[논문]Music Intervention Leads to Increased Insular Connectivity and Improved Clinical Symptoms in Schizophrenia

He, Hui; Yang, Mi; Duan, Mingjun; Chen, Xi; Lai, Yongxiu; Xia, Yang; Shao, Junming; Biswal, Bharat B.; Luo, Cheng; Yao, Dezhong

doi:10.3389/fnins.2017.00744

Music Intervention Leads to Increased Insular Connectivity and Improved Clinical Symptoms in Schizophrenia 원문보기

Frontiers in neuroscience, v.11, 2017년, pp.744 -

He, Hui (The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China , Chengdu , China) , Yang, Mi (The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China , Chengdu , China) , Duan, Mingjun (The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China , Chengdu , China) , Chen, Xi (The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China , Chengdu , China) , Lai, Yongxiu (The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China , Chengdu , China) , Xia, Yang (The Clinical Hospital of) , Shao, Junming , Biswal, Bharat B. , Luo, Cheng , Yao, Dezhong

Abstract ▼ AI-Helper

Schizophrenia is a syndrome that is typically accompanied by delusions and hallucinations that might be associated with insular pathology. Music intervention, as a complementary therapy, is commonly used to improve psychiatric symptoms in the maintenance stage of schizophrenia. In this study, we employed a longitudinal design to assess the effects of listening to Mozart music on the insular functional connectivity (FC) in patients with schizophrenia. Thirty-six schizophrenia patients were randomly divided into two equal groups as follows: the music intervention (MTSZ) group, which received a 1-month music intervention series combined with antipsychotic drugs, and the no-music intervention (UMTSZ) group, which was treated solely with antipsychotic drugs. Resting-state functional magnetic resonance imaging (fMRI) scans were performed at the following three timepoints: baseline, 1 month after baseline and 6 months after baseline. Nineteen healthy participants were recruited as controls. An FC analysis seeded in the insular subregions and machine learning techniques were used to examine intervention-related changes. After 1 month of listening to Mozart music, the MTSZ showed increased FC in the dorsal anterior insula (dAI) and posterior insular (PI) networks, including the dAI-ACC, PI-pre/postcentral cortices, and PI-ACC connectivity. However, these enhanced FCs had vanished in follow-up visits after 6 months. Additionally, a support vector regression on the FC of the dAI-ACC at baseline yielded a significant prediction of relative symptom remission in response to music intervention. Furthermore, the validation analyses revealed that 1 month of music intervention could facilitate improvement of the insular FC in schizophrenia. Together, these findings revealed that the insular cortex could potentially be an important region in music intervention for patients with schizophrenia, thus improving the patients' psychiatric symptoms through normalizing the salience and sensorimotor networks.

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참고문헌 (82)

Baumgartner T. Lutz K. Schmidt C. F. Jancke L. ( 2006 ). The emotional power of music: how music enhances the feeling of affective pictures . Brain Res. 1075 , 151 ？ 164 . 10.1016/j.brainres.2005.12.065 16458860

상세보기
Blood A. J. Zatorre R. J. ( 2001 ). Intensely pleasurable responses to music correlate with activity in brain regions implicated in reward and emotion . Proc. Natl. Acad. Sci. U.S.A. 98 , 11818 ？ 11823 . 10.1073/pnas.191355898 11573015

상세보기
Brattico E. Bogert B. Jacobsen T. ( 2013 ). Toward a neural chronometry for the aesthetic experience of music . Front. Psychol. 4 : 206 . 10.3389/fpsyg.2013.00206 23641223

상세보기
Bruscia K. E. ( 1998 ). Defining Music Therapy. Spring House Books .
Cao W. Cao X. Hou C. Li T. Cheng Y. Jiang L. . ( 2016 ). Effects of cognitive training on resting-state functional connectivity of default mode, salience, and central executive networks . Front. Aging Neurosci. 8 : 70 . 10.3389/fnagi.2016.00070 27148042

상세보기
Chan Y. M. Lee P. W. Ng T. Y. Ngan H. Y. Wong L. C. ( 2003 ). The use of music to reduce anxiety for patients undergoing colposcopy: a randomized trial . Gynecol. Oncol. 91 , 213 ？ 217 . 10.1016/S0090-8258(03)00412-8 14529684

상세보기
Chang C. C. Lin C. J. ( 2011 ). LIBSVM: a library for support vector machines . ACM Trans. Intell. Syst. Technol. 2 : 27 10.1145/1961189.1961199

상세보기
Chang L. J. Yarkoni T. Khaw M. W. Sanfey A. G. ( 2013 ). Decoding the role of the insula in human cognition: functional parcellation and large-scale reverse inference . Cereb. Cortex 23 , 739 ？ 749 . 10.1093/cercor/bhs065 22437053

상세보기
Chen X. Duan M. Xie Q. Lai Y. Dong L. Cao W. . ( 2015 ). Functional disconnection between the visual cortex and the sensorimotor cortex suggests a potential mechanism for self-disorder in schizophrenia . Schizophr. Res. 166 , 151 ？ 157 . 10.1016/j.schres.2015.06.014 26143483

상세보기
Coppola G. Toro A. Operto F. F. Ferrarioli G. Pisano S. Viggiano A. . ( 2015 ). Mozart's music in children with drug-refractory epileptic encephalopathies . Epilepsy Behav. 50 , 18 ？ 22 . 10.1016/j.yebeh.2015.05.038 26093514

상세보기
Couture S. M. Penn D. L. Roberts D. L. ( 2006 ). The functional significance of social cognition in schizophrenia: a review . Schizophr. Bull. 32 ( Suppl. 1 ), S44 ？ S63 . 10.1093/schbul/sbl029 16916889

상세보기
Craig A. D. ( 2002 ). How do you feel? Interoception: the sense of the physiological condition of the body . Nat. Rev. Neurosci. 3 , 655 ？ 666 . 10.1038/nrn894 12154366

상세보기
Craig A. D. ( 2004 ). Human feelings: why are some more aware than others? Trends Cogn. Sci. 8 , 239 ？ 241 . 10.1016/j.tics.2004.04.004 15165543

상세보기
Craig A. D. ( 2011 ). Significance of the insula for the evolution of human awareness of feelings from the body . Ann. N.Y. Acad. Sci. 1225 , 72 ？ 82 . 10.1111/j.1749-6632.2011.05990.x 21534994

상세보기
Critchley H. D. ( 2005 ). Neural mechanisms of autonomic, affective, and cognitive integration . J. Comp. Neurol. 493 , 154 ？ 166 . 10.1002/cne.20749 16254997

상세보기
Damasio A. ( 2001 ). Fundamental feelings . Nature 413 : 781 . 10.1038/35101669 11677584

상세보기
Deen B. Pitskel N. B. Pelphrey K. A. ( 2011 ). Three systems of insular functional connectivity identified with cluster analysis . Cereb. Cortex 21 , 1498 ？ 1506 . 10.1093/cercor/bhq186 21097516

상세보기
Dong D. Wang Y. Chang X. Luo C. Yao D. ( 2017 ). Dysfunction of large-scale brain networks in schizophrenia: a meta-analysis of resting-state functional connectivity . Schizophr. Bull . [Epub ahead of print]. 10.1093/schbul/sbx034 28338943

상세보기
Forman S. D. Cohen J. D. Fitzgerald M. Eddy W. F. Mintun M. A. Noll D. C. ( 1995 ). Improved assessment of significant activation in functional magnetic resonance imaging (fMRI): use of a cluster-size threshold . Magn. Reson. Med. 33 , 636 ？ 647 . 10.1002/mrm.1910330508 7596267

상세보기
Fornito A. Zalesky A. Pantelis C. Bullmore E. T. ( 2012 ). Schizophrenia, neuroimaging and connectomics . Neuroimage 62 , 2296 ？ 2314 . 10.1016/j.neuroimage.2011.12.090 22387165

상세보기
Foster N. A. Valentine E. R. ( 2001 ). The effect of auditory stimulation on autobiographical recall in dementia . Exp. Aging Res. 27 , 215 ？ 228 . 10.1080/036107301300208664 11441644

상세보기
Gardiner M. F. Fox A. Knowles F. Jeffrey D. ( 1996 ). Learning improved by arts training . Nature 381 : 284 . 10.1038/381284a0 8692266

상세보기
Glicksohn J. Cohen Y. ( 2000 ). Can music alleviate cognitive dysfunction in schizophrenia? Psychopathology 33 , 43 ？ 47 . 10.1159/000029118 10601827

상세보기
Gold C. Solli H. P. Kruger V. Lie S. A. ( 2009 ). Dose-response relationship in music therapy for people with serious mental disorders: systematic review and meta-analysis . Clin. Psychol. Rev. 29 , 193 ？ 207 . 10.1016/j.cpr.2009.01.001 19269725

상세보기
Guetin S. Portet F. Picot M. Pommie C. Messaoudi M. Djabelkir L. . ( 2009 ). Effect of music therapy on anxiety and depression in patients with Alzheimer's type dementia: randomised, controlled study . Dement. Geriatr. Cogn. Disord. 28 , 36 ？ 46 . 10.1159/000229024 19628939

상세보기
Habibi A. Damasio A. ( 2014 ). Music, feelings, and the human brain . Psychomusicol. Music Mind Brain 24 , 92 ？ 102 . 10.1037/pmu0000033

상세보기
Hayashi N. Tanabe Y. Nakagawa S. Noguchi M. Iwata C. Koubuchi Y. . ( 2002 ). Effects of group musical therapy on inpatients with chronic psychoses: a controlled study . Psychiatry Clin. Neurosci. 56 , 187 ？ 193 . 10.1046/j.1440-1819.2002.00953.x 11952923

상세보기
Javitt D. C. ( 2009 ). Sensory processing in schizophrenia: neither simple nor intact . Schizophr. Bull. 35 , 1059 ？ 1064 . 10.1093/schbul/sbp110 19833806

상세보기
Jiang Y. Duan M. Chen X. Chang X. He H. Li Y. . ( 2017 ). Common and distinct dysfunctional patterns contribute to triple network model in schizophrenia and depression: a preliminary study . Prog. Neuropsychopharmacol. Biol. Psychiatry 79 ( Pt B ), 302 ？ 310 . 10.1016/j.pnpbp.2017.07.007 28705767

상세보기
Kaufman A. S. ( 2001 ). WAIS-III IQs, Horn's theory, and generational changes from young adulthood to old age . Intelligence 29 , 131 ？ 167 . 10.1016/S0160-2896(00)00046-5

상세보기
Kaufmann T. Skatun K. C. Alnæs D. Doan N. T. Duff E. P. Tønnesen S. . ( 2015 ). Disintegration of sensorimotor brain networks in schizophrenia . Schizophr. Bull. 41 , 1326 ？ 1335 . 10.1093/schbul/sbv060 25943122

상세보기
Kleber B. Friberg A. Zeitouni A. Zatorre R. ( 2017 ). Experience-dependent modulation of right anterior insula and sensorimotor regions as a function of noise-masked auditory feedback in singers and nonsingers . Neuroimage 147 , 97 ？ 110 . 10.1016/j.neuroimage.2016.11.059 27916664

상세보기
Koelsch S. Fritz T. V Cramon DY. Muller K. Friederici A. D. ( 2006 ). Investigating emotion with music: an fMRI study . Hum. Brain Mapp. 27 , 239 ？ 250 . 10.1002/hbm.20180 16078183

상세보기
Kurth F. Zilles K. Fox P. T. Laird A. R. Eickhoff S. B. ( 2010 ). A link between the systems: functional differentiation and integration within the human insula revealed by meta-analysis . Brain Struct. Funct. 214 , 519 ？ 534 . 10.1007/s00429-010-0255-z 20512376

상세보기
Li G. He H. Huang M. Zhang X. Lu J. Lai Y. . ( 2015 ). Identifying enhanced cortico-basal ganglia loops associated with prolonged dance training . Sci. Rep. 5 : 10271 . 10.1038/srep10271 26035693

상세보기
Li J. Luo C. Peng Y. Xie Q. Gong J. Dong L. . ( 2014 ). Probabilistic diffusion tractography reveals improvement of structural network in musicians . PLoS ONE 9 : e105508 . 10.1371/journal.pone.0105508 25157896

상세보기
Liang X. Zou Q. He Y. Yang Y. ( 2013 ). Coupling of functional connectivity and regional cerebral blood flow reveals a physiological basis for network hubs of the human brain . Proc. Natl. Acad. Sci. U.S.A. 110 , 1929 ？ 1934 . 10.1073/pnas.1214900110 23319644

상세보기
Linnman C. Coombs G. III. Goff D. C. Holt D. J. ( 2013 ). Lack of insula reactivity to aversive stimuli in schizophrenia . Schizophr. Res. 143 , 150 ？ 157 . 10.1016/j.schres.2012.10.038 23201307

상세보기
Lovero K. L. Simmons A. N. Aron J. L. Paulus M. P. ( 2009 ). Anterior insular cortex anticipates impending stimulus significance . Neuroimage 45 , 976 ？ 983 . 10.1016/j.neuroimage.2008.12.070 19280711

상세보기
Lu S. F. Lo C. H. Sung H. C. Hsieh T. C. Yu S. C. Chang S. C. ( 2013 ). Effects of group music intervention on psychiatric symptoms and depression in patient with schizophrenia . Complement. Ther. Med. 21 , 682 ？ 688 . 10.1016/j.ctim.2013.09.002 24280478

상세보기
Luo C. Guo Z. W. Lai Y. X. Liao W. Liu Q. Kendrick K. M. . ( 2012 ). Musical training induces functional plasticity in perceptual and motor networks: insights from resting-state FMRI . PLoS ONE 7 : e36568 . 10.1371/journal.pone.0036568 22586478

상세보기
Luo C. Tu S. Peng Y. Gao S. Li J. Dong L. . ( 2014 ). Long-term effects of musical training and functional plasticity in salience system . Neural Plast. 2014 : 180138 . 10.1155/2014/180138 25478236

상세보기
Menon V. Uddin L. Q. ( 2010 ). Saliency, switching, attention and control: a network model of insula function . Brain Struct. Funct. 214 , 655 ？ 667 . 10.1007/s00429-010-0262-0 20512370

상세보기
Mitchell R. L. Elliott R. Barry M. Cruttenden A. Woodruff P. W. ( 2004 ). Neural response to emotional prosody in schizophrenia and in bipolar affective disorder . Br. J. Psychiatry 184 , 223 ？ 230 . 10.1192/bjp.184.3.223 14990520

상세보기
Moran L. V. Tagamets M. A. Sampath H. O'Donnell A. Stein E. A. Kochunov P. . ( 2013 ). Disruption of anterior insula modulation of large-scale brain networks in schizophrenia . Biol. Psychiatry 74 , 467 ？ 474 . 10.1016/j.biopsych.2013.02.029 23623456

상세보기
Morrison R. L. Bellack A. S. Mueser K. T. ( 1988 ). Deficits in facial-affect recognition and schizophrenia . Schizophr. Bull. 14 , 67 ？ 83 . 10.1093/schbul/14.1.67 3291095

상세보기
Mossler K. Chen X. Heldal T. O. Gold C. ( 2011 ). Music therapy for people with schizophrenia and schizophrenia-like disorders . Cochrane Database Syst. Rev. CD004025 10.1002/14651858.CD004025.pub3 22161383

상세보기
Namkung H. Kim S. H. Sawa A. ( 2017 ). The insula: an underestimated brain area in clinical neuroscience, psychiatry, and neurology . Trends Neurosci. 40 , 200 ？ 207 . 10.1016/j.tins.2017.02.002 28314446

상세보기
Nieuwenhuys R. ( 2012 ). The insular cortex: a review . Prog. Brain Res. 195 , 123 ？ 163 . 10.1016/B978-0-444-53860-4.00007-6 22230626

상세보기
Nomi J. S. Farrant K. Damaraju E. Rachakonda S. Calhoun V. D. Uddin L. Q. ( 2016 ). Dynamic functional network connectivity reveals unique and overlapping profiles of insula subdivisions . Hum. Brain Mapp. 37 , 1770 ？ 1787 . 10.1002/hbm.23135 26880689

상세보기
Palaniyappan L. Mallikarjun P. Joseph V. Liddle P. F. ( 2011 ). Appreciating symptoms and deficits in schizophrenia: right posterior insula and poor insight . Prog. Neuropsychopharmacol. Biol. Psychiatry 35 , 523 ？ 527 . 10.1016/j.pnpbp.2010.12.008 21182887

상세보기
Pavlicevic M. Trevarthen C. Duncan J. ( 1994 ). Improvisational music therapy and the rehabilitation of persons suffering from chronic schizophrenia . J. Music Ther. 53 , 2955 ？ 2959 . 10.1093/jmt/31.2.86
Power J. D. Barnes K. A. Snyder A. Z. Schlaggar B. L. Petersen S. E. ( 2012 ). Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion . Neuroimage 59 , 2142 ？ 2154 . 10.1016/j.neuroimage.2011.10.018 22019881

상세보기
Rauscher F. H. Shaw G. L. Ky K. N. ( 1993 ). Music and spatial task performance . Nature 365 : 611 . 10.1038/365611a0 8413624

상세보기
Rauscher F. H. Shaw G. L. Levine L. J. Wright E. L. Dennis W. R. Newcomb R. L. ( 1997 ). Music training causes long-term enhancement of preschool children's spatial-temporal reasoning . Neurol. Res. 19 , 2 ？ 8 . 10.1080/01616412.1997.11740765 9090630

상세보기
Rector N. A. Beck A. T. ( 2001 ). Cognitive behavioral therapy for schizophrenia: an empirical review . J. Nerv. Ment. Dis. 189 , 278 ？ 287 . 10.1097/00005053-200105000-00002 11379970

상세보기
Rojo N. Amengual J. Juncadella M. Rubio F. Camara E. Marco-Pallares J. . ( 2011 ). Music-supported therapy induces plasticity in the sensorimotor cortex in chronic stroke: a single-case study using multimodal imaging (fMRI-TMS) . Brain Inj. 25 , 787 ？ 793 . 10.3109/02699052.2011.576305 21561296

상세보기
Rolvsjord R. ( 2001 ). Sophie learns to play her songs of tears . Nordic J. Music Ther. 10 , 77 ？ 85 . 10.1080/08098130109478020

상세보기
Shepherd A. M. Matheson S. L. Laurens K. R. Carr V. J. Green M. J. ( 2012 ). Systematic meta-analysis of insula volume in schizophrenia . Biol. Psychiatry 72 , 775 ？ 784 . 10.1016/j.biopsych.2012.04.020 22621997

상세보기
Singer T. Critchley H. D. Preuschoff K. ( 2009 ). A common role of insula in feelings, empathy and uncertainty . Trends Cogn. Sci. 13 , 334 ？ 340 . 10.1016/j.tics.2009.05.001 19643659

상세보기
Sloboda J. A. O'Neill S. A. Ivaldi A. ( 2001 ). Functions of music in everyday life: an exploratory study using the experience sampling method . Music. Sci. 5 , 9 ？ 32 . 10.1177/102986490100500102

상세보기
Solli H. P. ( 2008 ). “Shut up and play!” Improvisational use of popular music for a man with schizophrenia . Nordic J. Music Ther. 17 , 67 ？ 77 . 10.1080/08098130809478197

상세보기
Stephani C. Fernandez-Baca Vaca G. Maciunas R. Koubeissi M. Luders H. O. ( 2011 ). Functional neuroanatomy of the insular lobe . Brain Struct. Funct. 216 , 137 ？ 149 . 10.1007/s00429-010-0296-3 21153903

상세보기
Strauss E. Sherman E. M. Spreen O. ( 2006 ). A Compendium of Neuropsychological Tests: Administration, Norms, and Commentary . Oxford : Oxford University Press .
Talwar N. Crawford M. J. Maratos A. Nur U. McDermott O. Procter S. ( 2006 ). Music therapy for in-patients with schizophrenia: exploratory randomised controlled trial . Br. J. Psychiatry 189 , 405 ？ 409 . 10.1192/bjp.bp.105.015073 17077429

상세보기
Tamkin A. S. Kunce J. T. ( 1985 ). A comparison of three neuropsychological tests: the Weigl, Hooper, and Benton . J. Clin. Psychol. 41 , 660 ？ 664 . 4044848

상세보기
Tang W. Yao X. Zheng Z. ( 1994 ). Rehabilitative effect of music therapy for residual schizophrenia. A one-month randomised controlled trial in Shanghai . Br. J. Psychiatry Suppl . 164 , 38 ？ 44 .
Trost W. Ethofer T. Zentner M. Vuilleumier P. ( 2012 ). Mapping aesthetic musical emotions in the brain . Cereb. Cortex 22 , 2769 ？ 2783 . 10.1093/cercor/bhr353 22178712

상세보기
Uddin L. Q. Kinnison J. Pessoa L. Anderson M. L. ( 2014 ). Beyond the tripartite cognition-emotion-interoception model of the human insular cortex . J. Cogn. Neurosci. 26 , 16 ？ 27 . 10.1162/jocn_a_00462 23937691

상세보기
Ulrich G. Houtmans T. Gold C. ( 2007 ). The additional therapeutic effect of group music therapy for schizophrenic patients: a randomized study . Acta Psychiatr. Scand. 116 , 362 ？ 370 . 10.1111/j.1600-0447.2007.01073.x 17919155

상세보기
Walther S. Strik W. ( 2012 ). Motor symptoms and schizophrenia . Neuropsychobiology 66 , 77 ？ 92 . 10.1159/000339456 22814247

상세보기
Waters F. A. Badcock J. C. ( 2010 ). First-rank symptoms in schizophrenia: reexamining mechanisms of self-recognition . Schizophr. Bull. 36 , 510 ？ 517 . 10.1093/schbul/sbn112 18753307

상세보기
Wechsler D. ( 1981 ). WAIS-R Manual: Wechsler Adult Intelligence Scale-Revised . New York, NY : Psychological Corporation .
White T. P. Joseph V. Francis S. T. Liddle P. F. ( 2010 ). Aberrant salience network (bilateral insula and anterior cingulate cortex) connectivity during information processing in schizophrenia . Schizophr. Res. 123 , 105 ？ 115 . 10.1016/j.schres.2010.07.020 20724114

상세보기
Williams L. M. Das P. Liddell B. J. Olivieri G. Peduto A. S. David A. S. . ( 2007 ). Fronto-limbic and autonomic disjunctions to negative emotion distinguish schizophrenia subtypes . Psychiatry Res. 155 , 29 ？ 44 . 10.1016/j.pscychresns.2006.12.018 17398080

상세보기
Wojtalik J. A. Smith M. J. Keshavan M. S. Eack S. M. ( 2017 ). A systematic and meta-analytic review of neural correlates of functional outcome in schizophrenia . Schizophr. Bull . 43 , 1329 ？ 1347 . 10.1093/schbul/sbx008 28204755

상세보기
Wylie K. P. Tregellas J. R. ( 2010 ). The role of the insula in schizophrenia . Schizophr. Res. 123 , 93 ？ 104 . 10.1016/j.schres.2010.08.027 20832997

상세보기
Xing Y. Xia Y. Kendrick K. Liu X. Wang M. Wu D. . ( 2016 ). Mozart, Mozart rhythm and retrograde Mozart effects: evidences from behaviours and neurobiology bases . Sci. Rep. 6 : 18744 . 10.1038/srep18744 26795072

상세보기
Yang G. J. Murray J. D. Repovs G. Cole M. W. Savic A. Glasser M. F. . ( 2014 ). Altered global brain signal in schizophrenia . Proc. Natl. Acad. Sci. U.S.A. 111 , 7438 ？ 7443 . 10.1073/pnas.1405289111 24799682

상세보기
Yeo B. T. Krienen F. M. Eickhoff S. B. Yaakub S. N. Fox P. T. Buckner R. L. . ( 2014 ). Functional specialization and flexibility in human association cortex . Cereb. Cortex 25 , 3654 ？ 3672 . 10.1093/cercor/bhu217 25249407

상세보기
Zamorano A. M. Cifre I. Montoya P. Riquelme I. Kleber B. ( 2017 ). Insula-based networks in professional musicians: evidence for increased functional connectivity during resting state fMRI . Hum. Brain Mapp. 38 , 4834 ？ 4849 . 10.1002/hbm.23682 28737256

상세보기
Zatorre R. J. Salimpoor V. N. ( 2013 ). From perception to pleasure: music and its neural substrates . Proc. Natl. Acad. Sci. U.S.A. 110 ( Suppl. 2 ), 10430 ？ 10437 . 10.1073/pnas.1301228110 23754373

상세보기

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Music Intervention Leads to Increased Insular Connectivity and Improved Clinical Symptoms in Schizophrenia 원문보기

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