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Aquaporin-4 Water Channel in the Brain and Its Implication for Health and Disease 원문보기

Cells, v.8 no.2, 2019년, pp.90 -   

Mader, Simone (Institute of Clinical Neuroimmunology, Biomedical Center and University Hospital, Ludwig-Maximilians University Munich, D-82152 Martinsried, Germany) ,  Brimberg, Lior (The Feinstein Institute for Medical Research, The Center for Autoimmune, Musculoskeletal and Hematopoietic Diseases, Northwell Health System, Manhasset, NY 11030, USA)

Abstract AI-Helper 아이콘AI-Helper

Aquaporin-4 (AQP4) is a water channel expressed on astrocytic endfeet in the brain. The role of AQP4 has been studied in health and in a range of pathological conditions. Interest in AQP4 has increased since it was discovered to be the target antigen in the inflammatory autoimmune disease neuromyeli...

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참고문헌 (120)

  1. 1. Badaut J. Brunet J.F. Regli L. Aquaporins in the brain: From aqueduct to “multi-duct” Metab. Brain Dis. 2007 22 251 263 10.1007/s11011-007-9057-2 17701333 

  2. 2. Rash J.E. Yasumura T. Hudson C.S. Agre P. Nielsen S. Direct immunogold labeling of aquaporin-4 in square arrays of astrocyte and ependymocyte plasma membranes in rat brain and spinal cord Proc. Natl. Acad. Sci. USA 1998 95 11981 11986 10.1073/pnas.95.20.11981 9751776 

  3. 3. Nielsen S. Nagelhus E.A. Amiry-Moghaddam M. Bourque C. Agre P. Ottersen O.P. Specialized membrane domains for water transport in glial cells: High-resolution immunogold cytochemistry of aquaporin-4 in rat brain J. Neurosci. 1997 17 171 180 10.1523/JNEUROSCI.17-01-00171.1997 8987746 

  4. 4. Hasegawa H. Ma T. Skach W. Matthay M.A. Verkman A.S. Molecular cloning of a mercurial-insensitive water channel expressed in selected water-transporting tissues J. Biol. Chem. 1994 269 5497 5500 7509789 

  5. 5. Jung J.S. Bhat R.V. Preston G.M. Guggino W.B. Baraban J.M. Agre P. Molecular characterization of an aquaporin cDNA from brain: Candidate osmoreceptor and regulator of water balance Proc. Natl. Acad. Sci. USA 1994 91 13052 13056 10.1073/pnas.91.26.13052 7528931 

  6. 6. Murlidharan G. Crowther A. Reardon R.A. Song J. Asokan A. Glymphatic fluid transport controls paravascular clearance of AAV vectors from the brain JCI Insight 2016 1 e88034 10.1172/jci.insight.88034 27699236 

  7. 7. Verkman A.S. Binder D.K. Bloch O. Auguste K. Papadopoulos M.C. Three distinct roles of aquaporin-4 in brain function revealed by knockout mice Biochim. Biophys. Acta 2006 1758 1085 1093 10.1016/j.bbamem.2006.02.018 16564496 

  8. 8. Nagelhus E.A. Ottersen O.P. Physiological roles of aquaporin-4 in brain Physiol. Rev. 2013 93 1543 1562 10.1152/physrev.00011.2013 24137016 

  9. 9. Zhao Z.A. Li P. Ye S.Y. Ning Y.L. Wang H. Peng Y. Yang N. Zhao Y. Zhang Z.H. Chen J.F. Perivascular AQP4 dysregulation in the hippocampal CA1 area after traumatic brain injury is alleviated by adenosine A2A receptor inactivation Sci. Rep. 2017 7 2254 10.1038/s41598-017-02505-6 28533515 

  10. 10. Aoki K. Uchihara T. Tsuchiya K. Nakamura A. Ikeda K. Wakayama Y. Enhanced expression of aquaporin 4 in human brain with infarction Acta Neuropathol. 2003 106 121 124 10.1007/s00401-003-0709-y 12715185 

  11. 11. Hubbard J.A. Szu J.I. Binder D.K. The role of aquaporin-4 in synaptic plasticity, memory and disease Brain Res. Bull. 2018 136 118 129 10.1016/j.brainresbull.2017.02.011 28274814 

  12. 12. Papadopoulos M.C. Verkman A.S. Aquaporin 4 and neuromyelitis optica Lancet Neurol. 2012 11 535 544 10.1016/S1474-4422(12)70133-3 22608667 

  13. 13. Zeppenfeld D.M. Simon M. Haswell J.D. D’Abreo D. Murchison C. Quinn J.F. Grafe M.R. Woltjer R.L. Kaye J. Iliff J.J. Association of Perivascular Localization of Aquaporin-4 With Cognition and Alzheimer Disease in Aging Brains JAMA Neurol. 2017 74 91 99 10.1001/jamaneurol.2016.4370 27893874 

  14. 14. Reemst K. Noctor S.C. Lucassen P.J. Hol E.M. The Indispensable Roles of Microglia and Astrocytes during Brain Development Front. Hum. Neurosci. 2016 10 566 27877121 

  15. 15. Aprea J. Calegari F. Long non-coding RNAs in corticogenesis: Deciphering the non-coding code of the brain EMBO J. 2015 34 2865 2884 10.15252/embj.201592655 26516210 

  16. 16. Fallier-Becker P. Vollmer J.P. Bauer H.C. Noell S. Wolburg H. Mack A.F. Onset of aquaporin-4 expression in the developing mouse brain Int. J. Dev. Neurosci. 2014 36 81 89 10.1016/j.ijdevneu.2014.06.001 24915007 

  17. 17. Feng X. Papadopoulos M.C. Liu J. Li L. Zhang D. Zhang H. Verkman A.S. Ma T. Sporadic obstructive hydrocephalus in Aqp4 null mice J. Neurosci. Res. 2009 87 1150 1155 10.1002/jnr.21927 18951529 

  18. 18. Papadopoulos M.C. Verkman A.S. Aquaporin water channels in the nervous system Nat. Rev. Neurosci. 2013 14 265 277 10.1038/nrn3468 23481483 

  19. 19. Walz T. Fujiyoshi Y. Engel A. The AQP structure and functional implications Handb. Exp. Pharmacol. 2009 31 56 

  20. 20. Ho J.D. Yeh R. Sandstrom A. Chorny I. Harries W.E. Robbins R.A. Miercke L.J. Stroud R.M. Crystal structure of human aquaporin 4 at 1.8 A and its mechanism of conductance Proc. Natl. Acad. Sci. USA 2009 106 7437 7442 10.1073/pnas.0902725106 19383790 

  21. 21. Lu M. Lee M.D. Smith B.L. Jung J.S. Agre P. Verdijk M.A. Merkx G. Rijss J.P. Deen P.M. The human AQP4 gene: Definition of the locus encoding two water channel polypeptides in brain Proc. Natl. Acad. Sci. USA 1996 93 10908 10912 10.1073/pnas.93.20.10908 8855281 

  22. 22. Rossi A. Moritz T.J. Ratelade J. Verkman A.S. Super-resolution imaging of aquaporin-4 orthogonal arrays of particles in cell membranes J. Cell Sci. 2012 125 4405 4412 10.1242/jcs.109603 22718347 

  23. 23. Furman C.S. Gorelick-Feldman D.A. Davidson K.G. Yasumura T. Neely J.D. Agre P. Rash J.E. Aquaporin-4 square array assembly: Opposing actions of M1 and M23 isoforms Proc. Natl. Acad. Sci. USA 2003 100 13609 13614 10.1073/pnas.2235843100 14597700 

  24. 24. Crane J.M. Bennett J.L. Verkman A.S. Live cell analysis of aquaporin-4 m1/m23 interactions and regulated orthogonal array assembly in glial cells J. Biol. Chem. 2009 284 35850 35860 10.1074/jbc.M109.071670 19843522 

  25. 25. Yang B. van Hoek A.N. Verkman A.S. Very high single channel water permeability of aquaporin-4 in baculovirus-infected insect cells and liposomes reconstituted with purified aquaporin-4 Biochemistry 1997 36 7625 7632 10.1021/bi970231r 9200715 

  26. 26. Hiroaki Y. Tani K. Kamegawa A. Gyobu N. Nishikawa K. Suzuki H. Walz T. Sasaki S. Mitsuoka K. Kimura K. Implications of the aquaporin-4 structure on array formation and cell adhesion J. Mol. Biol. 2006 355 628 639 10.1016/j.jmb.2005.10.081 16325200 

  27. 27. Silberstein C. Bouley R. Huang Y. Fang P. Pastor-Soler N. Brown D. Van Hoek A.N. Membrane organization and function of M1 and M23 isoforms of aquaporin-4 in epithelial cells Am. J. Physiol. Renal Physiol. 2004 287 F501 F511 10.1152/ajprenal.00439.2003 15149973 

  28. 28. Verkman A.S. Ratelade J. Rossi A. Zhang H. Tradtrantip L. Aquaporin-4: Orthogonal array assembly, CNS functions, and role in neuromyelitis optica Acta Pharmacol. Sin. 2011 32 702 710 10.1038/aps.2011.27 21552296 

  29. 29. Mader S. Lutterotti A. Di Pauli F. Kuenz B. Schanda K. Aboul-Enein F. Khalil M. Storch M.K. Jarius S. Kristoferitsch W. Patterns of antibody binding to aquaporin-4 isoforms in neuromyelitis optica PLoS ONE 2010 5 e10455 10.1371/journal.pone.0010455 20463974 

  30. 30. Nicchia G.P. Mastrototaro M. Rossi A. Pisani F. Tortorella C. Ruggieri M. Lia A. Trojano M. Frigeri A. Svelto M. Aquaporin-4 orthogonal arrays of particles are the target for neuromyelitis optica autoantibodies Glia 2009 57 1363 1373 10.1002/glia.20855 19229993 

  31. 31. Crane J.M. Lam C. Rossi A. Gupta T. Bennett J.L. Verkman A.S. Binding affinity and specificity of neuromyelitis optica autoantibodies to aquaporin-4 M1/M23 isoforms and orthogonal arrays J. Biol. Chem. 2011 286 16516 16524 10.1074/jbc.M111.227298 21454592 

  32. 32. Miyazaki K. Abe Y. Iwanari H. Suzuki Y. Kikuchi T. Ito T. Kato J. Kusano-Arai O. Takahashi T. Nishiyama S. Establishment of monoclonal antibodies against the extracellular domain that block binding of NMO-IgG to AQP4 J. Neuroimmunol. 2013 260 107 116 10.1016/j.jneuroim.2013.03.003 23746426 

  33. 33. Neely J.D. Amiry-Moghaddam M. Ottersen O.P. Froehner S.C. Agre P. Adams M.E. Syntrophin-dependent expression and localization of Aquaporin-4 water channel protein Proc. Natl. Acad. Sci. USA 2001 98 14108 14113 10.1073/pnas.241508198 11717465 

  34. 34. Saadoun S. Papadopoulos M.C. Davies D.C. Krishna S. Bell B.A. Aquaporin-4 expression is increased in oedematous human brain tumours J. Neurol. Neurosurg. Psychiatry 2002 72 262 265 10.1136/jnnp.72.2.262 11796780 

  35. 35. Solenov E. Watanabe H. Manley G.T. Verkman A.S. Sevenfold-reduced osmotic water permeability in primary astrocyte cultures from AQP-4-deficient mice, measured by a fluorescence quenching method Am. J. Physiol. Cell Physiol. 2004 286 C426 C432 10.1152/ajpcell.00298.2003 14576087 

  36. 36. Haj-Yasein N.N. Vindedal G.F. Eilert-Olsen M. Gundersen G.A. Skare O. Laake P. Klungland A. Thoren A.E. Burkhardt J.M. Ottersen O.P. Glial-conditional deletion of aquaporin-4 (Aqp4) reduces blood-brain water uptake and confers barrier function on perivascular astrocyte endfeet Proc. Natl. Acad. Sci. USA 2011 108 17815 17820 10.1073/pnas.1110655108 21990350 

  37. 37. Skucas V.A. Mathews I.B. Yang J. Cheng Q. Treister A. Duffy A.M. Verkman A.S. Hempstead B.L. Wood M.A. Binder D.K. Impairment of select forms of spatial memory and neurotrophin-dependent synaptic plasticity by deletion of glial aquaporin-4 J. Neurosci. 2011 31 6392 6397 10.1523/JNEUROSCI.6249-10.2011 21525279 

  38. 38. Zhang J. Li Y. Chen Z.G. Dang H. Ding J.H. Fan Y. Hu G. Glia protein aquaporin-4 regulates aversive motivation of spatial memory in Morris water maze CNS Neurosci. Ther. 2013 19 937 944 10.1111/cns.12191 24165567 

  39. 39. Zhou J. Kong H. Hua X. Xiao M. Ding J. Hu G. Altered blood-brain barrier integrity in adult aquaporin-4 knockout mice Neuroreport 2008 19 1 5 10.1097/WNR.0b013e3282f2b4eb 18281883 

  40. 40. Saadoun S. Tait M.J. Reza A. Davies D.C. Bell B.A. Verkman A.S. Papadopoulos M.C. AQP4 gene deletion in mice does not alter blood-brain barrier integrity or brain morphology Neuroscience 2009 161 764 772 10.1016/j.neuroscience.2009.03.069 19345723 

  41. 41. Manley G.T. Fujimura M. Ma T. Noshita N. Filiz F. Bollen A.W. Chan P. Verkman A.S. Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke Nat. Med. 2000 6 159 163 10.1038/72256 10655103 

  42. 42. Papadopoulos M.C. Manley G.T. Krishna S. Verkman A.S. Aquaporin-4 facilitates reabsorption of excess fluid in vasogenic brain edema FASEB J. 2004 18 1291 1293 10.1096/fj.04-1723fje 15208268 

  43. 43. Lennon V.A. Wingerchuk D.M. Kryzer T.J. Pittock S.J. Lucchinetti C.F. Fujihara K. Nakashima I. Weinshenker B.G. A serum autoantibody marker of neuromyelitis optica: Distinction from multiple sclerosis Lancet 2004 364 2106 2112 10.1016/S0140-6736(04)17551-X 15589308 

  44. 44. Lennon V.A. Kryzer T.J. Pittock S.J. Verkman A.S. Hinson S.R. IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel J. Exp. Med. 2005 202 473 477 10.1084/jem.20050304 16087714 

  45. 45. Jarius S. Probst C. Borowski K. Franciotta D. Wildemann B. Stoecker W. Wandinger K.P. Standardized method for the detection of antibodies to aquaporin-4 based on a highly sensitive immunofluorescence assay employing recombinant target antigen J. Neurol. Sci. 2010 291 52 56 10.1016/j.jns.2010.01.002 20117794 

  46. 46. Weinshenker B.G. Wingerchuk D.M. Vukusic S. Linbo L. Pittock S.J. Lucchinetti C.F. Lennon V.A. Neuromyelitis optica IgG predicts relapse after longitudinally extensive transverse myelitis Ann. Neurol. 2006 59 566 569 10.1002/ana.20770 16453327 

  47. 47. Wingerchuk D.M. Banwell B. Bennett J.L. Cabre P. Carroll W. Chitnis T. de Seze J. Fujihara K. Greenberg B. Jacob A. International consensus diagnostic criteria for neuromyelitis optica spectrum disorders Neurology 2015 85 177 189 10.1212/WNL.0000000000001729 26092914 

  48. 48. Palace J. Leite M.I. Nairne A. Vincent A. Interferon Beta treatment in neuromyelitis optica: Increase in relapses and aquaporin 4 antibody titers Arch Neurol. 2010 67 1016 1017 10.1001/archneurol.2010.188 20697055 

  49. 49. Waters P. Reindl M. Saiz A. Schanda K. Tuller F. Kral V. Nytrova P. Sobek O. Nielsen H.H. Barington T. Multicentre comparison of a diagnostic assay: Aquaporin-4 antibodies in neuromyelitis optica J. Neurol. Neurosurg. Psychiatry 2016 87 1005 1015 10.1136/jnnp-2015-312601 27113605 

  50. 50. Waters P.J. McKeon A. Leite M.I. Rajasekharan S. Lennon V.A. Villalobos A. Palace J. Mandrekar J.N. Vincent A. Bar-Or A. Serologic diagnosis of NMO: A multicenter comparison of aquaporin-4-IgG assays Neurology 2012 78 665 671 665–671; discussion 669 10.1212/WNL.0b013e318248dec1 22302543 

  51. 51. Takahashi T. Fujihara K. Nakashima I. Misu T. Miyazawa I. Nakamura M. Watanabe S. Shiga Y. Kanaoka C. Fujimori J. Anti-aquaporin-4 antibody is involved in the pathogenesis of NMO: A study on antibody titre Brain 2007 130 1235 1243 10.1093/brain/awm062 17449477 

  52. 52. Mader S. Gredler V. Schanda K. Rostasy K. Dujmovic I. Pfaller K. Lutterotti A. Jarius S. Di Pauli F. Kuenz B. Complement activating antibodies to myelin oligodendrocyte glycoprotein in neuromyelitis optica and related disorders J. Neuroinflamm. 2011 8 184 10.1186/1742-2094-8-184 22204662 

  53. 53. Kitley J. Woodhall M. Leite M.I. Palace J. Vincent A. Waters P. Aquaporin-4 antibody isoform binding specificities do not explain clinical variations in NMO Neurol. Neuroimmunol. Neuroinflamm. 2015 2 e121 10.1212/NXI.0000000000000121 26140280 

  54. 54. Di Pauli F. Mader S. Rostasy K. Schanda K. Bajer-Kornek B. Ehling R. Deisenhammer F. Reindl M. Berger T. Temporal dynamics of anti-MOG antibodies in CNS demyelinating diseases Clin. Immunol. 2011 138 247 254 10.1016/j.clim.2010.11.013 21169067 

  55. 55. Verkman A.S. Phuan P.W. Asavapanumas N. Tradtrantip L. Biology of AQP4 and anti-AQP4 antibody: Therapeutic implications for NMO Brain Pathol. 2013 23 684 695 10.1111/bpa.12085 24118484 

  56. 56. Fryer J.P. Lennon V.A. Pittock S.J. Jenkins S.M. Fallier-Becker P. Clardy S.L. Horta E. Jedynak E.A. Lucchinetti C.F. Shuster E.A. AQP4 autoantibody assay performance in clinical laboratory service Neurol. Neuroimmunol. Neuroinflamm. 2014 1 e11 10.1212/NXI.0000000000000011 25340055 

  57. 57. Huang P. Takai Y. Kusano-Arai O. Ramadhanti J. Iwanari H. Miyauchi T. Sakihama T. Han J.Y. Aoki M. Hamakubo T. The binding property of a monoclonal antibody against the extracellular domains of aquaporin-4 directs aquaporin-4 toward endocytosis Biochem. Biophys. Rep. 2016 7 77 83 10.1016/j.bbrep.2016.05.017 28955892 

  58. 58. Bradl M. Lassmann H. Oligodendrocytes: Biology and pathology Acta Neuropathol. 2010 119 37 53 10.1007/s00401-009-0601-5 19847447 

  59. 59. Bradl M. Misu T. Takahashi T. Watanabe M. Mader S. Reindl M. Adzemovic M. Bauer J. Berger T. Fujihara K. Neuromyelitis optica: Pathogenicity of patient immunoglobulin in vivo Ann. Neurol. 2009 66 630 643 10.1002/ana.21837 19937948 

  60. 60. Bennett J.L. Lam C. Kalluri S.R. Saikali P. Bautista K. Dupree C. Glogowska M. Case D. Antel J.P. Owens G.P. Intrathecal pathogenic anti-aquaporin-4 antibodies in early neuromyelitis optica Ann. Neurol. 2009 66 617 629 10.1002/ana.21802 19938104 

  61. 61. Pohl M. Kawakami N. Kitic M. Bauer J. Martins R. Fischer M.T. Machado-Santos J. Mader S. Ellwart J.W. Misu T. T cell-activation in neuromyelitis optica lesions plays a role in their formation Acta Neuropathol. Commun. 2013 1 85 10.1186/2051-5960-1-85 24367907 

  62. 62. Pohl M. Fischer M.T. Mader S. Schanda K. Kitic M. Sharma R. Wimmer I. Misu T. Fujihara K. Reindl M. Pathogenic T cell responses against aquaporin 4 Acta Neuropathol. 2011 122 21 34 10.1007/s00401-011-0824-0 21468722 

  63. 63. Jones M.V. Huang H. Calabresi P.A. Levy M. Pathogenic aquaporin-4 reactive T cells are sufficient to induce mouse model of neuromyelitis optica Acta Neuropathol. Commun. 2015 3 28 10.1186/s40478-015-0207-1 25990016 

  64. 64. Shimizu F. Schaller K.L. Owens G.P. Cotleur A.C. Kellner D. Takeshita Y. Obermeier B. Kryzer T.J. Sano Y. Kanda T. Glucose-regulated protein 78 autoantibody associates with blood-brain barrier disruption in neuromyelitis optica Sci. Transl. Med. 2017 9 eaai9111 10.1126/scitranslmed.aai9111 28679661 

  65. 65. Hillebrand S. Schanda K. Nigritinou M. Tsymala I. Bohm D. Peschl P. Takai Y. Fujihara K. Nakashima I. Misu T. Circulating AQP4-specific auto-antibodies alone can induce neuromyelitis optica spectrum disorder in the rat Acta Neuropathol. 2018 1 19 

  66. 66. Takeshita Y. Obermeier B. Cotleur A.C. Spampinato S.F. Shimizu F. Yamamoto E. Sano Y. Kryzer T.J. Lennon V.A. Kanda T. Effects of neuromyelitis optica-IgG at the blood-brain barrier in vitro Neurol. Neuroimmunol. Neuroinflamm. 2017 4 e311 10.1212/NXI.0000000000000311 28018943 

  67. 67. Yick L.W. Ma O.K. Ng R.C. Kwan J.S. Chan K.H. Aquaporin-4 Autoantibodies from Neuromyelitis Optica Spectrum Disorder Patients Induce Complement-Independent Immunopathologies in Mice Front. Immunol. 2018 9 1438 10.3389/fimmu.2018.01438 29988553 

  68. 68. Nishiyama S. Misu T. Nuriya M. Takano R. Takahashi T. Nakashima I. Yasui M. Itoyama Y. Aoki M. Fujihara K. Complement-dependent and -independent aquaporin 4-antibody-mediated cytotoxicity in human astrocytes: Pathogenetic implications in neuromyelitis optica Biochem. Biophys. Rep. 2016 7 45 51 10.1016/j.bbrep.2016.05.012 29114578 

  69. 69. Hinson S.R. Pittock S.J. Lucchinetti C.F. Roemer S.F. Fryer J.P. Kryzer T.J. Lennon V.A. Pathogenic potential of IgG binding to water channel extracellular domain in neuromyelitis optica Neurology 2007 69 2221 2231 10.1212/01.WNL.0000289761.64862.ce 17928579 

  70. 70. Lucchinetti C.F. Mandler R.N. McGavern D. Bruck W. Gleich G. Ransohoff R.M. Trebst C. Weinshenker B. Wingerchuk D. Parisi J.E. A role for humoral mechanisms in the pathogenesis of Devic’s neuromyelitis optica Brain 2002 125 1450 1461 10.1093/brain/awf151 12076996 

  71. 71. Papadopoulos M.C. Bennett J.L. Verkman A.S. Treatment of neuromyelitis optica: State-of-the-art and emerging therapies Nat. Rev. Neurol. 2014 10 493 506 10.1038/nrneurol.2014.141 25112508 

  72. 72. Bergman I. Basse P.H. Barmada M.A. Griffin J.A. Cheung N.K. Comparison of in vitro antibody-targeted cytotoxicity using mouse, rat and human effectors Cancer Immunol. Immunother. 2000 49 259 266 10.1007/s002620000120 10941909 

  73. 73. Saadoun S. Waters P. Bell B.A. Vincent A. Verkman A.S. Papadopoulos M.C. Intra-cerebral injection of neuromyelitis optica immunoglobulin G and human complement produces neuromyelitis optica lesions in mice Brain 2010 133 349 361 10.1093/brain/awp309 20047900 

  74. 74. Nytrova P. Potlukova E. Kemlink D. Woodhall M. Horakova D. Waters P. Havrdova E. Zivorova D. Vincent A. Trendelenburg M. Complement activation in patients with neuromyelitis optica J. Neuroimmunol. 2014 274 185 191 10.1016/j.jneuroim.2014.07.001 25109258 

  75. 75. Misu T. Hoftberger R. Fujihara K. Wimmer I. Takai Y. Nishiyama S. Nakashima I. Konno H. Bradl M. Garzuly F. Presence of six different lesion types suggests diverse mechanisms of tissue injury in neuromyelitis optica Acta Neuropathol. 2013 125 815 827 10.1007/s00401-013-1116-7 23579868 

  76. 76. Ratelade J. Asavapanumas N. Ritchie A.M. Wemlinger S. Bennett J.L. Verkman A.S. Involvement of antibody-dependent cell-mediated cytotoxicity in inflammatory demyelination in a mouse model of neuromyelitis optica Acta Neuropathol. 2013 126 699 709 10.1007/s00401-013-1172-z 23995423 

  77. 77. Trebst C. Jarius S. Berthele A. Paul F. Schippling S. Wildemann B. Borisow N. Kleiter I. Aktas O. Kumpfel T. Update on the diagnosis and treatment of neuromyelitis optica: Recommendations of the Neuromyelitis Optica Study Group (NEMOS) J. Neurol. 2014 261 1 16 10.1007/s00415-013-7169-7 24272588 

  78. 78. Kleiter I. Gahlen A. Borisow N. Fischer K. Wernecke K.D. Wegner B. Hellwig K. Pache F. Ruprecht K. Havla J. Neuromyelitis optica: Evaluation of 871 attacks and 1,153 treatment courses Ann. Neurol. 2016 79 206 216 10.1002/ana.24554 26537743 

  79. 79. Cree B.A. Lamb S. Morgan K. Chen A. Waubant E. Genain C. An open label study of the effects of rituximab in neuromyelitis optica Neurology 2005 64 1270 1272 10.1212/01.WNL.0000159399.81861.D5 15824362 

  80. 80. Gredler V. Mader S. Schanda K. Hegen H. Di Pauli F. Kuenz B. Deisenhammer F. Berger T. Reindl M. Lutterotti A. Clinical and immunological follow-up of B-cell depleting therapy in CNS demyelinating diseases J. Neurol. Sci. 2013 328 77 82 10.1016/j.jns.2013.02.024 23522498 

  81. 81. Mealy M.A. Kim S.H. Schmidt F. Lopez R. Jimenez Arango J.A. Paul F. Wingerchuk D.M. Greenberg B.M. Kim H.J. Levy M. Aquaporin-4 serostatus does not predict response to immunotherapy in neuromyelitis optica spectrum disorders Mult. Scler. 2018 24 1737 1742 10.1177/1352458517730131 28857723 

  82. 82. Sfikakis P.P. Souliotis V.L. Fragiadaki K.G. Moutsopoulos H.M. Boletis J.N. Theofilopoulos A.N. Increased expression of the FoxP3 functional marker of regulatory T cells following B cell depletion with rituximab in patients with lupus nephritis Clin. Immunol. 2007 123 66 73 10.1016/j.clim.2006.12.006 17275413 

  83. 83. Reis E.A. Athanazio D.A. Lima I. Oliveira e Silva N. Andrade J.C. Jesus R.N. Barbosa L.M. Reis M.G. Santiago M.B. NK and NKT cell dynamics after rituximab therapy for systemic lupus erythematosus and rheumatoid arthritis Rheumatol. Int. 2009 29 469 475 10.1007/s00296-008-0719-0 18821073 

  84. 84. Tradtrantip L. Zhang H. Saadoun S. Phuan P.W. Lam C. Papadopoulos M.C. Bennett J.L. Verkman A.S. Anti-aquaporin-4 monoclonal antibody blocker therapy for neuromyelitis optica Ann. Neurol. 2012 71 314 322 10.1002/ana.22657 22271321 

  85. 85. Soltys J.N. Meyer S.A. Schumann H. Gibson E.A. Restrepo D. Bennett J.L. Determining the Spatial Relationship of Membrane-Bound Aquaporin-4 Autoantibodies by STED Nanoscopy Biophys. J. 2017 112 1692 1702 10.1016/j.bpj.2017.03.012 28445760 

  86. 86. Mao X. Enno T.L. Del Bigio M.R. Aquaporin 4 changes in rat brain with severe hydrocephalus Eur. J. Neurosci. 2006 23 2929 2936 10.1111/j.1460-9568.2006.04829.x 16819982 

  87. 87. Skjolding A.D. Rowland I.J. Sogaard L.V. Praetorius J. Penkowa M. Juhler M. Hydrocephalus induces dynamic spatiotemporal regulation of aquaporin-4 expression in the rat brain Cereb. Fluid Res. 2010 7 20 10.1186/1743-8454-7-20 21054845 

  88. 88. Tourdias T. Dragonu I. Fushimi Y. Deloire M.S. Boiziau C. Brochet B. Moonen C. Petry K.G. Dousset V. Aquaporin 4 correlates with apparent diffusion coefficient and hydrocephalus severity in the rat brain: A combined MRI-histological study Neuroimage 2009 47 659 666 10.1016/j.neuroimage.2009.04.070 19409501 

  89. 89. Bloch O. Auguste K.I. Manley G.T. Verkman A.S. Accelerated progression of kaolin-induced hydrocephalus in aquaporin-4-deficient mice J. Cereb. Blood Flow Metab. 2006 26 1527 1537 10.1038/sj.jcbfm.9600306 16552421 

  90. 90. Castaneyra-Ruiz L. Gonzalez-Marrero I. Gonzalez-Toledo J.M. Castaneyra-Ruiz A. de Paz-Carmona H. Castaneyra-Perdomo A. Carmona-Calero E.M. Aquaporin-4 expression in the cerebrospinal fluid in congenital human hydrocephalus Fluids Barriers CNS 2013 10 18 10.1186/2045-8118-10-18 23659378 

  91. 91. Clardy S.L. Lucchinetti C.F. Krecke K.N. Lennon V.A. O’Toole O. Weinshenker B.G. Boyd C.D. Krieger S. McGraw C. Guo Y. Hydrocephalus in neuromyelitis optica Neurology 2014 82 1841 1843 10.1212/WNL.0000000000000428 24759842 

  92. 92. Magana S.M. Matiello M. Pittock S.J. McKeon A. Lennon V.A. Rabinstein A.A. Shuster E. Kantarci O.H. Lucchinetti C.F. Weinshenker B.G. Posterior reversible encephalopathy syndrome in neuromyelitis optica spectrum disorders Neurology 2009 72 712 717 10.1212/01.wnl.0000343001.36493.ae 19237699 

  93. 93. Iliff J.J. Wang M. Liao Y. Plogg B.A. Peng W. Gundersen G.A. Benveniste H. Vates G.E. Deane R. Goldman S.A. A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid beta Sci. Transl. Med. 2012 4 147ra111 10.1126/scitranslmed.3003748 22896675 

  94. 94. Rasmussen M.K. Mestre H. Nedergaard M. The glymphatic pathway in neurological disorders Lancet Neurol. 2018 17 1016 1024 10.1016/S1474-4422(18)30318-1 30353860 

  95. 95. Karran E. Mercken M. De Strooper B. The amyloid cascade hypothesis for Alzheimer’s disease: An appraisal for the development of therapeutics Nat. Rev. Drug Discov. 2011 10 698 712 10.1038/nrd3505 21852788 

  96. 96. Shokri-Kojori E. Wang G.J. Wiers C.E. Demiral S.B. Guo M. Kim S.W. Lindgren E. Ramirez V. Zehra A. Freeman C. beta-Amyloid accumulation in the human brain after one night of sleep deprivation Proc. Natl. Acad. Sci. USA 2018 115 4483 4488 10.1073/pnas.1721694115 29632177 

  97. 97. Rainey-Smith S.R. Mazzucchelli G.N. Villemagne V.L. Brown B.M. Porter T. Weinborn M. Bucks R.S. Milicic L. Sohrabi H.R. Taddei K. Genetic variation in Aquaporin-4 moderates the relationship between sleep and brain Abeta-amyloid burden Transl. Psychiatry 2018 8 47 10.1038/s41398-018-0094-x 29479071 

  98. 98. Smith A.J. Verkman A.S. The “glymphatic” mechanism for solute clearance in Alzheimer’s disease: Game changer or unproven speculation? FASEB J. 2018 32 543 551 10.1096/fj.201700999 29101220 

  99. 99. Yang J. Li M.X. Luo Y. Chen T. Liu J. Fang P. Jiang B. Hu Z.L. Jin Y. Chen J.G. Chronic ceftriaxone treatment rescues hippocampal memory deficit in AQP4 knockout mice via activation of GLT-1 Neuropharmacology 2013 75 213 222 10.1016/j.neuropharm.2013.08.009 23973312 

  100. 100. Jessen N.A. Munk A.S. Lundgaard I. Nedergaard M. The Glymphatic System: A Beginner’s Guide Neurochem. Res. 2015 40 2583 2599 10.1007/s11064-015-1581-6 25947369 

  101. 101. Louveau A. Plog B.A. Antila S. Alitalo K. Nedergaard M. Kipnis J. Understanding the functions and relationships of the glymphatic system and meningeal lymphatics J. Clin. Investig. 2017 127 3210 3219 10.1172/JCI90603 28862640 

  102. 102. Zeng X.N. Sun X.L. Gao L. Fan Y. Ding J.H. Hu G. Aquaporin-4 deficiency down-regulates glutamate uptake and GLT-1 expression in astrocytes Mol. Cell. Neurosci. 2007 34 34 39 10.1016/j.mcn.2006.09.008 17074507 

  103. 103. Papadopoulos M.C. Verkman A.S. Potential utility of aquaporin modulators for therapy of brain disorders Prog. Brain Res. 2008 170 589 601 18655912 

  104. 104. Pirici I. Balsanu T.A. Bogdan C. Margaritescu C. Divan T. Vitalie V. Mogoanta L. Pirici D. Carare R.O. Muresanu D.F. Inhibition of Aquaporin-4 Improves the Outcome of Ischaemic Stroke and Modulates Brain Paravascular Drainage Pathways Int. J. Mol. Sci. 2017 19 46 10.3390/ijms19010046 29295526 

  105. 105. Misu T. Fujihara K. Kakita A. Konno H. Nakamura M. Watanabe S. Takahashi T. Nakashima I. Takahashi H. Itoyama Y. Loss of aquaporin 4 in lesions of neuromyelitis optica: Distinction from multiple sclerosis Brain 2007 130 1224 1234 10.1093/brain/awm047 17405762 

  106. 106. Tradtrantip L. Felix C.M. Spirig R. Morelli A.B. Verkman A.S. Recombinant IgG1 Fc hexamers block cytotoxicity and pathological changes in experimental in vitro and rat models of neuromyelitis optica Neuropharmacology 2018 133 345 353 10.1016/j.neuropharm.2018.02.002 29428821 

  107. 107. Xu Z. Xiao N. Chen Y. Huang H. Marshall C. Gao J. Cai Z. Wu T. Hu G. Xiao M. Deletion of aquaporin-4 in APP/PS1 mice exacerbates brain Abeta accumulation and memory deficits Mol. Neurodegener. 2015 10 58 10.1186/s13024-015-0056-1 26526066 

  108. 108. Foglio E. Rodella L.F. Aquaporins and neurodegenerative diseases Curr. Neuropharmacol. 2010 8 112 121 10.2174/157015910791233150 21119882 

  109. 109. Watanabe-Matsumoto S. Moriwaki Y. Okuda T. Ohara S. Yamanaka K. Abe Y. Yasui M. Misawa H. Dissociation of blood-brain barrier disruption and disease manifestation in an aquaporin-4-deficient mouse model of amyotrophic lateral sclerosis Neurosci. Res. 2018 133 48 57 10.1016/j.neures.2017.11.001 29154923 

  110. 110. Prydz A. Stahl K. Puchades M. Davarpaneh N. Nadeem M. Ottersen O.P. Gundersen V. Amiry-Moghaddam M. Subcellular expression of aquaporin-4 in substantia nigra of normal and MPTP-treated mice Neuroscience 2017 359 258 266 10.1016/j.neuroscience.2017.07.029 28735099 

  111. 111. Hoshi A. Tsunoda A. Tada M. Nishizawa M. Ugawa Y. Kakita A. Expression of Aquaporin 1 and Aquaporin 4 in the Temporal Neocortex of Patients with Parkinson’s Disease Brain Pathol. 2017 27 160 168 10.1111/bpa.12369 26919570 

  112. 112. Fan Y. Kong H. Shi X. Sun X. Ding J. Wu J. Hu G. Hypersensitivity of aquaporin 4-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine and astrocytic modulation Neurobiol. Aging 2008 29 1226 1236 10.1016/j.neurobiolaging.2007.02.015 17353068 

  113. 113. Desai B. Hsu Y. Schneller B. Hobbs J.G. Mehta A.I. Linninger A. Hydrocephalus: The role of cerebral aquaporin-4 channels and computational modeling considerations of cerebrospinal fluid Neurosurg. Focus 2016 41 E8 10.3171/2016.7.FOCUS16191 27581320 

  114. 114. Tome-Garcia J. Erfani P. Nudelman G. Tsankov A.M. Katsyv I. Tejero R. Bin Z. Walsh M. Friedel R.H. Zaslavsky E. Analysis of chromatin accessibility uncovers TEAD1 as a regulator of migration in human glioblastoma Nat. Commun. 2018 9 4020 10.1038/s41467-018-06258-2 30275445 

  115. 115. Maugeri R. Schiera G. Di Liegro C.M. Fricano A. Iacopino D.G. Di Liegro I. Aquaporins and Brain Tumors Int. J. Mol. Sci. 2016 17 778 784 10.3390/ijms17071029 27367682 

  116. 116. Katsel P. Byne W. Roussos P. Tan W. Siever L. Haroutunian V. Astrocyte and glutamate markers in the superficial, deep, and white matter layers of the anterior cingulate gyrus in schizophrenia Neuropsychopharmacology 2011 36 1171 1177 10.1038/npp.2010.252 21270770 

  117. 117. Rajkowska G. Hughes J. Stockmeier C.A. Javier Miguel-Hidalgo J. Maciag D. Coverage of blood vessels by astrocytic endfeet is reduced in major depressive disorder Biol. Psychiatry 2013 73 613 621 10.1016/j.biopsych.2012.09.024 23146357 

  118. 118. Lee T.S. Eid T. Mane S. Kim J.H. Spencer D.D. Ottersen O.P. de Lanerolle N.C. Aquaporin-4 is increased in the sclerotic hippocampus in human temporal lobe epilepsy Acta Neuropathol. 2004 108 493 502 10.1007/s00401-004-0910-7 15517312 

  119. 119. Binder D.K. Oshio K. Ma T. Verkman A.S. Manley G.T. Increased seizure threshold in mice lacking aquaporin-4 water channels Neuroreport 2004 15 259 262 10.1097/00001756-200402090-00009 15076748 

  120. 120. Edmonson C. Ziats M.N. Rennert O.M. Altered glial marker expression in autistic post-mortem prefrontal cortex and cerebellum Mol. Autism 2014 5 3 10.1186/2040-2392-5-3 24410870 

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