$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

Scar Prevention and Enhanced Wound Healing Induced by Polydeoxyribonucleotide in a Rat Incisional Wound-Healing Model 원문보기

International journal of molecular sciences, v.18 no.8, 2017년, pp.1698 -   

Jeong, Woonhyeok (Department of Plastic and Reconstructive Surgery, School of Medicine & Institute for Medical Science, Keimyung University, Dongsan Medical Center, Daegu 41931, Korea) ,  Yang, Chae Eun (psjeong0918@gmail.com (W.J.)) ,  Roh, Tai Suk (med69@dsmc.or.kr (J.H.K.)) ,  Kim, Jun Hyung (Department of Plastic and Reconstructive Surgery, Institute for Human Tissue Restoration, Yonsei University Health System, Severance Hospital, Seoul 03722, Korea) ,  Lee, Ju Hee (cheniya@yuhs.ac) ,  Lee, Won Jai (Department of Plastic and Reconstructive Surgery, Institute for Human Tissue Restoration, Gangnam Yonsei University Health System, Severance Hospital, Seoul 06273, Korea)

Abstract AI-Helper 아이콘AI-Helper

High-mobility group box protein-1 (HMGB-1) plays a central role in the inflammatory network, and uncontrolled chronic inflammation can lead to excessive scarring. The aim of this study was to evaluate the anti-inflammatory effects of polydeoxyribonucleotide (PDRN) on scar formation. Sprague-Dawley r...

주제어

참고문헌 (32)

  1. 1. Oryan A. Alemzadeh E. Moshiri A. Biological properties and therapeutic activities of honey in wound healing: A narrative review and meta-analysis J. Tissue Viability 2016 25 98 118 10.1016/j.jtv.2015.12.002 26852154 

  2. 2. Wang J. Ding J. Jiao H. Honardoust D. Momtazi M. Shankowsky H.A. Tredget E.E. Human hypertrophic scar-like nude mouse model: Characterization of the molecular and cellular biology of the scar process Wound Repair Regen. 2011 19 274 285 10.1111/j.1524-475X.2011.00672.x 21362096 

  3. 3. Wang J.F. Hori K. Ding J. Huang Y. Kwan P. Ladak A. Tredget E.E. Toll-like receptors expressed by dermal fibroblasts contribute to hypertrophic scarring J. Cell Physiol. 2011 226 1265 1273 10.1002/jcp.22454 20945369 

  4. 4. Ogawa R. Keloid and hypertrophic scars are the result of chronic inflammation in the reticular dermis Int. J. Mol. Sci. 2017 18 606 10.3390/ijms18030606 28287424 

  5. 5. Wulff B.C. Parent A.E. Meleski M.A. DiPietro L.A. Schrementi M.E. Wilgus T.A. Mast cells contribute to scar formation during fetal wound healing J. Investig. Dermatol. 2012 132 458 465 10.1038/jid.2011.324 21993557 

  6. 6. Dovi J.V. He L.K. DiPietro L.A. Accelerated wound closure in neutrophil-depleted mice J. Leukoc. Biol. 2003 73 448 455 10.1189/jlb.0802406 12660219 

  7. 7. Lucas T. Waisman A. Ranjan R. Roes J. Krieg T. Müller W. Roers A. Eming S.A. Differential roles of macrophages in diverse phases of skin repair J. Immunol. 2010 184 3964 3977 10.4049/jimmunol.0903356 20176743 

  8. 8. Brown J.J. Bayat A. Genetic susceptibility to raised dermal scarring Br. J. Dermatol. 2009 161 8 18 10.1111/j.1365-2133.2009.09258.x 19508304 

  9. 9. Bran G.M. Goessler U.R. Hormann K. Riedel F. Sadick H. Keloids: Current concepts of pathogenesis (review) Int. J. Mol. Med. 2009 24 283 293 10.3892/ijmm_00000231 19639219 

  10. 10. Shih B. Garside E. McGrouther D.A. Bayat A. Molecular dissection of abnormal wound healing processes resulting in keloid disease Wound Repair Regen. 2010 18 139 153 10.1111/j.1524-475X.2009.00553.x 20002895 

  11. 11. Al-Attar A. Mess S. Thomassen J.M. Kauffman C.L. Davison S.P. Keloid pathogenesis and treatment Plast. Reconstr. Surg. 2006 117 286 300 10.1097/01.prs.0000195073.73580.46 16404281 

  12. 12. Bianchi M.E. Manfredi A.A. High-mobility group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunity Immunol. Rev. 2007 220 35 46 10.1111/j.1600-065X.2007.00574.x 17979838 

  13. 13. Scaffidi P. Misteli T. Bianchi M.E. Release of chromatin protein HMGB1 by necrotic cells triggers inflammation Nature 2002 418 191 195 10.1038/nature00858 12110890 

  14. 14. Yoshizaki A. Komura K. Iwata Y. Ogawa F. Hara T. Muroi E. Takenaka M. Shimizu K. Hasegawa M. Fujimoto M. Clinical significance of serum HMGB-1 and sRAGE levels in systemic sclerosis: Association with disease severity J. Clin. Immunol. 2009 29 180 189 10.1007/s10875-008-9252-x 18825489 

  15. 15. Algandaby M.M. Breikaa R.M. Eid B.G. Neamatallah T.A. Abdel-Naim A.B. Ashour O.M. Icariin protects against thioacetamide-induced liver fibrosis in rats: Implication of anti-angiogenic and anti-autophagic properties Pharmacol. Rep. 2017 69 616 624 10.1016/j.pharep.2017.02.016 28505603 

  16. 16. Bitto A. Polito F. Irrera N. D’Ascola A. Avenoso A. Nastasi G. Campo G. Micali A. Bagnato G. Minutoli L. Polydeoxyribonucleotide reduces cytokine production and the severity of collagen-induced arthritis by stimulation of adenosine A 2A receptor Arthritis Rheum. 2011 63 3364 3371 10.1002/art.30538 21769841 

  17. 17. Rork T.H. Wallace K.L. Kennedy D.P. Marshall M.A. Lankford A.R. Linden J. Adenosine A 2A receptor activation reduces infarct size in the isolated, perfused mouse heart by inhibiting resident cardiac mast cell degranulation Am. J. Physiol. Heart Circ. Physiol. 2008 295 H1825 H1833 10.1152/ajpheart.495.2008 18757481 

  18. 18. Bitto A. Oteri G. Pisano M. Polito F. Irrera N. Minutoli L. Squadrito F. Altavilla D. Adenosine receptor stimulation by polynucleotides (PDRN) reduces inflammation in experimental periodontitis J. Clin. Periodontol. 2013 40 26 32 10.1111/jcpe.12010 23033941 

  19. 19. Bitto A. Polito F. Altavilla D. Minutoli L. Migliorato A. Squadrito F. Polydeoxyribonucleotide (PDRN) restores blood flow in an experimental model of peripheral artery occlusive disease J. Vasc. Surg. 2008 48 1292 1300 10.1016/j.jvs.2008.06.041 18971038 

  20. 20. Bitto A. Galeano M. Squadrito F. Minutoli L. Polito F. Dye J.F. Clayton E.A. Calò M. Venuti F.S. Vaccaro M. Polydeoxyribonucleotide improves angiogenesis and wound healing in experimental thermal injury Crit. Care Med. 2008 36 1594 1602 10.1097/CCM.0b013e318170ab5c 18434887 

  21. 21. Sini P. Denti A. Cattarini G. Daglio M. Tira M.E. Balduini C. Effect of polydeoxyribonucleotides on human fibroblasts in primary culture Cell Biochem. Funct. 1999 17 107 114 10.1002/(SICI)1099-0844(199906)17:2 3.0.CO;2-# 10377956 

  22. 22. Galeano M. Bitto A. Altavilla D. Minutoli L. Polito F. Calo M. Cascio P.L. d’Alcontres F.S. Squadrito F. Polydeoxyribonucleotide stimulates angiogenesis and wound healing in the genetically diabetic mouse Wound Repair Regen. 2008 16 208 217 10.1111/j.1524-475X.2008.00361.x 18318806 

  23. 23. Chan E.S. Fernandez P. Cronstein B.N. Adenosine in inflammatory joint diseases Purinergic Signal. 2007 3 145 152 10.1007/s11302-006-9046-7 18404428 

  24. 24. Altavilla D. Squadrito F. Polito F. Irrera N. Calo M. Lo Cascio P. Galeano M. Cava L.L. Minutoli L. Marini H. Activation of adenosine A 2A receptors restores the altered cell-cycle machinery during impaired wound healing in genetically diabetic mice Surgery 2011 149 253 261 10.1016/j.surg.2010.04.024 20570301 

  25. 25. Walmsley G.G. Maan Z.N. Wong V.W. Duscher D. Hu M.S. Zielins E.R. Wearda T. Muhonen E. McArdle A. Tevlin R. Scarless wound healing: Chasing the holy grail Plast. Reconstr. Surg. 2015 135 907 917 10.1097/PRS.0000000000000972 25719706 

  26. 26. Szpaderska A.M. DiPietro L.A. Inflammation in surgical wound healing: Friend or foe? Surgery 2005 137 571 573 10.1016/j.surg.2005.01.006 15855932 

  27. 27. Xue M. Jackson C.J. Extracellular matrix reorganization during wound healing and its impact on abnormal scarring Adv. Wound Care 2015 4 119 136 10.1089/wound.2013.0485 25785236 

  28. 28. Nakano A. Harada T. Morikawa S. Kato Y. Expression of leukocyte common antigen (CD45) on various human leukemia/lymphoma cell lines Acta. Pathol. Jpn. 1990 40 107 115 10.1111/j.1440-1827.1990.tb01549.x 2140233 

  29. 29. Vaccari T. Beltrame M. Ferrari S. Bianchi M.E. Hmg4 , a new member of the Hmg1/2 gene family Genomics 1998 49 247 252 10.1006/geno.1998.5214 9598312 

  30. 30. Andersson U. Wang H. Palmblad K. Aveberger A.C. Bloom O. Erlandsson-Harris H. Janson A. Kokkola R. Zhang M. Yang H. High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes J. Exp. Med. 2000 192 565 570 10.1084/jem.192.4.565 10952726 

  31. 31. Lee D.E. Trowbridge R.M. Ayoub N.T. Agrawal D.K. High-mobility group box protein-1, matrix metalloproteinases, and vitamin D in keloids and hypertrophic scars Plast. Reconstr. Surg. Glob. Open 2015 3 e425 10.1097/GOX.0000000000000391 26180726 

  32. 32. Dardenne A.D. Wulff B.C. Wilgus T.A. The alarmin HMGB-1 influences healing outcomes in fetal skin wounds Wound Repair Regen. 2013 21 282 291 10.1111/wrr.12028 23438257 

LOADING...
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로