$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

Effects of quercetin supplementation on glycemic control among patients with metabolic syndrome and related disorders: A systematic review and meta‐analysis of randomized controlled trials

Phytotherapy research : PTR, v.33 no.5, 2019년, pp.1330 - 1340  

Ostadmohammadi, Vahidreza (Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran) ,  Milajerdi, Alireza (Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran) ,  Ayati, Elnaz (Reproductive Health Research Center, Tehran University of Medical Science, Tehran, Iran) ,  Kolahdooz, Fariba (Indigenous and Global Health Research, Department of Medicine, University of Alberta, Edmonton, Canada) ,  Asemi, Zatollah (Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran)

Abstract AI-Helper 아이콘AI-Helper

This systematic review and meta‐analysis of randomized controlled trials was performed to determine the effect of quercetin supplementation on glycemic control among patients with metabolic syndrome and related disorders. Databases including PubMed, MEDLINE, EMBASE, Web of Science, and Cochran...

주제어

참고문헌 (42)

  1. Akbari , M. , Ostadmohammadi , V. , Lankarani , K. B. , Tabrizi , R. , Kolahdooz , F. , Khatibi , S. R. , & Asemi , Z. ( 2018 ). The effects of alpha‐lipoic acid supplementation on glucose control and lipid profiles among patients with metabolic diseases: A systematic review and meta‐analysis of randomized controlled trials . Metabolism , 87 , 56 – 69 . https://doi.org/10.1016/j.metabol.2018.07.002 

  2. Andres , S. , Pevny , S. , Ziegenhagen , R. , Bakhiya , N. , Schafer , B. , Hirsch‐Ernst , K. I. , & Lampen , A. ( 2018 ). Safety aspects of the use of quercetin as a dietary supplement . Molecular Nutrition & Food Research , 62 ( 1 ). https://doi.org/10.1002/mnfr.201700447 

  3. Askari , G. , Ghiasvand , R. , Feizi , A. , Ghanadian , S. M. , & Karimian , J. ( 2012 ). The effect of quercetin supplementation on selected markers of inflammation and oxidative stress . Journal of Research in Medical Sciences : The Official Journal of Isfahan University of Medical Sciences , 17 ( 7 ), 637 – 641 . 

  4. Biesinger , S. , Michaels , H. A. , Quadros , A. S. , Qian , Y. , Rabovsky , A. B. , Badger , R. S. , & Jalili , T. ( 2016 ). A combination of isolated phytochemicals and botanical extracts lowers diastolic blood pressure in a randomized controlled trial of hypertensive subjects . European Journal of Clinical Nutrition , 70 ( 1 ), 10 – 16 . https://doi.org/10.1038/ejcn.2015.88 

  5. Bondonno , N. P. , Bondonno , C. P. , Rich , L. , Mas , E. , Shinde , S. , Ward , N. C. , … Croft , K. D. ( 2016 ). Acute effects of quercetin‐3‐O‐glucoside on endothelial function and blood pressure: A randomized dose‐response study . The American Journal of Clinical Nutrition , 104 ( 1 ), 97 – 103 . https://doi.org/10.3945/ajcn.116.131268 

  6. Boots , A. W. , Wilms , L. C. , Swennen , E. L. , Kleinjans , J. C. , Bast , A. , & Haenen , G. R. ( 2008 ). In vitro and ex vivo anti‐inflammatory activity of quercetin in healthy volunteers . Nutrition , 24 ( 7–8 ), 703 – 710 . https://doi.org/10.1016/j.nut.2008.03.023 

  7. Brull , V. , Burak , C. , Stoffel‐Wagner , B. , Wolffram , S. , Nickenig , G. , Muller , C. , … Zimmermann , B. F. ( 2015 ). Effects of a quercetin‐rich onion skin extract on 24 h ambulatory blood pressure and endothelial function in overweight‐to‐obese patients with (pre‐)hypertension: A randomised double‐blinded placebo‐controlled cross‐over trial . The British Journal of Nutrition , 114 ( 8 ), 1263 – 1277 . https://doi.org/10.1017/s0007114515002950 

  8. Brull , V. , Burak , C. , Stoffel‐Wagner , B. , Wolffram , S. , Nickenig , G. , Muller , C. , … Egert , S. ( 2017 ). No effects of quercetin from onion skin extract on serum leptin and adiponectin concentrations in overweight‐to‐obese patients with (pre‐)hypertension: A randomized double‐blinded, placebo‐controlled crossover trial . European Journal of Nutrition , 56 ( 7 ), 2265 – 2275 . https://doi.org/10.1007/s00394‐016‐1267‐0 

  9. Chen , S. , Jiang , H. , Wu , X. , & Fang , J. ( 2016 ). Therapeutic effects of quercetin on inflammation, obesity, and type 2 diabetes . Mediators of Inflammation , 2016 , 9340637. https://doi.org/10.1155/2016/9340637, 1 – 5 . 

  10. Choi , E. Y. , Lee , H. , Woo , J. S. , Jang , H. H. , Hwang , S. J. , Kim , H. S. , … Kim , W. ( 2015 ). Effect of onion peel extract on endothelial function and endothelial progenitor cells in overweight and obese individuals . Nutrition , 31 ( 9 ), 1131 – 1135 . https://doi.org/10.1016/j.nut.2015.04.020 

  11. Conquer , J. A. , Maiani , G. , Azzini , E. , Raguzzini , A. , & Holub , B. J. ( 1998 ). Supplementation with quercetin markedly increases plasma quercetin concentration without effect on selected risk factors for heart disease in healthy subjects . The Journal of Nutrition , 128 ( 3 ), 593 – 597 . https://doi.org/10.1093/jn/128.3.593 

  12. Dower , J. I. , Geleijnse , J. M. , Gijsbers , L. , Zock , P. L. , Kromhout , D. , & Hollman , P. C. ( 2015 ). Effects of the pure flavonoids epicatechin and quercetin on vascular function and cardiometabolic health: A randomized, double‐blind, placebo‐controlled, crossover trial . The American Journal of Clinical Nutrition , 101 ( 5 ), 914 – 921 . https://doi.org/10.3945/ajcn.114.098590 

  13. Edwards , R. L. , Lyon , T. , Litwin , S. E. , Rabovsky , A. , Symons , J. D. , & Jalili , T. ( 2007 ). Quercetin reduces blood pressure in hypertensive subjects . The Journal of Nutrition , 137 ( 11 ), 2405 – 2411 . https://doi.org/10.1093/jn/137.11.2405 

  14. Egert , S. , Boesch‐Saadatmandi , C. , Wolffram , S. , Rimbach , G. , & Muller , M. J. ( 2010 ). Serum lipid and blood pressure responses to quercetin vary in overweight patients by apolipoprotein E genotype . The Journal of Nutrition , 140 ( 2 ), 278 – 284 . https://doi.org/10.3945/jn.109.117655 

  15. Egert , S. , Bosy‐Westphal , A. , Seiberl , J. , Kurbitz , C. , Settler , U. , Plachta‐Danielzik , S. , … Wolffram , S. ( 2009 ). Quercetin reduces systolic blood pressure and plasma oxidised low‐density lipoprotein concentrations in overweight subjects with a high‐cardiovascular disease risk phenotype: A double‐blinded, placebo‐controlled cross‐over study . The British Journal of Nutrition , 102 ( 7 ), 1065 – 1074 . https://doi.org/10.1017/s0007114509359127 

  16. Eid , H. M. , & Haddad , P. S. ( 2017 ). The antidiabetic potential of quercetin: Underlying mechanisms . Current Medicinal Chemistry , 24 ( 4 ), 355 – 364 . https://doi.org/10.2174/0929867323666160909153707 

  17. Eid , H. M. , Nachar , A. , Thong , F. , Sweeney , G. , & Haddad , P. S. ( 2015 ). The molecular basis of the antidiabetic action of quercetin in cultured skeletal muscle cells and hepatocytes . Pharmacognosy Magazine , 11 ( 41 ), 74 – 81 . https://doi.org/10.4103/0973‐1296.149708 

  18. Ford , E. S. ( 2005 ). Risks for all‐cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: A summary of the evidence . Diabetes Care , 28 ( 7 ), 1769 – 1778 . https://doi.org/10.2337/diacare.28.7.1769 

  19. Javadi , F. , Eghtesadi , S. , Ahmadzadeh , A. , Aryaeian , N. , Zabihiyeganeh , M. , Foroushani , A. R. , & Jazayeri , S. ( 2014 ). The effect of quercetin on plasma oxidative status, C‐reactive protein and blood pressure in women with rheumatoid arthritis . International Journal of Preventive Medicine , 5 ( 3 ), 293 – 301 . 

  20. Khorshidi , M. , Moini , A. , Alipoor , E. , Rezvan , N. , Gorgani‐Firuzjaee , S. , Yaseri , M. , & Hosseinzadeh‐Attar , M. J. ( 2018 ). The effects of quercetin supplementation on metabolic and hormonal parameters as well as plasma concentration and gene expression of resistin in overweight or obese women with polycystic ovary syndrome . Phytotherapy Research , 32 , 2282 – 2289 . https://doi.org/10.1002/ptr.6166 

  21. Kim , J. , Cha , Y. J. , Lee , K. H. , & Park , E. ( 2013 ). Effect of onion peel extract supplementation on the lipid profile and antioxidative status of healthy young women: A randomized, placebo‐controlled, double‐blind, crossover trial . Nutrition Research and Practice , 7 ( 5 ), 373 – 379 . https://doi.org/10.4162/nrp.2013.7.5.373 

  22. Kim , K. A. , & Yim , J. E. ( 2015 ). Antioxidative activity of onion peel extract in obese women: A randomized, double‐blind, placebo controlled study . Journal of Cancer Prevention , 20 ( 3 ), 202 – 207 . https://doi.org/10.15430/jcp.2015.20.3.202 

  23. Lee , J. S. , Cha , Y. J. , Lee , K. H. , & Yim , J. E. ( 2016 ). Onion peel extract reduces the percentage of body fat in overweight and obese subjects: A 12‐week, randomized, double‐blind, placebo‐controlled study . Nutrition Research and Practice , 10 ( 2 ), 175 – 181 . https://doi.org/10.4162/nrp.2016.10.2.175 

  24. Lee , K. H. , Park , E. , Lee , H. J. , Kim , M. O. , Cha , Y. J. , Kim , J. M. , … Shin , M. J. ( 2011 ). Effects of daily quercetin‐rich supplementation on cardiometabolic risks in male smokers . Nutrition Research and Practice , 5 ( 1 ), 28 – 33 . https://doi.org/10.4162/nrp.2011.5.1.28 

  25. Mahmoud , M. F. , Hassan , N. A. , El Bassossy , H. M. , & Fahmy , A. ( 2013 ). Quercetin protects against diabetes‐induced exaggerated vasoconstriction in rats: Effect on low grade inflammation . PLoS ONE , 8 ( 5 ), e63784 . https://doi.org/10.1371/journal.pone.0063784 

  26. Mazloom , Z. , Abdollahzadeh , S. M. , Dabbaghmanesh , M. H. , & Rezaianzadeh , A. ( 2014 ). The effect of quercetin supplementation on oxidative stress, glycemic control, lipid profile and insulin resistance in type 2 diabetes: A randomized clinical trial . Journal of Health Sciences and Surveillance System , 2 ( 1 ), 8 – 14 . 

  27. Mohammadi‐Sartang , M. , Mazloom , Z. , Sherafatmanesh , S. , Ghorbani , M. , & Firoozi , D. ( 2017 ). Effects of supplementation with quercetin on plasma C‐reactive protein concentrations: A systematic review and meta‐analysis of randomized controlled trials . European Journal of Clinical Nutrition , 71 ( 9 ), 1033 – 1039 . https://doi.org/10.1038/ejcn.2017.55 

  28. Murthy , V. L. , Abbasi , S. A. , Siddique , J. , Colangelo , L. A. , Reis , J. , Venkatesh , B. A. , … Shah , R. V. ( 2016 ). Transitions in metabolic risk and long‐term cardiovascular health: Coronary Artery Risk Development in Young Adults (CARDIA) study . Journal of the American Heart Association , 5 ( 10 ). https://doi.org/10.1161/jaha.116.003934 

  29. Nishimura , M. , Ohkawara , T. , Nakagawa , T. , Muro , T. , Sato , Y. , Satoh , H. , … Nishihira , J. ( 2017 ). A randomized, double‐blind, placebo‐controlled study evaluating the effects of quercetin‐rich onion on cognitive function in elderly subjects . Functional Foods in Health and Disease , 7 ( 6 ), 353 – 374 . 

  30. O'Neill , S. , & O'Driscoll , L. ( 2015 ). Metabolic syndrome: A closer look at the growing epidemic and its associated pathologies . Obesity Reviews , 16 ( 1 ), 1 – 12 . https://doi.org/10.1111/obr.12229 

  31. Overman , A. , Chuang , C. C. , & McIntosh , M. ( 2011 ). Quercetin attenuates inflammation in human macrophages and adipocytes exposed to macrophage‐conditioned media . International Journal of Obesity , 35 ( 9 ), 1165 – 1172 . https://doi.org/10.1038/ijo.2010.272 

  32. Pfeuffer , M. , Auinger , A. , Bley , U. , Kraus‐Stojanowic , I. , Laue , C. , Winkler , P. , … Schrezenmeir , J. ( 2013 ). Effect of quercetin on traits of the metabolic syndrome, endothelial function and inflammation in men with different APOE isoforms . Nutrition, Metabolism, and Cardiovascular Diseases , 23 ( 5 ), 403 – 409 . https://doi.org/10.1016/j.numecd.2011.08.010 

  33. Quindry , J. C. , McAnulty , S. R. , Hudson , M. B. , Hosick , P. , Dumke , C. , McAnulty , L. S. , … Nieman , D. ( 2008 ). Oral quercetin supplementation and blood oxidative capacity in response to ultramarathon competition . International Journal of Sport Nutrition and Exercise Metabolism , 18 ( 6 ), 601 – 616 . https://doi.org/10.1123/ijsnem.18.6.601 

  34. Rezvan , N. , Moini , A. , Gorgani‐Firuzjaee , S. , & Hosseinzadeh‐Attar , M. J. ( 2018 ). Oral quercetin supplementation enhances adiponectin receptor transcript expression in polycystic ovary syndrome patients: A randomized placebo‐controlled double‐blind clinical trial . Cell Journal , 19 ( 4 ), 627 – 633 . https://doi.org/10.22074/cellj.2018.4577 

  35. Rezvan , N. , Moini , A. , Janani , L. , Mohammad , K. , Saedisomeolia , A. , Nourbakhsh , M. , … Hosseinzadeh‐Attar , M. J. ( 2017 ). Effects of quercetin on adiponectin‐mediated insulin sensitivity in polycystic ovary syndrome: A randomized placebo‐controlled double‐blind clinical trial . Hormone and Metabolic Research , 49 ( 2 ), 115 – 121 . https://doi.org/10.1055/s‐0042‐118705 

  36. Rivera , L. , Moron , R. , Sanchez , M. , Zarzuelo , A. , & Galisteo , M. ( 2008 ). Quercetin ameliorates metabolic syndrome and improves the inflammatory status in obese Zucker rats . Obesity (Silver Spring) , 16 ( 9 ), 2081 – 2087 . https://doi.org/10.1038/oby.2008.315 

  37. Sahebkar , A. ( 2017 ). Effects of quercetin supplementation on lipid profile: A systematic review and meta‐analysis of randomized controlled trials . Critical Reviews in Food Science and Nutrition , 57 ( 4 ), 666 – 676 . https://doi.org/10.1080/10408398.2014.948609 

  38. Serban , M. C. , Sahebkar , A. , Zanchetti , A. , Mikhailidis , D. P. , Howard , G. , Antal , D. , … Lip , G. Y. ( 2016 ). Effects of quercetin on blood pressure: A systematic review and meta‐analysis of randomized controlled trials . Journal of the American Heart Association , 5 ( 7 ). https://doi.org/10.1161/jaha.115.002713 

  39. Shanely , R. A. , Knab , A. M. , Nieman , D. C. , Jin , F. , McAnulty , S. R. , & Landram , M. J. ( 2010 ). Quercetin supplementation does not alter antioxidant status in humans . Free Radical Research , 44 ( 2 ), 224 – 231 . https://doi.org/10.3109/10715760903407293 

  40. Shi , Y. , & Williamson , G. ( 2016 ). Quercetin lowers plasma uric acid in pre‐hyperuricaemic males: A randomised, double‐blinded, placebo‐controlled, cross‐over trial . The British Journal of Nutrition , 115 ( 5 ), 800 – 806 . https://doi.org/10.1017/s0007114515005310 

  41. Wang , Z. , Zhai , D. , Zhang , D. , Bai , L. , Yao , R. , Yu , J. , … Yu , C. ( 2017 ). Quercetin decreases insulin resistance in a polycystic ovary syndrome rat model by improving inflammatory microenvironment . Reproductive Sciences , 24 ( 5 ), 682 – 690 . https://doi.org/10.1177/1933719116667218 

  42. Zahedi , M. , Ghiasvand , R. , Feizi , A. , Asgari , G. , & Darvish , L. ( 2013 ). Does quercetin improve cardiovascular risk factors and inflammatory biomarkers in women with type 2 diabetes: A double‐blind randomized controlled clinical trial . International Journal of Preventive Medicine , 4 ( 7 ), 777 – 785 . 

관련 콘텐츠

이 논문과 함께 이용한 콘텐츠

저작권 관리 안내
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로