[논문]Swallowing markers in spinal and bulbar muscular atrophy

Banno, Haruhiko; Katsuno, Masahisa; Suzuki, Keisuke; Tanaka, Seiya; Suga, Noriaki; Hashizume, Atsushi; Mano, Tomoo; Araki, Amane; Watanabe, Hirohisa; Fujimoto, Yasushi; Yamamoto, Masahiko; Sobue, Gen

doi:10.1002/acn3.425

Swallowing markers in spinal and bulbar muscular atrophy 원문보기

Annals of clinical and translational neurology, v.4 no.8, 2017년, pp.534 - 543

Banno, Haruhiko (Department of Neurology Nagoya University Graduate School of Medicine 65 Tsurumai‐) , Katsuno, Masahisa (cho, Showa‐) , Suzuki, Keisuke (ku Nagoya 466‐) , Tanaka, Seiya (8550 Japan) , Suga, Noriaki (Department of Neurology Nagoya University Graduate School of Medicine 65 Tsurumai‐) , Hashizume, Atsushi (cho, Showa‐) , Mano, Tomoo (ku Nagoya 466‐) , Araki, Amane (8550 Japan) , Watanabe, Hirohisa (Department of Neurology Nagoya University Graduate School of Medicine 65 Tsurumai‐) , Fujimoto, Yasushi (cho, Showa‐) , Yamamoto, Masahiko (ku Nagoya 466‐) , Sobue, Gen (8550 Japan)

Abstract ▼ AI-Helper

AbstractObjectiveWe examined the characteristics of dysphagia in spinal and bulbar muscular atrophy, a hereditary neuromuscular disease causing weakness of limb, facial, and oropharyngeal muscles via a videofluoroscopic swallowing study, and investigated the plausibility of using these outcome measures for quantitative analysis.MethodsA videofluoroscopic swallowing study was performed on 111 consecutive patients with genetically confirmed spinal and bulbar muscular atrophy and 53 age‐ and sex‐matched healthy controls. Swallowing of 3‐mL liquid barium was analyzed by the Logemann's Videofluorographic Examination of Swallowing worksheet.ResultsOf more than 40 radiographic findings, the most pertinent abnormal findings in patients with spinal and bulbar muscular atrophy, included vallecular residue after swallow (residue just behind the tongue base), nasal penetration, and insufficient tongue movement (P < 0.001 for each) compared with healthy controls. Quantitative analyses showed that pharyngeal residue after initial swallowing, oral residue after initial swallowing, multiple swallowing sessions, and the penetration–aspiration scale were significantly worse in these patients (P ≤ 0.005 for each) than in controls. In patients with spinal and bulbar muscular atrophy, laryngeal penetration was observed more frequently in those without subjective dysphagia.InterpretationDysphagia of spinal and bulbar muscular atrophy was characterized by impaired tongue movement in the oral phase and nasal penetration followed by pharyngeal residues, which resulted in multiple swallowing sessions and laryngeal penetration. Although major limitations of reproducibility and radiation exposure still exist with videofluoroscopy, pharyngeal residue after initial swallowing and the penetration–aspiration scale might serve as potential outcome measures in clinical studies.

참고문헌 (39)

1 Kennedy WR , Alter M , Sung JH . Progressive proximal spinal and bulbar muscular atrophy of late onset A sex‐linked recessive trait . Neurology 1968 ; 18 : 671 – 680 . 4233749

상세보기
2 Sperfeld AD , Karitzky J , Brummer D , et al. X‐linked bulbospinal neuronopathy: kennedy disease . Arch Neurol 2002 ; 59 : 1921 – 1926 . 12470181

상세보기
3 Sobue G , Adachi H , Katsuno M . Spinal and Bulbar Muscular Atrophy (SBMA) In: Dickinson D , Weller RO , eds. Neurodegeneration: the molecular pathology of dementia and movement disorders , 2nd ed New York : Wiley‐Blackwell , 2011 : 307 – 314 .
4 Atsuta N , Watanabe H , Ito M , et al. Natural history of spinal and bulbar muscular atrophy (SBMA): a study of 223 Japanese patients . Brain 2006 ; 129 : 1446 – 1455 . 16621916

상세보기
5 La Spada AR , Wilson EM , Lubahn DB , et al. Androgen receptor gene mutations in X‐linked spinal and bulbar muscular atrophy . Nature 1991 ; 352 : 77 – 79 . 2062380

상세보기
6 Sobue G , Hashizume Y , Mukai E , et al. X‐linked recessive bulbospinal neuronopathy. A clinicopathological study . Brain 1989 ; 112 : 209 – 232 . 2917278

상세보기
7 Adachi H , Katsuno M , Minamiyama M , et al. Widespread nuclear and cytoplasmic accumulation of mutant androgen receptor in SBMA patients . Brain 2005 ; 128 : 659 – 670 . 15659427

상세보기
8 Banno H , Katsuno M , Suzuki K , et al. Pathogenesis and molecular targeted therapy of spinal and bulbar muscular atrophy (SBMA) . Cell Tissue Res 2012 ; 349 : 313 – 320 . 22476656

상세보기
9 Katsuno M , Adachi H , Doyu M , et al. Leuprorelin rescues polyglutamine‐dependent phenotypes in a transgenic mouse model of spinal and bulbar muscular atrophy . Nat Med 2003 ; 9 : 768 – 773 . 12754502

상세보기
10 Banno H , Katsuno M , Suzuki K , et al. Phase 2 trial of leuprorelin in patients with spinal and bulbar muscular atrophy . Ann Neurol 2009 ; 65 : 140 – 150 . 19259967

상세보기
11 Katsuno M , Banno H , Suzuki K , et al. Efficacy and safety of leuprorelin in patients with spinal and bulbar muscular atrophy (JASMITT study): a multicentre, randomised, double‐blind, placebo‐controlled trial . Lancet Neurol 2010 ; 9 : 875 – 884 . 20691641

상세보기
12 Logemann JA , Kahrilas PJ , Kobara M , Vakil NB . The benefit of head rotation on pharyngoesophageal dysphagia . Arch Phys Med Rehabil 1989 ; 70 : 767 – 771 . 2802957

상세보기
13 Logemann JA , Pauloski BR , Rademaker AW , et al. Temporal and biomechanical characteristics of oropharyngeal swallow in younger and older men . J Speech Lang Hear Res 2000 ; 43 : 1264 – 1274 . 11063246

상세보기
14 Logemann JA . Evaluation and treatment of swallowing disorders , 2nd ed Austin : PRO‐ED Inc , 1998 .
15 Rosenbek JC , Robbins J , Roecker EV , et al. A penetration‐aspiration scale . Dysphagia 1996 ; 11 : 93 – 98 . 8721066

상세보기
16 Cedarbaum JM . The ALSFRS‐R: a revised ALS functional rating scale that incorporates assessments of respiratory function. BDNF ALS Study Group (Phase III) . J Neurol Sci 1999 ; 169 : 13 – 21 . 10540002
17 Ohashi Y , Tashiro K , Itoyama Y , et al. Study of functional rating scale for amyotrophic lateral sclerosis: revised ALSFRS (ALSFRS‐R) Japanese version . No To Shinkei 2001 ; 53 : 346 – 355 . 11360474
18 Hashizume A , Katsuno M , Suzuki K , et al. A functional scale for spinal and bulbar muscular atrophy: cross‐sectional and longitudinal study . Neuromuscul Disord 2015 ; 25 : 554 – 562 . 25913211
19 McHorney CA , Robbins J , Lomax K , et al. The SWAL‐QOL and SWAL‐CARE outcomes tool for oropharyngeal dysphagia in adults: III. Documentation of reliability and validity . Dysphagia 2002 ; 17 : 97 – 114 . 11956835

상세보기
20 Wada M , Hoshino Y , Okudaira N . Assessment of quality of life for people with dysphagia: use of the SF‐36 and trial use of the SWAL‐QOL and SWAL‐CARE outcomes tool in Japan . Jpn J Dysphagia Rehabil 2003 ; 7 : 109 – 116 .
21 Manor Y , Giladi N , Cohen A , et al. Validation of a swallowing disturbance questionnaire for detecting dysphagia in patients with Parkinson's disease . Mov Disord 2007 ; 22 : 1917 – 1921 . 17588237
22 Yamamoto T , Ikeda K , Usui H , et al. Validation of the Japanese translation of the Swallowing Disturbance Questionnaire in Parkinson's disease patients . Qual Life Res 2012 ; 21 : 1299 – 1303 . 22001937

상세보기
23 Hashizume A , Katsuno M , Banno H , et al. Longitudinal changes of outcome measures in spinal and bulbar muscular atrophy . Brain 2012 ; 135 : 2838 – 2848 . 22773541
24 Fernández‐Rhodes LE , Kokkinis AD , White MJ , et al. Efficacy and safety of dutasteride in patients with spinal and bulbar muscular atrophy: a randomised placebo‐controlled trial . Lancet Neurol 2011 ; 10 : 140 – 147 . 21216197

상세보기
25 Robbins J , Hamilton JW , Lof GL , Kempster GB . Oropharyngeal swallowing in normal adults of different ages . Gastroenterology 1992 ; 103 : 823 – 829 . 1499933
26 Daggett A , Logemann J , Rademaker A , Pauloski B . Laryngeal penetration during deglutition in normal subjects of various ages . Dysphagia 2006 ; 21 : 270 – 274 . 17216388

상세보기
27 Pikus L , Levine MS , Yang YX , et al. Videofluoroscopic studies of swallowing dysfunction and the relative risk of pneumonia . AJR Am J Roentgenol 2003 ; 180 : 1613 – 1616 . 12760930
28 Warnecke T , Oelenberg S , Teismann I , et al. Dysphagia in X‐linked bulbospinal muscular atrophy (Kennedy disease) . Neuromuscul Disord 2009 ; 19 : 704 – 708 . 19616433
29 Mano T , Katsuno M , Banno H , et al. Tongue pressure as a novel biomarker of spinal and bulbar muscular atrophy . Neurology 2014 ; 82 : 255 – 262 . 24353334

상세보기
30 Ludlow CL , Humbert I , Saxon K , et al. Effects of surface electrical stimulation both at rest and during swallowing in chronic pharyngeal Dysphagia . Dysphagia 2007 ; 22 : 1 – 10 . 16718620

상세보기
31 Eisenhuber E , Schima W , Schober E , et al. Videofluoroscopic assessment of patients with dysphagia: pharyngeal retention is a predictive factor for aspiration . AJR Am J Roentgenol 2002 ; 178 : 393 – 398 . 11804901
32 Logemann JA , Williams RB , Rademaker A , et al. The relationship between observations and measures of oral and pharyngeal residue from videofluorography and scintigraphy . Dysphagia 2005 ; 20 : 226 – 231 . 16362511

상세보기
33 Pauloski BR , Rademaker AW , Lazarus C , et al. Relationship between manometric and videofluoroscopic measures of swallow function in healthy adults and patients treated for head and neck cancer with various modalities . Dysphagia 2009 ; 24 : 196 – 203 . 18956228

상세보기
34 Pearson WG Jr , Molfenter SM , Smith ZM , Steele CM . Image‐based measurement of post‐swallow residue: the normalized residue ratio scale . Dysphagia 2013 ; 28 : 167 – 177 . 23089830

상세보기
35 Kuhlemeier KV , Yates P , Palmer JB . Intra‐ and inter‐rater variation in the evaluation of videofluorographic swallowing studies . Dysphagia 1998 ; 13 : 142 – 147 . 9633153

상세보기
36 Wheeler‐Hegland K , Ashford J , Frymark T , et al. Evidence‐based systematic review: oropharyngeal dysphagia behavioral treatments. Part II–—impact of dysphagia treatment on normal swallow function . J Rehabil Res Dev 2009 ; 46 : 185 – 194 . 19533532
37 Leigh JH , Oh BM , Seo HG , et al. Influence of the chin‐down and chin‐tuck maneuver on the swallowing kinematics of healthy adults . Dysphagia 2015 ; 30 : 89 – 98 . 25358491

상세보기
38 Mano T , Katsuno M , Banno H , et al. Headlift exercise improves swallowing dysfunction in spinal and bulbar muscular atrophy . Eur Neurol 2015 ; 74 : 251 – 258 . 26624487

상세보기
39 Olthoff A , Carstens PO , Zhang S , et al. Evaluation of dysphagia by novel real‐time MRI . Neurology 2016 ; 87 : 2132 – 2138 . 27770070

상세보기

표제어: PCR

동의어: Packet Collision Rate

용어 설명 출처 목록 (6)

용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

Swallowing markers in spinal and bulbar muscular atrophy 원문보기

Abstract ▼ AI-Helper

참고문헌 (39)

이 논문을 인용한 문헌

관련 콘텐츠

원문 보기

원문 URL 링크

오픈액세스(OA) 유형

이 논문과 함께 이용한 콘텐츠

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트