[논문]Dementia And Physical Activity (DAPA) trial of moderate to high intensity exercise training for people with dementia: randomised controlled trial

Lamb, Sarah E; Sheehan, Bart; Atherton, Nicky; Nichols, Vivien; Collins, Helen; Mistry, Dipesh; Dosanjh, Sukhdeep; Slowther, Anne Marie; Khan, Iftekhar; Petrou, Stavros; Lall, Ranjit

doi:10.1136/bmj.k1675

Dementia And Physical Activity (DAPA) trial of moderate to high intensity exercise training for people with dementia: randomised controlled trial 원문보기

BMJ : British medical journal, v.361, 2018년, pp.k1675 -

Lamb, Sarah E (Centre for Rehabilitation Research and Centre for Statistics in Medicine, Nuffield Department of Orthopaedics Rheumatology & Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford OX3 7LD, UK) , Sheehan, Bart (Coventry and Warwickshire Partnership Trust, Coventry, UK) , Atherton, Nicky (Coventry and Warwickshire Partnership Trust, Coventry, UK) , Nichols, Vivien (Warwick Clinical Trials Unit, University of Warwick, Coventry, UK) , Collins, Helen (Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, UK) , Mistry, Dipesh (Warwick Clinical Trials Unit, University of Warwick, Coventry, UK) , Dosanjh, Sukhdeep (Warwick Clinical Trials Unit, University of Warwick, Coventry, UK) , Slowther, Anne Marie (Division of Health Sciences, University of Warwick, Coventry, UK) , Khan, Iftekhar (Warwick Clinical Trials Unit, University of Warwick, Coventry, UK) , Petrou, Stavros (Warwick Clinical Trials Unit, University of Warwick, Coventry, UK) , Lall, Ranjit (Warwick Clinical Trials Unit, University of Warwick, Coventry, UK)

Abstract ▼ AI-Helper

AbstractObjectiveTo estimate the effect of a moderate to high intensity aerobic and strength exercise training programme on cognitive impairment and other outcomes in people with mild to moderate dementia.DesignMulticentre, pragmatic, investigator masked, randomised controlled trial.SettingNational Health Service primary care, community and memory services, dementia research registers, and voluntary sector providers in 15 English regions.Participants494 people with dementia: 329 were assigned to an aerobic and strength exercise programme and 165 were assigned to usual care. Random allocation was 2:1 in favour of the exercise arm.InterventionsUsual care plus four months of supervised exercise and support for ongoing physical activity, or usual care only. Interventions were delivered in community gym facilities and NHS premises.Main outcome measuresThe primary outcome was score on the Alzheimer’s disease assessment scale-cognitive subscale (ADAS-cog) at 12 months. Secondary outcomes included activities of daily living, neuropsychiatric symptoms, health related quality of life, and carer quality of life and burden. Physical fitness (including the six minute walk test) was measured in the exercise arm during the intervention.ResultsThe average age of participants was 77 (SD 7.9) years and 301/494 (61%) were men. By 12 months the mean ADAS-cog score had increased to 25.2 (SD 12.3) in the exercise arm and 23.8 (SD 10.4) in the usual care arm (adjusted between group difference −1.4, 95% confidence interval −2.6 to −0.2, P=0.03). This indicates greater cognitive impairment in the exercise group, although the average difference is small and clinical relevance uncertain. No differences were found in secondary outcomes or preplanned subgroup analyses by dementia type (Alzheimer’s disease or other), severity of cognitive impairment, sex, and mobility. Compliance with exercise was good. Over 65% of participants (214/329) attended more than three quarters of scheduled sessions. Six minute walking distance improved over six weeks (mean change 18.1 m, 95% confidence interval 11.6 m to 24.6 m).ConclusionA moderate to high intensity aerobic and strength exercise training programme does not slow cognitive impairment in people with mild to moderate dementia. The exercise training programme improved physical fitness, but there were no noticeable improvements in other clinical outcomes.Trial registrationCurrent Controlled Trials ISRCTN10416500.

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Dementia And Physical Activity (DAPA) trial of moderate to high intensity exercise training for people with dementia: randomised controlled trial 원문보기

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