다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기
Molecules a journal of synthetic chemistry and natural product chemistry, v.23 no.10, 2018년, pp.2415 -
Jude, Shintu (R&D Centre, Aurea Biolabs (P) Ltd., Kolenchery, Cochin-Kerala 682311, India) , Amalraj, Augustine (shintu.jude@plantlipids.com (S.J.)) , Kunnumakkara, Ajaikumar B. (amalraj.a@plantlipids.com (A.A.)) , Divya, Chandradhara (R&D Centre, Aurea Biolabs (P) Ltd., Kolenchery, Cochin-Kerala 682311, India) , Löffler, Bernd-Michael (shintu.jude@plantlipids.com (S.J.)) , Gopi, Sreeraj (amalraj.a@plantlipids.com (A.A.))
AI-Helper
Specific and sensitive ultra-high performance liquid chromatography-quadrupole time of flight-mass spectroscopy (UPLC-QTOF-MS) methods have been developed for the determination of curcuminoids and curcumin metabolites in human blood plasma. The UPLC-QTOF-MS method used a binary solvent delivery syst...
1. Cao Y. Xu R.X. Liu Z. A high-throughput quantification method of curcuminoids and curcumin metabolites in human plasma via high-performance liquid chromatography/tandem mass spectrometry J. Chromatogr. B 2014 949 70 78 10.1016/j.jchromb.2013.12.039 24480327
2. Huang Y.-S. Hsieh T.-J. Lu C.-Y. Simple analytical strategy for MALDI-TOF-MS and nanoUPLC–MS/MS: Quantitating curcumin in food condiments and dietary supplements and screening of acrylamide-induced ROS protein indicators reduced by curcumin Food Chem. 2015 174 571 576 10.1016/j.foodchem.2014.11.115 25529721
3. Anand P. Sundaram C. Jhurani S. Kunnumakkara A.B. Aggarwal B.B. Curcumin and cancer: An “old-age” disease with an “age-old” solution Cancer Lett. 2008 267 133 164 10.1016/j.canlet.2008.03.025 18462866
4. Amalraj A. Pius A. Gopi S. Gopi S. Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives—A review J. Tradit. Complement. Med. 2017 7 205 233 10.1016/j.jtcme.2016.05.005 28417091
5. Dhillon N. Aggarwal B.B. Newman R.A. Wolff R.A. Kunnumakkara A.B. Abbruzzese J.L. Ng C.S. Badmaev V. Kurzrock R. Phase II trial of curcumin in patients with advanced pancreatic cancer Clin. Cancer Res. 2008 14 4491 4499 10.1158/1078-0432.CCR-08-0024 18628464
6. Anand P. Kunnumakkara A.B. Newman R.A. Aggarwal B.B. Bioavailability of curcumin: Problems and promises Mol. Pharm. 2007 4 807 818 10.1021/mp700113r 17999464
7. Marczylo T.H. Steward W.P. Gescher A.J. Rapid analysis of curcumin and curcumin metabolites in rat biomatrices using a novel Ultraperformance Liquid Chromatography (UPLC) method J. Agric. Food Chem. 2009 57 797 803 10.1021/jf803038f 19152267
8. Dempe J.S. Scheerle R.K. Pfeiffer E. Metzler M. Metabolism and permeability of curcumin in cultured Caco-2 cells Mol. Nutr. Food Res. 2013 57 1543 1549 10.1002/mnfr.201200113 22930441
9. Motomu S. Kiyotaka N. Akio W. Tsuyoshi T. Teiko Y. Shigefumi K. Fumiko K. Teruo M. Comparison of the effects of curcumin and curcumin glucuronidein human hepatocellular carcinoma HepG2 cells Food Chem. 2014 151 126 132 24423511
10. Lou Y. Zheng J. Hu H. Lee J. Zeng S. Application of ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry to identify curcumin metabolites produced by human intestinal bacteria J. Chromatogr. B 2015 985 38 47 10.1016/j.jchromb.2015.01.014 25658514
11. Asai A. Miyazawa T. Occurrence of orally administered curcuminoid as glucuronide and glucuronide/sulfate conjugates in rat plasma Life Sci. 2000 67 2785 2793 10.1016/S0024-3205(00)00868-7 11105995
12. Ireson C.R. Orr S. Jones D.J.L. Verschoyle R. Lim C.K. Luo J.L. Howells L. Plummer S.M. Jukes R.M. Williams Steward W.P. Characterization of metabolites of the chemopreventive agent curcumin in humans and rat hepatocytes and in rat plasma and evaluation of their ability to inhibit phorbol ester-induced prostaglandin E2 production Cancer Res. 2001 61 1058 1064 11221833
13. Gopi S. Jacob J. Mathur K.Y. Acute and subchronic oral toxicity studies of hydrogenated curcuminoid formulation ‘CuroWhite’ in rats Toxicol. Rep. 2016 3 817 825 10.1016/j.toxrep.2016.10.007 28959609
14. Ireson C.R. Jones D.J. Orr S. Coughtrie M.W. Boocock D.J. Williams M.L. Farmer P.B. Steward W.P. Gescher A.J. Metabolism of the cancer chemopreventive agent curcumin in human and rat intestine Cancer Epidemiol. Biomark. Prev. 2002 11 105 111
15. Amalraj A. Jude S. Varma K. Jacob J. Gopi S. Oluwafemi O.S. Thomas S. Preparation of a novel bioavailable curcuminoid formulation (Cureit™) using Polar-Nonpolar-Sandwich (PNS) technology and its characterization and applications Mater. Sci. Eng. C 2017 75 359 367 10.1016/j.msec.2017.02.068 28415473
16. Gopi S. George R. Jude S. Sriraam V.T. Cell culture study on the cytotoxic effects of “Cureit”—A novel bio available curcumin-anti cancer effects J. Chem. Pharm. Res. 2014 6 96 100
17. Gopi S. George R. Sriraam V.T. Cell culture study on the effect of bioavailable curcumin—“Cureit” on elastase inhibition activity Br. Biomed. Bull. 2014 2 545 549
18. Gopi S. George R. Sriraam V.T. Antioxidant potential of “Cureit”—A novel bioavailable curcumin formulation Asian J. Pharm. Tech. Innov. 2014 2 123 127
19. Gopi S. George R. Sriraam V.T. Cell culture study on the effects of “Cureit” hyaluronidase inhibition—Anti aging effects Int. J. Curr. Res. 2014 6 8473 8474
20. Gopi S. George R. Thomas M. Jude S. A pilot cross-over study to assess the human bioavailability of “Cureit”—A bioavailable curcumin in complete natural matrix Asian J. Pharm. Tech. Innov. 2015 3 92 96
21. Ahmad N. Warsi M.H. Iqbal Z. Samim M. Ahmad F.J. Quantification of curcumin, demethoxycurcumin, and bisdemethoxycurcumin in rodent brain by UHPLC/ESI-Q-TOF-MS/MS after intra-nasal administration of curcuminoids loaded PNIPAM nanoparticles Drug Test. Anal. 2014 6 257 267 10.1002/dta.1472 23703969
22. Lin J.K. Pan M.H. Lin-Shiau S.Y. Recent studies on the biofunctions and biotransformations of curcumin Biofactors 2000 13 153 158 10.1002/biof.5520130125 11237176
23. Zhongfa L. Chiu M. Wang J. Chen W. Yen W. Fan-Havard P. Yee L.D. Chan K.K. Enhancement of curcumin oral absorption and pharmacokinetics of curcuminoids and curcumin metabolites in mice Cancer Chemother. Pharmacol. 2012 69 679 689 10.1007/s00280-011-1749-y 21968952
24. Vareed S.K. Kakarala M. Ruffin M.T. Crowell J.A. Normolle D.P. Djuric Z. Brenner D.E. Pharmacokinetics of curcumin conjugate metabolites in healthy human subjects Cancer Epidemiol. Biomarkers Prev. 2008 17 1411 1417 10.1158/1055-9965.EPI-07-2693 18559556
25. Liu Z. Xie Z. Jones W. Pavlovicz R.E. Liu S. Yu J. Li P.K. Lin J. Fuchs J.R. Marcucci G. Curcumin is a potent DNA hypomethylation agent Bioorg. Med. Chem. Lett. 2009 19 706 709 10.1016/j.bmcl.2008.12.041 19112019
26. Gopi S. Jacob J. Varma K. Jude S. Amalraj A. Arundhathy C.A. George R. Sreeraj T.R. Divya C. Kunnumakkara A.B. Comparative Oral Absorption of Curcumin in a Natural Turmeric Matrix with Two Other Curcumin Formulations: An Open-label Parallelarm Study Phytother. Res. 2017 31 1883 1891 10.1002/ptr.5931 29027274
27. Verma M.K. Najar I.A. Tikoo M.K. Singh G. Gupta D.K. Anand R. Khajuria R.K. Sharma S.C. Johri R.K. Development of a validated UPLC-qTOF-MS Method for the determination of curcuminoids and their pharmacokinetic study in mice Daru. J. Pharm. Sci. 2013 21 11 10.1186/2008-2231-21-11 23356399
28. Carlson R.V. Boyd K.M. Webb D.J. The revision of the Declaration of Helsinki: Past, present and future Br. J. Clin. Pharmacol. 2004 57 695 713 10.1111/j.1365-2125.2004.02103.x 15151515
*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.
오픈액세스 학술지에 출판된 논문
Copyright KISTI. All Rights Reserved.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.