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Corosolic acid isolated from Eriobotrya japonica leaves reduces glucose level in human hepatocellular carcinoma cells, zebrafish and rats 원문보기

Scientific reports, v.9, 2019년, pp.4388 -   

Xu, Shuwen (Center for New Drug Research and Development, College of Life Science, Nanjing Normal University, Nanjing, 210023 People’s Republic of China) ,  Wang, Gang (Center for New Drug Research and Development, College of Life Science, Nanjing Normal University, Nanjing, 210023 People’s Republic of China) ,  Peng, Wei (Center for New Drug Research and Development, College of Life Science, Nanjing Normal University, Nanjing, 210023 People’s Republic of China) ,  Xu, Yandi (Center for New Drug Research and Development, College of Life Science, Nanjing Normal University, Nanjing, 210023 People’s Republic of China) ,  Zhang, Yu (Center for New Drug Research and Development, College of Life Science, Nanjing Normal University, Nanjing, 210023 People’s Republic of China) ,  Ge, Ying (Center for New Drug Research and Development, College of Life Science, Nanjing Normal University, Nanjing, 210023 People’s Republic of China) ,  Jing, Yue (Central Laboratory of Stomatology, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, 210008 People) ,  Gong, Zhunan

Abstract AI-Helper 아이콘AI-Helper

Type 2 diabetes (T2D) with high morbidity and mortality is characterized by abnormal glucose and lipid metabolism due in part to insulin resistance in liver, which lead to elevated hyperglycemia and hyperlipidemia. This study sough to explore the effects of corosolic acid (CA) in different T2D model...

참고문헌 (50)

  1. 1. Hartstra AV Bouter KE Backhed F Nieuwdorp M Insights into the role of the microbiome in obesity and type 2 diabetes Diabetes care 2015 38 159 165 10.2337/dc14-0769 25538312 

  2. 2. Liu X Glucosidase inhibitory activity and antioxidant activity of flavonoid compound and triterpenoid compound from Agrimonia Pilosa Ledeb BMC complementary and alternative medicine 2014 14 12 10.1186/1472-6882-14-12 24410924 

  3. 3. Lee SY Rhodiola crenulata extract suppresses hepatic gluconeogenesis via activation of the AMPK pathway Phytomedicine 2015 22 477 486 10.1016/j.phymed.2015.01.016 25925970 

  4. 4. Theodoulou FL Eastmond PJ Seed storage oil catabolism: a story of give and take Current opinion in plant biology 2012 15 322 328 10.1016/j.pbi.2012.03.017 22516438 

  5. 5. Waltner-Law M Elements of the glucocorticoid and retinoic acid response units are involved in cAMP-mediated expression of the PEPCK gene J Biol Chem 2003 278 10427 10435 10.1074/jbc.M211846200 12531892 

  6. 6. Cournarie F The inhibitory effect of glucose on phosphoenolpyruvate carboxykinase gene expression in cultured hepatocytes is transcriptional and requires glucose metabolism FEBS letters 1999 460 527 532 10.1016/S0014-5793(99)01407-6 10556529 

  7. 7. Tang Y Overexpression of PCK1 Gene Antagonizes Hepatocellular Carcinoma Through the Activation of Gluconeogenesis and Suppression of Glycolysis Pathways Cell Physiol Biochem 2018 47 344 355 10.1159/000489811 29768256 

  8. 8. Judy WV Antidiabetic activity of a standardized extract (Glucosol) from Lagerstroemia speciosa leaves in Type II diabetics. A dose-dependence study Journal of ethnopharmacology 2003 87 115 117 10.1016/S0378-8741(03)00122-3 12787964 

  9. 9. Senat MV Effect of Glyburide vs Subcutaneous Insulin on Perinatal Complications Among Women With Gestational Diabetes: A Randomized Clinical Trial Jama 2018 319 1773 1780 10.1001/jama.2018.4072 29715355 

  10. 10. Abuissa H Jones PG Marso SP O’Keefe JH Jr. Angiotensin-converting enzyme inhibitors or angiotensin receptor blockers for prevention of type 2 diabetes: a meta-analysis of randomized clinical trials Journal of the American College of Cardiology 2005 46 821 826 10.1016/j.jacc.2005.05.051 16139131 

  11. 11. Wu PP Zhang K Lu YJ He P Zhao SQ In vitro and in vivo evaluation of the antidiabetic activity of ursolic acid derivatives European journal of medicinal chemistry 2014 80 502 508 10.1016/j.ejmech.2014.04.073 24813878 

  12. 12. Hou W Triterpene acids isolated from Lagerstroemia speciosa leaves as alpha-glucosidase inhibitors Phytotherapy Research 2009 23 614 618 10.1002/ptr.2661 19107840 

  13. 13. Liby KT Yore MM Sporn MB Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer Nature reviews. Cancer 2007 7 357 369 10.1038/nrc2129 17446857 

  14. 14. Zong W Zhao G Corosolic acid isolation from the leaves of Eriobotrta japonica showing the effects on carbohydrate metabolism and differentiation of 3T3-L1 adipocytes Asia Pacific journal of clinical nutrition 2007 16 Suppl 1 346 352 17392131 

  15. 15. Park SH Oh SR Ahn KS Kim JG Lee HK Structure determination of a new lupane-type triterpene, tiarellic acid, isolated from Tiarella polyphylla Archives of pharmacal research 2002 25 57 60 10.1007/BF02975262 11885693 

  16. 16. Woo, S. M. et al . Corosolic Acid Induces Non-Apoptotic Cell Death through Generation of Lipid Reactive Oxygen Species Production in Human Renal Carcinoma Caki Cells. International journal of molecular sciences 19 , 10.3390/ijms19051309 (2018). 

  17. 17. Liu Q Determination of corosolic acid, a natural potential anti-diabetes compound, in rat plasma by high-performance liquid chromatography-mass spectrometry and its application to pharmacokinetic and bioavailability studies Planta medica 2011 77 1707 1711 10.1055/s-0030-1270993 21484671 

  18. 18. Fukushima M Effect of corosolic acid on postchallenge plasma glucose levels Diabetes research and clinical practice 2006 73 174 177 10.1016/j.diabres.2006.01.010 16549220 

  19. 19. Wen X Pentacyclic triterpenes. Part 5: synthesis and SAR study of corosolic acid derivatives as inhibitors of glycogen phosphorylases Bioorganic & medicinal chemistry letters 2007 17 5777 5782 10.1016/j.bmcl.2007.08.057 17869102 

  20. 20. Shi L Corosolic acid stimulates glucose uptake via enhancing insulin receptor phosphorylation European journal of pharmacology 2008 584 21 29 10.1016/j.ejphar.2008.01.020 18348886 

  21. 21. Jayakumar KS Corosolic acid content and SSR markers in Lagerstroemia speciosa (L.) Pers.: a comparative analysis among populations across the Southern Western Ghats of India Phytochemistry 2014 106 94 103 10.1016/j.phytochem.2014.07.004 25092227 

  22. 22. Sivakumar G Vail DR Nair V Medina-Bolivar F Lay JO Jr. Plant-based corosolic acid: future anti-diabetic drug? Biotechnol J 2009 4 1704 1711 10.1002/biot.200900207 19946881 

  23. 23. Tidke PS Patil CR Nrf2 activator corosolic acid meliorates alloxan induced diabetic nephropathy in mice Asian Pacific Journal of Tropical Biomedicine 2017 7 797 804 10.1016/j.apjtb.2017.08.010 

  24. 24. Miura T Antidiabetic effects of corosolic acid in KK-Ay diabetic mice Biological & pharmaceutical bulletin 2006 29 585 587 10.1248/bpb.29.585 16508174 

  25. 25. Miura T Takagi S Ishida T Management of Diabetes and Its Complications with Banaba (Lagerstroemia speciosa L.) and Corosolic Acid Evidence-based complementary and alternative medicine: eCAM 2012 2012 871495 10.1155/2012/871495 23082086 

  26. 26. Kang M-C Protective effect of fucoxanthin isolated from Ishige okamurae against high-glucose induced oxidative stress in human umbilical vein endothelial cells and zebrafish model Journal of Functional Foods 2014 11 304 312 10.1016/j.jff.2014.09.007 

  27. 27. Elo B Villano CM Govorko D White LA Larval zebrafish as a model for glucose metabolism: expression of phosphoenolpyruvate carboxykinase as a marker for exposure to anti-diabetic compounds J Mol Endocrinol 2007 38 433 440 10.1677/JME-06-0037 17446233 

  28. 28. Maddison LA Chen WB Nutrient Excess Stimulates beta-Cell Neogenesis in Zebrafish Diabetes 2012 61 2517 2524 10.2337/db11-1841 22721970 

  29. 29. Li, E.-N., Zhou, G.-D. & Kong, L.-Y. Chemical Constituents from the Leaves of Eriobotrya japonica . Vol. 7 (2009). 

  30. 30. Yang J Kalhan SC Hanson RW What is the metabolic role of phosphoenolpyruvate carboxykinase? J Biol Chem 2009 284 27025 27029 10.1074/jbc.R109.040543 19636077 

  31. 31. Montal ED PEPCK Coordinates the Regulation of Central Carbon Metabolism to Promote Cancer Cell Growth Mol Cell 2015 60 571 583 10.1016/j.molcel.2015.09.025 26481663 

  32. 32. Michel M Page-McCaw PS Chen W Cone RD Leptin signaling regulates glucose homeostasis, but not adipostasis, in the zebrafish Proc Natl Acad Sci USA 2016 113 3084 3089 10.1073/pnas.1513212113 26903647 

  33. 33. Gao HX Regier EE Close KL International Diabetes Federation World Diabetes Congress 2015 Journal of diabetes 2016 8 300 302 10.1111/1753-0407.12377 26778343 

  34. 34. Lebovitz HE Insulin resistance–a common link between type 2 diabetes and cardiovascular disease Diabetes, obesity & metabolism 2006 8 237 249 10.1111/j.1463-1326.2005.00521.x 

  35. 35. Ren B Apigenin and naringenin regulate glucose and lipid metabolism, and ameliorate vascular dysfunction in type 2 diabetic rats European journal of pharmacology 2016 773 13 23 10.1016/j.ejphar.2016.01.002 26801071 

  36. 36. Cersosimo E DeFronzo RA Insulin resistance and endothelial dysfunction: the road map to cardiovascular diseases Diabetes/metabolism research and reviews 2006 22 423 436 10.1002/dmrr.634 16506274 

  37. 37. Ha do T Selected compounds derived from Moutan Cortex stimulated glucose uptake and glycogen synthesis via AMPK activation in human HepG2 cells Journal of ethnopharmacology 2010 131 417 424 10.1016/j.jep.2010.07.010 20633632 

  38. 38. Penno, G. et al . Non-albuminuric renal impairment is a strong predictor of mortality in individuals with type 2 diabetes: the Renal Insufficiency And Cardiovascular Events (RIACE) Italian multicentre study. Diabetologia , 10.1007/s00125-018-4691-2 (2018). 

  39. 39. Engel N Oppermann C Falodun A Kragl U Proliferative effects of five traditional Nigerian medicinal plant extracts on human breast and bone cancer cell lines Journal of ethnopharmacology 2011 137 1003 1010 10.1016/j.jep.2011.07.023 21782919 

  40. 40. Kashyap D Tuli HS Sharma AK Ursolic acid (UA): A metabolite with promising therapeutic potential Life sciences 2016 146 201 213 10.1016/j.lfs.2016.01.017 26775565 

  41. 41. Hamid K Tetracyclic triterpenoids in herbal medicines and their activities in diabetes and its complications Curr Top Med Chem 2015 15 2406 2430 10.2174/1568026615666150619141940 26088353 

  42. 42. Stohs SJ Miller H Kaats GR A review of the efficacy and safety of banaba (Lagerstroemia speciosa L.) and corosolic acid Phytotherapy research: PTR 2012 26 317 324 10.1002/ptr.3664 22095937 

  43. 43. Miura T Corosolic acid induces GLUT4 translocation in genetically type 2 diabetic mice Biological & pharmaceutical bulletin 2004 27 1103 1105 10.1248/bpb.27.1103 15256748 

  44. 44. Cheng K Zhang P Liu J Xie J Sun H Practical synthesis of bredemolic acid, a natural inhibitor of glycogen phosphorylase J Nat Prod 2008 71 1877 1880 10.1021/np8003886 18847277 

  45. 45. Yamada K Dietary corosolic acid ameliorates obesity and hepatic steatosis in KK-Ay mice Biological & pharmaceutical bulletin 2008 31 651 655 10.1248/bpb.31.651 18379057 

  46. 46. Yamada K Effect of corosolic acid on gluconeogenesis in rat liver Diabetes research and clinical practice 2008 80 48 55 10.1016/j.diabres.2007.11.011 18177973 

  47. 47. Davies GF Khandelwal RL Wu L Juurlink BH Roesler WJ Inhibition of phosphoenolpyruvate carboxykinase (PEPCK) gene expression by troglitazone: a peroxisome proliferator-activated receptor-gamma (PPARgamma)-independent, antioxidant-related mechanism Biochemical pharmacology 2001 62 1071 1079 10.1016/S0006-2952(01)00764-X 11597575 

  48. 48. Rennekamp AJ Peterson RT 15 years of zebrafish chemical screening Current opinion in chemical biology 2015 24 58 70 10.1016/j.cbpa.2014.10.025 25461724 

  49. 49. Asaoka Y Terai S Sakaida I Nishina H The expanding role of fish models in understanding non-alcoholic fatty liver disease Dis Model Mech 2013 6 905 914 10.1242/dmm.011981 23720231 

  50. 50. Manigandan K Jayaraj RL Jagatheesh K Elangovan N Taxifolin mitigates oxidative DNA damage in vitro and protects zebrafish (Danio rerio) embryos against cadmium toxicity Environ Toxicol Pharmacol 2015 39 1252 1261 10.1016/j.etap.2015.04.021 26002187 

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