참고문헌 (136)

1. 1 Jiang S. Fan J. Wang Q. Diosgenin induces ROS-dependent autophagy and cytotoxicity via mTOR signaling pathway in chronic myeloid leukemia cells Phytomedicine 2016 23 3 243 252 10.1016/j.phymed.2016.01.010 26969378 

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2. 2 Salvador J. A. R. Carvalho J. F. S. Neves M. A. C. Anticancer steroids: linking natural and semi-synthetic compounds Natural Product Reports 2013 30 2 324 374 10.1039/c2np20082a 2-s2.0-84872556406 23151898 

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3. 3 Tong Q.-Y. He Y. Zhao Q.-B. Qing Y. Huang W. Wu X.-H. Cytotoxicity and apoptosis-inducing effect of steroidal saponins from D ioscorea zingiberensis Wright against cancer cells Steroids 2012 77 12 1219 1227 10.1016/j.steroids.2012.04.019 2-s2.0-84864476664 22575181 

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4. 4 Podolak I. Galanty A. Sobolewska D. Saponins as cytotoxic agents: a review Phytochemistry Reviews 2010 9 3 425 474 10.1007/s11101-010-9183-z 2-s2.0-77956339773 20835386 

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5. 5 Chen Y. Tang Y.-M. Yu S.-L. Advances in the pharmacological activities and mechanisms of diosgenin Chinese Journal of Natural Medicines 2015 13 8 578 587 10.1016/S1875-5364(15)30053-4 2-s2.0-84940195677 26253490 

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6. 6 Selim S. Al Jaouni S. Anticancer and apoptotic effects on cell proliferation of diosgenin isolated from Costus speciosus (Koen.) Sm BMC Complementary and Alternative Medicine 2015 15 1, article no. 301 10.1186/s12906-015-0836-8 2-s2.0-84940513773 

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7. 7 Raju J. Mehta R. Cancer chemopreventive and therapeutic effects of diosgenin, a food saponin Nutrition and Cancer 2009 61 1 27 35 10.1080/01635580802357352 2-s2.0-58149154359 19116873 19116873 

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8. 8 Shao B. Guo H. Cui Y. Ye M. Han J. Guo D. Steroidal saponins from Smilax china and their anti-inflammatory activities Phytochemistry 2007 68 5 623 630 10.1016/j.phytochem.2006.10.026 2-s2.0-33847142871 17166529 

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9. 9 Dong J. Lei C. Lu D. Wang Y. Direct biotransformation of dioscin into diosgenin in rhizome of Dioscorea zingiberensis by Penicillium dioscin Indian Journal of Microbiology 2015 55 2 200 206 10.1007/s12088-014-0507-3 2-s2.0-84925513644 25805907 

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10. 10 Al Jasem Y. Khan M. Taha A. Thiemann T. Preparation of steroidal hormones with an emphasis on transformations of phytosterols and cholesterol—a review Mediterranean Journal of Chemistry 2014 3 2 796 830 10.13171/mjc.3.2.2014.18.04.15 

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11. 11 Huang B. Du D. Zhang R. Synthesis, characterization and biological studies of diosgenyl analogues Bioorganic and Medicinal Chemistry Letters 2012 22 24 7330 7334 10.1016/j.bmcl.2012.10.086 2-s2.0-84870254697 23153797 23153797 

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12. 12 Raju J. Rao C. V. Diosgenin, a steroid saponin constituent of yams and fenugreek: emerging evidence for applications in medicine Bioactive Compounds in Phytomedicine 2012 InTech 125 142 

13. 13 Yang H. Yin H. Shen Y. A more ecological and efficient approach for producing diosgenin from Dioscorea zingiberensis tubers via pressurized biphase acid hydrolysis Journal of Cleaner Production 2016 131 10 19 10.1016/j.jclepro.2016.05.030 

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14. 14 Manda V. K. Avula B. Ali Z. Characterization of in vitro ADME properties of diosgenin and dioscin from dioscorea villosa Planta Medica 2013 79 15 1421 1428 10.1055/s-0033-1350699 2-s2.0-84886098000 23970424 23970424 

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15. 15 Manivannan J. Arunagiri P. Sivasubramanian J. Balamurugan E. Diosgenin prevents hepatic oxidative stress, lipid peroxidation and molecular alterations in chronic renal failure rats International Journal of Nutrition, Pharmacology, Neurological Diseases 2013 3 3 289 294 10.4103/2231-0738.114870 

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16. 16 Roghani-Dehkordi F. Roghani M. Baluchnejadmojarad T. Diosgenin mitigates streptozotocin diabetes-induced vascular dysfunction of the rat aorta: the involved mechanisms Journal of Cardiovascular Pharmacology 2015 66 6 584 592 10.1097/fjc.0000000000000308 2-s2.0-84951151731 26309100 

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17. 17 Choi K.-W. Park H.-J. Jung D.-H. Inhibition of TNF- α -induced adhesion molecule expression by diosgenin in mouse vascular smooth muscle cells via downregulation of the MAPK, Akt and NF- κ B signaling pathways Vascular Pharmacology 2010 53 5-6 273 280 10.1016/j.vph.2010.09.007 2-s2.0-78349306352 20932938 

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18. 18 Esfandiarei M. Lam J. T. N. Yazdi S. A. Diosgenin modulates vascular smooth muscle cell function by regulating cell viability, migration, and calcium homeostasis Journal of Pharmacology and Experimental Therapeutics 2011 336 3 925 939 10.1124/jpet.110.172684 2-s2.0-79951976363 21177478 21177478 

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19. 19 Liu K. Zhao W. Gao X. Huang F. Kou J. Liu B. Diosgenin ameliorates palmitate-induced endothelial dysfunction and insulin resistance via blocking IKK β and IRS-1 pathways Atherosclerosis 2012 223 2 350 358 10.1016/j.atherosclerosis.2012.06.012 2-s2.0-84864763990 22766331 22766331 

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20. 20 Yang H.-P. Yue L. Jiang W.-W. Liu Q. Kou J.-P. Yu B.-Y. Diosgenin inhibits tumor necrosis factor-induced tissue factor activity and expression in THP-1 cells via down-regulation of the NF- κ B, Akt, and MAPK signaling pathways Chinese Journal of Natural Medicines 2013 11 6 608 615 10.1016/s1875-5364(13)60070-9 2-s2.0-84890182434 24345501 

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21. 21 Kalailingam P. Kannaian B. Tamilmani E. Kaliaperumal R. Efficacy of natural diosgenin on cardiovascular risk, insulin secretion, and beta cells in streptozotocin (STZ)-induced diabetic rats Phytomedicine 2014 21 10 1154 1161 10.1016/j.phymed.2014.04.005 2-s2.0-84905016365 24889525 

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22. 22 Gong G. Qin Y. Huang W. Anti-thrombosis effect of diosgenin extract from Dioscorea zingiberensis C.H. Wright in vitro and in vivo Phytomedicine 2011 18 6 458 463 10.1016/j.phymed.2010.08.015 2-s2.0-79955006421 21036572 

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23. 23 Chen P.-S. Shih Y.-W. Huang H.-C. Cheng H.-W. Diosgenin, a steroidal saponin, inhibits migration and invasion of human prostate cancer pc-3 cells by reducing matrix metalloproteinases expression PLoS ONE 2011 6 5 e20164 10.1371/journal.pone.0020164 2-s2.0-79956370706 21629786 21629786 

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24. 24 Lepage C. Léger D. Y. Bertrand J. Martin F. Beneytout J. L. Liagre B. Diosgenin induces death receptor-5 through activation of p38 pathway and promotes TRAIL-induced apoptosis in colon cancer cells Cancer Letters 2011 301 2 193 202 10.1016/j.canlet.2010.12.003 2-s2.0-78651461704 21195543 21195543 

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25. 25 Kim D. S. Jeon B. K. Lee Y. E. Woo W. H. Mun Y. J. Diosgenin induces apoptosis in HepG2 cells through generation of reactive oxygen species and mitochondrial pathway Evidence-Based Complementary and Alternative Medicine 2012 2012 8 981675 10.1155/2012/981675 2-s2.0-84863639477 

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26. 26 Hamid A. A. Hasanain M. Singh A. Synthesis of novel anticancer agents through opening of spiroacetal ring of diosgenin Steroids 2014 87 108 118 10.1016/j.steroids.2014.05.025 2-s2.0-84903304139 24929045 24929045 

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27. 27 Léger D. Y. Liagre B. Jean P. Diosgenin dose-dependent apoptosis and differentiation induction in human erythroleukemia cell line and sedimentation field-flow fractionation monitoring Analytical Biochemistry 2004 335 2 267 278 10.1016/j.ab.2004.09.008 15556566 

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28. 28 Das S. Dey K. K. Dey G. Antineoplastic and apoptotic potential of traditional medicines thymoquinone and diosgenin in squamous cell carcinoma PLoS ONE 2012 7 10 e46641 10.1371/journal.pone.0046641 2-s2.0-84867567251 

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29. 29 Li Y. Wang X. Cheng S. Diosgenin induces G2/M cell cycle arrest and apoptosis in human hepatocellular carcinoma cells Oncology Reports 2015 33 2 693 698 10.3892/or.2014.3629 2-s2.0-84919451895 25434486 25434486 

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30. 30 Mao Z.-J. Tang Q.-J. Zhang C.-A. Anti-proliferation and anti-invasion effects of diosgenin on gastric cancer BGC-823 cells with HIF-1 α shRNAS International Journal of Molecular Sciences 2012 13 5 6521 6533 10.3390/ijms13056521 2-s2.0-84861534971 22754381 22754381 

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31. 31 Mohammad R. Y. Somayyeh G. Gholamreza H. Majid M. Yousef R. Diosgenin inhibits hTERT gene expression in the A549 lung cancer cell line Asian Pacific Journal of Cancer Prevention 2013 14 11 6945 6948 10.7314/APJCP.2013.14.11.6945 2-s2.0-84892448366 24377630 24377630 

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32. 32 Sung B. Prasad S. Yadav V. R. Aggarwal B. B. Cancer cell signaling pathways targeted by spice-derived nutraceuticals Nutrition and Cancer 2012 64 2 173 197 10.1080/01635581.2012.630551 2-s2.0-84862248921 22149093 

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33. 33 Patel K. Gadewar M. Tripathi R. A review on pharmacological and analytical aspects of diosgenin: a concise report Natural Products and Bioprospecting 2012 2 2 46 52 10.1007/s13659-012-0014-3 

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34. 34 Ghosh S. More P. Derle A. Diosgenin functionalized iron oxide nanoparticles as novel nanomaterial against breast cancer Journal of Nanoscience and Nanotechnology 2015 15 12 9464 9472 10.1166/jnn.2015.11704 2-s2.0-84950249837 26682367 

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35. 35 Corbiere C. Liagre B. Bianchi A. Different contribution of apoptosis to the antiproliferative effects of diosgenin and other plant steroids, hecogenin and tigogenin, on human 1547 osteosarcoma cells International Journal of Oncology 2003 22 4 899 905 2-s2.0-0642348024 12632085 

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36. 36 Srinivasan S. Koduru S. Kumar R. Venguswamy G. Kyprianou N. Damodaran C. Diosgenin targets Akt-mediated prosurvival signaling in human breast cancer cells International Journal of Cancer 2009 125 4 961 967 10.1002/ijc.24419 2-s2.0-67650067290 19384950 19384950 

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37. 37 Rahmati-Yamchi M. Ghareghomi S. Haddadchi G. Milani M. Aghazadeh M. Daroushnejad H. Fenugreek extract diosgenin and pure diosgenin inhibit the hTERT gene expression in A549 lung cancer cell line Molecular Biology Reports 2014 41 9 6247 6252 10.1007/s11033-014-3505-y 2-s2.0-84906934929 24973886 24973886 

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38. 38 Leger D. Y. Liagre B. L. I. Corbière C. Cook-Moreau J. Beneytout J.-L. Diosgenin induces cell cycle arrest and apoptosis in HEL cells with increase in intracellular calcium level, activation of cPLA2 and COX-2 overexpression International journal of oncology 2004 25 3 555 562 2-s2.0-8844274306 15289856 

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39. 39 Liagre B. Bertrand J. Leger D. Y. Beneytout J.-L. Diosgenin, a plant steroid, induces apoptosis in COX-2 deficient K562 cells with activation of the p38 MAP kinase signalling and inhibition of NF-kappaB binding International Journal of Molecular Medicine 2005 16 6 1095 1101 2-s2.0-33644878740 16273292 

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40. 40 Liu M.-J. Wang Z. Ju Y. Wong R. N.-S. Wu Q.-Y. Diosgenin induces cell cycle arrest and apoptosis in human leukemia K562 cells with the disruption of Ca 2+ homeostasis Cancer Chemotherapy and Pharmacology 2005 55 1 79 90 10.1007/s00280-004-0849-3 2-s2.0-11244325805 15372201 

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41. 41 Li F. Fernandez P. P. Rajendran P. Hui K. M. Sethi G. Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells Cancer Letters 2010 292 2 197 207 10.1016/j.canlet.2009.12.003 2-s2.0-77951908366 20053498 20053498 

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42. 42 He Z. Chen H. Li G. Diosgenin inhibits the migration of human breast cancer MDA-MB-231 cells by suppressing Vav2 activity Phytomedicine 2014 21 6 871 876 10.1016/j.phymed.2014.02.002 2-s2.0-84901189738 24656238 24656238 

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43. 43 Kumar B. N. P. Puvvada N. Rajput S. Sequential release of drugs from hollow manganese ferrite nanocarriers for breast cancer therapy Journal of Materials Chemistry B 2015 3 1 90 101 10.1039/c4tb01098a 2-s2.0-84915820640 

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44. 44 Li C. Dai L. Liu K. Deng L. Pei T. Lei J. A self-assembled nanoparticle platform based on poly(ethylene glycol)-diosgenin conjugates for co-delivery of anticancer drugs RSC Advances 2015 5 91 74828 74834 10.1039/c5ra15375a 2-s2.0-84941220172 

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45. 45 Jung D.-H. Park H.-J. Byun H.-E. Diosgenin inhibits macrophage-derived inflammatory mediators through downregulation of CK2, JNK, NF- κ B and AP-1 activation International Immunopharmacology 2010 10 9 1047 1054 10.1016/j.intimp.2010.06.004 2-s2.0-77955919158 20601188 

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46. 46 Lin Y. Jia R. Liu Y. Diosgenin inhibits superoxide generation in FMLP-activated mouse neutrophils via multiple pathways Free Radical Research 2014 48 12 1485 1493 10.3109/10715762.2014.966705 2-s2.0-84908665736 25246240 25246240 

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47. 47 Chen Y. Xu X. Zhang Y. Diosgenin regulates adipokine expression in perivascular adipose tissue and ameliorates endothelial dysfunction via regulation of AMPK Journal of Steroid Biochemistry and Molecular Biology 2016 155 155 165 10.1016/j.jsbmb.2015.07.005 2-s2.0-84946911785 26277096 

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48. 48 Huang C.-H. Ku C.-Y. Jan T.-R. Diosgenin attenuates allergen-induced intestinal inflammation and IgE production in a murine model of food allergy Planta Medica 2009 75 12 1300 1305 10.1055/s-0029-1185578 2-s2.0-70449441241 19343624 

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49. 49 Ahmed L. A. Obaid A. A. Z. Zaki H. F. Agha A. M. Role of oxidative stress, inflammation, nitric oxide and transforming growth factor-beta in the protective effect of diosgenin in monocrotaline-induced pulmonary hypertension in rats European Journal of Pharmacology 2014 740 379 387 10.1016/j.ejphar.2014.07.026 2-s2.0-84906569212 25062790 25062790 

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50. 50 Kim J. E. Go J. Koh E. K. Diosgenin effectively suppresses skin inflammation induced by phthalic anhydride in IL-4/Luc/CNS-1 transgenic mice Bioscience, Biotechnology, and Biochemistry 2016 80 5 891 901 10.1080/09168451.2015.1135040 

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51. 51 Wang L. Ma T. Zheng Y. Lv S. Li Y. Liu S. Diosgenin inhibits IL-1 β -induced expression of inflammatory mediators in human osteoarthritis chondrocytes International Journal of Clinical and Experimental Pathology 2015 8 5 4830 4836 2-s2.0-84937842092 26191174 

52. 52 Guo Y. Xing E. Liang X. Song H. Dong W. Effects of total saponins from Rhizoma Dioscoreae nipponicae on expression of vascular endothelial growth factor and angiopoietin-2 and Tie-2 receptors in the synovium of rats with rheumatoid arthritis Journal of the Chinese Medical Association 2016 79 5 264 271 10.1016/j.jcma.2015.10.012 26947206 

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53. 53 Sautour M. Miyamoto T. Dongmo A. Antifungal steroid saponins from dioscorea cayenensis Planta Medica 2004 70 1 90 92 10.1055/s-2004-815467 14765305 

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54. 54 Yang C.-R. Zhang Y. Jacob M. R. Khan S. I. Zhang Y.-J. Li X.-C. Antifungal activity of C-27 steroidal saponins Antimicrobial Agents and Chemotherapy 2006 50 5 1710 1714 10.1128/AAC.50.5.1710-1714.2006 2-s2.0-33646441280 16641439 16641439 

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55. 55 Khan H. Saeed M. Rauf A. Khan M. A. Muhammad N. Antimicrobial and inhibition on heat-induced protein denaturation of constituents isolated from Polygonatum verticillatum rhizomes Natural Product Research 2015 29 22 2160 2163 10.1080/14786419.2014.996150 2-s2.0-84942259459 25553804 

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56. 56 Rabablert J. Tiewcharoen S. Auewarakul P. Anti-amebic activity of diosgenin on Naegleria fowleri trophozoites The Southeast Asian Journal of Tropical Medicine and Public Health 2015 46 827 834 26863853 

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57. 57 Turchan J. Pocernich C. B. Gairola C. Oxidative stress in HIV demented patients and protection ex vivo with novel antioxidants Neurology 2003 60 2 307 314 10.1212/01.wnl.0000042048.85204.3d 2-s2.0-0037469162 12552050 

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58. 58 Wang Y.-J. Pan K.-L. Hsieh T.-C. Chang T.-Y. Lin W.-H. Hsu J. T.-A. Diosgenin, a plant-derived sapogenin, exhibits antiviral activity in vitro against hepatitis C virus Journal of Natural Products 2011 74 4 580 584 10.1021/np100578u 2-s2.0-79955369703 21391660 

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59. 59 Sangeetha M. K. Shrishri Mal N. Atmaja K. Sali V. K. Vasanthi H. R. PPAR's and Diosgenin a chemico biological insight in NIDDM Chemico-Biological Interactions 2013 206 2 403 410 10.1016/j.cbi.2013.08.014 2-s2.0-84888294917 24001619 24001619 

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60. 60 Kanchan D. M. Somani G. S. Peshattiwar V. V. Kaikini A. A. Sathaye S. Renoprotective effect of diosgenin in streptozotocin induced diabetic rats Pharmacological Reports 2016 68 2 370 377 10.1016/j.pharep.2015.10.011 2-s2.0-84954348914 26922541 

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61. 61 Fuller S. Stephens J. M. Diosgenin, 4-hydroxyisoleucine, and fiber from fenugreek: mechanisms of actions and potential effects on metabolic syndrome Advances in Nutrition 2015 6 2 189 197 10.3945/an.114.007807 2-s2.0-84943238922 25770257 

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62. 62 Son I. S. Kim J. H. Sohn H. Y. Son K. H. Kim J.-S. Kwon C.-S. Antioxidative and hypolipidemic effects of diosgenin, a steroidal saponin of yam ( Dioscorea spp.), on high-cholesterol fed rats Bioscience, Biotechnology and Biochemistry 2007 71 12 3063 3071 10.1271/bbb.70472 2-s2.0-37649008319 

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63. 63 Harijono T. E. Ariestiningsih A. D. Wardani N. A. K. The effect of crude diosgenin extract from purple and yellow greater yams ( Dioscorea alata ) on the lipid profile of dyslipidemia rats Emirates Journal of Food and Agriculture 2016 28 506 512 

64. 64 Uemura T. Hirai S. Mizoguchi N. Diosgenin present in fenugreek improves glucose metabolism by promoting adipocyte differentiation and inhibiting inflammation in adipose tissues Molecular Nutrition and Food Research 2010 54 11 1596 1608 10.1002/mnfr.200900609 2-s2.0-78349261237 20540147 

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65. 65 Uemura T. Goto T. Kang M.-S. Diosgenin, the main aglycon of fenugreek, inhibits LXR α activity in HepG2 cells and decreases plasma and hepatic triglycerides in obese diabetic mice Journal of Nutrition 2011 141 1 17 23 10.3945/jn.110.125591 2-s2.0-78650498453 21106928 

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66. 66 Lv Y.-C. Yang J. Yao F. Diosgenin inhibits atherosclerosis via suppressing the MiR-19b-induced downregulation of ATP-binding cassette transporter A1 Atherosclerosis 2015 240 1 80 89 10.1016/j.atherosclerosis.2015.02.044 2-s2.0-84924352917 25765596 25765596 

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67. 67 Saravanan G. Ponmurugan P. Deepa M. A. Senthilkumar B. Modulatory effects of diosgenin on attenuating the key enzymes activities of carbohydrate metabolism and glycogen content in streptozotocin-induced diabetic rats Canadian Journal of Diabetes 2014 38 6 409 414 10.1016/j.jcjd.2014.02.004 2-s2.0-84912533012 24993510 

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68. 68 Ghosh S. More P. Derle A. Diosgenin from Dioscorea bulbifera: novel hit for treatment of type II diabetes mellitus with inhibitory activity against α -amylase and α -glucosidase PLoS ONE 2014 9 9 e106039 10.1371/journal.pone.0106039 2-s2.0-84930647697 

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69. 69 Mayakrishnan T. Nakkala J. R. Jeepipalli S. P. K. Fenugreek seed extract and its phytocompounds- trigonelline and diosgenin arbitrate their hepatoprotective effects through attenuation of endoplasmic reticulum stress and oxidative stress in type 2 diabetic rats European Food Research and Technology 2015 240 1 223 232 10.1007/s00217-014-2322-9 2-s2.0-84920078121 

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70. 70 Wang W.-C. Liu S.-F. Chang W.-T. The effects of diosgenin in the regulation of renal proximal tubular fibrosis Experimental Cell Research 2014 323 2 255 262 10.1016/j.yexcr.2014.01.028 2-s2.0-84897476934 24525371 

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71. 71 Zhang R. Huang B. Du D. Anti-thrombosis effect of diosgenyl saponins in vitro and in vivo Steroids 2013 78 11 1064 1070 10.1016/j.steroids.2013.07.003 2-s2.0-84881502498 23891646 23891646 

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72. 72 Zheng H. Wei Z. Xin G. Preventive effect of a novel diosgenin derivative on arterial and venous thrombosis in vivo Bioorganic & Medicinal Chemistry Letters 2016 26 14 3364 3369 10.1016/j.bmcl.2016.05.032 27217000 

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73. 73 Li W. Wang H. Wei Z. Supramolecular prodrug micelles based on the complementary multiple hydrogen bonds as drug delivery platform for thrombosis therapy RSC Advances 2016 6 67 62478 62484 10.1039/c6ra11110f 

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74. 74 Badalzadeh R. Yousefi B. Majidinia M. Ebrahimi H. Anti-arrhythmic effect of diosgenin in reperfusion-induced myocardial injury in a rat model: activation of nitric oxide system and mitochondrial K ATP channel Journal of Physiological Sciences 2014 64 6 393 400 10.1007/s12576-014-0333-8 2-s2.0-84921921407 25150984 

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75. 75 Jayachandran K. S. Vasanthi A. H. R. Gurusamy N. Steroidal saponin diosgenin from Dioscorea bulbifera protects cardiac cells from hypoxia-reoxygenation injury through modulation of pro-survival and pro-death molecules Pharmacognosy Magazine 2016 12 supplement 1 S14 S20 27041852 

76. 76 Badalzadeh R. Yousefi B. Tajaddini A. Ahmadian N. Diosgenin-induced protection against myocardial ischaemia-reperfusion injury is mediated by mitochondrial K ATP channels in a rat model Perfusion 2015 30 7 565 571 10.1177/0267659114566064 2-s2.0-84942608706 25552273 

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77. 77 Ebrahimi H. Badalzadeh R. Mohammadi M. Yousefi B. Diosgenin attenuates inflammatory response induced by myocardial reperfusion injury: role of mitochondrial ATP-sensitive potassium channels Journal of Physiology and Biochemistry 2014 70 2 425 432 10.1007/s13105-014-0320-9 2-s2.0-84904640729 24535716 

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78. 78 Badalzadeh R. Yavari R. Chalabiani D. Mitochondrial ATP-sensitive K + channels mediate the antioxidative influence of diosgenin on myocardial reperfusion injury in rat hearts General physiology and biophysics 2015 34 3 323 329 10.4149/gpb_2015009 2-s2.0-84941051723 26001291 

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79. 79 Zhao S. Niu F. Xu C.-Y. Diosgenin prevents bone loss on retinoic acid-induced osteoporosis in rats Irish Journal of Medical Science 2015 185 3 581 587 10.1007/s11845-015-1309-2 2-s2.0-84931458646 26089290 

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80. 80 Zhang Z. Song C. Fu X. High-dose diosgenin reduces bone loss in ovariectomized rats via attenuation of the RANKL/OPG ratio International Journal of Molecular Sciences 2014 15 9 17130 17147 10.3390/ijms150917130 2-s2.0-84907867472 25257532 25257532 

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81. 81 Tikhonova M. A. Ting C.-H. Kolosova N. G. Improving bone microarchitecture in aging with diosgenin treatment: a study in senescence-accelerated OXYS rats Chinese Journal of Physiology 2015 58 5 322 331 10.4077/cjp.2015.bad325 2-s2.0-84946923211 26387656 

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82. 82 Cai H. Wang Z. Zhang H.-Q. Diosgenin relieves goiter via the inhibition of thyrocyte proliferation in a mouse model of Graves' disease Acta Pharmacologica Sinica 2014 35 1 65 73 10.1038/aps.2013.133 2-s2.0-84891771090 24241350 

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83. 83 Tohda C. Lee Y.-A. Goto Y. Nemere I. Diosgenin-induced cognitive enhancement in normal mice is mediated by 1,25D 3 -MARRS Scientific Reports 2013 3, article no. 3395 10.1038/srep03395 2-s2.0-84889062142 

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84. 84 Tambe R. Jain P. Patil S. Ghumatkar P. Sathaye S. Protective effects of diosgenin in pentylenetetrazole induced kindling model of epilepsy in mice Neurochemistry Neuropharmacology Journals. Open Access 2015 1, article 106 

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