig C Krech T Merki HS Bactericidal factors in gastric-juice Eur J Gastroenerol Hepatol 1992 4 885 891
5 Kopic S Geibel JP Update on the mechanisms of gastric acid secretion Curr Gastroenterol Rep 2010 12 458 464 10.1007/s11894-010-0137-9 20821079

상세보기
6 Correa P Human gastric carcinogenesis: a multistep and multifactorial process. First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention Cancer Res 1992 52 6735 6740 1458460

상세보기
7 Kong YJ Yi HG Dai JC Wei MX Histological changes of gastric mucosa after Helicobacter pylori eradication: a systematic review and meta-analysis World J Gastroenterol 2014 20 5903 5911 10.3748/wjg.v20.i19.5903 4024801 --> 24914352

상세보기
8 Rokkas T Pistiolas D Sechopoulos P Robotis I Margantinis G The long-term impact of Helicobacter pylori eradication on gastric histology: a systematic review and meta-analysis Helicobacter 2007 12 Suppl 2 32 38 10.1111/j.1523-5378.2007.00563.x 17991174

상세보기
9 Toyokawa T Suwaki K Miyake Y Nakatsu M Ando M Eradication of Helicobacter pylori infection improved gastric mucosal atrophy and prevented progression of intestinal metaplasia, especially in the elderly population: a long-term prospective cohort study J Gastroenterol Hepatol 2010 25 544 547 10.1111/j.1440-1746.2009.05995.x 19817964

상세보기
10 Kang JM Kim N Shin CM Predictive factors for improvement of atrophic gastritis and intestinal metaplasia after Helicobacter pylori eradication: a three-year follow-up study in Korea Helicobacter 2012 17 86 95 10.1111/j.1523-5378.2011.00918.x 22404438

상세보기
11 Iijima K Sekine H Koike T Imatani A Ohara S Shimosegawa T Long-term effect of Helicobacter pylori eradication on the reversibility of acid secretion in profound hypochlorhydria Aliment Pharmacol Ther 2004 19 1181 1188 10.1111/j.1365-2036.2004.01948.x 15153171

상세보기
12 Osawa H Kita H Ohnishi H Helicobacter pylori eradication induces marked increase in H+/K+-adenosine triphosphatase expression without altering parietal cell number in human gastric mucosa Gut 2006 55 152 157 10.1136/gut.2005.066464 15872000

상세보기
13 Kim MS Kim N Kim SE Long-term follow up Helicobacter pylori reinfection rate after second-line treatment: bismuth-containing quadruple therapy versus moxifloxacin-based triple therapy BMC Gastroenterol 2013 13 138 10.1186/1471-230X-13-138 3848835 --> 24050512

상세보기
14 Kim SE Park YS Kim N Effect of Helicobacter pylori eradication on functional dyspepsia J Neurogastroenterol Motil 2013 19 233 243 10.5056/jnm.2013.19.2.233 3644660 --> 23667755

상세보기
15 Delgado S Cabrera-Rubio R Mira A Suárez A Mayo B Microbiological survey of the human gastric ecosystem using culturing and pyrosequencing methods Microb Ecol 2013 65 763 772 10.1007/s00248-013-0192-5 23397369

상세보기
16 Dixon MF Genta RM Yardley JH Correa P Classification and grading of gastritis: the updated Sydney system. International Workshop on the Histopathology of Gastritis, Houston 1994 Am J Surg Pathol 1996 20 1161 1181 10.1097/00000478-199610000-00001 8827022

상세보기
17 Kishikawa H Nishida J Ichikawa H Fasting gastric pH of Japanese subjects stratified by IgG concentration against Helicobacter pylori and pepsinogen status Helicobacter 2011 16 427 433 10.1111/j.1523-5378.2011.00868.x 22059393

상세보기
18 Yoon H Kim N Lee HS Helicobacter pylori-negative gastric cancer in South Korea: incidence and clinicopathologic characteristics Helicobacter 2011 16 382 388 10.1111/j.1523-5378.2011.00859.x 21923684

상세보기
19 Kim JJ Kim N Hwang S Relationship of interleukin-1beta levels and gastroesophageal reflux disease in Korea J Gastroenterol Hepatol 2013 28 90 98 10.1111/j.1440-1746.2012.07274.x 23020284

상세보기
20 Hoffman JS King WW Fox JG Janik D Cave DR Rabbit and ferret parietal cell inhibition by Helicobacter species Dig Dis Sci 1995 40 147 152 10.1007/BF02063958 7529671

상세보기
21 Cave DR Vargas M Effect of a Campylobacter pylori protein on acid secretion by parietal cells Lancet 1989 2 187 189 10.1016/S0140-6736(89)90372-3 2568521

상세보기
22 Beales IL Calam J Interleukin 1 beta and tumour necrosis factor alpha inhibit acid secretion in cultured rabbit parietal cells by multiple pathways Gut 1998 42 227 234 10.1136/gut.42.2.227 1726991 --> 9536948

상세보기
23 Amedei A Munari F Bella CD Helicobacter pylori secreted peptidyl prolyl cis, trans-isomerase drives Th17 inflammation in gastric adenocarcinoma Intern Emerg Med 2014 9 303 309 10.1007/s11739-012-0867-9 23054412

상세보기
24 Kuipers EJ Uyterlinde AM Peña AS Long-term sequelae of Helicobacter pylori gastritis Lancet 1995 345 1525 1528 10.1016/S0140-6736(95)91084-0 7791437

상세보기
25 Kishikawa H Kimura K Ito A Association between increased gastric juice acidity and sliding hiatal hernia development in humans PLoS One 2017 12 e0170416 10.1371/journal.pone.0170416 5249152 --> 28107506

상세보기
26 El-Omar EM Oien K Murray LS Increased prevalence of precancerous changes in relatives of gastric cancer patients: critical role of H. pylori Gastroenterology 2000 118 22 30 10.1016/S0016-5085(00)70410-0 10611150

상세보기
27 Kiyohira K Yoshihara M Ito M Haruma K Tanaka S Chayama K Serum pepsinogen concentration as a marker of Helicobacter pylori infection and the histologic grade of gastritis; evaluation of gastric mucosa by serum pepsinogen levels J Gastroenterol 2003 38 332 338 10.1007/s005350300060 12743772

상세보기
28 Porzionato A Macchi V Parenti A Matturri L De Caro R Peripheral chemoreceptors: postnatal development and cytochemical findings in sudden infant death syndrome Histol Histopathol 2008 23 351 365 18072092

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DOI : 10.5009/gnl17063
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