[논문]Effects of transcranial LED therapy on the cognitive rehabilitation for diffuse axonal injury due to severe acute traumatic brain injury: study protocol for a randomized controlled trial

Santos, Joã; o Gustavo Rocha Peixoto dos; Zaninotto, Ana Luiza Costa; Zâ; ngaro, Renato Amaro; Carneiro, Ana Maria Costa; Neville, Iuri Santana; de Andrade, Almir Ferreira; Teixeira, Manoel Jacobsen; Paiva, Wellingson Silva

doi:10.1186/s13063-018-2632-5

Effects of transcranial LED therapy on the cognitive rehabilitation for diffuse axonal injury due to severe acute traumatic brain injury: study protocol for a randomized controlled trial 원문보기

Trials, v.19 no.1, 2018년, pp.249 -

Santos, João Gustavo Rocha Peixoto dos (Department of Neurological Surgery, University of Sã) , Zaninotto, Ana Luiza Costa (o Paulo School of Medicine, 255 Dr. Ené) , Zângaro, Renato Amaro (as de Carvalho Aguiar Av., Sã) , Carneiro, Ana Maria Costa (o Paulo, SP 05403-010 Brazil) , Neville, Iuri Santana (Division of Neuropsychology, University of Sã) , de Andrade, Almir Ferreira (o Paulo General Hospital, Sã) , Teixeira, Manoel Jacobsen (o Paulo, Brazil) , Paiva, Wellingson Silva (Center for Innovation, Technology and Education (CITÉ)

Abstract ▼ AI-Helper

BackgroundPhotobiomodulation describes the use of red or near-infrared light to stimulate or regenerate tissue. It was discovered that near-infrared wavelengths (800–900 nm) and red (600 nm) light-emitting diodes (LED) are able to penetrate through the scalp and skull and have the potential to improve the subnormal cellular activity of compromised brain tissue. Different experimental and clinical studies were performed to test LED therapy for traumatic brain injury (TBI) with promising results. One of the proposals of this present study is to develop different approaches to maximize the positive effects of this therapy and improve the quality of life of TBI patients.Methods/designThis is a double-blinded, randomized, controlled trial of patients with diffuse axonal injury (DAI) due to a severe TBI in an acute stage (less than 8 h). Thirty two patients will be randomized to active coil helmet and inactive coil (sham) groups in a 1:1 ratio. The protocol includes 18 sessions of transcranial LED stimulation (627 nm, 70 mW/cm2, 10 J/cm2) at four points of the frontal and parietal regions for 30 s each, totaling 120 s, three times per week for 6 weeks, lasting 30 min. Patients will be evaluated with the Glasgow Outcome Scale Extended (GOSE) before stimulation and 1, 3, and 6 months after the first stimulation. The study hypotheses are as follows: (1) transcranial LED therapy (TCLT) will improve the cognitive function of DAI patients and (2) TCLT will promote beneficial hemodynamic changes in cerebral circulation.DiscussionThis study evaluates early and delayed effects of TCLT on the cognitive rehabilitation for DAI following severe acute TBI. There is a paucity of studies regarding the use of this therapy for cognitive improvement in TBI. There are some experimental studies and case series presenting interesting results for TBI cognitive improvement but no clinical trials.Trial registrationClinicalTrials.gov, NCT03281759. Registered on 13 September 2017.Electronic supplementary materialThe online version of this article (10.1186/s13063-018-2632-5) contains supplementary material, which is available to authorized users.

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참고문헌 (71)

1. Langlois JA Rutland-Brown W Thomas KE Incidence of traumatic brain injury in the United States, 2003 J Head Trauma Rehabil 2006 21 6 544 548 10.1097/00001199-200611000-00009 17122685

상세보기
2. Faul M, Xu L, Wald MM, Coronado VG. Traumatic brain injury in the United States: emergency department visits, hospitalizations, and deaths. 2013. https://www.cdc.gov/TraumaticBrainInjury/data/index.html . Accessed 5 May 2017.
3. Corrigan JD Selassie AW Orman JA The epidemiology of traumatic brain injury J Head Trauma Rehabil 2010 25 2 72 80 10.1097/HTR.0b013e3181ccc8b4 20234226

상세보기
4. Selassie AW Zaloshnja E Langlois JA Miller T Jones P Steiner C Incidence of long-term disability following traumatic brain injury hospitalization in the United States J Head Trauma Rehabil 2008 23 2 123 131 10.1097/01.HTR.0000314531.30401.39 18362766

상세보기
5. Parizel PM Ozsarlak O Van Goethem JW Imaging findings in diffuse axonal injury after closed head trauma Eur Radiol 1998 8 960 965 10.1007/s003300050496 9683701

상세보기
6. Meythaler JM Peduzzi JD Eleftheriou E Novack TA Current concepts: diffuse axonal injury-associated traumatic brain injury Arch Phys Med Rehabil 2001 82 10 1461 1471 10.1053/apmr.2001.25137 11588754

상세보기
7. Adams JH Mitchell DE Graham DI Doyle D Diffuse brain damage of immediate impact type: its relationship to “primary brain-stem damage” in head injury Brain 1977 100 489 502 10.1093/brain/100.3.489 589428

상세보기
8. McLellan, DR. The structural bases of coma and recovery: insights from brain injury in humans and experimental animals. In: Sandel ME, Ellis DW, editors. The coma-emerging patient. Philadelphia: Hanley & Belfus; 1990. p. 389–407.
9. Donnell AJ Kim MS Silva MA Vanderploeg RD Incidence of postconcussion symptoms in psychiatric diagnostic groups, mild traumatic brain injury, and comorbid conditions Clin Neuropsychol 2012 26 7 1092 1101 10.1080/13854046.2012.713984 22935025

상세보기
10. Naeser MA Hamblin MR Traumatic brain injury: a major medical problem that could be treated using transcranial, red/near-infrared LED photobiomodulation Photomed Laser Surg 2015 33 9 443 446 10.1089/pho.2015.3986 26280257

상세보기
11. Niogi SN Mukherjee P Ghajar J Johnson C Kolster RA Sarkar R Lee H Meeker M Zimmerman RD Manley GT McCandliss BD Extent of microstructural white matter injury in postconcussive syndrome correlates with impaired cognitive reaction time: a 3T diffusion tensor imaging study of mild traumatic brain injury AJNR Am J Neuroradiol 2008 29 967 973 10.3174/ajnr.A0970 18272556

상세보기
12. Bazarian JJ Mcclung J Shah MN Cheng YT Flesher W Kraus J Mild traumatic brain injury in the United States, 1998–2000 Brain Inj 2005 19 113 21 10.1080/02699050410001720158

상세보기
13. Cantu RC Slobounov S Sebastianelli W Concussion classification: ongoing controversy Foundations of sports-related brain injuries 2006 New York Springer 87 110
14. Wang H Duan G Zhang J Clinical features and CT diagnostic criteria for diffuse axonal brain injury Zhonghua Wai Ke Za Zhi 1996 34 4 229 231 9387688

상세보기
15. Lindel R Gentry LR Imaging of closed head injury Radiology 1994 191 1 17 10.1148/radiology.191.1.8134551 8134551

상세보기
16. Su E Bell M Laskowitz D Grant G Diffuse axonal injury Translational research in traumatic brain injury 2016 Boca Raton CRC Press/Taylor and Francis Group
17. Bazarian JJ Zhong J Blyth B Zhu T Kavcic V Peterson D Diffusion tensor imaging detects clinically important axonal damage after mild traumatic brain injury: a pilot study J Neurotrauma 2007 24 1447 1459 10.1089/neu.2007.0241 17892407

상세보기
18. Basser PJ Pierpaoli C Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI J Magn Reson B 1996 111 3 209 219 10.1006/jmrb.1996.0086 8661285

상세보기
19. Naeser MA Saltmarche A Krengel MH Hamblin MR Knight JA Improved cognitive function after transcranial, light-emitting diode treatments in chronic, traumatic brain injury: two case reports Photomed Laser Surg 2011 29 351 358 10.1089/pho.2010.2814 21182447

상세보기
20. Hamblin MR Shining light on the head: photobiomodulation for brain disorders BBA Clinical 2016 6 113 124 10.1016/j.bbacli.2016.09.002 27752476

상세보기
21. De Freitas LF Hamblin MR Proposed mechanisms of photobiomodulation or low-level light therapy IEEE J Sel Top Quantum Electron 2016 22 7000417 10.1109/JSTQE.2016.2561201 28070154

상세보기
22. Wan S Parrish JA Anderson RR Madden M Transmittance of nonionizing radiation in human tissues Photochem Photobiol 1981 34 679 681 10.1111/j.1751-1097.1981.tb09063.x 6458827

상세보기
23. Pitzschke A Lovisa B Seydoux O Zellweger M Pfleiderer M Tardy Y Wagnières G Red and NIR light dosimetry in the human deep brain Phys Med Biol 2015 60 2921 2937 10.1088/0031-9155/60/7/2921 25789711

상세보기
24. Whelan HT Smits RL Jr Buchman EV Whelan NT Turner SG Margolis DA Cevenini V Stinson H Ignatius R Martin T Cwiklinski J Philippi AF Graf WR Hodgson B Gould L Kane M Chen G Caviness J Effects of NASA light-emitting diode irradiation on wound healing J Clin Laser Med Surg 2001 19 305 314 10.1089/104454701753342758 11776448

상세보기
25. Oron U Yaakobi T Oron A Hayam G Gepstein L Rubin O Wolf T Ben HS Attenuation of infarct size in rats and dogs after myocardial infarction by low-energy laser irradiation Lasers Surg Med 2001 28 204 211 10.1002/lsm.1039 11295753

상세보기
26. Naeser M Ho M Martin PE Treglia EM Krengel M Hamblin MR Baker EH Improved language after scalp application of red/near-infrared light-emitting diodes: pilot study supporting a new, noninvasive treatment for chronic aphasia Procedia Soc Behav Sci 2012 61 138 139 10.1016/j.sbspro.2012.10.116

상세보기
27. Xuan W Vatansever F Huang L Hamblin MR Transcranial low-level laser therapy enhances learning, memory, and neuroprogenitor cells after traumatic brain injury in mice J Biomed Opt 2014 19 108003 10.1117/1.JBO.19.10.108003 25292167

상세보기
28. Desmet KD Paz DA Corry JJ Eells JT Wong-Riley MT Henry MM Buchmann EV Connelly MP Dovi JV Liang HL Henshel DS Yeager RL Millsap DS Lim J Gould LJ Das R Jett M Hodgson BD Margolis D Whelan HT Clinical and experimental applications of NIR-LED photobiomodulation Photomed Laser Surg 2006 24 2 121 128 10.1089/pho.2006.24.121 16706690

상세보기
29. Karu T Primary and secondary mechanisms of action of visible to near-IR radiation on cells J Photochem Photobiol B 1999 49 1 17 10.1016/S1011-1344(98)00219-X 10365442

상세보기
30. Wong-Riley MT Liang HL Eells JT Chance B Henry MM Buchmann E Kane M Whelan HT Photobiomodulation directly benefits primary neurons functionally inactivated by toxins: role of cytochrome c oxidase J Biol Chem 2005 280 4761 4771 10.1074/jbc.M409650200 15557336

상세보기
31. Homsi S Piaggio T Croci N Noble F Plotkine M Marchand-Leroux C Jafarian-Tehrani M Blockade of acute microglial activation by minocycline promotes neuroprotection and reduces locomotor hyperactivity after closed head injury in mice: a twelve-week follow-up study J Neurotrauma 2010 27 5 911 21 10.1089/neu.2009.1223 20166806

상세보기
32. Sompol P Xu Y Ittarat W Daosukho C St Clair D NF-kappa B-associated MnSOD induction protects against beta-amyloid-induced neuronal apoptosis J Mol Neurosci 2006 29 279 288 10.1385/JMN:29:3:279

상세보기
33. Schiffer F Johnston AL Ravichandran C Polcari A Teicher MH Webb RH Hamblin MR Psychological benefits 2 and 4 weeks after a single treatment with near infrared light to the forehead: a pilot study of 10 patients with major depression and anxiety Behav Brain Funct 2009 5 46 10.1186/1744-9081-5-46 19995444

상세보기
34. Ambrogini P Lattanzi D Ciuffoli S Betti M Fanelli M Cuppini R Physical exercise and environment exploration affect synaptogenesis in adult-generated neurons in the rat dentate gyrus: possible role of BDNF Brain Res 2013 1534 1 12 10.1016/j.brainres.2013.08.023 23973748

상세보기
35. Richardson RM Sun D Bullock MR Neurogenesis after traumatic brain injury Neurosurg Clin N Am 2007 18 1 169 181 10.1016/j.nec.2006.10.007 17244562

상세보기
36. Naeser MA Martins PI Ho MD Krengel MH1 Bogdanova Y Knight JA Yee MK1 Zafonte R Frazier J Hamblin MR Koo BB Transcranial, red/near-infrared light-emitting diode therapy to improve cognition in chronic traumatic brain injury Photomed Laser Surg 2016 34 12 610 626 10.1089/pho.2015.4037 28001756

상세보기
37. Xuan W Agrawal T Huang L Gupta GK Hamblin MR Low-level laser therapy for traumatic brain injury in mice increases brain derived neurotrophic factor (BDNF) and synaptogenesis J Biophotonics 2015 8 502 511 10.1002/jbio.201400069 25196192

상세보기
38. Wu Q Huang Y-Y Dhital S Low level laser therapy for traumatic brain injury SPIE Proc 2010 7552 755206 755208 10.1117/12.841014
39. Haeussinger FB, Heinzel S, Hahn T, Schecklmann M, Ehlis AC, Fallgatter AJ. Simulation of near-infrared light absorption considering individual head and prefrontal cortex anatomy: implications for optical neuroimaging. PLoS One. 2011;6
40. Strangman GE Zhang Q Li Z Scalp and skull influence on near infrared photon propagation in the Colin27 brain template NeuroImage 2014 85 136 149 10.1016/j.neuroimage.2013.04.090 23660029

상세보기
41. Okada E Delpy DT Near-infrared light propagation in an adult head model. II. Effect of superficial tissue thickness on the sensitivity of the near-infrared spectroscopy signal Appl Opt 2003 42 2915 2922 10.1364/AO.42.002915 12790440

상세보기
42. Jagdeo JR, Adams LE, Brody NI, Siegel DM. Transcranial red and near infrared light transmission in a cadaveric model. PLoS One. 2012;7
43. The Brain Trauma Foundation The American Association of Neurological Surgeons. The Joint Section on Neurotrauma and Critical Care. Age J Neurotrauma 2000 17 573 581 10.1089/neu.2000.17.573 10937903

상세보기
44. Gennarelli TA Cooper PR Cerebral concussion and diffuse brain injuries Head injury 1993 3 Baltimore Williams & Wilkins 137 158
45. Smith DH Meaney DF Shull WH Diffuse axonal injury in head trauma J Head Trauma Rehabil 2003 18 4 307 316 10.1097/00001199-200307000-00003 16222127

상세보기
46. Tomei G Sganzerla E Spagnoli D Guerra P Lucarini C Gaini SM Villani R Posttraumatic diffuse cerebral lesions. Relationship between clinical course, CT findings and ICP J Neurosurg Sci 1991 35 2 61 75 1757805
47. Gennarelli TA Wodzin E Abbreviated Injury Scale 2005—update 2008 2008 Des Plaines AAAM
48. Ohle R McIsaac SM Woo MY Perry JJ Sonography of the optic nerve sheath diameter for detection of raised intracranial pressure compared to computed tomography J Ultrasound Med 2015 34 1285 1294 10.7863/ultra.34.7.1285 26112632

상세보기
49. Hendricks HT Heeren AH Vos PE Dysautonomia after severe traumatic brain injury Eur J Neurol 2010 17 9 1172 1177 10.1111/j.1468-1331.2010.02989.x 20298427

상세보기
50. Bullock MR, Chesnut RM, Clifton GL, The Brain Trauma Foundation, The American Association of Neurological Surgeons, The Joint Section on Neurotrauma and Critical Care. Guidelines for the management of severe traumatic brain injury. Brain Trauma Foundation. J Neurotrauma. 2000:17:449-554.
51. Khuman J Zhang J Park J Carroll JD Donahue C Whalen MJ Low-level laser light therapy improves cognitive deficits and inhibits microglial activation after controlled cortical impact in mice J Neurotrauma 2012 29 2 408 417 10.1089/neu.2010.1745 21851183

상세보기
52. Salgado ASI Zangaro RA Parreira RB Kerppers II The effects of transcranial LED therapy (TCLT) on cerebral blood flow in the elderly women Lasers Med Sci 2015 30 339 10.1007/s10103-014-1669-2 25277249

상세보기
53. Marklund N The neurological wake-up test—a role in neurocritical care monitoring of traumatic brain injury patients? Front Neurol 2017 8 540 10.3389/fneur.2017.00540 29089921

상세보기
54. U.S. Food and Drug Administration. Class II special controls guidance document: low level laser system for aesthetic use - guidance for industry and FDA staff. 2011. https://www.fda.gov/RegulatoryInformation/Guidances/ucm251260.htm#5 . Accessed 10 Nov 2017.
55. Pettigrew LE Wilson JT Teasdele GM Assessing disability after head injury: improved use of the Glasgow Outcome Scale J Neurosurg 1998 89 6 939 943 10.3171/jns.1998.89.6.0939 9833819

상세보기
56. Jennett B Bond M Assessment of outcome after severe brain damage Lancet 1975 1 7905 480 484 10.1016/S0140-6736(75)92830-5 46957

상세보기
57. Jennett B Snoek J Bond MR Brooks N Disability after severe head injury: observations on the use of the Glasgow Outcome Scale J Neurol Neurosurg Psychiatry 1981 44 285 293 10.1136/jnnp.44.4.285 6453957

상세보기
58. Adams JH Doyle D Ford I Gennarelli TA Graham DI McLellan DR Diffuse axonal injury in head injury: definition, diagnosis and grading Histopathology 1989 15 1 49 59 10.1111/j.1365-2559.1989.tb03040.x 2767623

상세보기
59. Marshall LF Marshall SB Klauber MR Clark MB Eisenberg HM Jane JA Luerssen TG Marmarou A Foulkes MA A new classification of head injury based on computerized tomography J Neurosurg 1991 75 S14 S20
60. Maas AI Hukkelhoven CW Marshall LF Steyerberg EW Prediction of outcome in traumatic brain injury with computed tomographic characteristics: a comparison between the computed tomographic classification and combinations of computed tomographic predictors Neurosurgery 2005 57 6 1173 1182 10.1227/01.NEU.0000186013.63046.6B 16331165

상세보기
61. Bagiella E Novack TA Ansel B Measuring outcome in traumatic brain injury treatment trials: recommendations from the traumatic brain injury clinical trials network J Head Trauma Rehabil 2010 25 5 375 382 10.1097/HTR.0b013e3181d27fe3 20216459

상세보기
62. Edwards P Arango M Balica L Cottingham R El-Sayed H Farrell B Fernandes J Gogichaisvili T Golden N Hartzenberg B Husain M Ulloa MI Jerbi Z Khamis H Komolafe E Laloe V Lomas G Ludwig S Mazairac G Munoz Sanchez Mde L Nasi L Olldashi F Plunkett P Roberts I Sandercock P Shakur H Soler C Stocker R Svoboda P Trenkler S CRASH trial collaborators Final results of MRC CRASH, a randomised placebo-controlled trial of intravenous corticosteroid in adults with head injury-outcomes at 6 months Lancet 2005 365 1957 1959 10.1016/S0140-6736(05)74212-4 15936423

상세보기
63. de CA VR Paiva WS de Oliveira DV Teixeira MJ de Andrade AF de Sousa RMC Diffuse axonal injury: epidemiology, outcome and associated risk factors Front Neurol 2016 7 178 27812349
64. Harris PA Taylor R Thielke R Payne J Gonzalez N Conde JG Research electronic data capture (REDCap)—a metadata-driven methodology and workflow process for providing translational research informatics support J Biomed Inform 2009 42 2 377 381 10.1016/j.jbi.2008.08.010 18929686

상세보기
65. U.S. Department of Health and Human Services. Health Insurance Portability and Accountability Act of 1996 (HIPAA) privacy, security and breach notification rules, vol. 104: USA public law; 1996. p. 191.
66. Oron A Oron U Streeter J de Taboada L Alexandrovich A Trembovler V Shohami E Low-level laser therapy applied transcranially to mice following traumatic brain injury significantly reduces long-term neurological deficits J Neurotrauma 2007 24 4 651 656 10.1089/neu.2006.0198 17439348

상세보기
67. Michalikova S Ennaceur A van Rensburg R Chazot PL Emotional responses and memory performance of middle-aged CD1 mice in a 3D maze: effects of low infrared light Neurobiol Learn Mem 2008 89 4 480 488 10.1016/j.nlm.2007.07.014 17855128

상세보기
68. Bogdanova Y Martin P Ho MD Krengel MH Ho VT Yee MK Knight JA Hamblin M Naeser MA LED therapy improves sleep and cognition in chronic moderate TBI: pilot case studies Arch Phys Med Rehabil 2014 95 e77 10.1016/j.apmr.2014.07.247

상세보기
69. Naeser MA Martin PI Frazier J Hamblin MR Knight JA Meehan WP 3rd Baker EH Significant improvements in cognitive performance post-transcranial, red/near-infrared light-emitting diode treatments in chronic, mild traumatic brain injury: open-protocol study J Neurotrauma 2014 31 1008 1017 10.1089/neu.2013.3244 24568233

상세보기
70. Henderson TA Morries LD SPECT perfusion imaging demonstrates improvement of traumatic brain injury with transcranial near-infrared laser phototherapy Adv Mind Body Med 2015 29 27 33 26535475
71. King JT Jr Carlier PM Marion DW Early Glasgow Outcome Scale scores predict long-term functional outcome in patients with severe traumatic brain injury J Neurotrauma 2005 22 9 947 954 10.1089/neu.2005.22.947 16156710

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Effects of transcranial LED therapy on the cognitive rehabilitation for diffuse axonal injury due to severe acute traumatic brain injury: study protocol for a randomized controlled trial 원문보기

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