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NTIS 바로가기Scientific reports, v.9, 2019년, pp.4862 -
Yao, Wen (0000 0004 1936 8796grid.430387.bDepartment of Pharmacology, Physiology & Neuroscience New Jersey Medical School, Brain Health Institute, Jacqueline Krieger Klein Center in Alzheimer’s Disease and Neurodegeneration Research, Rutgers, The State University of New Jersey, 185 South Orange Ave, Newark, NJ 07103 USA) , Yin, Tao (0000 0004 1936 8796grid.430387.bDepartment of Pharmacology, Physiology & Neuroscience New Jersey Medical School, Brain Health Institute, Jacqueline Krieger Klein Center in Alzheimer’s Disease and Neurodegeneration Research, Rutgers, The State University of New Jersey, 185 South Orange Ave, Newark, NJ 07103 USA) , Tambini, Marc D. (0000 0004 1936 8796grid.430387.bDepartment of Pharmacology, Physiology & Neuroscience New Jersey Medical School, Brain Health Institute, Jacqueline Krieger Klein Center in Alzheimer’s Disease and Neurodegeneration Research, Rutgers, The State University of New Jersey, 185 South Orange Ave, Newark, NJ 07103 USA) , D’Adamio, Luciano (0000 0004 1936 8796grid.430387.bDepartment of Pharma)
Mutations in the Integral membrane protein 2B (ITM2b/BRI2) gene, which codes for a protein called BRI2, cause familial British and Danish dementia (FBD and FDD). Loss of BRI2 function and/or accumulation of amyloidogenic mutant BRI2-derived peptides have been proposed to mediate FDD and FBD pathogen...
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