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Melatonin Synthesis and Function: Evolutionary History in Animals and Plants 원문보기

Frontiers in Endocrinology, v.10, 2019년, pp.249 -   

Zhao, Dake (Biocontrol Engineering Research Center of Plant Disease and Pest, Yunnan University , Kunming , China) ,  Yu, Yang (State Key Laboratory for Conservation and Utilization of Bio-resources in Yunnan, Yunnan University , Kunming , China) ,  Shen, Yong (College of Agriculture and Biotechnology, Yunnan Agricultural University , Kunming , China) ,  Liu, Qin (School of Landscape and Horticulture, Yunnan Vocational and Technical College of Agriculture , Kunming , China) ,  Zhao, Zhiwei (State Key Laboratory for Conservation and Utilization of Bio-resources in Yunnan, Yunnan University , Kunming , China) ,  Sharma, Ramaswamy (Department of Cell Systems and Anatomy, The University of Texas Health Science Center at San Antonio (UT Health) , San Antonio, TX , United States) ,  Reiter, Russel J. (Department of Cell Systems and Anatomy, The University of Texas Health Science Center at San Antonio (UT Health) , San Antonio, TX , Unit)

Abstract AI-Helper 아이콘AI-Helper

Melatonin is an ancient molecule that can be traced back to the origin of life. Melatonin's initial function was likely that as a free radical scavenger. Melatonin presumably evolved in bacteria; it has been measured in both α-proteobacteria and in photosynthetic cyanobacteria. In early evolut...

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참고문헌 (214)

  1. 1. Lerner AB Case JD Takahashi Y Lee TH Mori W Isolation of melatonin, the pineal gland factor that lightens melanocyteS 1 . J Am Chem Soc. ( 1958 ) 80 : 2587 10.1021/ja01543a060 

  2. 2. Dubbels R Reiter R Klenke E Goebel A Schnakenberg E Ehlers C . Melatonin in edible plants identified by radioimmunoassay and by high performance liquid chromatography-mass spectrometry . J Pineal Res. ( 1995 ) 18 : 28 – 31 . 10.1111/j.1600-079X.1995.tb00136.x 7776176 

  3. 3. Hattori A Migitaka H Iigo M Itoh M Yamamoto K Ohtani-Kaneko R . Identification of melatonin in plants and its effects on plasma melatonin levels and binding to melatonin receptors in vertebrates . Biochem Mol Biol Int. ( 1995 ) 35 : 627 – 34 . 7773197 

  4. 4. Manchester LC Tan DX Reiter RJ Qi W Karbownik M Calvo JR High levels of melatonin in edible seeds: possible function in germ cell protection . Life Sci. ( 2000 ) 67 : 3023 – 9 . 10.1016/S0024-3205(00)00896-1 11125839 

  5. 5. Reiter RJ Tan DX Galano A . Melatonin: exceeding expectations . Physiology. ( 2014 ) 29 : 325 – 33 . 10.1152/physiol.00011.2014 25180262 

  6. 6. Shi H Chen K Wei Y He C . Fundamental issues of melatonin-mediated stress signaling in plants . Front Plant Sci. ( 2016 ) 7 : 1124 . 10.3389/fpls.2016.01124 27512404 

  7. 7. Tan DX Hardeland R Back K Manchester LC Alatorre-Jimenez MA Reiter RJ . On the significance of an alternate pathway of melatonin synthesis via 5-methoxytryptamine: comparisons across species . J Pineal Res. ( 2016 ) 61 : 27 – 40 . 10.1111/jpi.12336 27112772 

  8. 8. Manchester LC Coto-Montes A Boga JA Andersen LPH Zhou Z Galano A . Melatonin: an ancient molecule that makes oxygen metabolically tolerable . J Pineal Res. ( 2015 ) 59 : 403 – 19 . 10.1111/jpi.12267 26272235 

  9. 9. Pshenichnyuk SA Modelli A Jones D Lazneva EF Komolov AS . Low-energy electron interaction with melatonin and related compounds . J Phys Chem B. ( 2017 ) 121 : 3965 – 74 . 10.1021/acs.jpcb.7b01408 28394598 

  10. 10. Reiter RJ Tan DX Rosales-Corral S Galano A Jou MJ Acuna-Castroviejo D . Melatonin mitigates mitochondrial meltdown: interactions with SIRT3 . Int J Mol Sci. ( 2018 ) 19 : E2439 . 10.3390/ijms19082439 30126181 

  11. 11. Margulis L Symbiotic theory of the origin of eukaryotic organelles; criteria for proof . Symp Soc Exp Biol. ( 1975 ) 29 : 21 – 38 . 

  12. 12. Tan DX Manchester LC Liu X Rosales-Corral SA Acuna-Castroviejo D Reiter RJ . Mitochondria and chloroplasts as the original sites of melatonin synthesis: a hypothesis related to melatonin's primary function and evolution in eukaryotes . J Pineal Res. ( 2013 ) 54 : 127 – 38 . 10.1111/jpi.12026 23137057 

  13. 13. Reiter RJ Rosales-Corral S Tan DX Jou MJ Galano A Xu B . Melatonin as a mitochondria-targeted antioxidant: one of evolution's best ideas . Cell Mol Life Sci. ( 2017 ) 74 : 3863 – 81 . 10.1007/s00018-017-2609-7 28864909 

  14. 14. Tan DX Chen LD Poeggeler B Manchester LC Reiter RJ Melatonin: a potent, endogenous hydroxyl radical scavenger . Endocr J. ( 1993 ) 1 : 57 – 60 . 

  15. 15. Tan DX Manchester LC Esteban-Zubero E Zhou Z Reiter R . Melatonin as a potent and inducible endogenous antioxidant: synthesis and metabolism . Molecules. ( 2015 ) 20 : 18886 . 10.3390/molecules201018886 26501252 

  16. 16. Galano A Reiter RJ . Melatonin and its metabolites vs. oxidative stress: from individual actions to collective protection . J Pineal Res. ( 2018 ) 65 : e12514 . 10.1111/jpi.12514 29888508 

  17. 17. Galano A Tan DX Reiter RJ . Melatonin: a versatile protector against oxidative DNA damage . Molecules. ( 2018 ) 23 : E530 . 10.3390/molecules23030530 29495460 

  18. 18. Tan DX Hardeland R Manchester LC Paredes SD Korkmaz A Sainz RM . The changing biological roles of melatonin during evolution: from an antioxidant to signals of darkness, sexual selection and fitness . Biol Rev. ( 2010 ) 85 : 607 – 23 . 10.1111/j.1469-185X.2009.00118.x 20039865 

  19. 19. Lochner A Marais E Huisamen B . Melatonin and cardioprotection against ischaemia/reperfusion injury: what's new? A review . J Pineal Res. ( 2018 ) 65 : e12490 . 10.1111/jpi.12490 29570845 

  20. 20. Onaolapo AY Onaolapo OJ . Circadian dysrhythmia-linked diabetes mellitus: examining melatonin's roles in prophylaxis and management . World J Diabetes . ( 2018 ) 9 : 99 – 114 . 10.4239/wjd.v9.i7.99 30079146 

  21. 21. Tamtaji OR Mobini M Reiter RJ Azami A Gholami MS Asemi Z Melatonin, a toll-like receptor inhibitor: current status and future perspectives . J Cell Physiol. ( 2018 ) 2018 : 27698 10.1002/jcp.27698 

  22. 22. Back K Tan DX Reiter RJ Melatonin biosynthesis in plants: multiple pathways catalyze tryptophan to melatonin in the cytoplasm or chloroplasts . J Pineal Res. ( 2016 ) 61 : 426 – 37 . 10.1111/jpi.12364 27600803 

  23. 23. Ye T Yin X Yu L Zheng SJ Cai WJ Wu Y Metabolic analysis of the melatonin biosynthesis pathway using chemical labeling coupled with liquid chromatography-mass spectrometry . J Pineal Res. 2018 : e12531 10.1111/jpi.12531 

  24. 24. Tan DX Zheng X Kong J Manchester L Hardeland R Kim S . Fundamental Issues related to the origin of melatonin and melatonin isomers during evolution: relation to their biological functions . Int J Mol Sci. ( 2014 ) 15 : 15858 . 10.3390/ijms150915858 25207599 

  25. 25. Lee K Choi GH Back K . Cadmium-induced melatonin synthesis in rice requires light, hydrogen peroxide, and nitric oxide: key regulatory roles for tryptophan decarboxylase and caffeic acid O -methyltransferase . J Pineal Res. ( 2017 ) 63 : e12441 . 10.1111/jpi.12441 28793366 

  26. 26. Byeon Y Lee HY Lee K Park S Back K . Cellular localization and kinetics of the rice melatonin biosynthetic enzymes SNAT and ASMT . J Pineal Res. ( 2014 ) 56 : 107 – 14 . 10.1111/jpi.12103 24134674 

  27. 27. Byeon Y Lee HY Hwang OJ Lee HJ Lee K Back K . Coordinated regulation of melatonin synthesis and degradation genes in rice leaves in response to cadmium treatment . J Pineal Res. ( 2015 ) 58 : 470 – 8 . 10.1111/jpi.12232 25783167 

  28. 28. Lee HY Byeon Y Lee K Lee HJ Back K . Cloning of Arabidopsis serotonin N-acetyltransferase and its role with caffeic acid O -methyltransferase in the biosynthesis of melatonin in vitro despite their different subcellular localizations . J Pineal Res. ( 2014 ) 57 : 418 – 26 . 10.1111/jpi.12181 25250906 

  29. 29. Rodriguez IR Mazuruk K Schoen TJ Chader GJ . Structural analysis of the human hydroxyindole- O -methyltransferase gene. Presence of two distinct promoters . J Biol Chem. ( 1994 ) 269 : 31969 – 77 . 7989373 

  30. 30. Estrada-Rodgers L Levy GN Weber WW . Characterization of a hormone response element in the mouse N -Acetyltransferase 2 (Nat2 * ) promoter . Gene Expr. ( 1998 ) 7 : 13 – 24 . 9572394 

  31. 31. Korkmaz A Reiter RJ Topal T Manchester LC Oter S Tan DX . Melatonin: an established antioxidant worthy of use in clinical trials . Mol Med. ( 2009 ) 15 : 43 – 50 . 10.2119/molmed.2008.00117 19011689 

  32. 32. Muxel SM Laranjeira-Silva MF Carvalho-Sousa CE Floeter-Winter LM Markus RP . The RelA/cRel nuclear factor-κB (NF-κB) dimer, crucial for inflammation resolution, mediates the transcription of the key enzyme in melatonin synthesis in RAW 264 .7 macrophages. J Pineal Res. ( 2016 ) 60 : 394 – 404 . 10.1111/jpi.12321 26887983 

  33. 33. Cai SY Zhang Y Xu YP Qi ZY Li MQ Ahammed GJ . HsfA1a upregulates melatonin biosynthesis to confer cadmium tolerance in tomato plants . J Pineal Res. ( 2017 ) 62 : e12387 . 10.1111/jpi.12387 28095626 

  34. 34. Zhang J Qiu J Zhou Y Wang Y Li H Zhang T . LIM homeobox transcription factor Isl1 is required for melatonin synthesis in the pig pineal gland . J Pineal Res. ( 2018 ) 65 : e12481 . 10.1111/jpi.12481 29480946 

  35. 35. Luo G Ono S Beukes NJ Wang DT Xie S Summons RE . Rapid oxygenation of earth's atmosphere 2 .33 billion years ago. Sci Adv. ( 2016 ) 2 : e1600134 . 10.1126/sciadv.1600134 27386544 

  36. 36. Izon G Zerkle AL Williford KH Farquhar J Poulton SW Claire MW . Biological regulation of atmospheric chemistry en route to planetary oxygenation . Proc Natl Acad Sci USA. ( 2017 ) 114 : 201618798 . 10.1073/pnas.1618798114 28289223 

  37. 37. Taverne YJ Merkus D Bogers AJ Halliwell B Duncker DJ Lyons TW . Reactive oxygen species: radical factors in the evolution of animal life: a molecular timescale from earth's earliest history to the rise of complex life . Bioessays. ( 2018 ) 40 : 1700158 . 10.1002/bies.201700158 29411901 

  38. 38. Kump LR Barley ME . Increased subaerial volcanism and the rise of atmospheric oxygen 2 .5 billion years ago. Nature. ( 2007 ) 448 : 1033 – 6 . 10.1038/nature06058 17728754 

  39. 39. Reiter RJ Rosales-Corral S Zhou X Tan DX Role of SIRT3/SOD2 signaling in mediating the antioxidant actions of melatonin in mitochondria . Curr Trends Endocrinol. ( 2017 ) 9 : 45 – 9 . 

  40. 40. Donaghy L Hong HK Jauzein C Choi KS . The known and unknown sources of reactive oxygen and nitrogen species in haemocytes of marine bivalve molluscs . Fish Shellfish Immunol. ( 2015 ) 42 : 91 – 7 . 10.1016/j.fsi.2014.10.030 25449373 

  41. 41. Dharmaraja AT . Role of reactive oxygen species (ROS) in therapeutics and drug resistance in cancer and bacteria . J Med Chem. ( 2017 ) 60 : 3221 – 40 . 10.1021/acs.jmedchem.6b01243 28135088 

  42. 42. Casteilla L Rigoulet M Pénicaud L . Mitochondrial ROS metabolism: modulation by uncoupling proteins . IUBMB Life. ( 2001 ) 52 : 181 – 8 . 10.1080/15216540152845984 11798031 

  43. 43. Treberg JR Braun K Zacharias P Kroeker K Multidimensional mitochondrial energetics: applications to the study of electron leak and hydrogen peroxide metabolism . Comp Biochem Physiol B Biochem Mol Biol. ( 2018 ) 224 : 121 – 8 . 10.1016/j.cbpb.2017.12.013 29253629 

  44. 44. Case A . On the origin of superoxide dismutase: an evolutionary perspective of superoxide-mediated redox signaling . Antioxidants. ( 2017 ) 6 : 82 . 10.3390/antiox6040082 29084153 

  45. 45. Manchester LC Poeggeler B Alvares FL Ogden GB Reiter RJ . Melatonin immunoreactivity in the photosynthetic prokaryote Rhodospirillum rubrum : implications for an ancient antioxidant system . Chem Mol Biol Res. ( 1995 ) 41 : 391 – 5 . 8867786 

  46. 46. Mayo JC Sainz RM González Menéndez P Cepas V Tan DX Reiter RJ . Melatonin and sirtuins: a “not-so unexpected” relationship . J Pineal Res. ( 2017 ) 62 : e12391 . 10.1111/jpi.12391 28109165 

  47. 47. Acuña-Castroviejo D Martín M Macías M Escames G León J Khaldy H . Melatonin, mitochondria, and cellular bioenergetics . J Pineal Res. ( 2001 ) 30 : 65 – 74 . 10.1034/j.1600-079X.2001.300201.x 11270481 

  48. 48. Leon J Acuna-Castroviejo D Escames G Tan DX Reiter RJ . Melatonin mitigates mitochondrial malfunction . J Pineal Res. ( 2005 ) 38 : 1 – 9 . 10.1111/j.1600-079X.2004.00181.x 15617531 

  49. 49. Hardeland R Melatonin and retinoid orphan receptors: demand for new interpretation after their exclusion as nuclear melatonin receptors . Melatonin Res. ( 2018 ) 65 : e12525 10.32794/mr11250005 

  50. 50. Hardeland R Tan DX Reiter RJ Kynuramines, metabolites of melatonin and other indoles: the resurrection of an almost forgotten class of biogenic animals . J Pineal Res. ( 2009 ) 47 : 109 – 26 . 10.1111/j.1600-079X.2009.00701.x 19573038 

  51. 51. Galano A Tan DX Reiter RJ . On the free radical scavenging activities of melatonin's metabolites, AFMK and AMK . J Pineal Res. ( 2013 ) 54 : 245 – 57 . 10.1111/jpi.12010 22998574 

  52. 52. Jou MJ Peng TI Reiter RJ Protective stabilization of mitochondrial permeability transition and mitochondrial oxidation during mitochondrial Ca 2+ stress by melatonin's cascade metabolites C3-OHM and AFMK in RBA1 astrocytes . J Pineal Res. ( 2018 ) 2018 : e12538 10.1111/jpi.12538 

  53. 53. Hevia D Mayo JC Tan DX Rodriguez-Garcia A Sainz RM . Melatonin enhances photo-oxidation of 2′, 7′-dichlorodihydrofluorescein by an antioxidant reaction that renders N 1-acetyl- N 2-formyl-5-methoxykynuramine (AFMK) . PloS ONE . ( 2014 ) 9 : e109257 . 10.1371/journal.pone.0109257 25275380 

  54. 54. Vielma JR Bonilla E Chacin-Bonilla L Mora M Medina-Leendertz S Bravo Y . Effects of melatonin on oxidative stress, and resistance to bacterial, parasitic, and viral infections: a review . Acta Trop. ( 2014 ) 137 : 31 – 8 . 10.1016/j.actatropica.2014.04.021 24811367 

  55. 55. Reiter RJ Mayo JC Tan DX Sainz RM Alatorre-Jimenez M Qin L . Melatonin as an antioxidant: under promises but over delivers . J Pineal Gland. ( 2016 ) 61 : 253 – 78 . 10.1111/jpi.12360 27500468 

  56. 56. Hardeland R . Taxon- and site-specific melatonin catabolism . Molecules. ( 2017 ) 22 : E2015 . 10.3390/molecules22112015 29160833 

  57. 57. Lee K Zawadzka A Czarnocki Z Reiter RJ Back K . Molecular cloning of melatonin 3-hydroxylase and its production of cyclic 3-hydroxymelatonin in rice ( Oryza sativa ) . J Pineal Res. ( 2016 ) 61 : 470 – 8 . 10.1111/jpi.12361 27500558 

  58. 58. Vass I . Role of charge recombination processes in photodamage and photoprotection of the photosystem II complex . Physiol Plant. ( 2011 ) 142 : 6 – 16 . 10.1111/j.1399-3054.2011.01454.x 21288250 

  59. 59. Vass I . Molecular mechanisms of photodamage in the Photosystem II complex . Biochim Biophys Acta. ( 2012 ) 1817 : 209 – 17 . 10.1016/j.bbabio.2011.04.014 21565163 

  60. 60. Hardeland R Fuhrberg B Uria H Behrmann G Meyer TJ Burkhardt S . Chronobiology of indoleamines in the dinoflagellate Gonyaulax polyedra: metabolism and effects related to circadian rhythmicity and photoperiodism . Braz J Med Biol Rep. ( 1996 ) 29 : 119 – 23 . 8731341 

  61. 61. Latifi A Ruiz M Zhang CC . Oxidative stress in cyanobacteria . FEMS Microbiol Rev. ( 2009 ) 33 : 258 – 78 . 10.1111/j.1574-6976.2008.00134.x 18834454 

  62. 62. Claustrat B Brun J Chazot G . The basic physiology and pathophysiology of melatonin . Sleep Med Rev. ( 2005 ) 9 : 11 – 24 . 10.1016/j.smrv.2004.08.001 15649735 

  63. 63. Venegas C García JA Escames G Ortiz F López A Doerrier C . Extrapineal melatonin: analysis of its subcellular distribution and daily fluctuations . J Pineal Res. ( 2012 ) 52 : 217 – 27 . 10.1111/j.1600-079X.2011.00931.x 21884551 

  64. 64. Roth JJ Gern WA Roth EL Ralph CL Jacobson E . Nonpineal melatonin in the alligator ( Alligator mississippiensis ) . Science. ( 1980 ) 210 : 548 – 50 . 10.1126/science.7423204 7423204 

  65. 65. Oksche A The development of the concept of photoneuroendocrine systems: historical perspective . In: Klein DC Moor RY Reppert SM editors. Suprachiasmatic Nucleus. New York, NY : Oxford University Press ( 1991 ). pp. 5 – 11 . 

  66. 66. Kolář J Johnson CH Macháčková I . Presence and possible role of melatonin in a short-day flowering plant, Chenopodium rubrum . Adv Exp Med Biol. ( 1999 ) 460 : 391 – 3 . 10.1007/0-306-46814-X_46 10810539 

  67. 67. Hardeland R . Melatonin, hormone of darkness and more - occurrence, control mechanisms, actions and bioactive metabolites . Cellular and Molecular Life Sci. ( 2008 ) 65 : 2001 – 18 . 10.1007/s00018-008-8001-x 18344019 

  68. 68. Johnson CH . Precise circadian clocks in prokaryotic cyanobacteria . Curr Issues Mol Biol. ( 2004 ) 6 : 103 – 10 . 15119821 

  69. 69. Mori T Mchaourab H Johnson CH . Circadian clocks: unexpected biochemical cogs . Curr Biol. ( 2015 ) 25 : R842 – 4 . 10.1016/j.cub.2015.08.026 26439342 

  70. 70. Tan DX Manchester LC Di Mascio R Martinez GR Prado FM Reiter RJ . Novel rhythms of N 1-acetyl- N 2-formyl-5-methoxykynuramine and its precursor melatonin in the water hyacinth: importance in phytoremediation . FASEB J. ( 2007 ) 21 : 1724 – 9 . 10.1096/fj.06-7745com 17314136 

  71. 71. Poeggeler B . Melatonin, aging, and age-related diseases . Endocrine. ( 2005 ) 27 : 201 – 12 . 10.1385/ENDO:27:2:201 16217133 

  72. 72. Jou MJ Peng TI Yu PZ Jou SB Reiter RJ Chen JY . Melatonin protects against common deletion of mitochondrial DNA-augmented mitochondrial oxidative stress and apoptosis . J Pineal Res. ( 2007 ) 43 : 389 – 403 . 10.1111/j.1600-079X.2007.00490.x 17910608 

  73. 73. Majidinia M Reiter RJ Shakouri SK Yousefi B . The role of melatonin, a multitasking molecule, in retarding the processes of ageing . Ageing Res Rev. ( 2018 ) 47 : 198 – 213 . 10.1016/j.arr.2018.07.010 30092361 

  74. 74. Nabavi SM Nabavi SF Sureda A Xiao J Dehpour AR Shirooie S Anti-inflammatory effects of Melatonin: a mechanistic review . Crit Rev Food Sci Nutr. ( 2018 ) 14 : 1 – 13 . 10.1080/10408398.2018.1487927 

  75. 75. Pevet P Klosen P Felder-Schmittbuhl MP . The hormone melatonin: animal studies . Best Pract Res Clin Endocrinol Metab. ( 2017 ) 31 : 547 – 59 . 10.1016/j.beem.2017.10.010 29224667 

  76. 76. Simonneaux V . Naughty melatonin: how mothers tick off their fetus . Endocrinology. ( 2011 ) 152 : 1734 – 8 . 10.1210/en.2011-0226 21511985 

  77. 77. Reiter RJ Tan DX Sharma R Historical perspective and evaluation of the mechanisms by which melatonin mediates seasonal reproduction in mammals . Melaton Res. ( 2018 ) 1 : 58 – 76 . 10.32794/mr11250004 

  78. 78. Carrillo-Vico A Reiter RJ Lardone PJ Herrera JL Fernández-Montesinos R Guerrero JM . The modulatory role of melatonin on immune responsiveness . Curr Opin Investig Drugs. ( 2006 ) 7 : 423 – 31 . 16729718 

  79. 79. Claustrat B Leston J . Melatonin: physiological effects in humans . Neurochirurgie. ( 2015 ) 61 : 77 – 84 . 10.1016/j.neuchi.2015.03.002 25908646 

  80. 80. Kriegsfeld LJ Ubuka T Bentley GE Tsutsui K . Seasonal control of gonadotropin-inhibitory hormone (GnIH) in birds and mammals . Front Neuroendocrinol. ( 2015 ) 37 : 65 – 75 . 10.1016/j.yfrne.2014.12.001 25511257 

  81. 81. Mendivil-Perez M Soto-Mercado V Guerra-Librero A Fernandez-Gil BI Florido J Shen YQ . Melatonin enhances neural stem cell differentiation and engraftment by increasing mitochondrial function . J Pineal Res. ( 2017 ) 63 : e12415 . 10.1111/jpi.12415 28423196 

  82. 82. Najafi M Shirazi A Motevaseli E Rezaeyan AH Salajegheh A Rezapoor S . Melatonin as an anti-inflammatory agent in radiotherapy . Inflammopharmacology. ( 2017 ) 25 : 403 – 13 . 10.1007/s10787-017-0332-5 28255737 

  83. 83. Bondy S Campbell A . Mechanisms underlying tumor suppressive properties of melatonin . Int J Mol Sci. ( 2018 ) 19 : E2205 . 10.3390/ijms19082205 30060531 

  84. 84. Hill SM Belancio VP Dauchy RT Xiang S Brimer S Mao L . Melatonin: an inhibitor of breast cancer . Endocr Relat Cancer. ( 2015 ) 22 : R183 – 204 . 10.1530/ERC-15-0030 25876649 

  85. 85. Gonzalez-Gonzalez A Mediavilla MD Sanchez-Barcelo EJ . Melatonin: a molecule for reducing breast cancer risk . Molecules. ( 2018 ) 23 : E336 . 10.3390/molecules23020336 29415446 

  86. 86. Bizzarri M Proietti S Cucina A Reiter RJ . Molecular mechanisms of the pro-apoptotic actions of melatonin in cancer: a review . Exp Opin Ther Targets. ( 2013 ) 17 : 1483 – 96 . 10.1517/14728222.2013.834890 24032643 

  87. 87. Leja-Szpak A Jaworek J Pierzchalski P Reiter RJ . Melatonin induces pro-apoptotic signaling pathway in human pancreatic carcinoma cells (PANC-1) . J Pineal Res. ( 2010 ) 49 : 248 – 55 . 10.1111/j.1600-079X.2010.00789.x 20626591 

  88. 88. Quintana C Cabrera J Perdomo J Estévez F Loro JF Reiter RJ . Melatonin enhances hyperthermia-induced apoptotic cell death in human leukemia cells . J Pineal Res. ( 2016 ) 61 : 381 – 95 . 10.1111/jpi.12356 27465521 

  89. 89. Su SC Hsieh MJ Yang WE Chung WH Reiter RJ Yang S . Cancer metastasis: mechanisms of inhibition by melatonin . J Pineal Res. ( 2017 ) 62 : 12370 . 10.1111/jpi.12370 27706852 

  90. 90. Reiter RJ . The mammalian pineal gland: structure and function . Am J Anat. ( 1981 ) 162 : 287 – 313 . 10.1002/aja.1001620402 7325124 

  91. 91. Dodt E Meissl H The pineal and parietal organs of lower vertebrates . Experientia. ( 1982 ) 36 : 996 – 1000 . 10.1007/BF01955342 

  92. 92. Kramm CM de Gip WJ Korf HW Rod-opsin immunoreaction in the pineal organ of the pigmented mouse does not indicate the presence of a functional photopigment . Cell Tissue Res. ( 1993 ) 274 : 71 – 8 . 10.1007/BF00327987 8242713 

  93. 93. Moore RY . Neural control of the pineal gland . Behav Brain Res. ( 1996 ) 73 : 125 – 30 . 10.1016/0166-4328(96)00083-6 8788489 

  94. 94. Cardinali DP Vacas MI . Feedback control of pineal function by reproductive hormones – a neuroendocrine paradigm . J Neural Trans Suppl. ( 1978 ) 175 – 201 . 38297 

  95. 95. Reiter RJ Richardson BA . Some perturbations that disturb the circadian melatonin rhythm . Chronobiol Int. ( 1992 ) 9 : 314 – 21 . 10.3109/07420529209064541 1423740 

  96. 96. Reiter RJ Hester RJ . Interrelationships of the pineal gland, the superior ganglia and the photoperiod in the regulation of the endocrine systems of hamsters . Endocrinology. ( 1966 ) 79 : 1168 – 70 . 10.1210/endo-79-6-1168 5951523 

  97. 97. Klein DC Berg GR Pineal gland: stimulation of melatonin production by norepinephrine involves cyclic AMP-mediated stimulation of N-acetyltransferase . Adv Biochem Psychopharmacol. ( 1970 ) 31 : 241 – 63 . 

  98. 98. Markus RP Fernandes PA Kinker GS da Silveira Cruz-Machado S Marcola M . Immune-pineal axis - acute inflammatory responses coordinate melatonin synthesis by pinealocytes and phagocytes . Br J Pharmacol. ( 2017 ) 175 : 3239 – 50 . 10.1111/bph.14083 29105727 

  99. 99. Markus R Cecon E Pires-Lapa M Immune-pineal axis: nuclear factor κB (NF-kB) mediates the shift in the melatonin source from pinealocytes to immune competent cells . Int J Mol Sci. ( 2013 ) 14 : 10979 – 97 . 10.3390/ijms140610979 23708099 

  100. 100. Tan DX Manchester LC Hardeland R Lopez-Burillo S Mayo JC Sainz RM . Melatonin: a hormone, a tissue factor, an autocoid, a paracoid, and an antioxidant vitamin . J Pineal Res. ( 2003 ) 34 : 75 – 8 . 10.1034/j.1600-079X.2003.02111.x 12485375 

  101. 101. Suofu V Li W Jean-Alphonse FG Jia J Khattar NK Li J . Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release . Proc Natl Acad Sci USA. ( 2017 ) 114 : E7997 – 8006 . 10.1073/pnas.1705768114 28874589 

  102. 102. Acuna-Castroviejo D Noguiera-Navarro MT Reiter RJ Escames G Melatonin actions in the heart: more than a hormone . Melaton Res. ( 2018 ) 1 : 21 – 6 . 10.32794/mr11250002 

  103. 103. Huo X Wang C Yu Z Wang S Peng S Zhang S . Human transporters, PEPT1/2, facilitate melatonin transportation into mitochondria of cancer cells: an implication of the therapeutic potential . J Pineal Res. ( 2017 ) 62 : 12390 . 10.1111/jpi.12390 28099762 

  104. 104. Tosches MA Bucher D Vopalensky P Arendt D . Melatonin signaling controls circadian swimming behavior in marine zooplankton . Cell. ( 2014 ) 159 : 46 – 57 . 10.1016/j.cell.2014.07.042 25259919 

  105. 105. Arnao MB Hernández-Ruiz J . Functions of melatonin in plants: a review . J Pineal Res. ( 2015 ) 59 : 133 – 50 . 10.1111/jpi.12253 26094813 

  106. 106. Hu W Yang H Tie W Yan Y Ding Z Liu Y . Natural variation in banana varieties highlights the role of melatonin in postharvest ripening and quality . J Agric Food Chem. ( 2017 ) 65 : 9987 – 94 . 10.1021/acs.jafc.7b03354 29077394 

  107. 107. Liang C Li A Yu H Li W Liang C Guo S . Melatonin regulates root architecture by modulating auxin response in rice . Front Plant Sci. ( 2017 ) 8 : 134 . 10.3389/fpls.2017.00134 28223997 

  108. 108. Zhang N Zhang HJ Sun QQ Cao YY Li X Zhao B . Proteomic analysis reveals a role of melatonin in promoting cucumber seed germination under high salinity by regulating energy production . Sci Rep. ( 2017 ) 7 : 503 . 10.1038/s41598-017-00566-1 28356562 

  109. 109. Reiter JR Tan DX Zhou Z Cruz HM Fuentes-Broto L Galano A . Phytomelatonin: assisting plants to survive and thrive . Molecules. ( 2015 ) 20 : 7396 – 437 . 10.3390/molecules20047396 25911967 

  110. 110. Reiter RJ Tan DX Manchester LC Pilar TM Terron PM Koppisepi S . Medical implications of melatonin: receptor-mediated and receptor-independent actions . Adv Med Sci. ( 2007 ) 52 : 11 – 28 . 18217386 

  111. 111. Slominski RM Reiter RJ Schlabritz-Loutsevitch N Ostrom RS Slominski AT . Melatonin membrane receptors in peripheral tissues: Distribution and functions . Mol Cell Endocrinol. ( 2012 ) 351 : 152 – 66 . 10.1016/j.mce.2012.01.004 22245784 

  112. 112. Jockers R Maurice P Boutin JA Delagrange P . Melatonin receptors, heterodimerization, signal transduction and binding sites: what's new? Br J Pharmacol. ( 2008 ) 154 : 1182 – 95 . 10.1038/bjp.2008.184 18493248 

  113. 113. Jockers R Delagrange P Dubocovich ML Markus RP Renault N Tosini G . Update on melatonin receptors: IUPHAR Review 20 . Br J Pharmacol. ( 2016 ) 173 : 2702 – 25 . 10.1111/bph.13536 27314810 

  114. 114. Dubocovich ML Delagrange P Krause DN Sugden D Cardinali DP Olcese J . International Union of Basic and Clinical Pharmacology . LXXV Nomenclature, classification, and pharmacology of G protein-coupled melatonin receptors . Pharmacol Rev. ( 2010 ) 62 : 343 – 80 . 10.1124/pr.110.002832 20605968 

  115. 115. Alkozi HA Sánchez JM Doadrio AL Pintor J . Docking studies for melatonin receptors . Expert Opin Drug Discov. ( 2017 ) 13 : 241 – 8 . 10.1080/17460441.2018.1419184 29271261 

  116. 116. Wei Y Chang Y Zeng H Liu G He C Shi H . RAV transcription factors are essential for disease resistance against cassava bacterial blight via activation of melatonin biosynthesis genes . J Pineal Res. ( 2018 ) 64 : e12454 . 10.1111/jpi.12454 29151275 

  117. 117. Lee HY Back K Melatonin is required for H 2 O 2 - and NO-mediated defense signaling through MAPKKK3 and OXI1 in Arabidopsis thaliana . J Pineal Res. ( 2017 ) 62 : e12379 10.1111/jpi.12379 

  118. 118. Yu Y Lv Y Shi Y Li T Chen Y Zhao D . The role of phyto-melatonin and related metabolites in response to stress . Molecules. ( 2018 ) 23 : 1887 . 10.3390/molecules23081887 30060559 

  119. 119. Boutin JA Saunier C Guenin SP Berger S Moulharat N Gohier A . Studies of the melatonin binding site location onto quinone reductase 2 by directed mutagenesis . Arch Biochem Biophys. ( 2008 ) 477 : 12 – 9 . 10.1016/j.abb.2008.04.040 18502195 

  120. 120. Cassagnes LE Chhour M Pério P Sudor J Gayon R Ferry G . Oxidative stress and neurodegeneration: the possible contribution of quinone reductase 2 . Free Radic Biol Med. ( 2018 ) 120 : 56 – 61 . 10.1016/j.freeradbiomed.2018.03.002 29526807 

  121. 121. Reybier K Perio P Ferry G Bouajila J Delagrange P Boutin JA . Insights into the redox cycle of human quinone reductase 2 . Free Radic Res. ( 2011 ) 45 : 1184 – 95 . 10.3109/10715762.2011.605788 21762045 

  122. 122. Choi GH Lee HY Back K . Chloroplast overexpression of rice caffeic acid O -methyltransferase increases melatonin production in chloroplasts via the 5-methoxytryptamine pathway in transgenic rice plants . J Pineal Res. ( 2017 ) 63 : e12412 . 10.1111/jpi.12412 28378373 

  123. 123. Wu YH Ursinus J Zhou JN Scheer FA Ai-Min B Jockers R . Alterations of melatonin receptors MT1 and MT2 in the hypothalamic suprachiasmatic nucleus during depression . J Affect Disord. ( 2013 ) 148 : 357 – 67 . 10.1016/j.jad.2012.12.025 23357659 

  124. 124. Benleulmi-Chaachoua A Chen L Sokolina K Wong V Jurisica I Emerit MB . Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons . J Pineal Res. ( 2016 ) 60 : 95 – 108 . 10.1111/jpi.12294 26514267 

  125. 125. Hardeland R . Melatonin: signaling mechanisms of a pleiotropic agent . Biofactors. ( 2009 ) 35 : 183 – 92 . 10.1002/biof.23 19449447 

  126. 126. Cutando A Aneiros-Fernandez J Lopez-Valverde A Arias-Santiago S Aneiros-Cachaza J Reiter RJ . A new perspective in oral health: potential importance and actions of melatonin receptors MT1, MT2, MT3, and RZR/ROR in the oral cavity . Arch Oral Biol. ( 2011 ) 56 : 944 – 50 . 10.1016/j.archoralbio.2011.03.004 21459362 

  127. 127. Liu J Clough SJ Hutchinson AJ Adamah-Biassi EB Popovska-Gorevski M Dubocovich ML . MT1 and MT2 melatonin receptors: a therapeutic perspective . Ann Rev Pharmacol Toxicol. ( 2016 ) 56 : 361 – 83 . 10.1146/annurev-pharmtox-010814-124742 26514204 

  128. 128. Liu J Clough SJ Dubocovich ML . Role of the MT1 and MT2 melatonin receptors in mediating depressive- and anxiety-like behaviors in C3H/HeN mice . Genes Brain Behav. ( 2017 ) 16 : 546 – 53 . 10.1111/gbb.12369 28160436 

  129. 129. Oishi A Cecon E Jockers R . Melatonin receptor signaling: impact of receptor oligomerization on receptor function . Int Rev Cell Mol Biol. ( 2018 ) 338 : 59 – 77 . 10.1016/bs.ircmb.2018.02.002 29699692 

  130. 130. Boutin JA Ferry G . Is there sufficient evidence that the melatonin binding Site MT3 is Quinone Reductase 2? J Pharmacol Exp Ther. ( 2019 ) 368 : 59 – 65 . 10.1124/jpet.118.253260 30389722 

  131. 131. Hill SM Frasch T Xiang S Yuan L Duplessis T Mao L . Molecular mechanisms of melatonin anticancer effects . Integr Cancer Ther. ( 2009 ) 8 : 337 – 46 . 10.1177/1534735409353332 20050373 

  132. 132. Wang RX Liu H Xu L Zhang H Zhou RX . Involvement of nuclear receptor RZR/RORgamma in melatonin-induced HIF-1alpha inactivation in SGC-7901 human gastric cancer cells . Oncol Rep. ( 2015 ) 34 : 2541 – 6 . 10.3892/or.2015.4238 26330273 

  133. 133. Zhao Y Xu L Ding S Lin N Ji Q Gao L . Novel protective role of the circadian nuclear receptor retinoic acid-related orphan receptor-alpha in diabetic cardiomyopathy . J Pineal Res. ( 2017 ) 62 : e12378 . 10.1111/jpi.12378 27862268 

  134. 134. Boutin JA . Quinone reductase 2 as a promising target of melatonin therapeutic actions . Expert Opin Ther Targets. ( 2016 ) 20 : 303 – 17 . 10.1517/14728222.2016.1091882 26465080 

  135. 135. Benitez-King G Huerto-Delgadillo L Anton-Tay F . Binding of 3H-melatonin to calmodulin . Life Sci. ( 1993 ) 53 : 201 – 7 . 10.1016/0024-3205(93)90670-X 8321083 

  136. 136. Menendez-Menendez J Martinez-Campa C . Melatonin: an anti-tumor agent in hormone-dependent cancers . Int J Endocrinol. ( 2018 ) 2018 : 3271948 . 10.1155/2018/3271948 30386380 

  137. 137. Mendoza-Vargas L Solis-Chagoyan H Benitez-King G Fuentes-Pardo B . MT2-like melatonin receptor modulates amplitude receptor potential in visual cells of crayfish during a 24-hour cycle . Comp Biochem Physiol A. ( 2009 ) 154 : 486 – 92 . 10.1016/j.cbpa.2009.07.025 19666131 

  138. 138. Maciel FE Geihs MA Cruz BP Vargas MA Allodi S Marins LF . Melatonin as a signaling molecule for metabolism regulation in response to hypoxia in the crab Neohelice granulata . Int J Mol Sci. ( 2014 ) 15 : 22405 – 20 . 10.3390/ijms151222405 25486055 

  139. 139. Li G Zhang Y Ni Y Wang Y Xu B Guo X . Identification of a melatonin receptor type 1A gene (AccMTNR1A) in Apis cerana cerana and its possible involvement in the response to low temperature stress . Naturwissenschaften. ( 2018 ) 105 : 24 . 10.1007/s00114-018-1546-0 29569081 

  140. 140. Csaba G . Biogenic amines at a low level of evolution: production, functions and regulation in the unicellular Tetrahymena . Acta Microbiol Immunol Hungar. ( 2015 ) 62 : 93 – 108 . 10.1556/030.62.2015.2.1 26132831 

  141. 141. Arnao MB Hernández-Ruiz J . Growth conditions influence the melatonin content of tomato plants . Food Chem. ( 2013 ) 138 : 1212 – 4 . 10.1016/j.foodchem.2012.10.077 23411233 

  142. 142. Shi H Jiang C Ye T Tan DX Reiter RJ Zhang H . Comparative physiological, metabolomic, and transcriptomic analyses reveal mechanisms of improved abiotic stress resistance in bermudagrass [Cynodon dactylon (L) . Pers] by exogenous melatonin. J Exp Bot. ( 2015 ) 66 : 681 – 94 . 10.1093/jxb/eru373 25225478 

  143. 143. Tosini G Owino S Guillaume JL Jockers R . Understanding melatonin receptor pharmacology: latest insights from mouse models, and their relevance to human disease . Bioessays. ( 2014 ) 36 : 778 – 87 . 10.1002/bies.201400017 24903552 

  144. 144. Reiter RJ Tan DX Rosales-Corral S Manchester LC . The universal nature, unequal distribution and antioxidant functions of melatonin and its derivatives . Mini Rev Med Chem. 13 : 373 – 84 . 10.2174/138955713804999810 23190034 

  145. 145. Hardeland R . Melatonin in plants - diversity of levels and multiplicity of functions . Front Plant Sci. ( 2016 ) 7 : 198 . 10.3389/fpls.2016.00198 26925091 

  146. 146. Hardeland R . Melatonin in plants and other phototrophs: advances and gaps concerning the diversity of functions . J Exp Bot. ( 2015 ) 66 : 627 – 46 . 10.1093/jxb/eru386 25240067 

  147. 147. Bochkov DV Sysolyatin SV Kalashnikov AI Surmacheva IA . Shikimic acid: review of its analytical, isolation, and purification techniques from plant and microbial sources . J Chem Biol. ( 2012 ) 5 : 5 – 17 . 10.1007/s12154-011-0064-8 22826715 

  148. 148. Fuhrberg B Hardeland R Poeggeler B Behrmann C Dramatic rises of melatonin and 5-methoxytryptamine in Gonyaulax exposed to decreased temperature . J Interdiscip Cycle Res. ( 1997 ) 28 : 144 – 50 . 10.1076/brhm.28.1.144.12978 

  149. 149. De Luca V Marineau C Brisson N . Molecular cloning and analysis of cDNA encoding a plant tryptophan decarboxylase: comparison with animal dopa decarboxylases . Proc Natl Acad Sci USA. ( 1989 ) 86 : 2582 – 6 . 10.1073/pnas.86.8.2582 2704736 

  150. 150. Park M Kang K Park S Back K . Conversion of 5-hydroxytryptophan into serotonin by tryptophan decarboxylase in plants, Escherichia coli , and yeast . Biosci Biotech Bioch . ( 2008 ) 72 : 2456 – 8 . 10.1271/bbb.80220 18776677 

  151. 151. Axelrod J Weissbach H . Enzymatic O -methylation of N -acetylserotonin to melatonin . Science. ( 1960 ) 131 : 1312 . 10.1126/science.131.3409.1312 13795316 

  152. 152. Weissbach H Redfield BG Axelrod J . Biosynthesis of melatonin: enzymic conversion of serotonin to N -acetylserotonin . Biochim Biophys Acta. ( 1960 ) 43 : 352 – 3 . 10.1016/0006-3002(60)90453-4 13784117 

  153. 153. Kang K Lee K Park S Byeon Y Back K . Molecular cloning of rice serotonin N -acetyltransferase, the penultimate gene in plant melatonin biosynthesis . J Pineal Res. ( 2013 ) 55 : 7 – 13 . 10.1111/jpi.12011 22998587 

  154. 154. Byeon Y Choi GH Lee HY Back K . Melatonin biosynthesis requires N -acetylserotonin methyltransferase activity of caffeic acid O -methyltransferase in rice . J Exp Bot. ( 2015 ) 66 : 6917 – 25 . 10.1093/jxb/erv396 26276868 

  155. 155. Byeon Y Lee HJ Lee HY Back K . Cloning and functional characterization of the Arabidopsis N -acetylserotonin O -methyltransferase responsible for melatonin synthesis . J Pineal Res. ( 2016 ) 60 : 65 – 73 . 10.1111/jpi.12289 26484897 

  156. 156. Klein DC Arylalkylamine N -acetyltransferase: “the timezyme” . J Biol Chem. ( 2007 ) 282 : 4233 – 7 . 10.1074/jbc.R600036200 17164235 

  157. 157. Kang K Kong K Park S Natsagdorj U Kim YS Back K . Molecular cloning of a plant N -acetylserotonin methyltransferase and its expression characteristics in rice . J Pineal Res. ( 2011 ) 50 : 304 – 9 . 10.1111/j.1600-079X.2010.00841.x 21210840 

  158. 158. Tan DX Hardeland R Manchester LC Korkmaz A Ma S Rosales-Corral S . Functional roles of melatonin in plants, and perspectives in nutritional and agricultural science . J Exp Bot. ( 2012 ) 63 : 577 – 97 . 10.1093/jxb/err256 22016420 

  159. 159. Lee K Back K . Overexpression of rice serotonin N -acetyltransferase 1 in transgenic rice plants confers resistance to cadmium and senescence and increases grain yield . J Pineal Res. ( 2017 ) 62 : e12392 . 10.1111/jpi.12392 28118490 

  160. 160. Byeon Y Lee HY Lee K Back K . Caffeic acid O -methyltransferase is involved in the synthesis of melatonin by methylating N -acetylserotonin in Arabidopsis . J Pineal Res. ( 2014 ) 57 : 219 – 27 . 10.1111/jpi.12160 25039887 

  161. 161. Lee K Lee HY Back K . Rice histone deacetylase 10 and Arabidopsis histone deacetylase 14 genes encode N -acetylserotonin deacetylase, which catalyzes conversion of N -acetylserotonin into serotonin, a reverse reaction for melatonin biosynthesis in plants . J Pineal Res. ( 2017 ) 64 : e12460 . 10.1111/jpi.12460 29247559 

  162. 162. Esser C Ahmadinejad N Wiegand C Rotte C Sebastiani F Gelius-Dietrich G . A genome phylogeny for mitochondria among α-Proteobacteria and a predominantly eubacterial ancestry of yeast nuclear genes . Mol Biol Evol. ( 2004 ) 21 : 1643 – 60 . 10.1093/molbev/msh160 15155797 

  163. 163. Archibald JM . Endosymbiosis and eukaryotic cell evolution . Curr Biol. ( 2015 ) 25 : R911 – 21 . 10.1016/j.cub.2015.07.055 26439354 

  164. 164. Gentil J Hempel F Moog D Zauner S Maier U . Origin of complex algae by secondary endosymbiosis: a journey through time . Protoplasma. ( 2017 ) 254 : 1835 – 43 . 10.1007/s00709-017-1098-8 28290059 

  165. 165. Wang L Feng C Zheng X Guo Y Zhou F Shan D . Plant mitochondria synthesize melatonin and enhance the tolerance of plants to drought stress . J Pineal Res. ( 2017 ) 63 : e12429 . 10.1111/jpi.12429 28599069 

  166. 166. Zheng X Tan DX Allan AC Zuo B Zhao Y Reiter RJ . Chloroplastic biosynthesis of melatonin and its involvement in protection of plants from salt stress . Sci Rep. ( 2017 ) 7 : 41236 . 10.1038/srep41236 28145449 

  167. 167. Byeon Y Lee K Park YI Park S Back K . Molecular cloning and functional analysis of serotonin N -acetyltransferase from the cyanobacterium Synechocystis sp . PCC 6803. J Pineal Res. ( 2013 ) 55 : 371 – 6 . 10.1111/jpi.12080 23952748 

  168. 168. Byeon Y Yool Lee H Choi DW Back K . Chloroplast-encoded serotonin N -acetyltransferase in the red alga Pyropia yezoensis : gene transition to the nucleus from chloroplasts . J Exp Bot. ( 2015 ) 66 : 709 – 17 . 10.1093/jxb/eru357 25183745 

  169. 169. Coon SL Klein DC . Evolution of arylalkylamine N -acetyltransferase: emergence and divergence . Mol Cell Endocrinol. ( 2006 ) 252 : 2 – 10 . 10.1016/j.mce.2006.03.039 16697105 

  170. 170. Kurland CG Andersson SGE . Origin and evolution of the mitochondrial proteome . Microbiol Mol Biol Rev. ( 2000 ) 64 : 786 – 820 . 10.1128/MMBR.64.4.786-820.2000 11104819 

  171. 171. Tan DX Reiter RJ Mitochondria: the birth place, battle ground and site of melatonin metabolism in cells . Melatonin Res. ( 2019 ) 2 : 44 – 66 . 10.32794/nr11250011 

  172. 172. Falcón J Coon SL Besseau L Cazaméa-Catalan D Fuentès M Magnanou E . Drastic neofunctionalization associated with evolution of the timezyme AANAT 500 Mya . Proc Natl Acad Sci USA . ( 2014 ) 111 : 314 – 9 . 10.1073/pnas.1312634110 24351931 

  173. 173. Shi L Tu BP . Acetyl-CoA and the regulation of metabolism: mechanisms and consequences . Curr Opin Cell Biol. ( 2015 ) 33 : 125 – 31 . 10.1016/j.ceb.2015.02.003 25703630 

  174. 174. Mehta MM Weinberg SE Chandel NS . Mitochondrial control of immunity: beyond ATP . Nat Rev Immunol. ( 2017 ) 17 : 608 . 10.1038/nri.2017.66 28669986 

  175. 175. Park S Byeon Y Kim YS Back K . Kinetic analysis of purified recombinant rice N-acetylserotonin methyltransferase and peak melatonin production in etiolated rice shoots . J Pineal Res. ( 2013 ) 54 : 139 – 44 . 10.1111/j.1600-079X.2012.01019.x 22747959 

  176. 176. Lecharny A Wagner E Stem extension rate in light-grown plants . Evidence for an endogenous circadian rhythm in Chenopodium rubrum. Physiol Plant. ( 1984 ) 60 : 437 – 43 . 10.1111/j.1399-3054.1984.tb06089.x 

  177. 177. Kolář J Macháčková I . Melatonin in higher plants: occurrence and possible functions . J Pineal Res. ( 2005 ) 39 : 333 – 41 . 10.1111/j.1600-079X.2005.00276.x 16207287 

  178. 178. Reiter RJ Tan DX Burkhardt S Manchester LC Melatonin in plants . Nutr Rev. ( 2001 ) 59 : 286 – 90 . 10.1111/j.1753-4887.2001.tb07018.x 11570431 

  179. 179. Murch SJ Simmons CB Saxena PK . Melatonin in feverfew and other medicinal plants . Lancet. ( 1997 ) 350 : 1598 – 9 . 10.1016/S0140-6736(05)64014-7 9393344 

  180. 180. Brown PN Turi CE Shipley PR Murch SJ . Comparisons of large ( Vaccinium macrocarpon Ait.) and small ( Vaccinium oxycoccos L., Vaccinium vitis-idaea L.) cranberry in British Columbia by phytochemical determination, antioxidant potential, and metabolomic profiling with chemometric analysis . Planta Med. ( 2012 ) 78 : 630 – 40 . 10.1055/s-0031-1298239 22337317 

  181. 181. Arnao MB Hernández-Ruiz J . Growth conditions determine different melatonin levels in Lupinus albus L . J Pineal Res. ( 2013 ) 55 : 149 – 55 . 10.1111/jpi.12055 23600673 

  182. 182. Tan DX Manchester LC Sainz RM Mayo JC Leon J Reiter RJ . Physiological ischemia/reperfusion phenomena and their relation to endogenous melatonin production: a hypothesis . Endocrine. ( 2005 ) 27 : 149 – 58 . 10.1385/ENDO:27:2:149 16217128 

  183. 183. Murch SJ KrishnaRaj S Saxena PK . Tryptophan is a precursor for melatonin and serotonin biosynthesis in in vitro regenerated St . John's wort (Hypericum perforatum L cv Anthos) plants . Plant Cell Rep. ( 2000 ) 19 : 698 – 704 . 10.1007/s002990000206 30754808 

  184. 184. Reiter RJ . Melatonin: the chemical expression of darkness . Mol Cell Endocrinol. ( 1991 ) 79 : C153 – 8 . 1936532 

  185. 185. Ebihara S Adachi A Hasegawa M Nogi T Yoshimura T Hirunagi K . In vivo microdialysis studies of pineal and ocular melatonin rhythms in birds . Neurosignals. ( 1997 ) 6 : 233 – 40 . 10.1159/000109133 9500661 

  186. 186. Kim TD Woo KC Cho S Ha DC Jang SK Kim KT . Rhythmic control of AANAT translation by hnRNP Q in circadian melatonin production . Genes Dev. ( 2007 ) 21 : 797 – 810 . 10.1101/gad.1519507 17403780 

  187. 187. Hardeland R Pandi-Perumal S Poeggeler B Melatonin in plants - focus on a vertebrate night hormone with cytoprotective properties . Funct Plant Sci Biotechnol. ( 2007 ) 1 : 32 – 45 . 

  188. 188. Byeon Y Back K . Melatonin synthesis in rice seedlings in vivo is enhanced at high temperatures and under dark conditions due to increased serotonin N -acetyltransferase and N -acetylserotonin methyltransferase activities . J Pineal Res. ( 2014 ) 56 : 189 – 95 . 10.1111/jpi.12111 24313332 

  189. 189. Park S Lee DE Jang H Byeon Y Kim YS Back K . Melatonin-rich transgenic rice plants exhibit resistance to herbicide-induced oxidative stress . J Pineal Res. ( 2013 ) 54 : 258 – 63 . 10.1111/j.1600-079X.2012.01029.x 22856683 

  190. 190. Liu T Borjigin J . N -acetyltransferase is not the rate-limiting enzyme of melatonin synthesis at night . J Pineal Res. ( 2005 ) 39 : 91 – 6 . 10.1111/j.1600-079X.2005.00223.x 15978063 

  191. 191. Zuo B Zheng X He P Wang L Lei Q Feng C . Overexpression of MzASMT improves melatonin production and enhances drought tolerance in transgenic Arabidopsis thaliana plants . J Pineal Res. ( 2014 ) 57 : 408 – 17 . 10.1111/jpi.12180 25250844 

  192. 192. Byeon Y Back K . Low melatonin production by suppression of either serotonin N -acetyltransferase or N -acetylserotonin methyltransferase in rice causes seedling growth retardation with yield penalty, abiotic stress susceptibility, and enhanced coleoptile growth under anoxic conditions . J Pineal Res. ( 2016 ) 60 : 348 – 59 . 10.1111/jpi.12317 26919041 

  193. 193. Klein DC . Evolution of the vertebrate pineal gland: the AANAT hypothesis . Chronobiol Int. ( 2006 ) 23 : 5 – 20 . 10.1080/07420520500545839 16687276 

  194. 194. Schomerus C Korf HW . Mechanisms regulating melatonin synthesis in the mammalian pineal organ . Ann N Y Acad Sci. ( 2005 ) 1057 : 372 – 83 . 10.1196/annals.1356.028 16399907 

  195. 195. Pozdeyev N Taylor C Haque R Chaurasia SS Visser A Thazyeen A . Photic regulation of arylalkylamine N-acetyltransferase binding to 14-3-3 proteins in retinal photoreceptor cells . J Neurosci. ( 2006 ) 26 : 9153 – 61 . 10.1523/jneurosci.1384-06.2006 16957072 

  196. 196. Byeon Y Park S Lee HY Kim YS Back K . Elevated production of melatonin in transgenic rice seeds expressing rice tryptophan decarboxylase . J Pineal Res. ( 2014 ) 56 : 275 – 82 . 10.1111/jpi.12120 24433490 

  197. 197. Li MQ Hasan MK Li CX Ahammed GJ Xia XJ Shi K . Melatonin mediates selenium-induced tolerance to cadmium stress in tomato plants . J Pineal Res. ( 2016 ) 61 : 291 – 302 . 10.1111/jpi.12346 27264631 

  198. 198. Shi H Chen Y Tan DX Reiter RJ Chan Z He C . Melatonin induces nitric oxide and the potential mechanisms relate to innate immunity against bacterial pathogen infection in Arabidopsis . J Pineal Res. ( 2015 ) 59 : 102 – 8 . 10.1111/jpi.12244 25960153 

  199. 199. Shi H Qian Y Tan DX Reiter RJ He C . Melatonin induces the transcripts of CBF/DREB1s and their involvement in both abiotic and biotic stresses in Arabidopsis . J Pineal Res. ( 2015 ) 59 : 334 – 42 . 10.1111/jpi.12262 26182834 

  200. 200. Shi H Reiter RJ Tan DX Chan Z . INDOLE-3-ACETIC ACID INDUCIBLE 17 positively modulates natural leaf senescence through melatonin-mediated pathway in Arabidopsis . J Pineal Res. ( 2015 ) 58 : 26 – 33 . 10.1111/jpi.12188 25324183 

  201. 201. Shi H Tan DX Reiter RJ Ye T Yang F Chan Z . Melatonin induces class A1 heat-shock factors (HSFA1s) and their possible involvement of thermotolerance in Arabidopsis . J Pineal Res. ( 2015 ) 58 : 335 – 42 . 10.1111/jpi.12219 25711624 

  202. 202. Shi H Wang X Tan DX Reiter RJ Chan Z . Comparative physiological and proteomic analyses reveal the actions of melatonin in the reduction of oxidative stress in Bermuda grass ( Cynodon dactylon (L). Pers) . J Pineal Res. ( 2015 ) 59 : 120 – 31 . 10.1111/jpi.12246 25958881 

  203. 203. Zhang N Sun Q Zhang H Cao Y Weeda S Ren S . Roles of melatonin in abiotic stress resistance in plants . J Exp Bot. ( 2015 ) 66 : 647 – 56 . 10.1093/jxb/eru336 25124318 

  204. 204. Ganguly S Weller JL Ho A Chemineau P Malpaux B Klein DC . Melatonin synthesis: 14-3-3-dependent activation and inhibition of arylalkylamine N -acetyltransferase mediated by phosphoserine-205 . Proc Natl Acad Sci USA. ( 2005 ) 102 : 1222 – 7 . 10.1073/pnas.0406871102 15644438 

  205. 205. Wei Y Liu G Bai Y Xia F He C Shi H . Two transcriptional activators of N -acetylserotonin O -methyltransferase 2 and melatonin biosynthesis in cassava . J Exp Bot. ( 2017 ) 68 : 4997 – 5006 . 10.1093/jxb/erx305 28992113 

  206. 206. Scortegagna M Galdzicki Z Rapoport SI Hanbauer I . Activator protein-1 DNA binding activation by hydrogen peroxide in neuronal and astrocytic primary cultures of trisomy-16 and diploid mice . Mol Brain Res. ( 1999 ) 73 : 144 – 50 . 10.1016/S0169-328X(99)00257-0 10581408 

  207. 207. Seematter G Binnert C Martin JL Tappy L . Relationship between stress, inflammation and metabolism . Curr Opin Clin Nutr Metab Care. ( 2004 ) 7 : 169 – 73 . 10.1097/00075197-200403000-00011 15075708 

  208. 208. da Silveira Cruz-Machado S Tamura EK Carvalho-Sousa CE Rocha VA Pinato L Fernandes PAC . Daily corticosterone rhythm modulates pineal function through NFkappaB-related gene transcriptional program . Sci Rep. ( 2017 ) 7 : 2091 . 10.1038/s41598-017-02286-y 28522814 

  209. 209. Muxel SM Pires-Lapa MA Monteiro AWA Cecon E Tamura EK Floeter-Winter LM . NF-κB drives the synthesis of melatonin in RAW 264 .7 macrophages by inducing the transcription of the arylalkylamine- N- acetyltransferase (AA-NAT) gene. PloS ONE. ( 2012 ) 7 : e52010 . 10.1371/journal.pone.0052010 23284853 

  210. 210. Chong NW Bernard M Klein DC . Characterization of the chicken serotonin N -acetyltransferase gene: activation via clock gene heterodimer/E-box interaction . J Biol Chem. ( 2000 ) 275 : 32991 – 8 . 10.1074/jbc.M005671200 10931848 

  211. 211. Haque R Chong NW Ali F Chaurasia SS Sengupta T Chun E . Melatonin synthesis in retina: cAMP-dependent transcriptional regulation of chicken arylalkylamine N -acetyltransferase by a CRE-like sequence and a TTATT repeat motif in the proximal promoter . J Neurochem. ( 2011 ) 119 : 6 – 17 . 10.1111/j.1471-4159.2011.07397.x 21790603 

  212. 212. Baler R Covington S Klein DC . Rat arylalkylamine N -acetyltransferase gene: upstream and intronic components of a bipartite promoter . Biol Cell. ( 1999 ) 91 : 699 – 705 . 10.1111/j.1768-322X.1999.tb01114.x 10668100 

  213. 213. Burke Z Wells T Carter D Klein D Baler R . Genetic targeting: the serotonin N -acetyltransferase promoter imparts circadian expression selectively in the pineal gland and retina of transgenic rats . J Neurochem. ( 1999 ) 73 : 1343 – 9 . 10.1046/j.1471-4159.1999.0731343.x 10501177 

  214. 214. Wei J Li DX Zhang JR Shan C Rengel Z Song ZB . Phytomelatonin receptor PMTR1-mediated signaling regulates stomatal closure in Arabidopsis thaliana . J Pineal Res. ( 2018 ) 65 : e12500 . 10.1111/jpi.12500 29702752 

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