[논문]Psychosocial interventions for Alzheimer’s disease cognitive symptoms: a Bayesian network meta-analysis

Duan, Yuting; Lu, Liming; Chen, Juexuan; Wu, Chunxiao; Liang, Jielin; Zheng, Yan; Wu, Jinjian; Rong, Peijing; Tang, Chunzhi

doi:10.1186/s12877-018-0864-6

Psychosocial interventions for Alzheimer’s disease cognitive symptoms: a Bayesian network meta-analysis 원문보기

BMC geriatrics, v.18, 2018년, pp.175 -

Duan, Yuting (Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, No.232 Waihuandong Road, Panyu District, Guangzhou, 510000 China) , Lu, Liming (Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, No.232 Waihuandong Road, Panyu District, Guangzhou, 510000 China) , Chen, Juexuan (Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, No.232 Waihuandong Road, Panyu District, Guangzhou, 510000 China) , Wu, Chunxiao (Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, No.232 Waihuandong Road, Panyu District, Guangzhou, 510000 China) , Liang, Jielin (Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, No.232 Waihuandong Road, Panyu District, Guangzhou, 510000 China) , Zheng, Yan (Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, No.232 Waihuandong Road, Panyu District, Guangzhou, 510000 China) , Wu, Jinjian (Medical College of Acu-Moxi and Rehabilitation, Guangzhou) , Rong, Peijing , Tang, Chunzhi

Abstract ▼ AI-Helper

BackgroundAlzheimer disease (AD) is the most common type of dementia with cognitive decline as one of the core symptoms in older adults. Numerous studies have suggested the value of psychosocial interventions to improve cognition in this population, but which one should be preferred are still matters of controversy. Consequently, we aim to compare and rank different psychosocial interventions in the management of mild to moderate AD with cognitive symptoms.MethodsWe did a network meta-analysis to identify both direct and indirect evidence in relevant studies. We searched MEDLINE, EMBASE, PsycINFO through the OVID database, CENTRAL through the Cochrane Library for clinical randomized controlled trials investigating psychosocial interventions of cognitive symptoms in patients with Alzheimer disease, published up to August 31, 2017. We included trials of home-based exercise(HE), group exercise(GE), walking program(WP), reminiscence therapy(RT), art therapy(AT) or the combination of psychosocial interventions and acetylcholinesterase inhibitor (ChEIs). We extracted the relevant information from these trials with a predefined data extraction sheet and assessed the risk of bias with the Cochrane risk of bias tool. The outcomes investigated were Mini–Mental State Examination (MMSE) and compliance. We did a pair-wise meta-analysis using the fixed-effects model and then did a random-effects network meta-analysis within a Bayesian framework.ResultsWe deemed 10 trials eligible, including 682 patients and 11 treatments. The quality of included study was rated as low in most comparison with Cochrane tools. Treatment effects from the network meta-analysis showed WP was better than control (SMD 4.89, 95% CI -0.07 to 10.00) while cognitive training and acetylcholinesterase inhibitor (CT + ChEIs) was significantly better than the other treatments, when compared with simple ChEIs treatment, assessed by MMSE. In terms of compliance, the pair-wise meta-analysis indicated that WP and HE are better than GE and AT, while CT + ChEIs, CST + ChEIs are better than other combined interventions.ConclusionOur study confirmed the effectiveness of psychosocial interventions for improving cognition or slowing down the progression of cognitive impairment in AD patients and recommended several interventions for clinical practice.Electronic supplementary materialThe online version of this article (10.1186/s12877-018-0864-6) contains supplementary material, which is available to authorized users.

주제어

참고문헌 (29)

1. Dubois B Hampel H Feldman HH Scheltens P Aisen P Andrieu S Bakardjian H Benali H Bertram L Blennow K Preclinical Alzheimer's disease: definition, natural history, and diagnostic criteria Alzheimers Dement 2016 12 3 292 323 10.1016/j.jalz.2016.02.002 27012484

상세보기
2. Karran E Mercken M De Strooper B The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics Nat Rev Drug Discov 2011 10 9 698 712 10.1038/nrd3505 21852788

상세보기
3. Salloway S Sperling R Fox NC Blennow K Klunk W Raskind M Sabbagh M Honig LS Porsteinsson AP Ferris S Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease N Engl J Med 2014 370 4 322 333 10.1056/NEJMoa1304839 24450891

상세보기
4. Vandenberghe R Rinne JO Boada M Katayama S Scheltens P Vellas B Tuchman M Gass A Fiebach JB Hill D Bapineuzumab for mild to moderate Alzheimer's disease in two global, randomized, phase 3 trials Alzheimers Res Ther 2016 8 1 18 10.1186/s13195-016-0189-7 27176461

상세보기
5. Epperly T Dunay MA Boice JL Alzheimer disease: pharmacologic and nonpharmacologic therapies for cognitive and functional symptoms Am Fam Physician 2017 95 12 771 778 28671413

상세보기
6. Yuill N Hollis V A systematic review of cognitive stimulation therapy for older adults with mild to moderate dementia: an occupational therapy perspective Occup Ther Int 2011 18 4 163 186 10.1002/oti.315 21425381

상세보기
7. Clare L Linden DE Woods RT Whitaker R Evans SJ Parkinson CH van Paasschen J Nelis SM Hoare Z Yuen KS Goal-oriented cognitive rehabilitation for people with early-stage Alzheimer disease: a single-blind randomized controlled trial of clinical efficacy Am J Geriatr Psychiatry 2010 18 10 928 939 10.1097/JGP.0b013e3181d5792a 20808145

상세보기
8. Guideline watch (October 2014) practice guidline for the treatment of patients with Alzheimer's disease and other dementias 2014
9. Graff MJ Adang EM Vernooij-Dassen MJ Dekker J Jonsson L Thijssen M Hoefnagels WH Rikkert MG Community occupational therapy for older patients with dementia and their care givers: cost effectiveness study Bmj 2008 336 7636 134 138 10.1136/bmj.39408.481898.BE 18171718

상세보기
10. Liberati A Altman DG Tetzlaff J Mulrow C Gotzsche PC Ioannidis JP Clarke M Devereaux PJ Kleijnen J Moher D The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration Bmj 2009 339 b2700 10.1136/bmj.b2700 19622552

상세보기
11. Dias S Welton NJ Caldwell DM Ades AE Checking consistency in mixed treatment comparison meta-analysis Stat Med 2010 29 7–8 932 944 10.1002/sim.3767 20213715

상세보기
12. Savovic J Weeks L Sterne JA Turner L Altman DG Moher D Higgins JP Evaluation of the Cochrane Collaboration's tool for assessing the risk of bias in randomized trials: focus groups, online survey, proposed recommendations and their implementation Systematic reviews 2014 3 37 10.1186/2046-4053-3-37 24731537

상세보기
13. Sofi F Valecchi D Bacci D Abbate R Gensini GF Casini A Macchi C Physical activity and risk of cognitive decline: a meta-analysis of prospective studies J Intern Med 2011 269 1 107 117 10.1111/j.1365-2796.2010.02281.x 20831630

상세보기
14. Young J, Angevaren M, Rusted J, Tabet N. Aerobic exercise to improve cognitive function in older people without known cognitive impairment. Cochrane Database Syst Rev. 2015;(4):Cd005381. 10.1002/14651858.CD005381.pub4.
15. Law LL Barnett F Yau MK Gray MA Effects of combined cognitive and exercise interventions on cognition in older adults with and without cognitive impairment: a systematic review Ageing Res Rev 2014 15 61 75 10.1016/j.arr.2014.02.008 24632497

상세보기
16. Heyn P Abreu BC Ottenbacher KJ The effects of exercise training on elderly persons with cognitive impairment and dementia: a meta-analysis Arch Phys Med Rehabil 2004 85 10 1694 1704 10.1016/j.apmr.2004.03.019 15468033

상세보기
17. Irazoki E Garcia-Casal JA Sanchez-Meca J Franco-Martin M Efficacy of group reminiscence therapy for people with dementia. Systematic literature review and meta-analysis Rev Neurol 2017 65 10 447 456 29130468
18. Yen HY, Lin LJ. A systematic review of reminiscence therapy for older adults in Taiwan. JNR: The journal of nursing research. 2017.
19. Lin HC, Yang YP, Cheng WY, Wang JJ. Distinctive effects between cognitive stimulation and reminiscence therapy on cognitive function and quality of life for different types of behavioural problems in dementia. Scand J Caring Sci. 2017. 10.1111/scs.12484.
20. Hattori H Hattori C Hokao C Mizushima K Mase T Controlled study on the cognitive and psychological effect of coloring and drawing in mild Alzheimer's disease patients Geriatr Gerontol Int 2011 11 4 431 437 10.1111/j.1447-0594.2011.00698.x 21518170

상세보기
21. Quintana-Hernandez DJ Miro-Barrachina MT Ibanez-Fernandez IJ Pino AS Quintana-Montesdeoca MP Rodriguez-de Vera B Morales-Casanova D Perez-Vieitez Mdel C Rodriguez-Garcia J Bravo-Caraduje N Mindfulness in the maintenance of cognitive capacities in Alzheimer's disease: a randomized clinical trial Journal of Alzheimer's disease : JAD 2016 50 1 217 232 10.3233/JAD-143009 26639952

상세보기
22. Niu YX Tan JP Guan JQ Zhang ZQ Wang LN Cognitive stimulation therapy in the treatment of neuropsychiatric symptoms in Alzheimer's disease: a randomized controlled trial Clin Rehabil 2010 24 12 1102 1111 10.1177/0269215510376004 20713437

상세보기
23. Tarraga L Boada M Modinos G Espinosa A Diego S Morera A Guitart M Balcells J Lopez OL Becker JT A randomised pilot study to assess the efficacy of an interactive, multimedia tool of cognitive stimulation in Alzheimer's disease J Neurol Neurosurg Psychiatry 2006 77 10 1116 1121 10.1136/jnnp.2005.086074 16820420

상세보기
24. D'Onofrio G Sancarlo D Addante F Ciccone F Cascavilla L Paris F Elia AC Nuzzaci C Picoco M Greco A A pilot randomized controlled trial evaluating an integrated treatment of rivastigmine transdermal patch and cognitive stimulation in patients with Alzheimer's disease Int J Geriatr Psychiatry 2015 30 9 965 975 10.1002/gps.4247 25504466

상세보기
25. Bergamaschi S Arcara G Calza A Villani D Orgeta V Mondini S One-year repeated cycles of cognitive training (CT) for Alzheimer's disease Aging Clin Exp Res 2013 25 4 421 426 10.1007/s40520-013-0065-2 23784727

상세보기
26. Ohman H Savikko N Strandberg TE Kautiainen H Raivio MM Laakkonen ML Tilvis R Pitkala KH Effects of exercise on cognition: the finnish Alzheimer disease exercise trial: a randomized, controlled trial J Am Geriatr Soc 2016 64 4 731 738 10.1111/jgs.14059 27037872

상세보기
27. Duru Asiret G Kapucu S The effect of reminiscence therapy on cognition, depression, and activities of daily living for patients with Alzheimer disease J Geriatr Psychiatry Neurol 2016 29 1 31 37 10.1177/0891988715598233 26251112

상세보기
28. Van BP Van GR Tolson D Wouters K Engelborghs S Van der Mussele S Effects of SolCos model-based individual reminiscence on older adults with mild to moderate dementia due to Alzheimer disease: a pilot study Journal of the American Medical Directors Association 2013 14 7 528.e529 528.e513
29. Venturelli M Scarsini R Schena F Six-month walking program changes cognitive and ADL performance in patients with Alzheimer American journal of Alzheimer's disease and other dementias 2011 26 5 381 388 10.1177/1533317511418956 21852281

상세보기

표제어: PCR

동의어: Packet Collision Rate

용어 설명 출처 목록 (6)

용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

Psychosocial interventions for Alzheimer’s disease cognitive symptoms: a Bayesian network meta-analysis 원문보기

Abstract ▼ AI-Helper

주제어

참고문헌 (29)

이 논문을 인용한 문헌

관련 콘텐츠

원문 보기

원문 URL 링크

오픈액세스(OA) 유형

연관된 기능

이 논문과 함께 이용한 콘텐츠

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트