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NTIS 바로가기Journal of analytical methods in chemistry, v.2016, 2016년, pp.4156293 -
Jesus, Mafalda (CICS-UBI, Health Sciences Research Centre, Universidade da Beira Interior, Covilhã) , Martins, Ana P. J. (, Portugal) , Gallardo, Eugenia (CICS-UBI, Health Sciences Research Centre, Universidade da Beira Interior, Covilhã) , Silvestre, Samuel (, Portugal)
Diosgenin, a steroidal sapogenin, occurs abundantly in plants such as Dioscorea alata, Smilax China, and Trigonella foenum graecum. This bioactive phytochemical not only is used as an important starting material for the preparation of several steroidal drugs in the pharmaceutical industry, but has r...
1 Jiang S. Fan J. Wang Q. Diosgenin induces ROS-dependent autophagy and cytotoxicity via mTOR signaling pathway in chronic myeloid leukemia cells Phytomedicine 2016 23 3 243 252 10.1016/j.phymed.2016.01.010 26969378
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6 Selim S. Al Jaouni S. Anticancer and apoptotic effects on cell proliferation of diosgenin isolated from Costus speciosus (Koen.) Sm BMC Complementary and Alternative Medicine 2015 15 1, article no. 301 10.1186/s12906-015-0836-8 2-s2.0-84940513773
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9 Dong J. Lei C. Lu D. Wang Y. Direct biotransformation of dioscin into diosgenin in rhizome of Dioscorea zingiberensis by Penicillium dioscin Indian Journal of Microbiology 2015 55 2 200 206 10.1007/s12088-014-0507-3 2-s2.0-84925513644 25805907
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11 Huang B. Du D. Zhang R. Synthesis, characterization and biological studies of diosgenyl analogues Bioorganic and Medicinal Chemistry Letters 2012 22 24 7330 7334 10.1016/j.bmcl.2012.10.086 2-s2.0-84870254697 23153797 23153797
12 Raju J. Rao C. V. Diosgenin, a steroid saponin constituent of yams and fenugreek: emerging evidence for applications in medicine Bioactive Compounds in Phytomedicine 2012 InTech 125 142
13 Yang H. Yin H. Shen Y. A more ecological and efficient approach for producing diosgenin from Dioscorea zingiberensis tubers via pressurized biphase acid hydrolysis Journal of Cleaner Production 2016 131 10 19 10.1016/j.jclepro.2016.05.030
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15 Manivannan J. Arunagiri P. Sivasubramanian J. Balamurugan E. Diosgenin prevents hepatic oxidative stress, lipid peroxidation and molecular alterations in chronic renal failure rats International Journal of Nutrition, Pharmacology, Neurological Diseases 2013 3 3 289 294 10.4103/2231-0738.114870
16 Roghani-Dehkordi F. Roghani M. Baluchnejadmojarad T. Diosgenin mitigates streptozotocin diabetes-induced vascular dysfunction of the rat aorta: the involved mechanisms Journal of Cardiovascular Pharmacology 2015 66 6 584 592 10.1097/fjc.0000000000000308 2-s2.0-84951151731 26309100
17 Choi K.-W. Park H.-J. Jung D.-H. Inhibition of TNF- α -induced adhesion molecule expression by diosgenin in mouse vascular smooth muscle cells via downregulation of the MAPK, Akt and NF- κ B signaling pathways Vascular Pharmacology 2010 53 5-6 273 280 10.1016/j.vph.2010.09.007 2-s2.0-78349306352 20932938
18 Esfandiarei M. Lam J. T. N. Yazdi S. A. Diosgenin modulates vascular smooth muscle cell function by regulating cell viability, migration, and calcium homeostasis Journal of Pharmacology and Experimental Therapeutics 2011 336 3 925 939 10.1124/jpet.110.172684 2-s2.0-79951976363 21177478 21177478
19 Liu K. Zhao W. Gao X. Huang F. Kou J. Liu B. Diosgenin ameliorates palmitate-induced endothelial dysfunction and insulin resistance via blocking IKK β and IRS-1 pathways Atherosclerosis 2012 223 2 350 358 10.1016/j.atherosclerosis.2012.06.012 2-s2.0-84864763990 22766331 22766331
20 Yang H.-P. Yue L. Jiang W.-W. Liu Q. Kou J.-P. Yu B.-Y. Diosgenin inhibits tumor necrosis factor-induced tissue factor activity and expression in THP-1 cells via down-regulation of the NF- κ B, Akt, and MAPK signaling pathways Chinese Journal of Natural Medicines 2013 11 6 608 615 10.1016/s1875-5364(13)60070-9 2-s2.0-84890182434 24345501
21 Kalailingam P. Kannaian B. Tamilmani E. Kaliaperumal R. Efficacy of natural diosgenin on cardiovascular risk, insulin secretion, and beta cells in streptozotocin (STZ)-induced diabetic rats Phytomedicine 2014 21 10 1154 1161 10.1016/j.phymed.2014.04.005 2-s2.0-84905016365 24889525
22 Gong G. Qin Y. Huang W. Anti-thrombosis effect of diosgenin extract from Dioscorea zingiberensis C.H. Wright in vitro and in vivo Phytomedicine 2011 18 6 458 463 10.1016/j.phymed.2010.08.015 2-s2.0-79955006421 21036572
23 Chen P.-S. Shih Y.-W. Huang H.-C. Cheng H.-W. Diosgenin, a steroidal saponin, inhibits migration and invasion of human prostate cancer pc-3 cells by reducing matrix metalloproteinases expression PLoS ONE 2011 6 5 e20164 10.1371/journal.pone.0020164 2-s2.0-79956370706 21629786 21629786
24 Lepage C. Léger D. Y. Bertrand J. Martin F. Beneytout J. L. Liagre B. Diosgenin induces death receptor-5 through activation of p38 pathway and promotes TRAIL-induced apoptosis in colon cancer cells Cancer Letters 2011 301 2 193 202 10.1016/j.canlet.2010.12.003 2-s2.0-78651461704 21195543 21195543
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28 Das S. Dey K. K. Dey G. Antineoplastic and apoptotic potential of traditional medicines thymoquinone and diosgenin in squamous cell carcinoma PLoS ONE 2012 7 10 e46641 10.1371/journal.pone.0046641 2-s2.0-84867567251
29 Li Y. Wang X. Cheng S. Diosgenin induces G2/M cell cycle arrest and apoptosis in human hepatocellular carcinoma cells Oncology Reports 2015 33 2 693 698 10.3892/or.2014.3629 2-s2.0-84919451895 25434486 25434486
30 Mao Z.-J. Tang Q.-J. Zhang C.-A. Anti-proliferation and anti-invasion effects of diosgenin on gastric cancer BGC-823 cells with HIF-1 α shRNAS International Journal of Molecular Sciences 2012 13 5 6521 6533 10.3390/ijms13056521 2-s2.0-84861534971 22754381 22754381
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34 Ghosh S. More P. Derle A. Diosgenin functionalized iron oxide nanoparticles as novel nanomaterial against breast cancer Journal of Nanoscience and Nanotechnology 2015 15 12 9464 9472 10.1166/jnn.2015.11704 2-s2.0-84950249837 26682367
35 Corbiere C. Liagre B. Bianchi A. Different contribution of apoptosis to the antiproliferative effects of diosgenin and other plant steroids, hecogenin and tigogenin, on human 1547 osteosarcoma cells International Journal of Oncology 2003 22 4 899 905 2-s2.0-0642348024 12632085
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37 Rahmati-Yamchi M. Ghareghomi S. Haddadchi G. Milani M. Aghazadeh M. Daroushnejad H. Fenugreek extract diosgenin and pure diosgenin inhibit the hTERT gene expression in A549 lung cancer cell line Molecular Biology Reports 2014 41 9 6247 6252 10.1007/s11033-014-3505-y 2-s2.0-84906934929 24973886 24973886
38 Leger D. Y. Liagre B. L. I. Corbière C. Cook-Moreau J. Beneytout J.-L. Diosgenin induces cell cycle arrest and apoptosis in HEL cells with increase in intracellular calcium level, activation of cPLA2 and COX-2 overexpression International journal of oncology 2004 25 3 555 562 2-s2.0-8844274306 15289856
39 Liagre B. Bertrand J. Leger D. Y. Beneytout J.-L. Diosgenin, a plant steroid, induces apoptosis in COX-2 deficient K562 cells with activation of the p38 MAP kinase signalling and inhibition of NF-kappaB binding International Journal of Molecular Medicine 2005 16 6 1095 1101 2-s2.0-33644878740 16273292
40 Liu M.-J. Wang Z. Ju Y. Wong R. N.-S. Wu Q.-Y. Diosgenin induces cell cycle arrest and apoptosis in human leukemia K562 cells with the disruption of Ca 2+ homeostasis Cancer Chemotherapy and Pharmacology 2005 55 1 79 90 10.1007/s00280-004-0849-3 2-s2.0-11244325805 15372201
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42 He Z. Chen H. Li G. Diosgenin inhibits the migration of human breast cancer MDA-MB-231 cells by suppressing Vav2 activity Phytomedicine 2014 21 6 871 876 10.1016/j.phymed.2014.02.002 2-s2.0-84901189738 24656238 24656238
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44 Li C. Dai L. Liu K. Deng L. Pei T. Lei J. A self-assembled nanoparticle platform based on poly(ethylene glycol)-diosgenin conjugates for co-delivery of anticancer drugs RSC Advances 2015 5 91 74828 74834 10.1039/c5ra15375a 2-s2.0-84941220172
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51 Wang L. Ma T. Zheng Y. Lv S. Li Y. Liu S. Diosgenin inhibits IL-1 β -induced expression of inflammatory mediators in human osteoarthritis chondrocytes International Journal of Clinical and Experimental Pathology 2015 8 5 4830 4836 2-s2.0-84937842092 26191174
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65 Uemura T. Goto T. Kang M.-S. Diosgenin, the main aglycon of fenugreek, inhibits LXR α activity in HepG2 cells and decreases plasma and hepatic triglycerides in obese diabetic mice Journal of Nutrition 2011 141 1 17 23 10.3945/jn.110.125591 2-s2.0-78650498453 21106928
66 Lv Y.-C. Yang J. Yao F. Diosgenin inhibits atherosclerosis via suppressing the MiR-19b-induced downregulation of ATP-binding cassette transporter A1 Atherosclerosis 2015 240 1 80 89 10.1016/j.atherosclerosis.2015.02.044 2-s2.0-84924352917 25765596 25765596
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