[논문]Detection of lawsone (2-hydroxy-1,4-naphthoquinone) in henna treated hair

Petzel-Witt, Silvana; Meier, Sylvia I.; Schubert-Zsilavecz, Manfred; Toennes, Stefan W.

doi:10.1016/j.forsciint.2019.01.037

Detection of lawsone (2-hydroxy-1,4-naphthoquinone) in henna treated hair

Forensic science international, v.297, 2019년, pp.184 - 188

Petzel-Witt, Silvana (Institute of Legal Medicine, Goethe-University Frankfurt) , Meier, Sylvia I. (Institute of Legal Medicine, Goethe-University Frankfurt) , Schubert-Zsilavecz, Manfred (Institute for Pharmaceutical Chemistry, Goethe-University Frankfurt) , Toennes, Stefan W. (Institute of Legal Medicine, Goethe-University Frankfurt)

Abstract ▼ AI-Helper

Abstract Hair analysis plays an important role in abstinence control in forensic toxicology. However, hair coloration affects the concentrations of xenobiotics and may lead to false negative results. For instance, henna has been shown to decrease ethyl glucuronide concentrations in hair. For analysis of the main henna ingredient lawsone (2-hydroxy-1,4-naphthoquinone), hair samples were washed, cut into small pieces (less than 5 mm), incubated (20 mg) in water and with internal standard (theophylline) for 24 h at 37 °C. Lawsone was analyzed in the supernatant using liquid chromatography with diode array detection. For quantitative assay, the absorption at 280 nm was found to be linear up to 250 ng/mg hair. The detection limit of lawsone was 2.2 ng/mg, precision and accuracy were better than 6%. Lawsone was only detectable in 12 henna-colored hair samples in concentrations from 27.3 to 253.7 (median 92.6) ng/mg. The analysis of lawsone is recommended in cases of suspected hair coloration where assessment of oxidative treatment was negative (e.g. no increase of 1H-pyrrole-2,3,5-tricarboxylic acid (PTCA) and unobtrusive fluorescence microscopy). Highlights Henna coloration is able to reduce ethyl glucuronide concentrations in hair. Lawsone is the coloring agent in henna. Lawsone can be analyzed with liquid chromatography with a diode array detector. Method can be used in combination with fluorescence microscopy or PTCA concentration. Forensic hair sample was tested positive for henna treatment with this method. Graphical abstract [DISPLAY OMISSION]

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참고문헌 (28)

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Detection of lawsone (2-hydroxy-1,4-naphthoquinone) in henna treated hair

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