$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

Anti-cancer Mechanism of Docosahexaenoic Acid in Pancreatic Carcinogenesis: A Mini-review 원문보기

Journal of cancer prevention, v.22 no.1, 2017년, pp.1 - 5  

Park, Mirae (Brian Korea 21 PLUS Project, Department of Food and Nutrition, College of Human Ecology, Yonsei University, Seoul, Korea) ,  Kim, Hyeyoung (Brian Korea 21 PLUS Project, Department of Food and Nutrition, College of Human Ecology, Yonsei University, Seoul, Korea)

Abstract AI-Helper 아이콘AI-Helper

Pancreatic cancer is a highly aggressive malignant tumor of the digestive system and radical resection, which is available to very few patients, might be the only possibility for cure. Since therapeutic choices are limited at the advanced stage, prevention is more important for reducing incidence in...

주제어

참고문헌 (39)

  1. 1 Zhang Q Chen S Zeng L Chen Y Lian G Qian C New developments in the early diagnosis of pancreatic cancer Expert Rev Gastroenterol Hepatol 2017 11 149 56 10.1080/17474124.2017.1271323 27937041 

  2. 2 Hidaka A Shimazu T Sawada N Yamaji T Iwasaki M Sasazuki S Fish, n-3 PUFA consumption, and pancreatic cancer risk in Japanese: a large, population-based, prospective cohort study Am J Clin Nutr 2015 102 1490 7 10.3945/ajcn.115.113597 26537936 

  3. 3 Macášek J Vecka M Žák A Urbánek M Krechler T Petruželka L Plasma fatty acid composition in patients with pancreatic cancer: correlations to clinical parameters Nutr Cancer 2012 64 946 55 10.1080/01635581.2012.716138 23061902 

  4. 4 He K Xun P Brasky TM Gammon MD Stevens J White E Types of fish consumed and fish preparation methods in relation to pancreatic cancer incidence: the VITAL Cohort Study Am J Epidemiol 2013 177 152 60 10.1093/aje/kws232 3590032 --> 23221729 

  5. 5 Mohammed A Janakiram NB Brewer M Duff A Lightfoot S Brush RS Endogenous n-3 polyunsaturated fatty acids delay progression of pancreatic ductal adenocarcinoma in Fat-1- p48(Cre/+)-LSL-Kras(G12D/+) mice Neoplasia 2012 14 1249 59 10.1593/neo.121508 23308056 

  6. 6 Arshad A Chung WY Isherwood J Mann CD Al-Leswas D Steward WP Cellular and plasma uptake of parenteral omega-3 rich lipid emulsion fatty acids in patients with advanced pancreatic cancer Clin Nutr 2014 33 895 9 10.1016/j.clnu.2013.09.017 24140233 

  7. 7 Hamacher R Schmid RM Saur D Schneider G Apoptotic pathways in pancreatic ductal adenocarcinoma Mol Cancer 2008 7 64 10.1186/1476-4598-7-64 2515336 --> 18652674 

  8. 8 Müerköster SS Lust J Arlt A Häsler R Witt M Sebens T Acquired chemoresistance in pancreatic carcinoma cells: induced secretion of IL-1beta and NO lead to inactivation of caspases Oncogene 2006 25 3973 81 10.1038/sj.onc.1209423 16474845 

  9. 9 Sarkar S Mandal C Sangwan R Mandal C Coupling G2/M arrest to the Wnt/β-catenin pathway restrains pancreatic adenocarcinoma Endocr Relat Cancer 2014 21 113 25 10.1530/ERC-13-0315 24402132 

  10. 10 Jamieson C Sharma M Henderson BR Targeting the β-catenin nuclear transport pathway in cancer Semin Cancer Biol 2014 27 20 9 10.1016/j.semcancer.2014.04.012 24820952 

  11. 11 Hosch SB Knoefel WT Metz S Stoecklein N Niendorf A Broelsch CE Early lymphatic tumor cell dissemination in pancreatic cancer: frequency and prognostic significance Pancreas 1997 15 154 9 10.1097/00006676-199708000-00007 9260200 

  12. 12 Rahbari NN Schmidt T Falk CS Hinz U Herber M Bork U Expression and prognostic value of circulating angiogenic cytokines in pancreatic cancer BMC Cancer 2011 11 286 10.1186/1471-2407-11-286 3144458 --> 21729304 

  13. 13 Merendino N Molinari R Loppi B Pessina G D’ Aquino M Tomassi G Induction of apoptosis in human pancreatic cancer cells by docosahexaenoic acid Ann N Y Acad Sci 2003 1010 361 4 10.1196/annals.1299.143 15033753 

  14. 14 Song KS Jing K Kim JS Yun EJ Shin S Seo KS Omega-3-polyunsaturated fatty acids suppress pancreatic cancer cell growth in vitro and in vivo via downregulation of Wnt/Beta-catenin signaling Pancreatology 2011 11 574 84 10.1159/000334468 22213040 

  15. 15 D’Eliseo D Pisu P Romano C Tubaro A De Nunzio C Morrone S Granzyme B is expressed in urothelial carcinoma and promotes cancer cell invasion Int J Cancer 2010 127 1283 94 10.1002/ijc.25135 20027633 

  16. 16 Zhuang W Wang G Li L Lin G Deng Z Omega-3 polyunsaturated fatty acids reduce vascular endothelial growth factor production and suppress endothelial wound repair J Cardiovasc Transl Res 2013 6 287 93 10.1007/s12265-012-9409-0 22993129 

  17. 17 Arshad A Chung WY Steward W Metcalfe MS Dennison AR Reduction in circulating pro-angiogenic and pro-inflammatory factors is related to improved outcomes in patients with advanced pancreatic cancer treated with gemcitabine and intravenous omega-3 fish oil HPB (Oxford) 2013 15 428 32 10.1111/hpb.12002 23458624 

  18. 18 Arlt A Müerköster SS Schäfer H Targeting apoptosis pathways in pancreatic cancer Cancer Lett 2013 332 346 58 10.1016/j.canlet.2010.10.015 21078544 

  19. 19 Fulda S Apoptosis pathways and their therapeutic exploitation in pancreatic cancer J Cell Mol Med 2009 13 1221 7 10.1111/j.1582-4934.2009.00748.x 4496136 --> 19382915 

  20. 20 von Bernstorff W Spanjaard RA Chan AK Lockhart DC Sadanaga N Wood I Pancreatic cancer cells can evade immune surveillance via nonfunctional Fas (APO-1/CD95) receptors and aberrant expression of functional Fas ligand Surgery 1999 125 73 84 10.1016/S0039-6060(99)70291-6 9889801 

  21. 21 Grimmig T Moench R Kreckel J Haack S Rueckert F Rehder R Toll like receptor 2, 4, and 9 signaling promotes autoregulative tumor cell growth and VEGF/PDGF expression in human pancreatic cancer Int J Mol Sci 2016 17 2060 10.3390/ijms17122060 

  22. 22 Witte D Zeeh F Gädeken T Gieseler F Rauch BH Settmacher U Proteinase-activated receptor 2 is a novel regulator of TGF-β signaling in pancreatic cancer J Clin Med 2016 5 111 10.3390/jcm5120111 

  23. 23 MacDonald BT Tamai K He X Wnt/beta-catenin signaling: components, mechanisms, and diseases Dev Cell 2009 17 9 26 10.1016/j.devcel.2009.06.016 2861485 --> 19619488 

  24. 24 Wu MY Xie X Xu ZK Xie L Chen Z Shou LM PP2A inhibitors suppress migration and growth of PANC-1 pancreatic cancer cells through inhibition on the Wnt/β-catenin pathway by phosphorylation and degradation of β-catenin Oncol Rep 2014 32 513 22 4091883 --> 24926961 

  25. 25 Stetler-Stevenson WG Aznavoorian S Liotta LA Tumor cell interactions with the extracellular matrix during invasion and metastasis Annu Rev Cell Biol 1993 9 541 73 10.1146/annurev.cb.09.110193.002545 8280471 

  26. 26 Spencer L Mann C Metcalfe M Webb M Pollard C Spencer D The effect of omega-3 FAs on tumour angiogenesis and their therapeutic potential Eur J Cancer 2009 45 2077 86 10.1016/j.ejca.2009.04.026 19493674 

  27. 27 Hawkins RA Sangster K Arends MJ Apoptotic death of pancreatic cancer cells induced by polyunsaturated fatty acids varies with double bond number and involves an oxidative mechanism J Pathol 1998 185 61 70 10.1002/(SICI)1096-9896(199805)185:1 3.0.CO;2-8 9713361 

  28. 28 Merendino N Loppi B D’Aquino M Molinari R Pessina G Romano C Docosahexaenoic acid induces apoptosis in the human PaCa-44 pancreatic cancer cell line by active reduced glutathione extrusion and lipid peroxidation Nutr Cancer 2005 52 225 33 10.1207/s15327914nc5202_12 16201853 

  29. 29 Fukui M Kang KS Okada K Zhu BT EPA, an omega-3 fatty acid, induces apoptosis in human pancreatic cancer cells: role of ROS accumulation, caspase-8 activation, and autophagy induction J Cell Biochem 2013 114 192 203 10.1002/jcb.24354 22903547 

  30. 30 Song EA Kim H Docosahexaenoic acid induces oxidative DNA damage and apoptosis, and enhances the chemosensitivity of cancer cells Int J Mol Sci 2016 17 1257 10.3390/ijms17081257 5000655 --> 

  31. 31 Zhang W Long Y Zhang J Wang C Modulatory effects of EPA and DHA on proliferation and apoptosis of pancreatic cancer cells J Huazhong Univ Sci Technolog Med Sci 2007 27 547 50 10.1007/s11596-007-0518-y 18060632 

  32. 32 Merendino N Costantini L Manzi L Molinari R D’Eliseo D Velotti F Dietary ω-3 polyunsaturated fatty acid DHA: a potential adjuvant in the treatment of cancer Biomed Res Int 2013 2013 310186 10.1155/2013/310186 23762838 

  33. 33 D’Eliseo D Manzi L Merendino N Velotti F Docosahexaenoic acid inhibits invasion of human RT112 urinary bladder and PT45 pancreatic carcinoma cells via down-modulation of granzyme B expression J Nutr Biochem 2012 23 452 7 10.1016/j.jnutbio.2011.01.010 21684140 

  34. 34 Strouch MJ Ding Y Salabat MR Melstrom LG Adrian K Quinn C A high omega-3 fatty acid diet mitigates murine pancreatic precancer development J Surg Res 2011 165 75 81 10.1016/j.jss.2009.04.022 19631339 

  35. 35 Swamy MV Citineni B Patlolla JM Mohammed A Zhang Y Rao CV Prevention and treatment of pancreatic cancer by curcumin in combination with omega-3 fatty acids Nutr Cancer 2008 60 Suppl 1 81 9 10.1080/01635580802416703 19003584 

  36. 36 Yu JH Kim H Role of janus kinase/signal transducers and activators of transcription in the pathogenesis of pancreatitis and pancreatic cancer Gut Liver 2012 6 417 22 10.5009/gnl.2012.6.4.417 3493719 --> 23170143 

  37. 37 Yu JH Kim H Oxidative stress and cytokines in the pathogenesis of pancreatic cancer J Cancer Prev 2014 19 97 102 10.15430/JCP.2014.19.2.97 4204162 --> 25337577 

  38. 38 Wang TM Hsieh SC Chen JW Chiang AN Docosahexaenoic acid and eicosapentaenoic acid reduce C-reactive protein expression and STAT3 activation in IL-6-treated HepG2 cells Mol Cell Biochem 2013 377 97 106 10.1007/s11010-013-1574-1 23361365 

  39. 39 Ji HG Piao JY Kim SJ Kim DH Lee HN Na HK Docosahexaenoic acid inhibits Helicobacter pylori-induced STAT3 phosphorylation through activation of PPARγ Mol Nutr Food Res 2016 60 1448 57 10.1002/mnfr.201600009 27079734 

LOADING...
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로