[논문]Evaluation of bleeding-related adverse events following acupuncture treatment in patients on anticoagulant or antiplatelet drugs: A prospective observational study

Lee, Minjun; Lee, Seunghoon; Kim, Eunseok; Cho, Ye-Eun; Kang, Jung Won; Lee, Jae-Dong

doi:10.1016/j.ctim.2018.08.006

Evaluation of bleeding-related adverse events following acupuncture treatment in patients on anticoagulant or antiplatelet drugs: A prospective observational study

Complementary therapies in medicine, v.41, 2018년, pp.23 - 28

Lee, Minjun (Department of Acupuncture & Moxibustion Medicine, Graduate School, Kyung Hee University, Seoul, South Korea) , Lee, Seunghoon (Department of Acupuncture & Moxibustion Medicine, Kyung Hee University, Seoul, South Korea) , Kim, Eunseok (Department of Acupuncture & Moxibustion Medicine, Daejeon University, Daejeon, South Korea) , Cho, Ye-Eun (Department of Acupuncture & Moxibustion Medicine, Graduate School, Kyung Hee University, Seoul, South Korea) , Kang, Jung Won (Department of Acupuncture & Moxibustion Medicine, Kyung Hee University, Seoul, South Korea) , Lee, Jae-Dong (Department of Acupuncture & Moxibustion Medicine, Kyung Hee University, Seoul, South Korea)

Abstract ▼ AI-Helper

Abstract Objective To evaluate the risk of bleeding-related adverse events after acupuncture treatment in patients receiving anticoagulant or antiplatelet drugs. Design and setting : A total of 428 inpatients who received acupuncture treatment underwent two assessments for bleeding-related adverse events, such as micro-bleeding, hematoma, and ecchymosis: 1) immediately after acupuncture treatment on the first day and 2) before acupuncture treatment on the following day. Additional analyses were performed using the number of acupuncture needles as independent variables. Multivariable analysis using factors likely related to bleeding and subgroup analysis according to regions of needle insertion were also performed. Results A total of 169 patients receiving anticoagulant or antiplatelet drugs (exposure group) and 259 patients not receiving either drug (non-exposure group) were studied. Sixty-five (38.5%) patients in the exposure group and 115 (44.4%) patients in the non-exposure group had bleeding-related mild adverse events. There was no difference in the risk of bleeding-related adverse events between the two groups per sessions (relative risk (RR) 0.87, 95% confidence interval (CI), 0.69–1.10) and per needles (RR 0.89, 95% CI 0.70–1.13). In multivariable analysis, thickness of needle only increased risk of bleeding. Subgroup analysis showed that taking these drugs did not increase the risk of bleeding in any of the regions. Conclusion Our findings suggest that anticoagulant and antiplatelet drugs do not increase the incidence of bleeding-related adverse events after acupuncture treatment. Highlights The relative risk of exposure of the unexposed group was 0.87 (95% CI 0.69–1.10), indicating that exposure to anticoagulants or antiplatelet agents did not increase the incidence of bleeding-related adverse events. In the additional analysis using the number of acupuncture needles, the relative risk of exposure of the unexposed group was 0.89 (95% CI 0.70–1.13), with no statistically significant difference. In multivariable analysis, thickness of needle only increased risk of bleeding, and subgroup analysis showed that taking the drugs did not increase the risk of bleeding in any of the body regions. All bleeding-related adverse events were asymptomatic and insignificant.

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참고문헌 (28)

PLoS One Wu 13 2018 Trends in use of acupuncture among adults in Taiwan from 2002 to 2011: a nationwide population-based study

상세보기
J Korean Med Park 31 78 2010 Systematic review of adverse events related to acupuncture and moxibustion in Korea
Br Med J MacPherson 323 486 2001 10.1136/bmj.323.7311.486 The York acupuncture safety study: prospective survey of 34000 treatments by traditional acupuncturists

상세보기
Br Med J White 323 485 2001 10.1136/bmj.323.7311.485 Adverse events following acupuncture: prospective survey of 32000 consultations with doctors and physiotherapists

상세보기
Arch Intern Med Melchart 164 104 2004 10.1001/archinte.164.1.104 Prospective investigation of adverse effects of acupuncture in 97733 patients

상세보기
Forschende Komplementarmedizin Witt 16 91 2009 Safety of acupuncture: results of a prospective observational study with 229,230 patients and introduction of a medical information and consent form

상세보기
Med Acupunct Furuse 29 155 2017 10.1089/acu.2017.1230 A multicenter prospective survey of adverse events associated with acupuncture and moxibustion in Japan

상세보기
Trauma Surg Acute Care Open Yeung 1 2016 10.1136/tsaco-2016-000022 Surgeon’s guide to anticoagulant and antiplatelet medications part two: antiplatelet agents and perioperative management of long-term anticoagulation

상세보기
BMJ Case Rep Kenz 2012 10.1136/bcr-2012-006676 Thigh haematoma following acupuncture treatment in a patient on warfarin

상세보기
Med Acupunct Nishimura 20 63 2008 10.1089/acu.2007.0604 Acute carpal tunnel syndrome induced by hemorrhage during acupuncture therapy

상세보기
Med Acupunct Han 22 207 2010 10.1089/acu.2009.0736 Acupuncture-induced intramuscular hematoma in patients taking anticoagulation drugs: an emerging clinical entity

상세보기
BMC Complement Altern Med Miller 12 107 2012 10.1186/1472-6882-12-S1-P107 Acupuncture treatment for hospitalized patients on anticoagulant therapy-a safety study

상세보기
Eur J Integr Med Kim 6 492 2014 10.1016/j.eujim.2014.04.004 Safety of acupuncture treatments for patients taking warfarin or antiplatelet medication: retrospective chart review study

상세보기
Br J Pharmacol Siller-Matula 159 502 2010 10.1111/j.1476-5381.2009.00555.x Pharmacokinetic, pharmacodynamic and clinical profile of novel antiplatelet drugs targeting vascular diseases

상세보기
PLoS ONE Choi 12 2017 A systematic review of the pharmacokinetic and pharmacodynamic interactions of herbal medicine with warfarin

상세보기
Common Terminology Criteria for Adverse Events (CTCAE) Version 4.0. National Cancer Institute. http://ctep.cancer.gov/protocolDevelopment/electronic_applications/ctc.htm/; (Accessed 27 March 2017).
WHO-UMC causality assessment. WHO Uppsala Monitoring Centre. http://who-umc.org/Graphics/24734.pdf/; (Accessed 27 March 2017).
J Cardiothorac Surg Chun 9 61 2014 10.1186/1749-8090-9-61 Life-threatening cardiac tamponade: a rare complication of acupuncture

상세보기
Evid Complement Altern Med Yamashita 5 391 2008 10.1093/ecam/nem086 Safety of acupuncture practice in Japan: Patient reactions, therapist negligence and error reduction strategies

상세보기
Acupunct Med Peuker 19 103 2001 10.1136/aim.19.2.103 Rare but serious complications of acupuncture:traumatic lesions

상세보기
Br Med J Ernst 320 513 2000 10.1136/bmj.320.7233.513 Acupuncture may be associated with serious adverse events
J Altern Complement Med Park 16 959 2010 10.1089/acm.2009.0415 Adverse events associated with acupuncture: a prospective survey

상세보기
Acupuncture Kim 28 65 2011 Prospective observational study of acupuncture adverse events: 50 patients hospitalized for peripheral facial palsy treatments
Evid Complement Altern Med Zhang 2012 2012 Neural acupuncture unit: A new concept for interpreting effects and mechanisms of acupuncture
Filshie 217 2016 Medical acupuncture: A western scientific approach
Muscle Nerve Lynch 38 1225 2008 10.1002/mus.21111 Complications of needle electromyography:Hematoma risk and correlation with anticoagulation and antiplatelet therapy

상세보기
Muscle Nerve Gertken 44 439 2011 10.1002/mus.22138 Risk of hematoma following needle electromyography of the paraspinal muscles

상세보기
Muscle Nerve Boon 45 9 2012 10.1002/mus.22227 Hematoma risk after needle electromyography

상세보기

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Evaluation of bleeding-related adverse events following acupuncture treatment in patients on anticoagulant or antiplatelet drugs: A prospective observational study

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Evaluation of bleeding-related adverse events following acupuncture treatment in patients on anticoagulant or antiplatelet drugs: A prospective observational study

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