최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기Nutrients, v.9 no.8, 2017년, pp.866 -
Pullar, Juliet M. , Carr, Anitra C. , Vissers, Margreet C. M.
The primary function of the skin is to act as a barrier against insults from the environment, and its unique structure reflects this. The skin is composed of two layers: the epidermal outer layer is highly cellular and provides the barrier function, and the inner dermal layer ensures strength and el...
1. Weller R.H. John A. Savin J. Dahl M. The Function and Structure of Skin 5th ed. Wiley-Blackwell Massachusetts, MA, USA 2008
2. Patton K.T. Thibodeau G.A. Anthony’s Textbook of Anatomy & Physiology Elsevier Amsterdam, The Netherlands 2012
3. Wickett R.R. Visscher M.O. Structure and function of the epidermal barrier Am. J. Infect. Control 2006 34 15 10.1016/j.ajic.2006.05.295
4. Marks R. The stratum corneum barrier: The final frontier J. Nutr. 2004 134 2017 2021
5. Proksch E. Brandner J.M. Jensen J.M. The skin: An indispensable barrier Exp. Dermatol. 2008 17 1063 1072 10.1111/j.1600-0625.2008.00786.x 19043850
6. Blume-Peytavi U. Kottner J. Sterry W. Hodin M.W. Griffiths T.W. Watson R.E. Hay R.J. Griffiths C.E. Age-associated skin conditions and diseases: Current perspectives and future options Gerontologist 2016 56 230 242 10.1093/geront/gnw003 26994263
8. Boelsma E. Van de Vijver L.P. Goldbohm R.A. Klopping-Ketelaars I.A. Hendriks H.F. Roza L. Human skin condition and its associations with nutrient concentrations in serum and diet Am. J. Clin. Nutr. 2003 77 348 355 12540393
9. Brescoll J. Daveluy S. A review of vitamin B12 in dermatology Am. J. Clin. Dermatol. 2015 16 27 33 10.1007/s40257-014-0107-3 25559140
10. Fedeles F. Murphy M. Rothe M.J. Grant-Kels J.M. Nutrition and bullous skin diseases Clin. Dermatol. 2010 28 627 643 10.1016/j.clindermatol.2010.03.036 21034987
11. Sauberlich H.E. A History of Scurvy and Vitamin C Vitamin C in Health and Disease 1st ed. Packer L. Fuchs J. Marcel Dekker, Inc. New York, NY, USA 1997 1 24
12. Talarico V. Aloe M. Barreca M. Galati M.C. Raiola G. Do you remember scurvy? Clin. Ther. 2014 165 253 256 25366945
13. Alqanatish J.T. Alqahtani F. Alsewairi W.M. Al-kenaizan S. Childhood scurvy: An unusual cause of refusal to walk in a child Pediatr. Rheumatol. 2015 13 23 10.1186/s12969-015-0020-1 26063195
14. Peterkofsky B. Ascorbate requirement for hydroxylation and secretion of procollagen: Relationship to inhibition of collagen synthesis in scurvy Am. J. Clin. Nutr. 1991 54 1135 1140
15. Ellinger S. Stehle P. Efficacy of vitamin supplementation in situations with wound healing disorders: Results from clinical intervention studies Curr. Opin. Clin. Nutr. Metab. Care 2009 12 588 595 10.1097/MCO.0b013e328331a5b5 19770648
16. Ross R. Benditt E.P. Wound healing and collagen formation: II. Fine structure in experimental scurvy J. Cell Biol. 1962 12 533 551 10.1083/jcb.12.3.533 14494203
17. Hodges R.E. Baker E.M. Hood J. Sauberlich H.E. March S.C. Experimental scurvy in man Am. J. Clin. Nutr. 1969 22 535 548 4977512
18. Hodges R.E. Hood J. Canham J.E. Sauberlich H.E. Baker E.M. Clinical manifestations of ascorbic acid deficiency in man Am. J. Clin. Nutr. 1971 24 432 443 5090631
19. Evans J.R. Lawrenson J.G. Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration Cochrane Database Syst. Rev. 2017 10.1002/14651858.CD000254.pub4
20. Placzek M. Gaube S. Kerkmann U. Gilbertz K.P. Herzinger T. Haen E. Przybilla B. Ultraviolet B-induced DNA damage in human epidermis is modified by the antioxidants ascorbic acid and D-alpha-tocopherol J. Investig. Dermatol 2005 124 304 307 10.1111/j.0022-202X.2004.23560.x 15675947
21. Stewart M.S. Cameron G.S. Pence B.C. Antioxidant nutrients protect against UVB-induced oxidative damage to DNA of mouse keratinocytes in culture J. Investig. Dermatol. 1996 106 1086 1089 10.1111/1523-1747.ep12339344 8618044
22. Baumann L. Skin ageing and its treatment J. Pathol. 2007 211 241 251 10.1002/path.2098 17200942
23. Zussman J. Ahdout J. Kim J. Vitamins and photoaging: Do scientific data support their use? J. Am. Acad. Dermatol. 2010 63 507 525 10.1016/j.jaad.2009.07.037 20189681
24. Langton A.K. Sherratt M.J. Griffiths C.E. Watson R.E. A new wrinkle on old skin: The role of elastic fibres in skin ageing Int. J. Cosmet. Sci. 2010 32 330 339 10.1111/j.1468-2494.2010.00574.x 20572890
25. Rhie G. Shin M.H. Seo J.Y. Choi W.W. Cho K.H. Kim K.H. Park K.C. Eun H.C. Chung J.H. Aging- and photoaging-dependent changes of enzymic and nonenzymic antioxidants in the epidermis and dermis of human skin in vivo J. Investig. Dermatol. 2001 117 1212 1217 10.1046/j.0022-202x.2001.01469.x 11710935
26. Shindo Y. Witt E. Han D. Epstein W. Packer L. Enzymic and non-enzymic antioxidants in epidermis and dermis of human skin J. Investig. Dermatol. 1994 102 122 124 10.1111/1523-1747.ep12371744 8288904
27. McArdle F. Rhodes L.E. Parslew R. Jack C.I. Friedmann P.S. Jackson M.J. UVR-induced oxidative stress in human skin in vivo: Effects of oral vitamin C supplementation Free Radic. Biol. Med. 2002 33 1355 1362 10.1016/S0891-5849(02)01042-0 12419467
28. Kirk J.E. Vitamins and Hormones Academic Press New York, NY, USA 1962 83 92
29. Schaus R. The vitamin C content of human pituitary, cerebral cortex, heart, and skeletal muscle and its relation to age Am. J. Clin. Nutr. 1957 5 3
30. Yavorsky M. Almaden P. King C.G. The vitamin C content of human tissues J. Biol. Chem. 1934 106 525 529
31. Lloyd B.B. Sinclair H.M. Chapter 1, pp. 369–471 Biochemistry and Physiology of Nutrition Bourne G.H. Kidder G.W. Academic Press New York, NY, USA 1953
32. Carr A.C. Bozonet S.M. Pullar J.M. Simcock J.W. Vissers M.C. Human skeletal muscle ascorbate is highly responsive to changes in vitamin C intake and plasma concentrations Am. J. Clin. Nutr. 2013 97 800 807 10.3945/ajcn.112.053207 23446899
33. Shindo Y. Witt E. Han D. Packer L. Dose-response effects of acute ultraviolet irradiation on antioxidants and molecular markers of oxidation in murine epidermis and dermis J. Investig. Dermatol. 1994 102 470 475 10.1111/1523-1747.ep12373027 8151122
34. Shindo Y. Witt E. Packer L. Antioxidant defense mechanisms in murine epidermis and dermis and their responses to ultraviolet light J. Investig. Dermatol. 1993 100 260 265 10.1111/1523-1747.ep12469048 8440901
35. Wheeler L.A. Aswad A. Connor M.J. Lowe N. Depletion of cutaneous glutathione and the induction of inflammation by 8-methoxypsoralen plus UVA radiation J. Investig. Dermatol. 1986 87 658 662 10.1111/1523-1747.ep12456380 2877029
36. Weber S.U. Thiele J.J. Cross C.E. Packer L. Vitamin C, uric acid, and glutathione gradients in murine stratum corneum and their susceptibility to ozone exposure J. Investig. Dermatol. 1999 113 1128 1132 10.1046/j.1523-1747.1999.00789.x 10594762
37. Steiling H. Longet K. Moodycliffe A. Mansourian R. Bertschy E. Smola H. Mauch C. Williamson G. Sodium-dependent vitamin C transporter isoforms in skin: Distribution, kinetics, and effect of UVB-induced oxidative stress Free Radic. Biol. Med. 2007 43 752 762 10.1016/j.freeradbiomed.2007.05.001 17664139
38. Lauer A.C. Groth N. Haag S.F. Darvin M.E. Lademann J. Meinke M.C. Dose-dependent vitamin C uptake and radical scavenging activity in human skin measured with in vivo electron paramagnetic resonance spectroscopy Skin Pharmacol. Physiol. 2013 26 147 154 10.1159/000350833 23689595
39. Mandl J. Szarka A. Banhegyi G. Vitamin C: Update on physiology and pharmacology Br. J. Pharmacol. 2009 157 1097 1110 10.1111/j.1476-5381.2009.00282.x 19508394
40. May J.M. The SLC23 family of ascorbate transporters: Ensuring that you get and keep your daily dose of vitamin C Br. J. Pharmacol. 2011 164 1793 1801 10.1111/j.1476-5381.2011.01350.x 21418192
41. Savini I. Rossi A. Pierro C. Avigliano L. Catani M.V. SVCT1 and SVCT2: Key proteins for vitamin C uptake Amino Acids 2008 34 347 355 10.1007/s00726-007-0555-7 17541511
42. Rajan D.P. Huang W. Dutta B. Devoe L.D. Leibach F.H. Ganapathy V. Prasad P.D. Human placental sodium-dependent vitamin C transporter (SVCT2): Molecular cloning and transport function Biochem. Biophys. Res. Commun. 1999 262 762 768 10.1006/bbrc.1999.1272 10471399
43. Levine M. Cantilena C.C. Dhariwal K.R. In situ kinetics and ascorbic acid requirements World Rev. Nutr. Diet 1993 72 114 127 8506699
44. Levine M. Conry-Cantilena C. Wang Y. Welch R.W. Washko P.W. Dhariwal K.R. Park J.B. Lazarev A. Graumlich J.F. King J. Vitamin C pharmacokinetics in healthy volunteers: Evidence for a recommended dietary allowance Proc. Natl. Acad. Sci. USA 1996 93 3704 3709 10.1073/pnas.93.8.3704 8623000
45. Levine M. Dhariwal K.R. Washko P. Welch R. Wang Y.H. Cantilena C.C. Yu R. Ascorbic acid and reaction kinetics in situ: A new approach to vitamin requirements J. Nutr. Sci. Vitaminol. 1992 38 169 172 10.3177/jnsv.38.Special_169
46. Levine M. Dhariwal K.R. Welch R.W. Wang Y. Park J.B. Determination of optimal vitamin C requirements in humans Am. J. Clin. Nutr. 1995 62 1347 1356
47. Carr A.C. Frei B. Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans Am. J. Clin. Nutr. 1999 69 1086 1107 10357726
48. Carr A.C. Bozonet S.M. Pullar J.M. Simcock J.W. Vissers M.C. A randomized steady-state bioavailability study of synthetic versus natural (kiwifruit-derived) vitamin C Nutrients 2013 5 3684 3695 10.3390/nu5093684 24067392
49. Costa A. Pereira E.S.P. Assumpção E.C. Dos Santos F.B.C. Ota F.S. De Oliveira Pereira M. Fidelis M.C. Fávaro R. Langen S.S.B. De Arruda L.H.F. Assessment of clinical effects and safety of an oral supplement based on marine protein, vitamin C, grape seed extract, zinc, and tomato extract in the improvement of visible signs of skin aging in men Clin. Cosmet. Investig. Dermatol. 2015 8 319 328 10.2147/CCID.S79447 26170708
50. Fuchs J. Kern H. Modulation of UV-light-induced skin inflammation by d -alpha-tocopherol and l -ascorbic acid: A clinical study using solar simulated radiation Free Radic. Biol. Med. 1998 25 1006 1012 10.1016/S0891-5849(98)00132-4 9870553
51. Nusgens B.V. Humbert P. Rougier A. Colige A.C. Haftek M. Lambert C.A. Richard A. Creidi P. Lapiere C.M. Topically applied vitamin C enhances the mRNA level of collagens I and III, their processing enzymes and tissue inhibitor of matrix metalloproteinase 1 in the human dermis J. Investig. Dermatol. 2001 116 853 859 10.1046/j.0022-202x.2001.01362.x 11407971
52. Humbert P.G. Haftek M. Creidi P. Lapiere C. Nusgens B. Richard A. Schmitt D. Rougier A. Zahouani H. Topical ascorbic acid on photoaged skin. Clinical, topographical and ultrastructural evaluation: Double-blind study vs. placebo Exp. Dermatol. 2003 12 237 244 10.1034/j.1600-0625.2003.00008.x 12823436
53. Lee W.R. Shen S.C. Kuo-Hsien W. Hu C.H. Fang J.Y. Lasers and microdermabrasion enhance and control topical delivery of vitamin C J. Investig. Dermatol. 2003 121 1118 1125 10.1046/j.1523-1747.2003.12537.x 14708614
54. Lin J.Y. Selim M.A. Shea C.R. Grichnik J.M. Omar M.M. Monteiro-Riviere N.A. Pinnell S.R. UV photoprotection by combination topical antioxidants vitamin C and vitamin E J. Am. Acad. Dermatol. 2003 48 866 874 10.1067/mjd.2003.425 12789176
55. Sauermann K. Jaspers S. Koop U. Wenck H. Topically applied vitamin C increases the density of dermal papillae in aged human skin BMC Dermatol. 2004 4 13 10.1186/1471-5945-4-13 15456516
56. Pinnell S.R. Cutaneous photodamage, oxidative stress, and topical antioxidant protection J. Am. Acad. Dermatol. 2003 48 1 22 10.1067/mjd.2003.16 12522365
57. Stamford N.P.J. Stability, transdermal penetration, and cutaneous effects of ascorbic acid and its derivatives J. Cosmet. Dermatol. 2012 11 310 317 10.1111/jocd.12006 23174055
58. Nayama S. Takehana M. Kanke M. Itoh S. Ogata E. Kobayashi S. Protective effects of sodium- l -ascorbyl-2 phosphate on the development of UVB-induced damage in cultured mouse skin Biol. Pharm. Bull. 1999 22 1301 1305 10.1248/bpb.22.1301 10746160
59. Kobayashi S. Takehana M. Itoh S. Ogata E. Protective effect of magnesium- l -ascorbyl-2 phosphate against skin damage induced by UVB irradiation Photochem. Photobiol. 1996 64 224 228 10.1111/j.1751-1097.1996.tb02447.x 8787018
60. Maia Campos P.M. Gaspar L.R. Goncalves G.M. Pereira L.H. Semprini M. Lopes R.A. Comparative effects of retinoic acid or glycolic acid vehiculated in different topical formulations Biomed. Res. Int. 2015 2015 650316 10.1155/2015/650316 25632398
61. Pinnell S.R. Yang H. Omar M. Monteiro-Riviere N. DeBuys H.V. Walker L.C. Wang Y. Levine M. Topical l -ascorbic acid: Percutaneous absorption studies Dermatol. Surg. 2001 27 137 142 10.1097/00042728-200102000-00008 11207686
62. Yamamoto I. Muto N. Murakami K. Akiyama J. Collagen synthesis in human skin fibroblasts is stimulated by a stable form of ascorbate, 2-O-alpha- d -glucopyranosyl- l -ascorbic acid J. Nutr. 1992 122 871 877 1552361
63. Yamamoto I. Suga S. Mitoh Y. Tanaka M. Muto N. Antiscorbutic activity of l -ascorbic acid 2-glucoside and its availability as a vitamin C supplement in normal rats and guinea pigs J. Pharmacobio-Dyn. 1990 13 688 695 10.1248/bpb1978.13.688 2093127
64. Jurkovic P. Sentjurc M. Gasperlin M. Kristl J. Pecar S. Skin protection against ultraviolet induced free radicals with ascorbyl palmitate in microemulsions Eur. J. Pharm. Biopharm. 2003 56 59 66 10.1016/S0939-6411(03)00062-6 12837482
65. Wu Y. Zheng X. Xu X.G. Li Y.H. Wang B. Gao X.H. Chen H.D. Yatskayer M. Oresajo C. Protective effects of a topical antioxidant complex containing vitamins C and E and ferulic acid against ultraviolet irradiation-induced photodamage in Chinese women J. Drugs Dermatol. 2013 12 464 468 23652896
66. Xu T.H. Chen J.Z. Li Y.H. Wu Y. Luo Y.J. Gao X.H. Chen H.D. Split-face study of topical 23.8% l -ascorbic acid serum in treating photo-aged skin J. Drugs Dermatol. 2012 11 51 56 22206077
67. Serrano G. Almudever P. Serrano J.M. Milara J. Torrens A. Exposito I. Cortijo J. Phosphatidylcholine liposomes as carriers to improve topical ascorbic acid treatment of skin disorders Clin. Cosmet. Investig. Dermatol. 2015 8 591 599 26719718
68. Carr A.C. Vissers M.C. Good nutrition matters: Hypovitaminosis C associated with depressed mood and poor wound healing N. Z. Med. J. 2012 125 107 109
69. Hinek A. Kim H.J. Wang Y. Wang A. Mitts T.F. Sodium l -ascorbate enhances elastic fibers deposition by fibroblasts from normal and pathologic human skin J. Dermatol. Sci. 2014 75 173 182 10.1016/j.jdermsci.2014.05.011 25015208
70. Ivanov V. Ivanova S. Kalinovsky T. Niedzwiecki A. Rath M. Inhibition of collagen synthesis by select calcium and sodium channel blockers can be mitigated by ascorbic acid and ascorbyl palmitate Am. J. Cardiovasc. Dis. 2016 6 26 35 27335688
71. Kivirikko K.I. Myllyla R. Pihlajaniemi T. Protein hydroxylation: Prolyl 4-hydroxylase, an enzyme with four cosubstrates and a multifunctional subunit FASEB J. 1989 3 1609 1617 2537773
72. May J.M. Harrison F.E. Role of vitamin C in the function of the vascular endothelium Antioxid. Redox Signal. 2013 19 2068 2083 10.1089/ars.2013.5205 23581713
73. Kishimoto Y. Saito N. Kurita K. Shimokado K. Maruyama N. Ishigami A. Ascorbic acid enhances the expression of type 1 and type 4 collagen and SVCT2 in cultured human skin fibroblasts Biochem. Biophys. Res. Commun. 2013 430 579 584 10.1016/j.bbrc.2012.11.110 23228664
74. May J.M. Qu Z.C. Transport and intracellular accumulation of vitamin C in endothelial cells: Relevance to collagen synthesis Arch. Biochem. Biophys. 2005 434 178 186 10.1016/j.abb.2004.10.023 15629121
75. Miller R.L. Elsas L.J. Priest R.E. Ascorbate action on normal and mutant human lysyl hydroxylases from cultured dermal fibroblasts J. Investig. Dermatol. 1979 72 241 247 10.1111/1523-1747.ep12531702 222849
76. Parsons K.K. Maeda N. Yamauchi M. Banes A.J. Koller B.H. Ascorbic acid-independent synthesis of collagen in mice Am. J. Physiol. Endocrinol. Metab. 2006 290 1131 1139 10.1152/ajpendo.00339.2005 16352673
77. Pihlajaniemi T. Myllyla R. Kivirikko K.I. Prolyl 4-hydroxylase and its role in collagen synthesis J. Hepatol. 1991 13 2 7 10.1016/0168-8278(91)90002-S
78. Duarte T.L. Cooke M.S. Jones G.D. Gene expression profiling reveals new protective roles for vitamin C in human skin cells Free Radic. Biol. Med. 2009 46 78 87 10.1016/j.freeradbiomed.2008.09.028 18973801
79. Takahashi Y. Takahashi S. Shiga Y. Yoshimi T. Miura T. Hypoxic induction of prolyl 4-hydroxylase alpha (I) in cultured cells J. Biol. Chem. 2000 275 14139 14146 10.1074/jbc.275.19.14139 10799490
80. Geesin J.C. Darr D. Kaufman R. Murad S. Pinnell S.R. Ascorbic acid specifically increases type I and type III procollagen messenger RNA levels in human skin fibroblast J. Investig. Dermatol. 1988 90 420 424 10.1111/1523-1747.ep12460849 3351329
81. Davidson J.M. LuValle P.A. Zoia O. Quaglino D. Jr. Giro M. Ascorbate differentially regulates elastin and collagen biosynthesis in vascular smooth muscle cells and skin fibroblasts by pretranslational mechanisms J. Biol. Chem. 1997 272 345 352 10.1074/jbc.272.1.345 8995268
82. Phillips C.L. Combs S.B. Pinnell S.R. Effects of ascorbic acid on proliferation and collagen synthesis in relation to the donor age of human dermal fibroblasts J. Investig. Dermatol. 1994 103 228 232 10.1111/1523-1747.ep12393187 7518857
83. Tajima S. Pinnell S.R. Ascorbic acid preferentially enhances type I and III collagen gene transcription in human skin fibroblasts J. Dermatol. Sci. 1996 11 250 253 10.1016/0923-1811(95)00640-0 8785178
84. Agrawal S. Kumar A. Dhali T.K. Majhi S.K. Comparison of oxidant-antioxidant status in patients with vitiligo and healthy population Kathmandu Univ. Med. J. 2014 12 132 136 10.3126/kumj.v12i2.13660
85. Nagata C. Nakamura K. Wada K. Oba S. Hayashi M. Takeda N. Yasuda K. Association of dietary fat, vegetables and antioxidant micronutrients with skin ageing in Japanese women Br. J. Nutr. 2010 103 1493 1498 10.1017/S0007114509993461 20085665
86. Bissett D.L. Chatterjee R. Hannon D.P. Photoprotective effect of superoxide-scavenging antioxidants against ultraviolet radiation-induced chronic skin damage in the hairless mouse Photodermatol. Photoimmunol. Photomed. 1990 7 56 62 2169296
87. Shukla A. Rasik A.M. Patnaik G.K. Depletion of reduced glutathione, ascorbic acid, vitamin E and antioxidant defence enzymes in a healing cutaneous wound Free Radic. Res. 1997 26 93 101 10.3109/10715769709097788 9257121
88. Steenvoorden D.P. Van Henegouwen G.M. The use of endogenous antioxidants to improve photoprotection J. Photochem. Photobiol. B 1997 41 1 10 10.1016/S1011-1344(97)00081-X 9440308
89. Darr D. Dunston S. Faust H. Pinnell S. Effectiveness of antioxidants (vitamin C and E) with and without sunscreens as topical photoprotectants Acta Derm Venereol. 1996 76 264 268 8869680
90. DeBuys H.V. Levy S.B. Murray J.C. Madey D.L. Pinnell S.R. Modern approaches to photoprotection Dermatol. Clin. 2000 18 577 590 10.1016/S0733-8635(05)70208-4 11059365
91. Dreher F. Gabard B. Schwindt D.A. Maibach H.I. Topical melatonin in combination with vitamins E and C protects skin from ultraviolet-induced erythema: A human study in vivo Br. J. Dermatol. 1998 139 332 339 10.1046/j.1365-2133.1998.02447.x 9767255
92. Mukai K. Kinetic study of the reaction of vitamin C derivatives with tocopheroxyl (vitamin E radical) and substituted phenoxyl radicals in solution Biochim. Biophys. Acta 1989 993 168 173 10.1016/0304-4165(89)90159-1
93. Tanaka K. Hashimoto T. Tokumaru S. Iguchi H. Kojo S. Interactions between vitamin C and vitamin E are observed in tissues of inherently scorbutic rats J. Nutr. 1997 127 2060 2064 9311965
94. Kameyama K. Sakai C. Kondoh S. Yonemoto K. Nishiyama S. Tagawa M. Murata T. Ohnuma T. Quigley J. Dorsky A. Inhibitory effect of magnesium l -ascorbyl-2-phosphate (VC-PMG) on melanogenesis in vitro and in vivo J. Am. Acad. Dermatol. 1996 34 29 33 10.1016/S0190-9622(96)90830-0 8543691
95. Matsuda S. Shibayama H. Hisama M. Ohtsuki M. Iwaki M. Inhibitory effects of a novel ascorbic derivative, disodium isostearyl 2-O- l -ascorbyl phosphate on melanogenesis Chem. Pharm. Bull. 2008 56 292 297 10.1248/cpb.56.292 18310938
96. Ebanks J.P. Wickett R.R. Boissy R.E. Mechanisms regulating skin pigmentation: The rise and fall of complexion coloration Int. J. Mol. Sci. 2009 10 4066 4087 10.3390/ijms10094066 19865532
97. Pasonen-Seppanen S. Suhonen T.M. Kirjavainen M. Suihko E. Urtti A. Miettinen M. Hyttinen M. Tammi M. Tammi R. Vitamin C enhances differentiation of a continuous keratinocyte cell line (REK) into epidermis with normal stratum corneum ultrastructure and functional permeability barrier Histochem. Cell. Biol. 2001 116 287 297 10.1007/s004180100312 11702187
98. Ponec M. Weerheim A. Kempenaar J. Mulder A. Gooris G.S. Bouwstra J. Mommaas A.M. The formation of competent barrier lipids in reconstructed human epidermis requires the presence of vitamin C J. Investig. Dermatol. 1997 109 348 355 10.1111/1523-1747.ep12336024 9284103
99. Savini I. Catani M.V. Rossi A. Duranti G. Melino G. Avigliano L. Characterization of keratinocyte differentiation induced by ascorbic acid: Protein kinase C involvement and vitamin C homeostasis J. Investig. Dermatol. 2002 118 372 379 10.1046/j.0022-202x.2001.01624.x 11841559
100. Uchida Y. Behne M. Quiec D. Elias P.M. Holleran W.M. Vitamin C stimulates sphingolipid production and markers of barrier formation in submerged human keratinocyte cultures J. Investig. Dermatol. 2001 117 1307 1313 10.1046/j.0022-202x.2001.01555.x 11710949
102. Marionnet C. Vioux-Chagnoleau C. Pierrard C. Sok J. Asselineau D. Bernerd F. Morphogenesis of dermal-epidermal junction in a model of reconstructed skin: Beneficial effects of vitamin C Exp. Dermatol. 2006 15 625 633 10.1111/j.1600-0625.2006.00454.x 16842601
103. Vissers M.C. Gunningham S.P. Morrison M.J. Dachs G.U. Currie M.J. Modulation of hypoxia-inducible factor-1 alpha in cultured primary cells by intracellular ascorbate Free Radic. Biol. Med. 2007 42 765 772 10.1016/j.freeradbiomed.2006.11.023 17320759
104. Vissers M.C. Kuiper C. Dachs G.U. Regulation of the 2-oxoglutarate-dependent dioxygenases and implications for cancer Biochem. Soc. Trans. 2014 42 945 951 10.1042/BST20140118 25109984
105. Vissers M.C. Lee W.G. Hampton M.B. Regulation of apoptosis by vitamin C. Specific protection of the apoptotic machinery against exposure to chlorinated oxidants J. Biol. Chem. 2001 276 46835 46840 10.1074/jbc.M107664200 11590157
106. Kao J. Huey G. Kao R. Stern R. Ascorbic acid stimulates production of glycosaminoglycans in cultured fibroblasts Exp. Mol. Pathol. 1990 53 1 10 10.1016/0014-4800(90)90020-E 2209807
107. Kang J.S. Kim H.N. Jung D.J. Kim J.E. Mun G.H. Kim Y.S. Cho D. Shin D.H. Hwang Y.I. Lee W.J. Regulation of UVB-induced IL-8 and MCP-1 production in skin keratinocytes by increasing vitamin C uptake via the redistribution of SVCT-1 from the cytosol to the membrane J. Investig. Dermatol. 2007 127 698 706 10.1038/sj.jid.5700572 17008880
108. Savini I. D’Angelo I. Ranalli M. Melino G. Avigliano L. Ascorbic acid maintenance in HaCaT cells prevents radical formation and apoptosis by UV-B Free Radic. Biol. Med. 1999 26 1172 1180 10.1016/S0891-5849(98)00311-6 10381188
109. Tebbe B. Wu S. Geilen C.C. Eberle J. Kodelja V. Orfanos C.E. l -Ascorbic acid inhibits UVA-induced lipid peroxidation and secretion of IL-1alpha and IL-6 in cultured human keratinocytes in vitro J. Investig. Dermatol. 1997 108 302 306 10.1111/1523-1747.ep12286468 9036929
110. Minor E.A. Court B.L. Young J.I. Wang G. Ascorbate induces ten-eleven translocation (Tet) methylcytosine dioxygenase-mediated generation of 5-hydroxymethylcytosine J. Biol. Chem. 2013 288 13669 13674 10.1074/jbc.C113.464800 23548903
111. Blaschke K. Ebata K.T. Karimi M.M. Zepeda-Martinez J.A. Goyal P. Mahapatra S. Tam A. Laird D.J. Hirst M. Rao A. Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells Nature 2013 500 222 226 10.1038/nature12362 23812591
112. Yin R. Mao S.Q. Zhao B. Chong Z. Yang Y. Zhao C. Zhang D. Huang H. Gao J. Li Z. Ascorbic acid enhances Tet-mediated 5-methylcytosine oxidation and promotes DNA demethylation in mammals J. Am. Chem. Soc. 2013 135 10396 10403 10.1021/ja4028346 23768208
113. Song C.X. He C. Potential functional roles of DNA demethylation intermediates Trends Biochem. Sci. 2013 38 480 484 10.1016/j.tibs.2013.07.003 23932479
114. Lian C.G. Xu Y. Ceol C. Wu F. Larson A. Dresser K. Xu W. Tan L. Hu Y. Zhan Q. Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma Cell 2012 150 1135 1146 10.1016/j.cell.2012.07.033 22980977
115. Gustafson C.B. Yang C. Dickson K.M. Shao H. Van Booven D. Harbour J.W. Liu Z.J. Wang G. Epigenetic reprogramming of melanoma cells by vitamin C treatment Clin. Epigenet. 2015 7 51 10.1186/s13148-015-0087-z 25977731
116. Kuiper C. Vissers M.C. Ascorbate as a co-factor for Fe- and 2-oxoglutarate dependent dioxygenases: Physiological activity in tumor growth and progression Front. Oncol. 2014 4 359 10.3389/fonc.2014.00359 25540771
117. Lin J.R. Qin H.H. Wu W.Y. He S.J. Xu J.H. Vitamin C protects against UV irradiation-induced apoptosis through reactivating silenced tumor suppressor genes p21 and p16 in a Tet-dependent DNA demethylation manner in human skin cancer cells Cancer Biother. Radiopharm. 2014 29 257 264 10.1089/cbr.2014.1647 25003799
118. Valacchi G. Sticozzi C. Belmonte G. Cervellati F. Demaude J. Chen N. Krol Y. Oresajo C. Vitamin C compound mixtures prevent ozone-induced oxidative damage in human keratinocytes as initial assessment of pollution protection PLoS ONE 2015 10 e0131097 10.1371/journal.pone.0131097 26270818
119. Valacchi G. Muresan X.M. Sticozzi C. Belmonte G. Pecorelli A. Cervellati F. Demaude J. Krol Y. Oresajo C. Ozone-induced damage in 3D-kkin model is prevented by topical vitamin C and vitamin E compound mixtures application J. Dermatol. Sci. 2016 82 209 212 10.1016/j.jdermsci.2016.02.007 26917348
120. Puizina-Ivic N. Skin aging Acta Dermatovenerol. Alp. Pannonica Adriat. 2008 17 47 54 18709289
121. Farage M.A. Miller K.W. Elsner P. Maibach H.I. Intrinsic and extrinsic factors in skin ageing: A review Int. J. Cosmet. Sci. 2008 30 87 95 10.1111/j.1468-2494.2007.00415.x 18377617
122. Fenske N.A. Lober C.W. Structural and functional changes of normal aging skin J. Am. Acad. Dermatol. 1986 15 571 585 10.1016/S0190-9622(86)70208-9 3534008
123. Kang S. Fisher G.J. Voorhees J.J. Photoaging: Pathogenesis, prevention, and treatment Clin. Geriatr. Med. 2001 17 643 659 10.1016/S0749-0690(05)70091-4 11535421
124. El-Domyati M. Attia S. Saleh F. Brown D. Birk D.E. Gasparro F. Ahmad H. Uitto J. Intrinsic aging vs. photoaging: A comparative histopathological, immunohistochemical, and ultrastructural study of skin Exp. Dermatol. 2002 11 398 405 10.1034/j.1600-0625.2002.110502.x 12366692
125. Lopez-Torres M. Shindo Y. Packer L. Effect of age on antioxidants and molecular markers of oxidative damage in murine epidermis and dermis J. Investig. Dermatol. 1994 102 476 480 10.1111/1523-1747.ep12373032 8151123
126. Naylor E.C. Watson R.E. Sherratt M.J. Molecular aspects of skin ageing Maturitas 2011 69 249 256 10.1016/j.maturitas.2011.04.011 21612880
127. White-Chu E.F. Reddy M. Dry skin in the elderly: Complexities of a common problem Clin. Dermatol. 2011 29 37 42 10.1016/j.clindermatol.2010.07.005 21146730
128. Papakonstantinou E. Roth M. Karakiulakis G. Hyaluronic acid: A key molecule in skin aging Derm.-Endocrinol. 2012 4 253 258 10.4161/derm.21923 23467280
129. Monnat R.J. Jr. “...Rewritten in the skin”: Clues to skin biology and aging from inherited disease J. Investig. Dermatol. 2015 135 1484 1490 10.1038/jid.2015.88 25810110
130. Rinnerthaler M. Bischof J. Streubel M.K. Trost A. Richter K. Oxidative stress in aging human skin Biomolecules 2015 5 545 589 10.3390/biom5020545 25906193
131. Draelos Z.D. Aging skin: The role of diet: Facts and controversies Clin. Dermatol. 2013 31 701 706 10.1016/j.clindermatol.2013.05.005 24160273
132. Marini A. Beauty from the inside. Does it really work? Hautarzt 2011 62 614 617 10.1007/s00105-011-2138-5 21732161
133. Cosgrove M.C. Franco O.H. Granger S.P. Murray P.G. Mayes A.E. Dietary nutrient intakes and skin-aging appearance among middle-aged American women Am. J. Clin. Nutr. 2007 86 1225 1231 17921406
134. Pezdirc K. Hutchesson M. Whitehead R. Ozakinci G. Perrett D. Collins C.E. Can dietary intake influence perception of and measured appearance? A systematic review Nutr. Res. 2015 35 175 197 10.1016/j.nutres.2014.12.002 25600848
135. Bertuccelli G. Zerbinati N. Marcellino M. Nanda Kumar N.S. He F. Tsepakolenko V. Cervi J. Lorenzetti A. Marotta F. Effect of a quality-controlled fermented nutraceutical on skin aging markers: An antioxidant-control, double-blind study Exp. Ther. Med. 2016 11 909 916 10.3892/etm.2016.3011 26998011
136. Qin H. Zheng X. Zhong X. Shetty A.K. Elias P.M. Bollag W.B. Aquaporin-3 in keratinocytes and skin: Its role and interaction with phospholipase D2 Arch. Biochem. Biophys. 2011 508 138 143 10.1016/j.abb.2011.01.014 21276418
137. Podda M. Traber M.G. Weber C. Yan L.J. Packer L. UV-irradiation depletes antioxidants and causes oxidative damage in a model of human skin Free Radic. Biol. Med. 1998 24 55 65 10.1016/S0891-5849(97)00142-1 9436614
138. Buettner G.R. Motten A.G. Chignell C.E. ESR detection of endogenous ascorbyl free radical in mouse skin: Enhancement of radical production during UV irradiation following topical application of chlorpromazine Photochem. Photobiol. 1987 46 161 162 10.1111/j.1751-1097.1987.tb04751.x 2819904
139. Miura K. Green A.C. Dietary antioxidants and melanoma: Evidence from cohort and intervention studies Nutr. Cancer 2015 67 867 876 10.1080/01635581.2015.1053499 26147450
140. Vile G.F. Tyrrell R.M. UVA radiation-induced oxidative damage to lipids and proteins in vitro and in human skin fibroblasts is dependent on iron and singlet oxygen Free Radic. Biol. Med. 1995 18 721 730 10.1016/0891-5849(94)00192-M 7750796
141. Sander C.S. Chang H. Salzmann S. Muller C.S. Ekanayake-Mudiyanselage S. Elsner P. Thiele J.J. Photoaging is associated with protein oxidation in human skin in vivo J. Investig. Dermatol. 2002 118 618 625 10.1046/j.1523-1747.2002.01708.x 11918707
142. Berneburg M. Plettenberg H. Krutmann J. Photoaging of human skin Photodermatol. Photoimmunol. Photomed. 2000 16 239 244 10.1034/j.1600-0781.2000.160601.x 11132125
143. Kligman L.H. Kligman A.M. The nature of photoaging: Its prevention and repair Photo-Dermatology 1986 3 215 227 3534809
144. Trojahn C. Dobos G. Blume-Peytavi U. Kottner J. The skin barrier function: Differences between intrinsic and extrinsic aging G. Ital. Dermatol. Venereol. 2015 150 687 692 26373867
145. Darr D. Combs S. Dunston S. Manning T. Pinnell S. Topical vitamin C protects porcine skin from ultraviolet radiation-induced damage Br. J. Dermatol. 1992 127 247 253 10.1111/j.1365-2133.1992.tb00122.x 1390169
146. Mikirova N.A. Ichim T.E. Riordan N.H. Anti-angiogenic effect of high doses of ascorbic acid J. Transl. Med. 2008 6 50 10.1186/1479-5876-6-50 18789157
147. Nakamura T. Pinnell S.R. Darr D. Kurimoto I. Itami S. Yoshikawa K. Streilein J.W. Vitamin C abrogates the deleterious effects of UVB radiation on cutaneous immunity by a mechanism that does not depend on TNF-alpha J. Investig. Dermatol. 1997 109 20 24 10.1111/1523-1747.ep12276349 9204949
148. Eberlein-Konig B. Placzek M. Przybilla B. Protective effect against sunburn of combined systemic ascorbic acid (vitamin C) and d-alpha-tocopherol (vitamin E) J. Am. Acad. Dermatol. 1998 38 45 48 10.1016/S0190-9622(98)70537-7 9448204
149. Crisan D. Roman I. Crisan M. Scharffetter-Kochanek K. Badea R. The role of vitamin C in pushing back the boundaries of skin aging: An ultrasonographic approach Clin. Cosmet. Investig. Dermatol. 2015 8 463 470 10.2147/CCID.S84903 26366101
150. Murray J.C. Burch J.A. Streilein R.D. Iannacchione M.A. Hall R.P. Pinnell S.R. A topical antioxidant solution containing vitamins C and E stabilized by ferulic acid provides protection for human skin against damage caused by ultraviolet irradiation J. Am. Acad. Dermatol. 2008 59 418 425 10.1016/j.jaad.2008.05.004 18603326
151. Amber K.T. Shiman M.I. Badiavas E.V. The use of antioxidants in radiotherapy-induced skin toxicity Integr. Cancer Ther. 2014 13 38 45 10.1177/1534735413490235 23729466
152. Lin F.H. Lin J.Y. Gupta R.D. Tournas J.A. Burch J.A. Selim M.A. Monteiro-Riviere N.A. Grichnik J.M. Zielinski J. Pinnell S.R. Ferulic acid stabilizes a solution of vitamins C and E and doubles its photoprotection of skin J. Investig. Dermatol. 2005 125 826 832 10.1111/j.0022-202X.2005.23768.x 16185284
153. Grether-Beck S. Marini A. Jaenicke T. Krutmann J. Effective photoprotection of human skin against infrared A radiation by topically applied antioxidants: Results from a vehicle controlled, double-blind, randomized study Photochem. Photobiol. 2015 91 248 250 10.1111/php.12375 25349107
154. Traikovich S.S. Use of topical ascorbic acid and its effects on photodamaged skin topography Arch. Otolaryngol. Head Neck Surg. 1999 125 1091 1098 10.1001/archotol.125.10.1091 10522500
155. Jungersted J.M. Hellgren L.I. Jemec G.B. Agner T. Lipids and skin barrier function--A clinical perspective Contact Dermat. 2008 58 255 262 10.1111/j.1600-0536.2008.01320.x 18416754
156. Rawlings A.V. Scott I.R. Harding C.R. Bowser P.A. Stratum corneum moisturization at the molecular level J. Investig. Dermatol. 1994 103 731 741 10.1111/1523-1747.ep12398620 7963664
157. Boyce S.T. Supp A.P. Swope V.B. Warden G.D. Vitamin C regulates keratinocyte viability, epidermal barrier, and basement membrane in vitro, and reduces wound contraction after grafting of cultured skin substitutes J. Investig. Dermatol. 2002 118 565 572 10.1046/j.1523-1747.2002.01717.x 11918700
158. Craven N.M. Watson R.E. Jones C.J. Shuttleworth C.A. Kielty C.M. Griffiths C.E. Clinical features of photodamaged human skin are associated with a reduction in collagen VII Br. J. Dermatol. 1997 137 344 350 10.1111/j.1365-2133.1997.tb03736.x 9349327
159. Sachs D.L. Rittie L. Chubb H.A. Orringer J. Fisher G. Voorhees J.J. Hypo-collagenesis in photoaged skin predicts response to anti-aging cosmeceuticals J. Cosmet. Dermatol. 2013 12 108 115 10.1111/jocd.12037 23725304
160. Contet-Audonneau J.L. Jeanmaire C. Pauly G. A histological study of human wrinkle structures: Comparison between sun-exposed areas of the face, with or without wrinkles, and sun-protected areas Br. J. Dermatol. 1999 140 1038 1047 10.1046/j.1365-2133.1999.02901.x 10354068
161. Thomas J.R. Dixon T.K. Bhattacharyya T.K. Effects of topicals on the aging skin process Facial Plast. Surg. Clin. North Am. 2013 21 55 60 10.1016/j.fsc.2012.11.009 23369589
162. Sorensen L.T. Toft B.G. Rygaard J. Ladelund S. Paddon M. James T. Taylor R. Gottrup F. Effect of smoking, smoking cessation, and nicotine patch on wound dimension, vitamin C, and systemic markers of collagen metabolism Surgery 2010 148 982 990 10.1016/j.surg.2010.02.005 20347467
163. Gurtner G.C. Werner S. Barrandon Y. Longaker M.T. Wound repair and regeneration Nature 2008 453 314 321 10.1038/nature07039 18480812
164. Rodero M.P. Khosrotehrani K. Skin wound healing modulation by macrophages Int. J. Clin. Exp. Pathol. 2010 3 643 653 20830235
165. Ilina O. Friedl P. Mechanisms of collective cell migration at a glance J. Cell Sci. 2009 122 3203 3208 10.1242/jcs.036525 19726629
166. Yun I.S. Yoo H.S. Kim Y.O. Rah D.K. Improved scar appearance with combined use of silicone gel and vitamin C for Asian patients: A comparative case series Aesthet. Plast. Surg. 2013 37 1176 1181 10.1007/s00266-013-0210-5 24091488
167. Thompson C. Fuhrman M.P. Nutrients and wound healing: Still searching for the magic bullet Nutr. Clin. Pract. 2005 20 331 347 10.1177/0115426505020003331 16207672
168. Young M.E. Malnutrition and wound healing Heart Lung 1988 17 60 67 3276649
169. Lund C.C. Crandon J.H. Ascorbic acid and human wound healing Ann. Surg. 1941 114 776 790 10.1097/00000658-194110000-00019 17857908
170. Basketter D.A. White I.R. Kullavanijaya P. Tresukosol P. Wichaidit M. McFadden J.P. Influence of vitamin C on the elicitation of allergic contact dermatitis to p-phenylenediamine Contact Dermat. 2016 74 368 372 10.1111/cod.12576 27027508
171. Barbosa E. Faintuch J. Machado Moreira E.A. Goncalves da Silva V.R. Lopes Pereima M.J. Martins Fagundes R.L. Filho D.W. Supplementation of vitamin E, vitamin C, and zinc attenuates oxidative stress in burned children: A randomized, double-blind, placebo-controlled pilot study J. Burn Care Res. 2009 30 859 866 10.1097/BCR.0b013e3181b487a8 19692922
172. Ubbink D.T. Santema T.B. Stoekenbroek R.M. Systemic wound care: A meta-review of cochrane systematic reviews Surg. Technol. Int. 2014 24 99 111 24700218
173. Furue M. Kadono T. “Inflammatory skin march” in atopic dermatitis and psoriasis Inflamm. Res. 2017 10.1007/s00011-017-1065-z
174. Han H. Roan F. Ziegler S.F. The atopic march: Current insights into skin barrier dysfunction and epithelial cell-derived cytokines Immunol. Rev. 2017 278 116 130 10.1111/imr.12546 28658558
175. Liakou A.I. Theodorakis M.J. Melnik B.C. Pappas A. Zouboulis C.C. Nutritional clinical studies in dermatology J. Drugs Dermatol. 2013 12 1104 1109 24085045
176. Rackett S.C. Rothe M.J. Grant-Kels J.M. Diet and dermatology. The role of dietary manipulation in the prevention and treatment of cutaneous disorders J. Am. Acad. Dermatol. 1993 29 447 461 10.1016/0190-9622(93)70210-K 8349862
177. Pappas A. Liakou A. Zouboulis C.C. Nutrition and skin Rev. Endocr. Metab. Disord. 2016 17 443 448 10.1007/s11154-016-9374-z 27401878
178. Leveque N. Robin S. Muret P. Mac-Mary S. Makki S. Berthelot A. Kantelip J.P. Humbert P. In vivo assessment of iron and ascorbic acid in psoriatic dermis Acta Derm. Venereol. 2004 84 2 5 10.1080/00015550310014717 15040469
180. Kallner A.B. Hartmann D. Hornig D.H. On the requirements of ascorbic acid in man: Steady-state turnover and body pool in smokers Am. J. Clin. Nutr. 1981 34 1347 1355 7258125
181. Evans-Olders R. Eintracht S. Hoffer L.J. Metabolic origin of hypovitaminosis C in acutely hospitalized patients Nutrition 2010 26 1070 1074 10.1016/j.nut.2009.08.015 20018480
182. Gan R. Eintracht S. Hoffer L.J. Vitamin C deficiency in a university teaching hospital J. Am. Coll. Nutr. 2008 27 428 433 10.1080/07315724.2008.10719721 18838532
183. Findik R.B. Ilkaya F. Guresci S. Guzel H. Karabulut S. Karakaya J. Effect of vitamin C on collagen structure of cardinal and uterosacral ligaments during pregnancy Eur. J. Obstet. Gynecol. Reprod. Biol. 2016 201 31 35 10.1016/j.ejogrb.2016.03.022 27042769
184. Silverstein R.J. Landsman A.S. The effects of a moderate and high dose of vitamin C on wound healing in a controlled guinea pig model J. Foot Ankle Surg. 1999 38 333 338 10.1016/S1067-2516(99)80004-0 10553546
185. Quevedo W.C. Jr. Holstein T.J. Dyckman J. McDonald C.J. Isaacson E.L. Inhibition of UVR-induced tanning and immunosuppression by topical applications of vitamins C and E to the skin of hairless (hr/hr) mice Pigment Cell Res. 2000 13 89 98 10.1034/j.1600-0749.2000.130207.x 10841030
186. Lee C. Yang H. Kim S. Kim M. Kang H. Kim N. An S. Koh J. Jung H. Evaluation of the anti-wrinkle effect of an ascorbic acid-loaded dissolving microneedle patch via a double-blind, placebo-controlled clinical study Int. J. Cosmet. Sci. 2016 38 375 381 10.1111/ics.12299 26648582
187. Valacchi G. Pecorelli A. Belmonte G. Pambianchi E. Cervellati F. Lynch S. Krol Y. Oresajo C. Protective Effects of Topical Vitamin C Compound Mixtures against Ozone-Induced Damage in Human Skin J. Investig. Dermatol. 2017 137 1373 1375 10.1016/j.jid.2017.01.034 28219661
*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.
오픈액세스 학술지에 출판된 논문
※ AI-Helper는 부적절한 답변을 할 수 있습니다.