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[해외논문] Network Inference Analysis Identifies SETDB1 as a Key Regulator for Reverting Colorectal Cancer Cells into Differentiated Normal-Like Cells 원문보기

Molecular cancer research, v.18 no.1, 2020년, pp.118 - 129  

Lee, Soobeom (Laboratory for Systems Biology and Bio-inspired Engineering, Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.) ,  Lee, Chansu (Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.) ,  Hwang, Chae Young (Laboratory for Systems Biology and Bio-inspired Engineering, Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.) ,  Kim, Dongsan (Laboratory for Systems Biology and Bio-inspired Engineering, Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.) ,  Han, Younghyun (Laboratory for Systems Biology and Bio-inspired Engineering, Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.) ,  Hong, Sung Noh (Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of K) ,  Kim, Seok-Hyung ,  Cho, Kwang-Hyun

Abstract AI-Helper 아이콘AI-Helper

Cancer cells exhibit properties of cells in a less differentiated state than the adjacent normal cells in the tissue. We explored whether cancer cells can be converted to a differentiated normal-like state by restoring the gene regulatory network (GRN) of normal cells. Here, we report that colorecta...

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