[논문]Abnormal neurite density and orientation dispersion in unilateral temporal lobe epilepsy detected by advanced diffusion imaging

Sone, Daichi; Sato, Noriko; Ota, Miho; Maikusa, Norihide; Kimura, Yukio; Matsuda, Hiroshi

doi:10.1016/j.nicl.2018.09.017

Abnormal neurite density and orientation dispersion in unilateral temporal lobe epilepsy detected by advanced diffusion imaging 원문보기

NeuroImage : Clinical, v.20, 2018년, pp.772 - 782

Sone, Daichi (Integrate Brain Imaging Center, National Center of Neurology and Psychiatry) , Sato, Noriko (Department of Radiology, National Center of Neurology and Psychiatry) , Ota, Miho (Department of Neuropsychiatry, Division of Clinical Medicine, Faculty of Medicine, University of Tsukuba) , Maikusa, Norihide (Integrate Brain Imaging Center, National Center of Neurology and Psychiatry) , Kimura, Yukio (Department of Radiology, National Center of Neurology and Psychiatry) , Matsuda, Hiroshi (Integrate Brain Imaging Center, National Center of Neurology and Psychiatry)

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Abstract Background Despite recent advances in diffusion MRI (dMRI), there is still limited information on neurite orientation dispersion and density imaging (NODDI) in temporal lobe epilepsy (TLE). This study aimed to demonstrate neurite density and dispersion in TLE with and without hippocampal sclerosis (HS) using whole-brain voxel-wise analyses. Material and methods We recruited 33 patients with unilateral TLE (16 left, 17 right), including 14 patients with HS (TLE-HS) and 19 MRI-negative 18F-fluorodeoxyglucose positron emission tomography (FDG-PET)-positive patients (MRI-/PET+ TLE). The NODDI toolbox calculated the intracellular volume fraction (ICVF) and orientation dispersion index (ODI). Conventional dMRI metrics, that is, fractional anisotropy (FA) and mean diffusivity (MD), were also estimated. After spatial normalization, all dMRI parameters (ICVF, ODI, FA, and MD) of the patients were compared with those of age- and sex-matched healthy controls using Statistical Parametric Mapping 12 (SPM12). As a complementary analysis, we added an atlas-based region of interest (ROI) analysis of relevant white matter tracts using tract-based spatial statistics. Results We found decreased neurite density mainly in the ipsilateral temporal areas of both right and left TLE, with the right TLE showing more severe and widespread abnormalities. In addition, etiology-specific analyses revealed a localized reduction in ICVF (i.e., neurite density) in the ipsilateral temporal pole in MRI-/PET+ TLE, whereas TLE-HS presented greater abnormalities, including FA and MD, in addition to a localized hippocampal reduction in ODI. The results of the atlas-based ROI analysis were consistent with the results of the SPM12 analysis. Conclusion NODDI may provide clinically relevant information as well as novel insights into the field of TLE. Particularly, in MRI-/PET+ TLE, neurite density imaging may have higher sensitivity than other dMRI parameters. The results may also contribute to better understanding of the pathophysiology of TLE with HS. Highlights We examined temporal lobe epilepsy (TLE) with or without hippocampal sclerosis (HS). Neurite orientation dispersion and density imaging (NODDI) was used. Ipsilateral reduction of neurite density was found in MRI-negative PET-positive TLE. More extensive abnormalities were presented in TLE with HS. NODDI may provide clinical relevance and novel insights into the field of TLE.

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참고문헌 (39)

Ahmadi ME, Hagler DJ, Jr., McDonald CR, Tecoma ES, Iragui VJ, Dale AM, et al. Side matters: diffusion tensor imaging tractography in left and right temporal lobe epilepsy. AJNR Am. J. Neuroradiol. 2009;30(9):1740–7. Epub 2009/06/11. doi: 10.3174/ajnr.A1650 . (PubMed PMID: 19509072; PubMed Central PMCID: PMCPmc2759860).

상세보기
Ashburner J. A fast diffeomorphic image registration algorithm NeuroImage 38 1 2007 95 113 (PubMed PMID: 17761438) 17761438

상세보기
Caciagli L. Bernasconi A. Wiebe S. Koepp M.J. Bernasconi N. Bernhardt B.C. A meta-analysis on progressive atrophy in intractable temporal lobe epilepsy: Time is brain? Neurology 89 5 2017 506–16. (PubMed PMID: 28687722; PubMed Central PMCID: PMCPMC5539734)

상세보기
Campos B.M. Coan A.C. Beltramini G.C. Liu M. Yassuda C.L. Ghizoni E. White matter abnormalities associate with type and localization of focal epileptogenic lesions Epilepsia 56 1 2015 125 132 (PubMed PMID: 25545559) 25545559

상세보기
Cendes F. Sakamoto A.C. Spreafico R. Bingaman W. Becker A.J. Epilepsies associated with hippocampal sclerosis Acta Neuropathol. 128 1 2014 21 37 (PubMed PMID: 24823761) 24823761

상세보기
Chassoux F. Rodrigo S. Semah F. Beuvon F. Landre E. Devaux B. FDG-PET improves surgical outcome in negative MRI Taylor-type focal cortical dysplasias Neurology 75 24 2010 2168 2175 (PubMed PMID: 21172840) 21172840

상세보기
Chiang S. Levin H.S. Wilde E. Haneef Z. White matter structural connectivity changes correlate with epilepsy duration in temporal lobe epilepsy Epilepsy Res. 120 2016 37 46 (PubMed PMID: 26709881; PubMed Central PMCID: PMCPMC4740226) 26709881

상세보기
Coan A.C. Kubota B. Bergo F.P. Campos B.M. Cendes F. 3T MRI quantification of hippocampal volume and signal in mesial temporal lobe epilepsy improves detection of hippocampal sclerosis AJNR Am. J. Neuroradiol. 35 1 2014 77 83 PubMed PMID: 23868151 23868151
Concha L. Beaulieu C. Collins D.L. Gross D.W. White-matter diffusion abnormalities in temporal-lobe epilepsy with and without mesial temporal sclerosis J. Neurol. Neurosurg. Psychiatry 80 3 2009 312 319 Epub 2008/11/04 10.1136/jnnp.2007.139287 (PubMed PMID: 18977826) 18977826

상세보기
Deleo F. Thom M. Concha L. Bernasconi A. Bernhardt B.C. Bernasconi N. Histological and MRI markers of white matter damage in focal epilepsy Epilepsy Res. 140 2018 29 38 Epub 2017/12/12 10.1016/j.eplepsyres.2017.11.010 (PubMed PMID: 29227798) 29227798

상세보기
Engel J. Jr. Introduction to temporal lobe epilepsy Epilepsy Res. 26 1 1996 141 150 (PubMed PMID: 8985696) 8985696

상세보기
Fujiyoshi K. Hikishima K. Nakahara J. Tsuji O. Hata J. Konomi T. Application of q-space diffusion MRI for the visualization of white matter J. Neurosci. 36 9 2016 2796 2808 (PubMed PMID: 26937016) 26937016

상세보기
Kamagata K. Hatano T. Okuzumi A. Motoi Y. Abe O. Shimoji K. Neurite orientation dispersion and density imaging in the substantia nigra in idiopathic Parkinson disease Eur. Radiol. 26 8 2016 2567 2577 (PubMed PMID: 26515546) 26515546

상세보기
Kashyap R. Dondi M. Paez D. Mariani G. Hybrid imaging worldwide-challenges and opportunities for the developing world: a report of a technical meeting organized by IAEA Semin. Nucl. Med. 43 3 2013 208 223 (PubMed PMID: 23561459) 23561459

상세보기
Keller S.S. Schoene-Bake J.C. Gerdes J.S. Weber B. Deppe M. Concomitant fractional anisotropy and volumetric abnormalities in temporal lobe epilepsy: cross-sectional evidence for progressive neurologic injury PLoS One 7 10 2012 e46791 (PubMed PMID: 23071638; PubMed Central PMCID: PMCPMC3469561)
Kuba R. Tyrlikova I. Chrastina J. Slana B. Pazourkova M. Hemza J. "MRI-negative PET-positive" temporal lobe epilepsy: invasive EEG findings, histopathology, and postoperative outcomes Epilepsy Behav. 22 3 2011 537 541 (PubMed PMID: 21962756) 21962756

상세보기
Kumar A. Chugani H.T. The role of radionuclide imaging in epilepsy, part 1: sporadic temporal and extratemporal lobe epilepsy J. Nucl. Med. 54 10 2013 1775 1781 (PubMed PMID: 23970368) 23970368

상세보기
Lemkaddem A. Daducci A. Kunz N. Lazeyras F. Seeck M. Thiran J.P. Connectivity and tissue microstructural alterations in right and left temporal lobe epilepsy revealed by diffusion spectrum imaging Neuroimage Clin. 5 2014 349–58. (PubMed PMID: 26236626; PubMed Central PMCID: PMCPMC4519999)
Leonardi M. Ustun T.B. The global burden of epilepsy Epilepsia 43 Suppl. 6 2002 21 25 (Epub 2002/08/23. PubMed PMID: 12190974)
Loi R.Q. Leyden K.M. Balachandra A. Uttarwar V. Hagler D.J. Jr. Paul B.M. Restriction spectrum imaging reveals decreased neurite density in patients with temporal lobe epilepsy Epilepsia 57 11 2016 1897–906. (PubMed PMID: 27735051; PubMed Central PMCID: PMCPMC5118147)

상세보기
Lopinto-Khoury C. Sperling M.R. Skidmore C. Nei M. Evans J. Sharan A. Surgical outcome in PET-positive, MRI-negative patients with temporal lobe epilepsy Epilepsia 53 2 2012 342 348 (PubMed PMID: 22192050) 22192050

상세보기
Loscher W. Schmidt D. Modern antiepileptic drug development has failed to deliver: ways out of the current dilemma Epilepsia 52 4 2011 657 678 (PubMed PMID: 21426333) 21426333

상세보기
Mueller S.G. Laxer K.D. Cashdollar N. Buckley S. Paul C. Weiner M.W. Voxel-based optimized morphometry (VBM) of gray and white matter in temporal lobe epilepsy (TLE) with and without mesial temporal sclerosis Epilepsia 47 5 2006 900–7. (PubMed PMID: 16686655; PubMed Central PMCID: PMCPMC2744650)

상세보기
Ota M. Noda T. Sato N. Hidese S. Teraishi T. Setoyama S. The use of diffusional kurtosis imaging and neurite orientation dispersion and density imaging of the brain in major depressive disorder J. Psychiatr. Res. 98 2018 22 29 (PubMed PMID: 29272758) 29272758

상세보기
Otte W.M. van Eijsden P. Sander J.W. Duncan J.S. Dijkhuizen R.M. Braun K.P. A meta-analysis of white matter changes in temporal lobe epilepsy as studied with diffusion tensor imaging Epilepsia 53 4 2012 659 667 (PubMed PMID: 22379949) 22379949

상세보기
Rathore C. Radhakrishnan K. Concept of epilepsy surgery and presurgical evaluation Epileptic. Disord. 17 1 2015 19 31 quiz 10.1684/epd.2014.0720 (PubMed PMID: 25652945) 25652945

상세보기
Reyes A. Uttarwar V.S. Chang Y.A. Balachandra A.R. Pung C.J. Hagler D.J. Jr. Decreased neurite density within frontostriatal networks is associated with executive dysfunction in temporal lobe epilepsy Epilepsy Behav. 78 2018 187 193 (PubMed PMID: 29126704; PubMed Central PMCID: PMCPMC5756677) 29126704

상세보기
Rostampour M. Hashemi H. Najibi S.M. Oghabian M.A. Detection of structural abnormalities of cortical and subcortical gray matter in patients with MRI-negative refractory epilepsy using neurite orientation dispersion and density imaging Phys. Med. 48 2018 47 54 (PubMed PMID: 29728228) 29728228

상세보기
Smith S.M. Jenkinson M. Johansen-Berg H. Rueckert D. Nichols T.E. Mackay C.E. Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data NeuroImage 31 4 2006 1487 1505 (PubMed PMID: 16624579) 16624579

상세보기
Sone D, Matsuda H, Ota M, Maikusa N, Kimura Y, Sumida K, et al. Graph Theoretical analysis of structural neuroimaging in temporal lobe epilepsy with and without psychosis. PLoS One. 2016a;11(7):e0158728. doi: 10.1371/journal.pone.0158728 . (PubMed PMID: 27385130; PubMed Central PMCID: PMCPMC4934878).

상세보기
Sone D. Ota M. Maikusa N. Kimura Y. Sumida K. Yokoyama K. White matter abnormalities in patients with temporal lobe epilepsy and amygdala enlargement: Comparison with hippocampal sclerosis and healthy subjects Epilepsy Res. 127 2016 221 228 (PubMed PMID: 27635630) 27635630

상세보기
Sone D. Watanabe M. Ota M. Imabayashi E. Rokicki J. Maikusa N. Subtle abnormality in neurite dispersion in idiopathic generalized epilepsy detected by an advanced diffusion imaging technique Epilepsy Seizure 10 1 2018 33 43

상세보기
Thom M. Review: hippocampal sclerosis in epilepsy: a neuropathology review Neuropathol. Appl. Neurobiol. 40 5 2014 520 543 (PubMed PMID: 24762203; PubMed Central PMCID: PMC4265206) 24762203

상세보기
Wakana S. Caprihan A. Panzenboeck M.M. Fallon J.H. Perry M. Gollub R.L. Reproducibility of quantitative tractography methods applied to cerebral white matter NeuroImage 36 3 2007 630–44. (PubMed PMID: 17481925; PubMed Central PMCID: PMCPMC2350213)

상세보기
Whelan C.D. Altmann A. Botia J.A. Jahanshad N. Hibar D.P. Absil J. Structural brain abnormalities in the common epilepsies assessed in a worldwide ENIGMA study Brain 141 2 2018 391 408 (PubMed PMID: 29365066; PubMed Central PMCID: PMCPMC5837616) 29365066
Wiebe S. Blume W.T. Girvin J.P. Eliasziw M. A randomized, controlled trial of surgery for temporal-lobe epilepsy N. Engl. J. Med. 345 5 2001 311 318 Epub 2001/08/04 10.1056/nejm200108023450501 (PubMed PMID: 11484687) 11484687

상세보기
Winston G.P. The potential role of novel diffusion imaging techniques in the understanding and treatment of epilepsy Quant Imaging Med Surg. 5 2 2015 279 287 (PubMed PMID: 25853085; PubMed Central PMCID: PMCPMC4379320) 25853085

상세보기
Winston G.P. Micallef C. Symms M.R. Alexander D.C. Duncan J.S. Zhang H. Advanced diffusion imaging sequences could aid assessing patients with focal cortical dysplasia and epilepsy Epilepsy Res. 108 2 2014 336–9. (PubMed PMID: 24315018; PubMed Central PMCID: PMCPMC3969285)

상세보기
Zhang H. Schneider T. Wheeler-Kingshott C.A. Alexander D.C. NODDI: practical in vivo neurite orientation dispersion and density imaging of the human brain NeuroImage 61 4 2012 1000 1016 (PubMed PMID: 22484410) 22484410

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Abnormal neurite density and orientation dispersion in unilateral temporal lobe epilepsy detected by advanced diffusion imaging 원문보기

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