[논문]Effect of Photon Hormesis on Dose Responses to Alpha Particles in Zebrafish Embryos

Ng, Candy Yuen Ping; Cheng, Shuk Han; Yu, Kwan Ngok

doi:10.3390/ijms18020385

Effect of Photon Hormesis on Dose Responses to Alpha Particles in Zebrafish Embryos 원문보기

International journal of molecular sciences, v.18 no.2, 2017년, pp.385 -

Ng, Candy Yuen Ping (Department of Physics and Materials Science, City University of Hong Kong, Hong Kong, China) , Cheng, Shuk Han (yuenpng3-c@my.cityu.edu.hk) , Yu, Kwan Ngok (Department of Biomedical Sciences, City University of Hong Kong, Hong Kong, China)

Abstract ▼ AI-Helper

Photon hormesis refers to the phenomenon where the biological effect of ionizing radiation with a high linear energy transfer (LET) value is diminished by photons with a low LET value. The present paper studied the effect of photon hormesis from X-rays on dose responses to alpha particles using embryos of the zebrafish (Danio rerio) as the in vivo vertebrate model. The toxicity of these ionizing radiations in the zebrafish embryos was assessed using the apoptotic counts at 20, 24, or 30 h post fertilization (hpf) revealed through acridine orange (AO) staining. For alpha-particle doses ≥ 4.4 mGy, the additional X-ray dose of 10 mGy significantly reduced the number of apoptotic cells at 24 hpf, which proved the presence of photon hormesis. Smaller alpha-particle doses might not have inflicted sufficient aggregate damages to trigger photon hormesis. The time gap T between the X-ray (10 mGy) and alpha-particle (4.4 mGy) exposures was also studied. Photon hormesis was present when T ≤ 30 min, but was absent when T = 60 min, at which time repair of damage induced by alpha particles would have completed to prevent their interactions with those induced by X-rays. Finally, the drop in the apoptotic counts at 24 hpf due to photon hormesis was explained by bringing the apoptotic events earlier to 20 hpf, which strongly supported the removal of aberrant cells through apoptosis as an underlying mechanism for photon hormesis.

주제어

참고문헌 (58)

1. Geetanjali P. Sarma A. Chatterjee A. The influence of reduced glutathione on chromosome damage induced by X-rays or heavy ion beams of different LETs and on the interaction of DNA lesions induced by radiations and bleomycin Mutat. Res. 2010 696 154 159 20100593
2. Barendsen G.N. Beusker T.L.J. Vergroesen A.J. Budke L. Effects of different ionizing radiations on human cells in tissue culture. II. Biological experiments Radiat. Res. 1960 13 841 849 10.2307/3570859 13686930

상세보기
3. Geard C.R. Chromosomal aberration production by “track segment” charged particles as a function of linear energy transfer Radiat. Prot. Dosim. 1985 13 1 4
4. Hendry J.H. Simon S.L. Wojcik A. Sohrabi M. Burkart W. Cardis E. Laurier D. Tirmarche M. Hayata I. Human exposure to high natural background radiation: What can it teach us about radiation risks? J. Radiol. Prot. 2009 29 A29 A42 10.1088/0952-4746/29/2A/S03 19454802

상세보기
5. Yu K.N. Guan Z.J. Stokes M.J. Young E.C.M. The assessment of the natural radiation dose committed to the Hong Kong people J. Environ. Radioact. 1992 17 31 48 10.1016/0265-931X(92)90033-P

상세보기
6. Yu K.N. Chan T.F. Young E.C.M. The variation of radon exhalation rates from building surfaces of different ages Health Phys. 1995 68 716 718 10.1097/00004032-199505000-00013 7730070

상세보기
7. Yu K.N. Young E.C.M. Li K.C. A study of factors affecting indoor radon properties Health Phys. 1996 71 179 184 10.1097/00004032-199608000-00008 8690600

상세보기
8. Yu K.N. Young E.C.M. Stokes M.J. Guan Z.J. Cho K.W. A survey of radon and thoron progeny for dwellings in Hong Kong Health Phys. 1997 73 373 377 10.1097/00004032-199708000-00010 9228173

상세보기
9. Yu K.N. Nikezic D. Ng F.M.F. Leung J.K.C. Long-term measurements of radon progeny concentrations with solid-state nuclear track detectors Radiat. Meas. 2005 40 560 568 10.1016/j.radmeas.2005.03.007

상세보기
10. Yu K.N. Lau B.M.F. Nikezic D. Assessment of environmental radon hazard using human respiratory tract models J. Hazard. Mater. 2006 132 98 110 10.1016/j.jhazmat.2005.11.087 16427190

상세보기
11. Durante M. Cucinotta F.A. Heavy ion carcinogenesis and human space exploration Nat. Rev. Cancer 2008 8 465 472 10.1038/nrc2391 18451812

상세보기
12. Simonsen L.C. Wilson J.W. Kim M.H. Cucinotta F.A. Radiation exposure for human mars exploration Health Phys. 2000 79 515 525 10.1097/00004032-200011000-00008 11045525

상세보기
13. Coderre J.A. Morris G.M. The radiation biology of boron neutron capture therapy Radiat. Res. 1999 151 1 18 10.2307/3579742 9973079

상세보기
14. Durand R.E. Olive P.L. Irradiation of multi-cell spheroids with fast neutrons versus X-rays: A qualitative difference in sub-lethal damage repair capacity or kinetics Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. 1976 30 589 592 10.1080/09553007614551481 1087298

상세보기
15. Ngo F.Q.H. Elkind M.M. Damage interaction in V79 Chinese hamster cells resulting from the combined exposure to X-rays and fast neutrons (Abstract Gg-5) Radiat. Res. 1977 70 706 707
16. McNally N.J. Deronde J. Hinchliffe M. The effect of sequential irradiation with X-rays and fast neutrons on the survival of V79 Chinese hamster cells Int. J. Radiat. Biol. 1984 45 301 310 10.1080/09553008414550441

상세보기
17. Ngo F.Q.H. Blakely E.A. Tobias C.A. Sequential exposures of mammalian cells to low- and high-LET radiation, I. Lethal effects following X-ray and neon-ion irradiation Radiat. Res. 1981 87 59 78 10.2307/3575541 7255673

상세보기
18. Murthy M.S.S. Madhvanath U. Subrahmanyam P. Rao B.S. Reddy N.M.S. Synergistic effect of simultaneous exposure to 60 Co gamma rays and 210 Po alpha rays in diploid yeast Radiat. Res. 1975 63 185 190 10.2307/3574318 1096226

상세보기
19. McNally N.J. Deronde J. Folkard M. Interaction between X-rays and alpha-particle damage in V-79 cells Int. J. Radiat. Biol. 1988 53 917 920 10.1080/09553008814551281

상세보기
20. Brooks A.L. Newton G.J. Shyr L.J. Seiler F.A. Scott B.R. The combined effects of alpha-particles and X-rays on cell killing and micronuclei induction in lung epithelial cells Int. J. Radiat. Biol. 1990 58 799 811 10.1080/09553009014552181 1977824
21. Rithidech K.N. Scott B.R. Evidence for radiation hormesis after in vitro exposure of human lymphocytes to low doses of ionizing radiation Dose Response 2008 6 252 271 10.2203/dose-response.07-024.Rithidech 18846261

상세보기
22. Calabrese E.J. Hormetic mechanisms Crit. Rev. Toxicol. 2013 43 580 606 10.3109/10408444.2013.808172 23875765

상세보기
23. Calabrese E.J. Hormesis: Why it is important to toxicology and toxicologists Environ. Toxicol. Chem. 2008 27 1452 1474 10.1897/07-541.1

상세보기
24. Calabrese E.J. Linda A.B. Toxicology rethinks its central belief Nature 2003 421 691 692 10.1038/421691a 12610596

상세보기
25. Calabrese E.J. Baldwin L.A. Defining hormesis Hum. Exp. Toxicol. 2002 21 91 97 10.1191/0960327102ht217oa 12102503

상세보기
26. Calabrese E.J. The emergence of the dose–response concept in biology and medicine Int. J. Mol. Sci. 2016 17 2034 10.3390/ijms17122034 27929392

상세보기
27. Ng C.Y.P. Kong E.Y. Konishi T. Kobayashi A. Suya N. Cheng S.H. Yu K.N. Low-dose neutron dose response of zebrafish embryos obtained from the Neutron exposure Accelerator System for Biological Effect Experiments (NASBEE) facility Radiat. Phys. Chem. 2015 114 12 17 10.1016/j.radphyschem.2015.05.020

상세보기
28. Scott B.R. Low-dose-radiation stimulated natural chemical and biological protection against lung cancer Dose Response 2008 6 299 318 10.2203/dose-response.07-025.Scott 18846259

상세보기
29. Scott B.R. Sanders C.L. Mitchel R.E.J. Boreham D.R. CT scans may reduce rather than increase the risk of cancer J. Am. Phys. Surg. 2008 13 8 11
30. Bauer G. Low dose radiation and intercellular induction of apoptosis: Potential implications for the control of oncogenesis Int. J. Radiat. Biol. 2007 83 873 888 10.1080/09553000701727523 18058371

상세보기
31. Portess D.I. Bauer G. Hill M.A. O’Neill P. Low-dose irradiation of nontransformed cells stimulates the selective removal of precancerous cells via intercellular induction of apoptosis Cancer Res. 2007 67 1246 1253 10.1158/0008-5472.CAN-06-2985 17283161

상세보기
32. Scott B.R. Di Palma J. Sparsely ionizing diagnostic and natural background radiation are likely preventing cancer and other genomic-instability associated diseases Dose Response 2006 5 230 255 10.2203/dose-response.06-002.Scott 18648608

상세보기
33. Ng C.Y.P. Kong E.Y. Kobayashi A. Suya N. Uchihori Y. Cheng S.H. Konishi T. Yu K.N. Neutron induced bystander effect among zebrafish embryos Radiat. Phys. Chem. 2015 117 153 159 10.1016/j.radphyschem.2015.08.009

상세보기
34. Bladen C.L. Lam W.K. Dynan W.S. Kozlowski D.J. DNA damage response and Ku80 function in the vertebrate embryo Nucleic Acids Res. 2005 33 3002 3010 10.1093/nar/gki613 15914672

상세보기
35. Choi V.W.Y. Konishi T. Oikawa M. Cheng S.H. Yu K.N. Threshold number of protons for inducing adaptive response in zebrafish embryos J. Radiol. Prot. 2013 33 91 100 10.1088/0952-4746/33/1/91 23295938

상세보기
36. Choi V.W.Y. Ng C.Y.P. Kobayashi A. Konishi T. Suya N. Ishikawa T. Cheng S.H. Yu K.N. Bystander effect between zebrafish embryos in vivo induced by high-dose X-rays Environ. Sci. Technol. 2013 47 6368 6376 10.1021/es401171h 23668636

상세보기
37. Choi V.W.Y. Ng C.Y.P. Kong M.K.Y. Cheng S.H. Yu K.N. Adaptive response to ionizing radiation induced by cadmium in zebrafish embryos J. Radiol. Prot. 2013 33 101 112 10.1088/0952-4746/33/1/101 23296313

상세보기
38. Choi V.W.Y. Ng C.Y.P. Kobayashi A. Konishi T. Oikawa M. Cheng S.H. Yu P.K.N. Exogenous carbon monoxide suppresses adaptive response induced in zebrafish embryos in vivo by microbeam protons J. Radiat. Res. 2014 55 i115 10.1093/jrr/rrt165

상세보기
39. Choi V.W.Y. Yu K.N. Embryos of the zebrafish Danio rerio in studies of non-targeted effects of ionizing radiation Cancer Lett. 2015 356 91 104 10.1016/j.canlet.2013.10.020 24176822

상세보기
40. Daroczi B. Kari G. McAleer M.F. Wolf J.C. Rodeck U. Dicker A.P. In vivo radioprotection by the fullerene nanoparticle DF-1 as assessed in a zebrafish model Clin. Cancer Res. 2006 12 7086 7091 10.1158/1078-0432.CCR-06-0514 17145832

상세보기
41. Geiger G.A. Parker S.E. Beothy A.P. Tucker J.A. Mullins M.C. Kao G.D. Zebrafish as a “Biosensor”? Effects of ionizing radiation and amifostine on embryonic viability and development Cancer Res. 2006 66 8172 8181 10.1158/0008-5472.CAN-06-0466 16912196

상세보기
42. Kong E.Y. Cheng S.H. Yu K.N. Biphasic and triphasic dose responses in zebrafish embryos to low-dose 150 kV X-rays with different hardness J. Radiat. Res. 2016 57 363 369 10.1093/jrr/rrw026 26951078

상세보기
43. Kong E.Y. Yeung W.K. Chan T.K.Y. Cheng S.H. Yu K.N. Exogenous nitric oxide suppresses in vivo X-ray-induced targeted and non-targeted effects in zebrafish embryos Int. J. Mol. Sci. 2016 17 1321 10.3390/ijms17081321 27529238

상세보기
44. McAleer M.F. Davidson C. Davidson W.R. Yentzer B.Y. Farber S.A. Rodeck U. Dicker A.P. Novel use of zebrafish as a vertebrate model to screen radiation protectors and sensitizers Int. J. Radiat. Oncol. Biol. Phys. 2005 61 10 13 10.1016/j.ijrobp.2004.09.046 15629588

상세보기
45. Ng C.Y.P. Pereira S. Cheng S.H. Adam-Guillermin C. Garnier-Laplace J. Yu K.N. Combined effects of depleted uranium and ionising radiation on zebrafish embryos Radiat. Prot. Dosim. 2015 167 311 315 10.1093/rpd/ncv269 25948823

상세보기
46. Ng C.Y.P. Cheng S.H. Yu K.N. Hormetic effect induced by depleted uranium in zebrafish embryos Aquat. Toxicol. 2016 175 184 191 10.1016/j.aquatox.2016.03.020 27060238

상세보기
47. Ng C.Y.P. Kong E.Y. Kobayashi A. Suya N. Uchihori Y. Cheng S.H. Konishi T. Yu K.N. Non-induction of radioadaptive response in zebrafish embryos by neutrons J. Radiat. Res. 2016 57 210 219 10.1093/jrr/rrv089 26850927

상세보기
48. Ng C.Y.P. Pereira S. Cheng S.H. Adam-Guillermin C. Garnier-Laplace J. Yu K.N. Combined effects of alpha particles and depleted uranium on zebrafish ( Danio rerio ) embryos J. Radiat. Res. 2016 57 343 355 10.1093/jrr/rrv104 26937024

상세보기
49. Yum E.H.W. Ng C.K.M. Lin A.C.C. Cheng S.H. Yu K.N. Effects of alpha particles on zebrafish embryos Appl. Radiat. Isot. 2010 68 714 717 10.1016/j.apradiso.2009.09.035 19837598

상세보기
50. Kong E.Y. Cheng S.H. Yu K.N. Zebrafish as an in vivo model to assess epigenetic effects of ionizing radiation Int. J. Mol. Sci. 2016 17 2108 10.3390/ijms17122108 27983682

상세보기
51. Barbazuk W.B. Korf I. Kadavi C. Heyen J. Tate S. Wun E. Bedell J.A. McPherson J.D. Johnson S.L. The syntenic relationship of the zebrafish and human genomes Genome Res. 2000 10 1351 1358 10.1101/gr.144700 10984453

상세보기
52. Karlsson J. von Hofsten J. Olsson P.E. Generating transparent zebrafish: A refined method to improve detection of gene expression during embryonic development Mar. Biotechnol. 2001 10 522 527 10.1007/s1012601-0053-4 14961324
53. Fox J.C. McNally N.J. Cell survival and DNA double-strand break repair following X-ray or neutron irradiation of V79 cells Int. J. Radiat. Biol. 1988 54 1021 1030 10.1080/09553008814552401 2903883

상세보기
54. Ngo F.Q.H. Han A. Elkind M.M. On the repair of sub-lethal damage in V79 Chinese hamster cells resulting from irradiation with fast neutrons or fast neutrons combined with X-rays Int. J. Radiat. Biol. 1977 32 507 511 10.1080/09553007714551291

상세보기
55. Ng C.Y.P. Cheng S.H. Yu K.N. Photon hormesis deactivates alpha-particle induced bystander effects between zebrafish embryos Radiat. Phys. Chem. 2017 133 72 80 10.1016/j.radphyschem.2016.12.025

상세보기
56. Yum E.H.W. Ng C.K.M. Lin A.C.C. Cheng S.H. Yu K.N. Experimental setup for studying the effects of alpha particles on zebrafish embryos Nucl. Instrum. Methods B 2007 264 171 176 10.1016/j.nimb.2007.07.024

상세보기
57. Kimmel C.B. Ballard W.W. Kimmel S.R. Ullmann B. Sshilling T.F. Stages of Embryonic Development of the Zebrafish Dev. Dyn. 1995 203 253 310 10.1002/aja.1002030302 8589427

상세보기
58. Milos N. Dingle A.D. Dynamics of pigment pattern formation in the zebrafish, BrachyDanio rerio . I. Establishment and regulation of the lateral line melanophore stripe during the first eight days of development J. Exp. Zool. A 1978 205 205 216 10.1002/jez.1402050205

상세보기

표제어: PCR

동의어: Packet Collision Rate

용어 설명 출처 목록 (6)

용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

Effect of Photon Hormesis on Dose Responses to Alpha Particles in Zebrafish Embryos 원문보기

Abstract ▼ AI-Helper

주제어

참고문헌 (58)

이 논문을 인용한 문헌

관련 콘텐츠

원문 보기

원문 URL 링크

오픈액세스(OA) 유형

이 논문과 함께 이용한 콘텐츠

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트