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The inhibitory effect of pyrogallol on tyrosinase activity and structure: Integration study of inhibition kinetics with molecular dynamics simulation

International journal of biological macromolecules, v.121, 2019년, pp.463 - 471  

Xiong, Shang-Ling (College of Biological and Environmental Sciences, Zhejiang Wanli University, Ningbo 315100, PR China) ,  Lim, Gyu Tae (Genome Editing Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Gwahak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea) ,  Yin, Shang-Jun (College of Biological and Environmental Sciences, Zhejiang Wanli University, Ningbo 315100, PR China) ,  Lee, Jinhyuk (Genome Editing Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Gwahak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea) ,  Si, Yue-Xiu (College of Biological and Environmental Sciences, Zhejiang Wanli University, Ningbo 315100, PR China) ,  Yang, Jun-Mo (Department of Dermatology, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul 135-710, Republic of Korea) ,  Park, Yong-Doo (College of Biological and Environmental Sciences, Zhejiang Wanli University, Ningbo 315100, PR China) ,  Qian, Guo-Ying (College of Biological and Environmental Sciences, Zhejiang Wanli University, Ningbo 315100, PR China)

Abstract AI-Helper 아이콘AI-Helper

Abstract Pyrogallol is naturally found in aquatic plant and has been proposed as a substrate of tyrosinase. In this study, we evaluated the dual effect of pyrogallol on tyrosinase as an inhibitor in the presence of L‑DOPA simultaneously via integrating methods of enzyme kinetics and computati...

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