[논문]Endothelium-Dependent Vasorelaxant Effect of Prunus Persica Branch on Isolated Rat Thoracic Aorta

Kim, Bumjung; Kim, Kwang-Woo; Lee, Somin; Jo, Cheolmin; Lee, Kyungjin; Ham, Inhye; Choi, Ho-Young

doi:10.3390/nu11081816

[해외논문] Endothelium-Dependent Vasorelaxant Effect of Prunus Persica Branch on Isolated Rat Thoracic Aorta 원문보기

Nutrients, v.11 no.8, 2019년, pp.1816 -

Kim, Bumjung (Department of Herbal Pharmacology, College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea) , Kim, Kwang-Woo (Department of Herbal Pharmacology, Graduate School, Kyung Hee University, Seoul 02447, Korea) , Lee, Somin (Department of Biomedical Science and Technology, Graduate School, Kyung Hee University, Seoul 02447, Korea) , Jo, Cheolmin (Department of Herbal Pharmacology, Graduate School, Kyung Hee University, Seoul 02447, Korea) , Lee, Kyungjin (Department of Herbal Pharmacology, College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea) , Ham, Inhye (Department of Herbal Pharmacology, College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea) , Choi, Ho-Young (Department of Herbal Pharmacology, College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea)

Abstract ▼ AI-Helper

Peach (Prunus persica (L.) Batsch) is a popular fruit consumed by people worldwide, owing to its pleasant flavor and high mineral nutrient content. A few plants from the genus Prunus, such as Prunus yedoensis, Prunus cerasus, and Prunus serotina have shown vasorelaxant and vasodilatory effects, to date, no study has investigated the vasorelaxation effects of the P. persica branch extract (PPE). The vasorelaxant effect of PPE was endothelium-dependent, and it was related to the NO-sGC-cGMP, vascular prostacyclin, and muscarinic receptor transduction pathway. K+ channels, such as the BKCa, KV, and KATP channels, were partially associated with PPE-induced vasorelaxation. PPE was effective in relaxing serotonin (5-HT)- or angiotensin II-induced contraction; furthermore, PPE attenuated Ca2+-induced vasoconstriction by IP3 receptors in the SR membrane, but its vasorelaxant effect was not associated with the influx of extracellular Ca2+ via receptor-operative Ca2+ channels or voltage-dependent Ca2+ channels. Recognizing the rising use of functional foods for hypertension treatment, our findings imply that PPE may be a natural antihypertensive agent.

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[해외논문] Endothelium-Dependent Vasorelaxant Effect of Prunus Persica Branch on Isolated Rat Thoracic Aorta 원문보기

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[해외논문] Endothelium-Dependent Vasorelaxant Effect of Prunus Persica Branch on Isolated Rat Thoracic Aorta 원문보기

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